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Leslie E. Orgel - One of the best experts on this subject based on the ideXlab platform.

  • Which 3-ribofuranosyl-substituted purine 5′-phosphates undergo template-directed oligomerization?
    Journal of Molecular Evolution, 1991
    Co-Authors: Aubrey R. Hill, Shiv Kumar, Vemanna D. Patil, Nelson J. Leonard, Leslie E. Orgel
    Abstract:

    We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic Acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic Acid, polyadenylic Acid, Polyinosinic Acid, and polyguanylic Acid were ineffective as templates in the systems that we investigated.

  • WHICH 3-RIBOFURANOSYL-SUBSTITUTED PURINE 5'-PHOSPHATES UNDERGO TEMPLATE-DIRECTED OLIGOMERIZATION ?
    Journal of molecular evolution, 1991
    Co-Authors: Aubrey R. Hill, Shiv Kumar, Vemanna D. Patil, Nelson J. Leonard, Leslie E. Orgel
    Abstract:

    We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic Acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic Acid, polyadenylic Acid, Polyinosinic Acid, and polyguanylic Acid were ineffective as templates in the systems that we investigated.

Aubrey R. Hill - One of the best experts on this subject based on the ideXlab platform.

  • Which 3-ribofuranosyl-substituted purine 5′-phosphates undergo template-directed oligomerization?
    Journal of Molecular Evolution, 1991
    Co-Authors: Aubrey R. Hill, Shiv Kumar, Vemanna D. Patil, Nelson J. Leonard, Leslie E. Orgel
    Abstract:

    We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic Acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic Acid, polyadenylic Acid, Polyinosinic Acid, and polyguanylic Acid were ineffective as templates in the systems that we investigated.

  • WHICH 3-RIBOFURANOSYL-SUBSTITUTED PURINE 5'-PHOSPHATES UNDERGO TEMPLATE-DIRECTED OLIGOMERIZATION ?
    Journal of molecular evolution, 1991
    Co-Authors: Aubrey R. Hill, Shiv Kumar, Vemanna D. Patil, Nelson J. Leonard, Leslie E. Orgel
    Abstract:

    We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic Acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic Acid, polyadenylic Acid, Polyinosinic Acid, and polyguanylic Acid were ineffective as templates in the systems that we investigated.

Rodrigue Savoie - One of the best experts on this subject based on the ideXlab platform.

  • A vibrational spectroscopic study of the metastable form of associated Polyinosinic Acid.
    Biopolymers, 1998
    Co-Authors: Christine Simard, Éric Gaudreau, Rodrigue Savoie
    Abstract:

    We have studied by Raman and ir spectroscopy the metastable complex formed by the self-association of Polyinosinic Acid in aqueous solution. The complex is easily prepared by quickly cooling to ca. 0 degrees C a warm solution of the polyribonucleotide to which a small amount of rubidium salt has been added. Upon heating, this metastable form melts cooperatively near 13 degrees C, well below the dissociation temperature of a stable four-stranded complex, which occurs at 47 degrees C in the same conditions. The presence of several components in the stretching-mode region of the carbonyl groups in the vibrational spectra of the metastable complex suggests that it also has a parallel four-stranded structure. The difference in structure between the two forms is believed to be caused by the presence of fewer metal ions in the central channel of the metastable complex, in agreement with conclusions reached in previous investigations. The Raman spectra further show that the ribose units in the metastable form have a C3'-endo conformation, in contrast with the stable form, for which we have previously suggested a mixed C2'-endo/C3'-endo conformation.

  • A vibrational spectroscopic study of the self‐association of Polyinosinic Acid and polyguanylic Acid in aqueous solution
    Biopolymers, 1994
    Co-Authors: Christine Simard, Rodrigue Savoie
    Abstract:

    We have studied by Raman and ir spectroscopy the structure of self-associated Polyinosinic Acid and polyguanylic Acid in aqueous solution. The results are consistent with the formation of a four-stranded complex, which melts cooperatively near 60 degrees C in the case of poly(I) in the presence of K+ ions. The conformation of the ribose in both systems is mixed C2'-endo/C3'-endo, giving a structure that is intermediate between the extremes proposed previously from x-ray diffraction studies. Characteristic Raman bands for the C2'-endo ribose conformation in polyribonucleotides are identified. The four-stranded structure of poly(I) appears to be very flexible, with approximately 15% of the tetrameric segments being disrupted and approximately 30% of the ribose units adopting a disordered conformation prior to melting. This disordering process increases to approximately 75% above the melting transition, with the remaining approximately 25% of the ribose units keeping an ordered C2'-endo or C3'-endo conformation.

Vemanna D. Patil - One of the best experts on this subject based on the ideXlab platform.

  • Which 3-ribofuranosyl-substituted purine 5′-phosphates undergo template-directed oligomerization?
    Journal of Molecular Evolution, 1991
    Co-Authors: Aubrey R. Hill, Shiv Kumar, Vemanna D. Patil, Nelson J. Leonard, Leslie E. Orgel
    Abstract:

    We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic Acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic Acid, polyadenylic Acid, Polyinosinic Acid, and polyguanylic Acid were ineffective as templates in the systems that we investigated.

  • WHICH 3-RIBOFURANOSYL-SUBSTITUTED PURINE 5'-PHOSPHATES UNDERGO TEMPLATE-DIRECTED OLIGOMERIZATION ?
    Journal of molecular evolution, 1991
    Co-Authors: Aubrey R. Hill, Shiv Kumar, Vemanna D. Patil, Nelson J. Leonard, Leslie E. Orgel
    Abstract:

    We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic Acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic Acid, polyadenylic Acid, Polyinosinic Acid, and polyguanylic Acid were ineffective as templates in the systems that we investigated.

Nelson J. Leonard - One of the best experts on this subject based on the ideXlab platform.

  • Which 3-ribofuranosyl-substituted purine 5′-phosphates undergo template-directed oligomerization?
    Journal of Molecular Evolution, 1991
    Co-Authors: Aubrey R. Hill, Shiv Kumar, Vemanna D. Patil, Nelson J. Leonard, Leslie E. Orgel
    Abstract:

    We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic Acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic Acid, polyadenylic Acid, Polyinosinic Acid, and polyguanylic Acid were ineffective as templates in the systems that we investigated.

  • WHICH 3-RIBOFURANOSYL-SUBSTITUTED PURINE 5'-PHOSPHATES UNDERGO TEMPLATE-DIRECTED OLIGOMERIZATION ?
    Journal of molecular evolution, 1991
    Co-Authors: Aubrey R. Hill, Shiv Kumar, Vemanna D. Patil, Nelson J. Leonard, Leslie E. Orgel
    Abstract:

    We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic Acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic Acid, polyadenylic Acid, Polyinosinic Acid, and polyguanylic Acid were ineffective as templates in the systems that we investigated.