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David Heber - One of the best experts on this subject based on the ideXlab platform.

  • cholesterol lowering effects of dietary Pomegranate Extract and inulin in mice fed an obesogenic diet
    Journal of Nutritional Biochemistry, 2018
    Co-Authors: Jieping Yang, Emma Grojean, Austin Ly, Rita Pisegna, Susanne M Henning, David Heber, Song Zhang, Zhaoping Li
    Abstract:

    Abstract Background It has been demonstrated in animal studies that both polyphenol-rich Pomegranate Extract (PomX) and the polysaccharide inulin, ameliorate metabolic changes induced by a high-fat diet, but little is known about the specific mechanisms. Objective This study evaluated the effect of PomX (0.25%) and inulin (9%) alone or in combination on cholesterol and lipid metabolism in mice. Methods Male C57BL/6 J mice were fed high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose)] diets supplemented with PomX (0.25%) and inulin (9%) alone or in combination for 4 weeks. At the end of intervention, serum and hepatic cholesterol, triglyceride levels, hepatic gene expression of key regulators of cholesterol and lipid metabolism as well as fecal cholesterol and bile acid excretion were determined. Results Dietary supplementation of the HF/HS diet with PomX and inulin decreased hepatic and serum total cholesterol. Supplementation with PomX and inulin together resulted in lower hepatic and serum total cholesterol compared to individual treatments. Compared to HF/HS control, PomX increased gene expression of Cyp7a1 and Cyp7b1, key regulators of bile acid synthesis pathways. Inulin decreased gene expression of key regulators of cholesterol de novo synthesis Srebf2 and Hmgcr and significantly increased fecal elimination of total bile acids and neutral sterols. Only PomX in combination with inulin reduced liver and lipid weight significantly compared to the HF/HS control group. PomX showed a trend to decrease liver triglyceride (TG) levels, while inulin or PomX-inulin combination had no effect on either serum or liver TG levels. Conclusion Dietary PomX and inulin supplementation decreased hepatic and serum total cholesterol by different mechanisms and the combination leading to a significant enhancement of the cholesterol-lowering effect.

  • dietary Pomegranate Extract and inulin affect gut microbiome differentially in mice fed an obesogenic diet
    Anaerobe, 2017
    Co-Authors: Song Zhang, Emma Grojean, Austin Ly, Rita Pisegna, Jieping Yang, Susanne M Henning, David Heber, Zhaoping Li
    Abstract:

    Growing evidence suggests that dysbiosis of gut microbiota is associated with pathogenesis of a variety of human diseases. Using dietary intervention to shape the composition and metabolism of the gut microbiota is increasingly recognized. In the present study, we investigated the effects of polysaccharide inulin and polyphenol-rich Pomegranate Extract (PomX) alone or in combination on the cecal microbiota composition and function in a diet induced obesity mouse model. Male C57BL/6 mice were randomly divided into four experimental groups and consumed either high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose, 17% energy from protein)] diet, HF/HS diet supplemented with PomX (0.25%), or inulin (9%) or PomX and inulin in combination for 4 weeks. In mice fed the PomX-diet the proportion of Turicibacteraceae and Ruminococcaceae was significantly increased compared to the control HF/HS diet. Supplementation with inulin alone and inulin + PomX combination significantly increased the proportion of Verrucomicrobiaceae (A. muciniphila) and decreased Clostridiaceae. Only mice fed the inulin diet experienced an increase in serum lipopolysaccharide (LPS) and monocyte chemoattractant protein 1 (MCP-1), which was reversed when feeding the inulin + PomX diet. Feeding the inulin + PomX diet was associated with a significant increase in Bifidobacteriaceae and Rikenellaceae, which may have contributed to the reduction of endotoxemia markers. Inulin supplementation showed lower species richness of gut microbiota compared to mice fed with HF/HS or HF/HS/PomX, and the reduction was reversed by the addition of PomX. Inulin alone and in combination with PomX had distinct microbial clusters determined by both weighted and unweighted UniFrac Beta-Diversity principle coordinate analysis. A total of 19 KEGG biological pathways were significantly regulated in the gut microbiota with PomX and inulin alone or combined treatment. Inulin significantly enhanced KEGG infectious disease-related pathway associated with increase of serum LPS and MCP-1. No changes in gene expression of ileal proinflammatory cytokine and tight junction genes were observed in mice treated with PomX and inulin. Our results demonstrated that the gut microbiota and their biological pathways were differentially effected by dietary PomX and inulin fed combined or alone. It is therefore very important to consider the interaction among bioactive components of food when evaluating potential prebiotic effects.

