The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Villepekka Seppa - One of the best experts on this subject based on the ideXlab platform.
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sources of variability in expiratory flow profiles during sleep in healthy young children
Respiratory Physiology & Neurobiology, 2020Co-Authors: Anton Hult, Javier Graciatabuenca, Davor Plavec, Romana Gjergja Juraski, Markku Partinen, Villepekka SeppaAbstract:Abstract Standard lung function tests are not feasible in young children, but recent studies show that the variability of expiratory tidal breathing flow-volume (TBFV) curves during sleep is a potential indirect marker of lower airway obstruction. However, the neurophysiological sources of the TBFV variability in normal subjects has not been established. We investigated sleep stages and body position changes as potential sources for the TBFV curve variability. Simultaneous impedance Pneumography (IP), polysomnography (PSG) and video recordings were done in 20 children aged 1.4–6.9 years without significant respiratory disorders during sleep. The early part of expiratory TBFV curves are less variable between cycles of REM than NREM sleep. However, within individual sleep cycles, TBFV curves during N3 are the least variable. The differences in TBFV curve shapes between sleep stages are the main source of overnight variability in TBFV curves and the changes in body position have a lesser impact.
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tidal breathing flow profiles during sleep in wheezing children measured by impedance Pneumography
Respiratory Physiology & Neurobiology, 2020Co-Authors: Javier Graciatabuenca, Jari Viik, Villepekka Seppa, Marita Paassilta, Milla Jauhiainen, Jussi KarjalainenAbstract:Abstract For the first time, impedance Pneumography (IP) enables a continuous analysis of the tidal breathing flow volume (TBFV), overnight. We studied how corticosteroid inhalation treatments, sleep stage, and time from sleep onset modify the nocturnal TBFV profiles of children. Seventy children, 1–5 years old and with recurrent wheezing, underwent three, full-night TBFVs recordings at home, using IP. The first recorded one week before ending a 3-months inhaled corticosteroids treatment, and remaining two, 2 and 4 weeks after treatment. TBFV profiles were grouped by hour from sleep onset and estimated sleep stage. Compared with on-medication, the off-medication profiles showed lower volume at exhalation peak flow, earlier interruption of expiration, and less convex middle expiration. The differences in the first two features were significant during non-rapid eye movement (NREM), and the differences in the third were more prominent during REM after 4 h of sleep. These combinations of TBFV features, sleep phase, and sleep time potentially indicate airflow limitation in young children.
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tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance Pneumography
Journal of Applied Physiology, 2019Co-Authors: Javier Graciatabuenca, Jari Viik, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Milla Jauhiainen, Kristiina Malmstrom, Pekka L MalmbergAbstract:Impedance Pneumography was used to investigate overnight tidal breathing flow volume (TBFV) indexes and their interactions with sleep phase [rapid eye movement (REM) vs. non-REM] at home in wheezin...
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airway obstruction is associated with reduced variability in specific parts of the tidal breathing flow volume curve in young children
ERJ Open Research, 2019Co-Authors: Villepekka Seppa, Jari Viik, Anton Hult, Javier Graciatabuenca, Marita Paassilta, Davor Plavec, Jussi KarjalainenAbstract:Impedance Pneumography recordings during sleep at night show reduced variability in specific parts of the expiratory flow–volume curve in children with recurrent wheezehttp://bit.ly/2Wkfap0
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nonlinear local projection filter for impedance Pneumography
Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) Nordic-Baltic Conference on Biomedical Engineering and Medical , 2017Co-Authors: Javier Gracia, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Pekka Malmberg, Jari ViikAbstract:The ability of impedance Pneumography (IP) for recording tidal flow during long periods of free breathing make it a promising tool for assessing temporal complexity of respiration. However, techniques quantifying complexity may be sensitive to the noise in the IP signal resulting from the current processing method. A nonlinear local projection filter (NLPF) is presented as the solution to the current linear processing method, failing to reduce noise without distorting the flow signal. Current and proposed NLPF methods were applied to and existing data set of raw IP recorded in 21 infants during a methacholine challenge test. Methods’ performance was compared in a battery of test using mouth flow as a reference. NLPF achieved lower sample-by-sample error, and higher frequency attenuation, while linearity with mouth flow was maintained. Therefore, we concluded that NLPF superiorly reduces noise without distorting respiratory information.
