The Experts below are selected from a list of 135 Experts worldwide ranked by ideXlab platform
Neil R. Cashman - One of the best experts on this subject based on the ideXlab platform.
-
Post-Poliomyelitis syndrome.
Muscle & nerve, 2004Co-Authors: Daria A. Trojan, Neil R. CashmanAbstract:Post-Poliomyelitis syndrome (PPS) is a common neurological disorder that occurs in a large proportion of individuals who have recovered from paralytic Poliomyelitis. The main clinical features are new weakness, muscular fatigability, general fatigue, and pain. The primary criteria necessary for the diagnosis of PPS are a history of paralytic Poliomyelitis, partial or complete recovery of neurological function followed by a period of stability (usually several decades), persistent new muscle weakness or abnormal muscle fatigability, and the exclusion of other causes of new symptoms. The cause of PPS remains unclear, but is likely due to a distal degeneration of enlarged post-Poliomyelitis motor units. Contributing factors to PPS may be aging (with motor neuron loss), overuse, and disuse. PPS is usually a slowly progressive neuromuscular disease. Although there is no specific treatment for PPS, an interdisciplinary management program can be useful in controlling symptoms.
Daria A. Trojan - One of the best experts on this subject based on the ideXlab platform.
-
Post-Poliomyelitis syndrome.
Muscle & nerve, 2004Co-Authors: Daria A. Trojan, Neil R. CashmanAbstract:Post-Poliomyelitis syndrome (PPS) is a common neurological disorder that occurs in a large proportion of individuals who have recovered from paralytic Poliomyelitis. The main clinical features are new weakness, muscular fatigability, general fatigue, and pain. The primary criteria necessary for the diagnosis of PPS are a history of paralytic Poliomyelitis, partial or complete recovery of neurological function followed by a period of stability (usually several decades), persistent new muscle weakness or abnormal muscle fatigability, and the exclusion of other causes of new symptoms. The cause of PPS remains unclear, but is likely due to a distal degeneration of enlarged post-Poliomyelitis motor units. Contributing factors to PPS may be aging (with motor neuron loss), overuse, and disuse. PPS is usually a slowly progressive neuromuscular disease. Although there is no specific treatment for PPS, an interdisciplinary management program can be useful in controlling symptoms.
Eckard Wimmer - One of the best experts on this subject based on the ideXlab platform.
-
Mechanism of Injury-Provoked Poliomyelitis
Journal of virology, 1998Co-Authors: Matthias Gromeier, Eckard WimmerAbstract:Skeletal muscle injury is known to predispose its sufferers to neurological complications of concurrent poliovirus infections. This phenomenon, labeled “provocation Poliomyelitis,” continues to cause numerous cases of childhood paralysis due to the administration of unnecessary injections to children in areas where poliovirus is endemic. Recently, it has been reported that intramuscular injections may also increase the likelihood of vaccine-associated paralytic Poliomyelitis in recipients of live attenuated poliovirus vaccines. We have studied this important risk factor for paralytic polio in an animal system for Poliomyelitis and have determined the pathogenic mechanism linking intramuscular injections and provocation Poliomyelitis. Skeletal muscle injury induces retrograde axonal transport of poliovirus and thereby facilitates viral invasion of the central nervous system and the progression of spinal cord damage. The pathogenic mechanism of provocation Poliomyelitis may differ from that of polio acquired in the absence of predisposing factors.
N.i. Markham - One of the best experts on this subject based on the ideXlab platform.
-
Provocation Poliomyelitis: vaccine associated paralytic Poliomyelitis related to a rectal abscess in an infant
The Journal of infection, 2003Co-Authors: A.r.j. Bosley, Gail Speirs, N.i. MarkhamAbstract:Abstract Objective . To describe a case of vaccine associated paralytic Poliomyelitis (VAPP) and relate this to current UK immunization policy. Method . A case report in which the clinical course and factors leading to the diagnosis are described and then related to reports of paralytic Poliomyelitis in the literature. Results . The child in this case was left severely disabled by paralytic Poliomyelitis. The pathological process was related to a pararectal abscess needing urgent drainage shortly after immunisation. Conclusion . The skeletal muscle damage due to the presence of the pararectal abscess may have acted as the ‘provocation' in the development of Poliomyelitis. Adoption of a policy of initial vaccination by the parenteral route as in the USA and European countries has been shown to greatly reduce this risk. The UK could adopt this policy which would minimise the risk of VAPP, as all recorded paralytic Poliomyelitis in the UK in the last decade has been vaccine related.
Abdul Rahman Saleh Al Frayh - One of the best experts on this subject based on the ideXlab platform.
-
acute paralytic Poliomyelitis presenting as guillain barre syndrome
Journal of Infection, 1991Co-Authors: Mulakkan David Yohannan, S Ramia, Abdul Rahman Saleh Al FrayhAbstract:Summary The initial clinical picture and CSF changes in four children with acute ascending paralysis simulated Guillain—Barre syndrome. However, diagnosis of Poliomyelitis was confirmed on the basis of isolation of wild poliovirus type 1 and high neutralising antibody to it. The four children had received primary vaccination with live attenuated oral Poliomyelitis vaccine. It is postulated that the clinical course of paralytic Poliomyelitis may be altered in children who have previously been vaccinated with live oral vaccine.