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Vinod K. Tiwari - One of the best experts on this subject based on the ideXlab platform.

  • an account of phytochemicals from Plumbago Zeylanica family plumbaginaceae a natural gift to human being
    Chronicles of Young Scientists, 2012
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    The semi-climbing sub-shrub Plumbago Zeylanica (family: Plumbaginaceae) is a widely accepted ethnomedicine around the world including India, Pakistan, Bangladesh, Sri Lanka, and Australia. The plant is credited with potential therapeutic properties including antiatherogenic, cardiotonic, hepatoprotective, and neuroprotective properties. The present review highlights the various medicinal and pharmacological aspects along with recent updates on phytochemical contents of the plant.

  • An antileishmanial prenyloxy-naphthoquinone from roots of Plumbago Zeylanica
    Natural product research, 2012
    Co-Authors: Bhuwan B. Mishra, Navneet Kishore, Vyasji Tripathi, Jalaj Kumar Gour, Rakesh K. Singh, Vinod K. Tiwari
    Abstract:

    Leishmania donovani, an obligate intracellular parasite of genus Leishmania causes visceral leishmaniasis that affects millions of people worldwide, especially in the Indian subcontinent and East Africa. Generic pentavalent antimonials have been the mainstay for therapy in the endemic regions due to efficacy and cost effectiveness but the growing incidence of their resistance has seriously hampered their use. This study discloses strong in vitro antileishmanial activity of 2-methyl-5 -(3′-methyl-but-2′-enyloxy)-[1,4]naphthoquinone (1), a prenyloxy-naphthoquinone isolated and characterised from roots of the plant Plumbago Zeylanica (family – Plumbaginaceae). The observed EC50 for the compound 1 against promastigote and amastigote forms of L. donovani was significantly (p 

  • An account of phytochemicals from Plumbago Zeylanica (Family: Plumbaginaceae): A natural gift to human being #
    Chronicles of Young Scientists, 2012
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    The semi-climbing sub-shrub Plumbago Zeylanica (family: Plumbaginaceae) is a widely accepted ethnomedicine around the world including India, Pakistan, Bangladesh, Sri Lanka, and Australia. The plant is credited with potential therapeutic properties including antiatherogenic, cardiotonic, hepatoprotective, and neuroprotective properties. The present review highlights the various medicinal and pharmacological aspects along with recent updates on phytochemical contents of the plant.

  • Difuranonaphthoquinones from Plumbago Zeylanica roots
    Phytochemistry Letters, 2010
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    Abstract The naphthoquinones, lapachol ( 1 ), plumbagin ( 2 ), 2-isopropenyl-9-methoxy-1,8-di-oxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 3 ), 9-hydroxy-2-isopropenyl-1,8-dioxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 4 ), 2-(1-hydroxy-1-methyl-ethyl)-9-methoxy-1,8-dioxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 5 ) and 5,7-dihydroxy-8-methoxy-2-methyl-1,4-naphthoquinone ( 6 ) were isolated isolated from roots of Plumbago Zeylanica . The new constituents ( 3 – 5 ) in addition to known compounds ( 1 , 2 and 6 ) were characterized by spectral analysis (UV, IR, 1D & 2D NMR and MS).

Ephrem Engidawork - One of the best experts on this subject based on the ideXlab platform.

  • Toxicity studies on dermal application of plant extract of Plumbago Zeylanica used in Ethiopian traditional medicine.
    Journal of ethnopharmacology, 2008
    Co-Authors: Kefale Teshome, Tsige Gebre-mariam, Kaleab Asres, Franklin Perry, Ephrem Engidawork
    Abstract:

    Plant-based therapeutic preparations are cyclically returning to complement dermatologic therapy, however, data on the toxicity profile of such plants are lacking. In the present study, Plumbago Zeylanica, a medicinal plant commonly used in Ethiopia for skin diseases was subjected to a systematic dermatotoxicity study. To this effect, the dermatotoxicity of 80% methanol extract of the root part of Plumbago Zeylanica was investigated in animals following standard procedures for irritation, sensitization, acute toxicity and repeated toxicity tests. Extraction of plant material with 80% methanol resulted in 9.45% of crude extract of Plumbago Zeylanica. The skin irritation test on rabbits showed Plumbago Zeylanica extract to be a moderate irritant, with a primary irritation index of 2.00. Sensitization test on mice by the Mouse Ear Swelling Test method revealed the extract to be non-sensitizer in a dose range of 4–10 mg/ml and the percent responder was zero. Acute dermal toxicity test on rats did not produce any overt signs of toxicity, except that there was a weight gain difference between the test and control groups of female rats. This was not, however, supported by other parameters, like the absolute and relative organ weights. Repeated dose toxicity test was associated with increased relative testis weight (P < 0.05) as well as higher values for Blood urea nitrogen and K + (P < 0.05) in both sexes with the highest dose (1000 mg/kg) group, although histopathological analyses failed to lend support to these observations. Taken together, the dermatotoxicity test results from this study suggest that Plumbago Zeylanica toxic effects might be limited to effects like moderate irritation.

Chengjen Chou - One of the best experts on this subject based on the ideXlab platform.

  • cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago Zeylanica
    Phytochemistry, 2003
    Co-Authors: Lingling Yang, Chengjen Chou
    Abstract:

    Two plumbagic acid glucosides, 3′-O-β-glucopyranosyl plumbagic acid and 3′-O-β-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago Zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.

Vyasji Tripathi - One of the best experts on this subject based on the ideXlab platform.

  • an account of phytochemicals from Plumbago Zeylanica family plumbaginaceae a natural gift to human being
    Chronicles of Young Scientists, 2012
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    The semi-climbing sub-shrub Plumbago Zeylanica (family: Plumbaginaceae) is a widely accepted ethnomedicine around the world including India, Pakistan, Bangladesh, Sri Lanka, and Australia. The plant is credited with potential therapeutic properties including antiatherogenic, cardiotonic, hepatoprotective, and neuroprotective properties. The present review highlights the various medicinal and pharmacological aspects along with recent updates on phytochemical contents of the plant.

  • An antileishmanial prenyloxy-naphthoquinone from roots of Plumbago Zeylanica
    Natural product research, 2012
    Co-Authors: Bhuwan B. Mishra, Navneet Kishore, Vyasji Tripathi, Jalaj Kumar Gour, Rakesh K. Singh, Vinod K. Tiwari
    Abstract:

    Leishmania donovani, an obligate intracellular parasite of genus Leishmania causes visceral leishmaniasis that affects millions of people worldwide, especially in the Indian subcontinent and East Africa. Generic pentavalent antimonials have been the mainstay for therapy in the endemic regions due to efficacy and cost effectiveness but the growing incidence of their resistance has seriously hampered their use. This study discloses strong in vitro antileishmanial activity of 2-methyl-5 -(3′-methyl-but-2′-enyloxy)-[1,4]naphthoquinone (1), a prenyloxy-naphthoquinone isolated and characterised from roots of the plant Plumbago Zeylanica (family – Plumbaginaceae). The observed EC50 for the compound 1 against promastigote and amastigote forms of L. donovani was significantly (p 

  • An account of phytochemicals from Plumbago Zeylanica (Family: Plumbaginaceae): A natural gift to human being #
    Chronicles of Young Scientists, 2012
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    The semi-climbing sub-shrub Plumbago Zeylanica (family: Plumbaginaceae) is a widely accepted ethnomedicine around the world including India, Pakistan, Bangladesh, Sri Lanka, and Australia. The plant is credited with potential therapeutic properties including antiatherogenic, cardiotonic, hepatoprotective, and neuroprotective properties. The present review highlights the various medicinal and pharmacological aspects along with recent updates on phytochemical contents of the plant.