Jari Viik - One of the best experts on this subject based on the ideXlab platform.
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tidal breathing flow profiles during sleep in wheezing children measured by impedance Pneumography
Respiratory Physiology & Neurobiology, 2020Co-Authors: Javier Graciatabuenca, Jari Viik, Villepekka Seppa, Marita Paassilta, Milla Jauhiainen, Jussi KarjalainenAbstract:Abstract For the first time, impedance Pneumography (IP) enables a continuous analysis of the tidal breathing flow volume (TBFV), overnight. We studied how corticosteroid inhalation treatments, sleep stage, and time from sleep onset modify the nocturnal TBFV profiles of children. Seventy children, 1–5 years old and with recurrent wheezing, underwent three, full-night TBFVs recordings at home, using IP. The first recorded one week before ending a 3-months inhaled corticosteroids treatment, and remaining two, 2 and 4 weeks after treatment. TBFV profiles were grouped by hour from sleep onset and estimated sleep stage. Compared with on-medication, the off-medication profiles showed lower volume at exhalation peak flow, earlier interruption of expiration, and less convex middle expiration. The differences in the first two features were significant during non-rapid eye movement (NREM), and the differences in the third were more prominent during REM after 4 h of sleep. These combinations of TBFV features, sleep phase, and sleep time potentially indicate airflow limitation in young children.
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tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance Pneumography
Journal of Applied Physiology, 2019Co-Authors: Javier Graciatabuenca, Jari Viik, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Milla Jauhiainen, Kristiina Malmstrom, Pekka L MalmbergAbstract:Impedance Pneumography was used to investigate overnight tidal breathing flow volume (TBFV) indexes and their interactions with sleep phase [rapid eye movement (REM) vs. non-REM] at home in wheezin...
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airway obstruction is associated with reduced variability in specific parts of the tidal breathing flow volume curve in young children
ERJ Open Research, 2019Co-Authors: Villepekka Seppa, Jari Viik, Anton Hult, Javier Graciatabuenca, Marita Paassilta, Davor Plavec, Jussi KarjalainenAbstract:Impedance Pneumography recordings during sleep at night show reduced variability in specific parts of the expiratory flow–volume curve in children with recurrent wheezehttp://bit.ly/2Wkfap0
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Electrode Comparison for Textile-Integrated Electrocardiogram and Impedance Pneumography Measurement
EMBEC & NBC 2017, 2018Co-Authors: Katariina Tuohimäki, Shadi Mahdiani, Vala Jeyhani, Pekka Iso-ketola, Jukka Vanhala, Antti Vehkaoja, Jari Viik, Matti MäntysaloAbstract:Wearable electronics is a quickly broadening category in sports, wellbeing and entertainment products. Also, fully textile-integrated electronics is used increasingly to improve user experience. Medical industry is interested in exploiting, especially the latter sub-category of wearable electronics in long-term home care. In this study, we report a textile-integrated electrocardiography (ECG) and impedance Pneumography (IP) measurement system. The performance of the system is evaluated by comparing the measurement accuracy for heart rate and respiration rate obtained with different electrode types and different measurement methods. Three electrode types: disposable, textile, and printed electrodes, are investigated and both, bipolar and tetrapolar measurement methods are compared by using a modified commercial evaluation board. Disposable electrodes provide the least noisy signal and the most stable results. However, the skin irritation caused by these electrodes prevents their use in long-term monitoring. The textile and printed electrodes did not seem to cause similar skin irritation. From the two measuring techniques, tetrapolar measuring method had higher noise levels, but heart rate and breathing were estimated with better accuracy compared to bipolar measuring method.