  • effects of dietary Pomegranate Extract and inulin in mice fed an obesogenic diet
    The FASEB Journal, 2017
    Co-Authors: Jieping Yang, Emma Grojean, Austin Ly, Rita Pisegna, Susanne M Henning, David Heber, Song Zhang, Zhaoping Li
    Abstract:

    BackgroundIt has been demonstrated in animal studies that both polyphenol rich Pomegranate Extract (PomX) and the oligosaccharide inulin, ameliorate metabolic changes induced by a high-fat diet, bu...

  • Effects of Pomegranate Extract on High Fat/High Sucrose Diet induced Obesity are Dependent on the Intestinal Formation of Urolithin A
    The FASEB Journal, 2016
    Co-Authors: Jieping Yang, Emma Grojean, Susanne M Henning, Ru-po Lee, Mark Hsu, David Heber
    Abstract:

    Recent studies strongly suggest the association of gut microbiota and obesity related diseases. Published data from a mouse study demonstrated that Pomegranate Extract (PomX) administration increas...

  • effects of Pomegranate Extract on high fat high sucrose diet induced obesity are dependent on the intestinal formation of urolithin a
    The FASEB Journal, 2016
    Co-Authors: Jieping Yang, Emma Grojean, Susanne M Henning, Ru-po Lee, Mark Hsu, David Heber
    Abstract:

    Recent studies strongly suggest the association of gut microbiota and obesity related diseases. Published data from a mouse study demonstrated that Pomegranate Extract (PomX) administration increas...

Susanne M Henning - One of the best experts on this subject based on the ideXlab platform.

  • cholesterol lowering effects of dietary Pomegranate Extract and inulin in mice fed an obesogenic diet
    Journal of Nutritional Biochemistry, 2018
    Co-Authors: Jieping Yang, Emma Grojean, Austin Ly, Rita Pisegna, Susanne M Henning, David Heber, Song Zhang, Zhaoping Li
    Abstract:

    Abstract Background It has been demonstrated in animal studies that both polyphenol-rich Pomegranate Extract (PomX) and the polysaccharide inulin, ameliorate metabolic changes induced by a high-fat diet, but little is known about the specific mechanisms. Objective This study evaluated the effect of PomX (0.25%) and inulin (9%) alone or in combination on cholesterol and lipid metabolism in mice. Methods Male C57BL/6 J mice were fed high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose)] diets supplemented with PomX (0.25%) and inulin (9%) alone or in combination for 4 weeks. At the end of intervention, serum and hepatic cholesterol, triglyceride levels, hepatic gene expression of key regulators of cholesterol and lipid metabolism as well as fecal cholesterol and bile acid excretion were determined. Results Dietary supplementation of the HF/HS diet with PomX and inulin decreased hepatic and serum total cholesterol. Supplementation with PomX and inulin together resulted in lower hepatic and serum total cholesterol compared to individual treatments. Compared to HF/HS control, PomX increased gene expression of Cyp7a1 and Cyp7b1, key regulators of bile acid synthesis pathways. Inulin decreased gene expression of key regulators of cholesterol de novo synthesis Srebf2 and Hmgcr and significantly increased fecal elimination of total bile acids and neutral sterols. Only PomX in combination with inulin reduced liver and lipid weight significantly compared to the HF/HS control group. PomX showed a trend to decrease liver triglyceride (TG) levels, while inulin or PomX-inulin combination had no effect on either serum or liver TG levels. Conclusion Dietary PomX and inulin supplementation decreased hepatic and serum total cholesterol by different mechanisms and the combination leading to a significant enhancement of the cholesterol-lowering effect.