  • Difuranonaphthoquinones from Plumbago Zeylanica roots
    Phytochemistry Letters, 2010
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    Abstract The naphthoquinones, lapachol ( 1 ), plumbagin ( 2 ), 2-isopropenyl-9-methoxy-1,8-di-oxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 3 ), 9-hydroxy-2-isopropenyl-1,8-dioxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 4 ), 2-(1-hydroxy-1-methyl-ethyl)-9-methoxy-1,8-dioxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 5 ) and 5,7-dihydroxy-8-methoxy-2-methyl-1,4-naphthoquinone ( 6 ) were isolated isolated from roots of Plumbago Zeylanica . The new constituents ( 3 – 5 ) in addition to known compounds ( 1 , 2 and 6 ) were characterized by spectral analysis (UV, IR, 1D & 2D NMR and MS).

Bhuwan B. Mishra - One of the best experts on this subject based on the ideXlab platform.

  • an account of phytochemicals from Plumbago Zeylanica family plumbaginaceae a natural gift to human being
    Chronicles of Young Scientists, 2012
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    The semi-climbing sub-shrub Plumbago Zeylanica (family: Plumbaginaceae) is a widely accepted ethnomedicine around the world including India, Pakistan, Bangladesh, Sri Lanka, and Australia. The plant is credited with potential therapeutic properties including antiatherogenic, cardiotonic, hepatoprotective, and neuroprotective properties. The present review highlights the various medicinal and pharmacological aspects along with recent updates on phytochemical contents of the plant.

  • An antileishmanial prenyloxy-naphthoquinone from roots of Plumbago Zeylanica
    Natural product research, 2012
    Co-Authors: Bhuwan B. Mishra, Navneet Kishore, Vyasji Tripathi, Jalaj Kumar Gour, Rakesh K. Singh, Vinod K. Tiwari
    Abstract:

    Leishmania donovani, an obligate intracellular parasite of genus Leishmania causes visceral leishmaniasis that affects millions of people worldwide, especially in the Indian subcontinent and East Africa. Generic pentavalent antimonials have been the mainstay for therapy in the endemic regions due to efficacy and cost effectiveness but the growing incidence of their resistance has seriously hampered their use. This study discloses strong in vitro antileishmanial activity of 2-methyl-5 -(3′-methyl-but-2′-enyloxy)-[1,4]naphthoquinone (1), a prenyloxy-naphthoquinone isolated and characterised from roots of the plant Plumbago Zeylanica (family – Plumbaginaceae). The observed EC50 for the compound 1 against promastigote and amastigote forms of L. donovani was significantly (p 

  • An account of phytochemicals from Plumbago Zeylanica (Family: Plumbaginaceae): A natural gift to human being #
    Chronicles of Young Scientists, 2012
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    The semi-climbing sub-shrub Plumbago Zeylanica (family: Plumbaginaceae) is a widely accepted ethnomedicine around the world including India, Pakistan, Bangladesh, Sri Lanka, and Australia. The plant is credited with potential therapeutic properties including antiatherogenic, cardiotonic, hepatoprotective, and neuroprotective properties. The present review highlights the various medicinal and pharmacological aspects along with recent updates on phytochemical contents of the plant.

  • Difuranonaphthoquinones from Plumbago Zeylanica roots
    Phytochemistry Letters, 2010
    Co-Authors: Navneet Kishore, Bhuwan B. Mishra, Vinod K. Tiwari, Vyasji Tripathi
    Abstract:

    Abstract The naphthoquinones, lapachol ( 1 ), plumbagin ( 2 ), 2-isopropenyl-9-methoxy-1,8-di-oxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 3 ), 9-hydroxy-2-isopropenyl-1,8-dioxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 4 ), 2-(1-hydroxy-1-methyl-ethyl)-9-methoxy-1,8-dioxa-dicyclopenta[ b,g ]naphthalene-4,10-dione ( 5 ) and 5,7-dihydroxy-8-methoxy-2-methyl-1,4-naphthoquinone ( 6 ) were isolated isolated from roots of Plumbago Zeylanica . The new constituents ( 3 – 5 ) in addition to known compounds ( 1 , 2 and 6 ) were characterized by spectral analysis (UV, IR, 1D & 2D NMR and MS).