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nonlinear local projection filter for impedance Pneumography
Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) Nordic-Baltic Conference on Biomedical Engineering and Medical , 2017Co-Authors: Javier Gracia, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Pekka Malmberg, Jari ViikAbstract:The ability of impedance Pneumography (IP) for recording tidal flow during long periods of free breathing make it a promising tool for assessing temporal complexity of respiration. However, techniques quantifying complexity may be sensitive to the noise in the IP signal resulting from the current processing method. A nonlinear local projection filter (NLPF) is presented as the solution to the current linear processing method, failing to reduce noise without distorting the flow signal. Current and proposed NLPF methods were applied to and existing data set of raw IP recorded in 21 infants during a methacholine challenge test. Methods’ performance was compared in a battery of test using mouth flow as a reference. NLPF achieved lower sample-by-sample error, and higher frequency attenuation, while linearity with mouth flow was maintained. Therefore, we concluded that NLPF superiorly reduces noise without distorting respiratory information.
Pekka L Malmberg - One of the best experts on this subject based on the ideXlab platform.
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tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance Pneumography
Journal of Applied Physiology, 2019Co-Authors: Javier Graciatabuenca, Jari Viik, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Milla Jauhiainen, Kristiina Malmstrom, Pekka L MalmbergAbstract:Impedance Pneumography was used to investigate overnight tidal breathing flow volume (TBFV) indexes and their interactions with sleep phase [rapid eye movement (REM) vs. non-REM] at home in wheezin...
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tidal flow variability measured by impedance Pneumography relates to childhood asthma risk
European Respiratory Journal, 2016Co-Authors: Villepekka Seppa, Jari Viik, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Pekka L MalmbergAbstract:Lung function variability is a fundamental feature of asthma but has been difficult to quantify in children due to methodological limitations. We assessed the feasibility and clinical implications of overnight flow variability measurement at home using impedance Pneumography in young children. 44 children aged 3–7 years with recurrent or persistent lower airway symptoms were recruited. Patients were divided into high- or lower-risk groups (HR and LR groups) based on their risk of asthma (modified Asthma Predictive Index), and a third group was formed of children who had a history of wheeze and who were treated with inhaled corticosteroids (ICS group). Tidal volume and the derived flow were recorded through skin electrodes using impedance Pneumography at home during sleep. Quantities describing overnight change in expiratory flow–volume minimum curve shape correlation (CSRmin) and respiratory chaoticity (minimum noise limit (NLmin)) were derived. Recordings were successful in 34 children. CSRmin differed between the HR and LR groups (p=0.002) and between the HR and ICS groups (p=0.003), indicating a stronger change in flow profile shape in the HR group. NLmin differed between the HR and LR groups (p=0.014), indicating momentarily lowered chaoticity in the HR group. Impedance Pneumography was found feasible for quantifying nocturnal lung function variability and the measured variability was associated with risk of asthma in young children. Impedance Pneumography enables home monitoring of lung function variability relating to risk of asthma in children
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tidal breathing flow measurement in awake young children by using impedance Pneumography
Journal of Applied Physiology, 2013Co-Authors: Villepekka Seppa, Jari Viik, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Pekka L MalmbergAbstract:Characteristics of tidal breathing (TB) relate to lung function and may be assessed even in young children. Thus far, the accuracy of impedance Pneumography (IP) in recording TB flows in young chil...
Mika J Makela - One of the best experts on this subject based on the ideXlab platform.
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tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance Pneumography
Journal of Applied Physiology, 2019Co-Authors: Javier Graciatabuenca, Jari Viik, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Milla Jauhiainen, Kristiina Malmstrom, Pekka L MalmbergAbstract:Impedance Pneumography was used to investigate overnight tidal breathing flow volume (TBFV) indexes and their interactions with sleep phase [rapid eye movement (REM) vs. non-REM] at home in wheezin...