  • dietary Pomegranate Extract and inulin affect gut microbiome differentially in mice fed an obesogenic diet
    Anaerobe, 2017
    Co-Authors: Song Zhang, Emma Grojean, Austin Ly, Rita Pisegna, Jieping Yang, Susanne M Henning, David Heber, Zhaoping Li
    Abstract:

    Growing evidence suggests that dysbiosis of gut microbiota is associated with pathogenesis of a variety of human diseases. Using dietary intervention to shape the composition and metabolism of the gut microbiota is increasingly recognized. In the present study, we investigated the effects of polysaccharide inulin and polyphenol-rich Pomegranate Extract (PomX) alone or in combination on the cecal microbiota composition and function in a diet induced obesity mouse model. Male C57BL/6 mice were randomly divided into four experimental groups and consumed either high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose, 17% energy from protein)] diet, HF/HS diet supplemented with PomX (0.25%), or inulin (9%) or PomX and inulin in combination for 4 weeks. In mice fed the PomX-diet the proportion of Turicibacteraceae and Ruminococcaceae was significantly increased compared to the control HF/HS diet. Supplementation with inulin alone and inulin + PomX combination significantly increased the proportion of Verrucomicrobiaceae (A. muciniphila) and decreased Clostridiaceae. Only mice fed the inulin diet experienced an increase in serum lipopolysaccharide (LPS) and monocyte chemoattractant protein 1 (MCP-1), which was reversed when feeding the inulin + PomX diet. Feeding the inulin + PomX diet was associated with a significant increase in Bifidobacteriaceae and Rikenellaceae, which may have contributed to the reduction of endotoxemia markers. Inulin supplementation showed lower species richness of gut microbiota compared to mice fed with HF/HS or HF/HS/PomX, and the reduction was reversed by the addition of PomX. Inulin alone and in combination with PomX had distinct microbial clusters determined by both weighted and unweighted UniFrac Beta-Diversity principle coordinate analysis. A total of 19 KEGG biological pathways were significantly regulated in the gut microbiota with PomX and inulin alone or combined treatment. Inulin significantly enhanced KEGG infectious disease-related pathway associated with increase of serum LPS and MCP-1. No changes in gene expression of ileal proinflammatory cytokine and tight junction genes were observed in mice treated with PomX and inulin. Our results demonstrated that the gut microbiota and their biological pathways were differentially effected by dietary PomX and inulin fed combined or alone. It is therefore very important to consider the interaction among bioactive components of food when evaluating potential prebiotic effects.

  • effects of dietary Pomegranate Extract and inulin in mice fed an obesogenic diet
    The FASEB Journal, 2017
    Co-Authors: Jieping Yang, Emma Grojean, Austin Ly, Rita Pisegna, Susanne M Henning, David Heber, Song Zhang, Zhaoping Li
    Abstract:

    BackgroundIt has been demonstrated in animal studies that both polyphenol rich Pomegranate Extract (PomX) and the oligosaccharide inulin, ameliorate metabolic changes induced by a high-fat diet, bu...

  • Effects of Pomegranate Extract on High Fat/High Sucrose Diet induced Obesity are Dependent on the Intestinal Formation of Urolithin A
    The FASEB Journal, 2016
    Co-Authors: Jieping Yang, Emma Grojean, Susanne M Henning, Ru-po Lee, Mark Hsu, David Heber
    Abstract:

    Recent studies strongly suggest the association of gut microbiota and obesity related diseases. Published data from a mouse study demonstrated that Pomegranate Extract (PomX) administration increas...

  • effects of Pomegranate Extract on high fat high sucrose diet induced obesity are dependent on the intestinal formation of urolithin a
    The FASEB Journal, 2016
    Co-Authors: Jieping Yang, Emma Grojean, Susanne M Henning, Ru-po Lee, Mark Hsu, David Heber
    Abstract:

    Recent studies strongly suggest the association of gut microbiota and obesity related diseases. Published data from a mouse study demonstrated that Pomegranate Extract (PomX) administration increas...

Jieping Yang - One of the best experts on this subject based on the ideXlab platform.

  • cholesterol lowering effects of dietary Pomegranate Extract and inulin in mice fed an obesogenic diet
    Journal of Nutritional Biochemistry, 2018
    Co-Authors: Jieping Yang, Emma Grojean, Austin Ly, Rita Pisegna, Susanne M Henning, David Heber, Song Zhang, Zhaoping Li
    Abstract:

