The Experts below are selected from a list of 4245 Experts worldwide ranked by ideXlab platform
Mauricio M. Victor - One of the best experts on this subject based on the ideXlab platform.
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The stereochemistry of the Nozaki-Hiyama-Kishi reaction and the construction of 10-membered lactones. The enantioselective total synthesis of (-)-decarestrictine D
Journal of the Brazilian Chemical Society, 2001Co-Authors: Ronaldo A. Pilli, Mauricio M. VictorAbstract:The use of the intramolecular Nozaki-Hiyama-Kishi reaction to construct 10-membered lactones is described. The influence of the nature of the protecting groups at C4 and C5 on the stereochemistry of the newly formed stereogenic center at C7 was investigated. The utility of this methodology has been demonstrated in the stereoselective total synthesis of (-)-decarestrictine D from 1,3-propanediol and Polyhydroxybutyrate (PHB) in 13 steps and 6.3% overall yield.
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total synthesis of decarestrictine d through a stereoselective intramolecular nozaki hiyama kishi reaction
Tetrahedron Letters, 1998Co-Authors: Ronaldo A. Pilli, Mauricio M. VictorAbstract:Abstract A concise total synthesis of (−)-decarestrictine D (1) from 1,3-propanediol and Polyhydroxybutyrate (PHB) is described. The approach involves the stereoselective intramolecular Nozaki-Hiyama-Kishi coupling to construct the decanolide ring and to set the proper configuration at C-7.
A. L. Iordanskii - One of the best experts on this subject based on the ideXlab platform.
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the investigation of the structure and properties of ozone sterilized nonwoven biopolymer materials for medical applications
Polymers, 2021Co-Authors: Anatoliy Olkhov, P M Tyubaeva, A A Popov, Anna Zykova, Vyacheslav Podmasteriev, A. L. IordanskiiAbstract:Nowadays, the development and research of nonwoven medical fibrous materials based on biopolymers is an area of a great practical interest. One of the most promising methods for producing nonwoven materials with a highly developed surface is electrospinning (ES). In this article, the possibility of efficient sterilization of ultrathin fibers based on Polyhydroxybutyrate (PHB) by ozone treatment was considered. The purpose of this work was to select the most optimal morphology of nonwoven materials for medical purposes and to establish the correlation between the supramolecular structure and the physical properties of fibrous materials while under the influence of an ozone sterilization process.
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Isopotential Mapping of Electron Beam Induced Dielectric Charging of the PHB Nonwoven Fabric Structures Using Sobel-Feldman Gradient Operator
2020 7th International Congress on Energy Fluxes and Radiation Effects (EFRE), 2020Co-Authors: Oleg V. Gradov, Anatoliy Olkhov, A. L. Iordanskii, Margaret A. Gradova, Svetlana N. KholuiskayaAbstract:The aim of this brief methodological report is to introduce a novel method for isopotential mapping of electron beam-induced dielectric charging of the nonwoven fabric fibers using Sobel-Feldman gradient operator and dynamic electron microscopy setup with an electron beam. Images of the dynamic behavior of a double layer of polyxydroxybutyrate dielectric fiber under the electron beam charging at three levels of magnification are presented for the first time in this report.
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thermooxidation and biodegradation of nonwoven biopolymer fibrous materials
Polymer Science. Series D, 2018Co-Authors: A. S. Chizhov, Anatoliy Olkhov, L S Shibryaeva, T.v. Monakhova, A. L. IordanskiiAbstract:This paper studies water absorption and processes of thermooxidative destruction and biodegradation of film and nonwoven fibrous materials based on the natural polymers polylactide and Polyhydroxybutyrate. Nonwoven fibrous materials were obtained by electrospinning, and film fibrous materials were obtained by watering onto the glass surface. It was determined that fibrous materials have high water absorption and a high oxidation rate in comparison with film materials, which significantly accelerates (by about five times) the processes of biodegradation under environmental conditions. Fibrous nonwoven material from biodegradable polymers is an important development as a disposable soil mulching material and a covering material that has a service life of less than 1.5 months under natural conditions.
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process optimization electrospinning fibrous material based оn Polyhydroxybutyrate
VIII INTERNATIONAL CONFERENCE ON “TIMES OF POLYMERS AND COMPOSITES”: From Aerospace to Nanotechnology, 2016Co-Authors: Anatoliy Olkhov, P M Tyubaeva, O V Staroverova, E E Mastalygina, A A Popov, A A Ischenko, A. L. IordanskiiAbstract:The article analyzes the influence of the main technological parameters of electrostatic spinning on the morphology and properties of ultrathin fibers on the basis of Polyhydroxybutyrate. It is found that the electric conductivity and viscosity of the spinning solution affects the process of forming fibers macrostructure. The fiber-based materials PHB lets control geometry and optimize the viscosity and conductivity of a spinning solution. The resulting fibers have found use in medicine, particularly in the construction elements musculoskeletal.