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nonlinear local projection filter for impedance Pneumography
Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) Nordic-Baltic Conference on Biomedical Engineering and Medical , 2017Co-Authors: Javier Gracia, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Pekka Malmberg, Jari ViikAbstract:The ability of impedance Pneumography (IP) for recording tidal flow during long periods of free breathing make it a promising tool for assessing temporal complexity of respiration. However, techniques quantifying complexity may be sensitive to the noise in the IP signal resulting from the current processing method. A nonlinear local projection filter (NLPF) is presented as the solution to the current linear processing method, failing to reduce noise without distorting the flow signal. Current and proposed NLPF methods were applied to and existing data set of raw IP recorded in 21 infants during a methacholine challenge test. Methods’ performance was compared in a battery of test using mouth flow as a reference. NLPF achieved lower sample-by-sample error, and higher frequency attenuation, while linearity with mouth flow was maintained. Therefore, we concluded that NLPF superiorly reduces noise without distorting respiratory information.
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measurement of tidal breathing flows in infants using impedance Pneumography
European Respiratory Journal, 2017Co-Authors: L P Malmberg, Jari Viik, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Kristiina Malmstrom, Merja Kajosaari, Mika J MakelaAbstract:Tidal breathing flow volume (TBFV) profiles have been used to characterise altered lung function. Impedance Pneumography (IP) is a novel option for assessing TBFV curves noninvasively. The aim of this study was to extend the application of IP for infants and to estimate the agreement between IP and direct pneumotachograph (PNT) measurements in assessing tidal airflow and flow-derived indices. Tidal flow profiles were recorded for 1 min simultaneously with PNT and uncalibrated IP at baseline in 44 symptomatic infants, and after methacholine-induced bronchoconstriction in a subgroup (n=20). The agreement expressed as the mean deviation from linearity ranged between 3.9 and 4.3% of tidal peak inspiratory flow, but was associated with specific airway conductance (p=0.002) and maximal flow at functional residual capacity ( V′ maxFRC) (p=0.004) at baseline. Acute bronchoconstriction induced by methacholine did not significantly affect the agreement of IP with PNT. TBFV indices derived from IP were slightly underestimated compared to PNT, but were equally well repeatable and associated with baseline V′ maxFRC (p=0.012 and p=0.013, respectively). TBFV profiles were consistent between IP and PNT in most infants, but the agreement was affected by reduced lung function. TBFV parameters were not interchangeable between IP and PNT, but had a similar association with lung function in infants. Impedance Pneumography is a novel noninvasive option for tidal flow profile and lung function monitoring in infants
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tidal flow variability measured by impedance Pneumography relates to childhood asthma risk
European Respiratory Journal, 2016Co-Authors: Villepekka Seppa, Jari Viik, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Pekka L MalmbergAbstract:Lung function variability is a fundamental feature of asthma but has been difficult to quantify in children due to methodological limitations. We assessed the feasibility and clinical implications of overnight flow variability measurement at home using impedance Pneumography in young children. 44 children aged 3–7 years with recurrent or persistent lower airway symptoms were recruited. Patients were divided into high- or lower-risk groups (HR and LR groups) based on their risk of asthma (modified Asthma Predictive Index), and a third group was formed of children who had a history of wheeze and who were treated with inhaled corticosteroids (ICS group). Tidal volume and the derived flow were recorded through skin electrodes using impedance Pneumography at home during sleep. Quantities describing overnight change in expiratory flow–volume minimum curve shape correlation (CSRmin) and respiratory chaoticity (minimum noise limit (NLmin)) were derived. Recordings were successful in 34 children. CSRmin differed between the HR and LR groups (p=0.002) and between the HR and ICS groups (p=0.003), indicating a stronger change in flow profile shape in the HR group. NLmin differed between the HR and LR groups (p=0.014), indicating momentarily lowered chaoticity in the HR group. Impedance Pneumography was found feasible for quantifying nocturnal lung function variability and the measured variability was associated with risk of asthma in young children. Impedance Pneumography enables home monitoring of lung function variability relating to risk of asthma in children
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tidal breathing flow measurement in awake young children by using impedance Pneumography
Journal of Applied Physiology, 2013Co-Authors: Villepekka Seppa, Jari Viik, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Pekka L MalmbergAbstract:Characteristics of tidal breathing (TB) relate to lung function and may be assessed even in young children. Thus far, the accuracy of impedance Pneumography (IP) in recording TB flows in young chil...