    Abstract Background It has been demonstrated in animal studies that both polyphenol-rich Pomegranate Extract (PomX) and the polysaccharide inulin, ameliorate metabolic changes induced by a high-fat diet, but little is known about the specific mechanisms. Objective This study evaluated the effect of PomX (0.25%) and inulin (9%) alone or in combination on cholesterol and lipid metabolism in mice. Methods Male C57BL/6 J mice were fed high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose)] diets supplemented with PomX (0.25%) and inulin (9%) alone or in combination for 4 weeks. At the end of intervention, serum and hepatic cholesterol, triglyceride levels, hepatic gene expression of key regulators of cholesterol and lipid metabolism as well as fecal cholesterol and bile acid excretion were determined. Results Dietary supplementation of the HF/HS diet with PomX and inulin decreased hepatic and serum total cholesterol. Supplementation with PomX and inulin together resulted in lower hepatic and serum total cholesterol compared to individual treatments. Compared to HF/HS control, PomX increased gene expression of Cyp7a1 and Cyp7b1, key regulators of bile acid synthesis pathways. Inulin decreased gene expression of key regulators of cholesterol de novo synthesis Srebf2 and Hmgcr and significantly increased fecal elimination of total bile acids and neutral sterols. Only PomX in combination with inulin reduced liver and lipid weight significantly compared to the HF/HS control group. PomX showed a trend to decrease liver triglyceride (TG) levels, while inulin or PomX-inulin combination had no effect on either serum or liver TG levels. Conclusion Dietary PomX and inulin supplementation decreased hepatic and serum total cholesterol by different mechanisms and the combination leading to a significant enhancement of the cholesterol-lowering effect.

  • dietary Pomegranate Extract and inulin affect gut microbiome differentially in mice fed an obesogenic diet
    Anaerobe, 2017
    Co-Authors: Song Zhang, Emma Grojean, Austin Ly, Rita Pisegna, Jieping Yang, Susanne M Henning, David Heber, Zhaoping Li
    Abstract:

    Growing evidence suggests that dysbiosis of gut microbiota is associated with pathogenesis of a variety of human diseases. Using dietary intervention to shape the composition and metabolism of the gut microbiota is increasingly recognized. In the present study, we investigated the effects of polysaccharide inulin and polyphenol-rich Pomegranate Extract (PomX) alone or in combination on the cecal microbiota composition and function in a diet induced obesity mouse model. Male C57BL/6 mice were randomly divided into four experimental groups and consumed either high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose, 17% energy from protein)] diet, HF/HS diet supplemented with PomX (0.25%), or inulin (9%) or PomX and inulin in combination for 4 weeks. In mice fed the PomX-diet the proportion of Turicibacteraceae and Ruminococcaceae was significantly increased compared to the control HF/HS diet. Supplementation with inulin alone and inulin + PomX combination significantly increased the proportion of Verrucomicrobiaceae (A. muciniphila) and decreased Clostridiaceae. Only mice fed the inulin diet experienced an increase in serum lipopolysaccharide (LPS) and monocyte chemoattractant protein 1 (MCP-1), which was reversed when feeding the inulin + PomX diet. Feeding the inulin + PomX diet was associated with a significant increase in Bifidobacteriaceae and Rikenellaceae, which may have contributed to the reduction of endotoxemia markers. Inulin supplementation showed lower species richness of gut microbiota compared to mice fed with HF/HS or HF/HS/PomX, and the reduction was reversed by the addition of PomX. Inulin alone and in combination with PomX had distinct microbial clusters determined by both weighted and unweighted UniFrac Beta-Diversity principle coordinate analysis. A total of 19 KEGG biological pathways were significantly regulated in the gut microbiota with PomX and inulin alone or combined treatment. Inulin significantly enhanced KEGG infectious disease-related pathway associated with increase of serum LPS and MCP-1. No changes in gene expression of ileal proinflammatory cytokine and tight junction genes were observed in mice treated with PomX and inulin. Our results demonstrated that the gut microbiota and their biological pathways were differentially effected by dietary PomX and inulin fed combined or alone. It is therefore very important to consider the interaction among bioactive components of food when evaluating potential prebiotic effects.

  • effects of dietary Pomegranate Extract and inulin in mice fed an obesogenic diet
    The FASEB Journal, 2017
    Co-Authors: Jieping Yang, Emma Grojean, Austin Ly, Rita Pisegna, Susanne M Henning, David Heber, Song Zhang, Zhaoping Li
    Abstract:

    BackgroundIt has been demonstrated in animal studies that both polyphenol rich Pomegranate Extract (PomX) and the oligosaccharide inulin, ameliorate metabolic changes induced by a high-fat diet, bu...

  • Effects of Pomegranate Extract on High Fat/High Sucrose Diet induced Obesity are Dependent on the Intestinal Formation of Urolithin A
    The FASEB Journal, 2016
    Co-Authors: Jieping Yang, Emma Grojean, Susanne M Henning, Ru-po Lee, Mark Hsu, David Heber
    Abstract:

    Recent studies strongly suggest the association of gut microbiota and obesity related diseases. Published data from a mouse study demonstrated that Pomegranate Extract (PomX) administration increas...

