The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Raymond Voltz - One of the best experts on this subject based on the ideXlab platform.
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the human Pnma family novel neuronal proteins implicated in paraneoplastic neurological disease
Journal of Neuroimmunology, 2005Co-Authors: Martina Schuller, Dieter E Jenne, Raymond VoltzAbstract:Using sera from patients with paraneoplastic neurological syndromes, several novel neuronal autoantigens such as the paraneoplastic Ma antigens (Pnma) have been identified. Here, we report the correction and completion of the previously published prototype member Pnma1, the brain and testis restricted expression of a third member (Pnma3) and the sequences for further partially uncharacterized members of this novel neuronal protein family. Murine and rat orthologs exist for this protein family. By analogy to the pro-apoptotic MOAP1, similar functional interactions may exist between members of the Pnma family and the bcl-2 family.
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short communication the human Pnma family novel neuronal proteins implicated in paraneoplastic neurological disease
2005Co-Authors: Dieter E Jenne, Raymond VoltzAbstract:Using sera from patients with paraneoplastic neurological syndromes, several novel neuronal autoantigens such as the paraneoplastic Ma antigens (Pnma) have been identified. Here, we report the correction and completion of the previously published prototype member Pnma1, the brain and testis restricted expression of a third member (Pnma3) and the sequences for further partially uncharacterized members of this novel neuronal protein family. Murine and rat orthologs exist for this protein family. By analogy to the pro-apoptotic MOAP1, similar functional interactions may exist between members of the Pnma family and the bcl-2 family. D 2005 Elsevier B.V. All rights reserved.
Robe Jerome - One of the best experts on this subject based on the ideXlab platform.
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polymer dynamics in an interface confined space nmr study of poly hexyl ethacrylate block poly acrylic acid and poly dodecyl methacrylate block poly acrylic acid micelles in d2o
Macromolecules, 2000Co-Authors: J Kritz, J Plestil, D Kurkova, Jiri Dybal, Cathy Zune, Robe JeromeAbstract:The mobility of distant methyl side groups in poly(hexyl methacrylate)-block-poly(sodium acrylate) (PHMA−PAANa) and poly(dodecyl methacrylate))-block-poly(sodium acrylate) (PLMA−PAANa) micelles, dispersed in D2O and characterized by SANS, was studied using 1H single and double quantum high-resolution and MAS NMR. Transverse and rotating-frame relaxation was studied at temperatures 320−345 K in the original micellar solutions and in the systems with their viscosity gradually increased by additions of high-molecular-weight poly(ethylene oxide) and with the micellar cores gradually swollen by chlorobenzene. The relaxation data were quantitatively evaluated using a pragmatic model based on Cohen-Addad's theory. The results obtained strongly indicate that the side groups are relatively immobilized to an even higher degree than in poly(2-ethylhexyl acrylate)-block-poly(acrylic acid) micelles at the same conditions. The most immobilized groups are at or near the interface. Possible underlying effects, including ...
Kuan Onn Tan - One of the best experts on this subject based on the ideXlab platform.
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Pnma family protein interaction network and cell signalling pathways implicated in cancer and apoptosis
Cellular Signalling, 2018Co-Authors: Siew Wai Pang, Chandrajit Lahiri, Chit Laa Poh, Kuan Onn TanAbstract:Paraneoplastic Ma Family (Pnma) comprises a growing number of family members which share relatively conserved protein sequences encoded by the human genome and is localized to several human chromosomes, including the X-chromosome. Based on sequence analysis, Pnma family members share sequence homology to the Gag protein of LTR retrotransposon, and several family members with aberrant protein expressions have been reported to be closely associated with the human Paraneoplastic Disorder (PND). In addition, gene mutations of specific members of Pnma family are known to be associated with human mental retardation or 3-M syndrome consisting of restrictive post-natal growth or dwarfism, and development of skeletal abnormalities. Other than sequence homology, the physiological function of many members in this family remains unclear. However, several members of this family have been characterized, including cell signalling events mediated by these proteins that are associated with apoptosis, and cancer in different cell types. Furthermore, while certain Pnma family members show restricted gene expression in the human brain and testis, other Pnma family members exhibit broader gene expression or preferential and selective protein interaction profiles, suggesting functional divergence within the family. Functional analysis of some members of this family have identified protein domains that are required for subcellular localization, protein-protein interactions, and cell signalling events which are the focus of this review paper.