Javier Graciatabuenca - One of the best experts on this subject based on the ideXlab platform.
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sources of variability in expiratory flow profiles during sleep in healthy young children
Respiratory Physiology & Neurobiology, 2020Co-Authors: Anton Hult, Javier Graciatabuenca, Davor Plavec, Romana Gjergja Juraski, Markku Partinen, Villepekka SeppaAbstract:Abstract Standard lung function tests are not feasible in young children, but recent studies show that the variability of expiratory tidal breathing flow-volume (TBFV) curves during sleep is a potential indirect marker of lower airway obstruction. However, the neurophysiological sources of the TBFV variability in normal subjects has not been established. We investigated sleep stages and body position changes as potential sources for the TBFV curve variability. Simultaneous impedance Pneumography (IP), polysomnography (PSG) and video recordings were done in 20 children aged 1.4–6.9 years without significant respiratory disorders during sleep. The early part of expiratory TBFV curves are less variable between cycles of REM than NREM sleep. However, within individual sleep cycles, TBFV curves during N3 are the least variable. The differences in TBFV curve shapes between sleep stages are the main source of overnight variability in TBFV curves and the changes in body position have a lesser impact.
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tidal breathing flow profiles during sleep in wheezing children measured by impedance Pneumography
Respiratory Physiology & Neurobiology, 2020Co-Authors: Javier Graciatabuenca, Jari Viik, Villepekka Seppa, Marita Paassilta, Milla Jauhiainen, Jussi KarjalainenAbstract:Abstract For the first time, impedance Pneumography (IP) enables a continuous analysis of the tidal breathing flow volume (TBFV), overnight. We studied how corticosteroid inhalation treatments, sleep stage, and time from sleep onset modify the nocturnal TBFV profiles of children. Seventy children, 1–5 years old and with recurrent wheezing, underwent three, full-night TBFVs recordings at home, using IP. The first recorded one week before ending a 3-months inhaled corticosteroids treatment, and remaining two, 2 and 4 weeks after treatment. TBFV profiles were grouped by hour from sleep onset and estimated sleep stage. Compared with on-medication, the off-medication profiles showed lower volume at exhalation peak flow, earlier interruption of expiration, and less convex middle expiration. The differences in the first two features were significant during non-rapid eye movement (NREM), and the differences in the third were more prominent during REM after 4 h of sleep. These combinations of TBFV features, sleep phase, and sleep time potentially indicate airflow limitation in young children.
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tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance Pneumography
Journal of Applied Physiology, 2019Co-Authors: Javier Graciatabuenca, Jari Viik, Villepekka Seppa, Anna S Pelkonen, Anne Kotaniemisyrjanen, Mika J Makela, Milla Jauhiainen, Kristiina Malmstrom, Pekka L MalmbergAbstract:Impedance Pneumography was used to investigate overnight tidal breathing flow volume (TBFV) indexes and their interactions with sleep phase [rapid eye movement (REM) vs. non-REM] at home in wheezin...
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airway obstruction is associated with reduced variability in specific parts of the tidal breathing flow volume curve in young children
ERJ Open Research, 2019Co-Authors: Villepekka Seppa, Jari Viik, Anton Hult, Javier Graciatabuenca, Marita Paassilta, Davor Plavec, Jussi KarjalainenAbstract:Impedance Pneumography recordings during sleep at night show reduced variability in specific parts of the expiratory flow–volume curve in children with recurrent wheezehttp://bit.ly/2Wkfap0