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influence of the film forming procedure on the interaction in Polyhydroxybutyrate polyurethane blends
Russian Journal of Applied Chemistry, 2015Co-Authors: Anatoliy Olkhov, V S Markin, Yu R Kosenko, M A Goldshtrakh, A. L. IordanskiiAbstract:The structural features of polymeric composites based on Polyhydroxybutyrate and segmented polyurethane were studied. A study by the methods of H-D exchange and IR spectroscopy revealed no intermolecular interaction between Polyhydroxybutyrate and polyurethane in the blends prepared using a single solvent. The interaction of the polymers is observed when using two solvents and performing high-temperature heat treatment.
Ronaldo A. Pilli - One of the best experts on this subject based on the ideXlab platform.
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The stereochemistry of the Nozaki-Hiyama-Kishi reaction and the construction of 10-membered lactones. The enantioselective total synthesis of (-)-decarestrictine D
Journal of the Brazilian Chemical Society, 2001Co-Authors: Ronaldo A. Pilli, Mauricio M. VictorAbstract:The use of the intramolecular Nozaki-Hiyama-Kishi reaction to construct 10-membered lactones is described. The influence of the nature of the protecting groups at C4 and C5 on the stereochemistry of the newly formed stereogenic center at C7 was investigated. The utility of this methodology has been demonstrated in the stereoselective total synthesis of (-)-decarestrictine D from 1,3-propanediol and Polyhydroxybutyrate (PHB) in 13 steps and 6.3% overall yield.
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total synthesis of decarestrictine d through a stereoselective intramolecular nozaki hiyama kishi reaction
Tetrahedron Letters, 1998Co-Authors: Ronaldo A. Pilli, Mauricio M. VictorAbstract:Abstract A concise total synthesis of (−)-decarestrictine D (1) from 1,3-propanediol and Polyhydroxybutyrate (PHB) is described. The approach involves the stereoselective intramolecular Nozaki-Hiyama-Kishi coupling to construct the decanolide ring and to set the proper configuration at C-7.
P M Tyubaeva - One of the best experts on this subject based on the ideXlab platform.
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the investigation of the structure and properties of ozone sterilized nonwoven biopolymer materials for medical applications
Polymers, 2021Co-Authors: Anatoliy Olkhov, P M Tyubaeva, A A Popov, Anna Zykova, Vyacheslav Podmasteriev, A. L. IordanskiiAbstract:Nowadays, the development and research of nonwoven medical fibrous materials based on biopolymers is an area of a great practical interest. One of the most promising methods for producing nonwoven materials with a highly developed surface is electrospinning (ES). In this article, the possibility of efficient sterilization of ultrathin fibers based on Polyhydroxybutyrate (PHB) by ozone treatment was considered. The purpose of this work was to select the most optimal morphology of nonwoven materials for medical purposes and to establish the correlation between the supramolecular structure and the physical properties of fibrous materials while under the influence of an ozone sterilization process.
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process optimization electrospinning fibrous material based оn Polyhydroxybutyrate
VIII INTERNATIONAL CONFERENCE ON “TIMES OF POLYMERS AND COMPOSITES”: From Aerospace to Nanotechnology, 2016Co-Authors: Anatoliy Olkhov, P M Tyubaeva, O V Staroverova, E E Mastalygina, A A Popov, A A Ischenko, A. L. IordanskiiAbstract:The article analyzes the influence of the main technological parameters of electrostatic spinning on the morphology and properties of ultrathin fibers on the basis of Polyhydroxybutyrate. It is found that the electric conductivity and viscosity of the spinning solution affects the process of forming fibers macrostructure. The fiber-based materials PHB lets control geometry and optimize the viscosity and conductivity of a spinning solution. The resulting fibers have found use in medicine, particularly in the construction elements musculoskeletal.
Elisa Rupérez - One of the best experts on this subject based on the ideXlab platform.
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Antibacterial PHAs coating for titanium implants
European Polymer Journal, 2017Co-Authors: Alejandra Rodriguez-contreras, Yolanda García, José María Manero, Elisa RupérezAbstract:Biomaterial-associated infection is a serious complication of modern implantation surgery. Thus, the improvement of implant surfaces is required to avoid the first stage for biofilm formation, bacterial adhesion. The current research addresses this issue by developing drug delivery systems (DDS) consisting of antibiotic-loaded polyhydroxyalkanoates (PHAs) coatings on titanium implants. Dip-coating technique was used to achieve optimal coatings with biodegradable biopolyesters, Polyhydroxybutyrate (PHB) and its copolymer, Polyhydroxybutyrate-co-hydroxyvalerate (PHBV). The coatings were completely characterized (wettability, topography, thickness and roughness), and studies of drug delivery, toxicity, antibacterial effect, and cell adhesion were performed. For both of biopolymers, surfaces were partially covered with 1 and 3 immersions, while with 6, they were completely covered. Although both antibiotic-loaded biopolymer coatings assure the protection against bacteria populations, PHBV coatings are closer to the desired release profile; its faster degradation provides for a greater and more stable drug release for a given period of time compared to PHB coatings. The use of coatings with different drug concentration per layer results in more controlled and homogeneous releases. The DDS designed not only assure to avoid the first stage of bacterial adhesion, but also their proliferation and biofilm formation, since the coatings degrade with time under physiological conditions, guaranteeing a prolonged drug release.