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Pnma2 mediates heterodimeric interactions and antagonizes chemo sensitizing activities mediated by members of Pnma family
Biochemical and Biophysical Research Communications, 2016Co-Authors: Yong Hoi Lee, Siew Wai Pang, Kuan Onn TanAbstract:Pnma2, a member of the Paraneoplastic Ma Family (Pnma), was identified through expression cloning by using anti-sera from patients with paraneoplastic disorder. Tissue expression studies showed that Pnma2 was predominantly expressed in normal human brain; however, the protein was shown to exhibit abnormal expression profile as it was found to be expressed in a number of tumour tissues obtained from paraneopalstic patients. The abnormal expression profile of Pnma2 suggests that it might play an important role in tumorigenesis; however, apart from protein expression and immunological studies, the physiological role of Pnma2 remains unclear. In order to determine potential role of Pnma2 in tumorigenesis, and its functional relationship with Pnma family members, MOAP-1 (Pnma4) and Pnma1, expression constructs encoding the respective proteins were generated for both in vitro and in vivo studies. Our investigations showed that over-expressed MOAP-1 and Pnma1 promoted apoptosis and chemo-sensitization in MCF-7 cells as evidenced by condensed nuclei and Annexin-V positive MCF-7 cells; however, the effects mediated by these proteins were significantly inhibited or abolished when co-expressed with Pnma2 in MCF-7 cells. Furthermore, co-immunoprecipitation study showed that Pnma1 and MOAP-1 failed to associate with each other but readily formed respective heterodimer with Pnma2, suggesting that Pnma2 functions as antagonist of MOAP-1 and Pnma1 through heterodimeric interaction.
Martina Schuller - One of the best experts on this subject based on the ideXlab platform.
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the human Pnma family novel neuronal proteins implicated in paraneoplastic neurological disease
Journal of Neuroimmunology, 2005Co-Authors: Martina Schuller, Dieter E Jenne, Raymond VoltzAbstract:Using sera from patients with paraneoplastic neurological syndromes, several novel neuronal autoantigens such as the paraneoplastic Ma antigens (Pnma) have been identified. Here, we report the correction and completion of the previously published prototype member Pnma1, the brain and testis restricted expression of a third member (Pnma3) and the sequences for further partially uncharacterized members of this novel neuronal protein family. Murine and rat orthologs exist for this protein family. By analogy to the pro-apoptotic MOAP1, similar functional interactions may exist between members of the Pnma family and the bcl-2 family.
Dieter E Jenne - One of the best experts on this subject based on the ideXlab platform.
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the human Pnma family novel neuronal proteins implicated in paraneoplastic neurological disease
Journal of Neuroimmunology, 2005Co-Authors: Martina Schuller, Dieter E Jenne, Raymond VoltzAbstract:Using sera from patients with paraneoplastic neurological syndromes, several novel neuronal autoantigens such as the paraneoplastic Ma antigens (Pnma) have been identified. Here, we report the correction and completion of the previously published prototype member Pnma1, the brain and testis restricted expression of a third member (Pnma3) and the sequences for further partially uncharacterized members of this novel neuronal protein family. Murine and rat orthologs exist for this protein family. By analogy to the pro-apoptotic MOAP1, similar functional interactions may exist between members of the Pnma family and the bcl-2 family.
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short communication the human Pnma family novel neuronal proteins implicated in paraneoplastic neurological disease
2005Co-Authors: Dieter E Jenne, Raymond VoltzAbstract:Using sera from patients with paraneoplastic neurological syndromes, several novel neuronal autoantigens such as the paraneoplastic Ma antigens (Pnma) have been identified. Here, we report the correction and completion of the previously published prototype member Pnma1, the brain and testis restricted expression of a third member (Pnma3) and the sequences for further partially uncharacterized members of this novel neuronal protein family. Murine and rat orthologs exist for this protein family. By analogy to the pro-apoptotic MOAP1, similar functional interactions may exist between members of the Pnma family and the bcl-2 family. D 2005 Elsevier B.V. All rights reserved.