  • effects of Pomegranate Extract on high fat high sucrose diet induced obesity are dependent on the intestinal formation of urolithin a
    The FASEB Journal, 2016
    Co-Authors: Jieping Yang, Emma Grojean, Susanne M Henning, Ru-po Lee, Mark Hsu, David Heber
    Abstract:

    Recent studies strongly suggest the association of gut microbiota and obesity related diseases. Published data from a mouse study demonstrated that Pomegranate Extract (PomX) administration increas...

Erica J Roelofs - One of the best experts on this subject based on the ideXlab platform.

  • effects of Pomegranate Extract on blood flow and vessel diameter after high intensity exercise in young healthy adults
    European Journal of Sport Science, 2017
    Co-Authors: Erica J Roelofs, Eric T Trexler, Abbie E Smithryan, Katie R. Hirsch, Meredith G. Mock
    Abstract:

    AbstractThe effects of Pomegranate Extract (PE) supplementation were evaluated on high-intensity exercise performance, blood flow, vessel diameter, oxygen saturation (SPO2), heart rate (HR), and blood pressure (BP). In a randomized, crossover design, nineteen recreationally resistance-trained participants were randomly assigned to PE (1000 mg) or placebo (PL), which were consumed 30 min prior to a repeated sprint ability (RSA) test and repetitions to fatigue (RTF) on bench and leg press. The RSA consisted of ten six-second sprints on a friction-loaded cycle ergometer with 30 s recovery. Brachial artery blood flow and vessel diameter were assessed by ultrasound. Blood flow, vessel diameter, SPO2, HR, and BP were assessed at baseline, 30 min post ingestion, immediately post exercise (IPost), and 30 min post exercise (30minPost). With PE, blood flow significantly increased IPost RSA (mean difference = 18.49 mL min−1; P < .05), and IPost and 30minPost RTF (P < .05) according to confidence intervals (CI). Vess...

  • Effects of Pomegranate Extract on blood flow and vessel diameter after high-intensity exercise in young, healthy adults.
    European journal of sport science, 2016
    Co-Authors: Erica J Roelofs, Eric T Trexler, Katie R. Hirsch, Abbie E. Smith-ryan, Meredith G. Mock
    Abstract:

    AbstractThe effects of Pomegranate Extract (PE) supplementation were evaluated on high-intensity exercise performance, blood flow, vessel diameter, oxygen saturation (SPO2), heart rate (HR), and blood pressure (BP). In a randomized, crossover design, nineteen recreationally resistance-trained participants were randomly assigned to PE (1000 mg) or placebo (PL), which were consumed 30 min prior to a repeated sprint ability (RSA) test and repetitions to fatigue (RTF) on bench and leg press. The RSA consisted of ten six-second sprints on a friction-loaded cycle ergometer with 30 s recovery. Brachial artery blood flow and vessel diameter were assessed by ultrasound. Blood flow, vessel diameter, SPO2, HR, and BP were assessed at baseline, 30 min post ingestion, immediately post exercise (IPost), and 30 min post exercise (30minPost). With PE, blood flow significantly increased IPost RSA (mean difference = 18.49 mL min−1; P 

  • The effects of Pomegranate Extract on anaerobic exercise performance & cardiovascular responses.
    Journal of The International Society of Sports Nutrition, 2015
    Co-Authors: Erica J Roelofs, Eric T Trexler, Katie R. Hirsch, Meredith G. Mock, Abbie E. Smith-ryan
    Abstract:

    Background During exercise, there is an increased demand for oxygen. Increasing blood flow may provide an ergogenic effect. Dietary nitrate supplementation, such as Pomegranate Extract (PE), has been linked to reduced vascular resistance, enhanced vasodilation, and increased blood flow to possibly improve exercise efficiency. The purpose of this study was to evaluate the effects of acute PE supplementation on anaerobic exercise, flow mediated dilation (FMD), oxygen saturation (SP02), heart rate (HR), and blood pressure (BP).

  • the effects of Pomegranate Extract on blood flow vessel diameter and exercise tolerance
    Journal of The International Society of Sports Nutrition, 2014
    Co-Authors: Malia N Melvin, Eric T Trexler, Erica J Roelofs, Hailee L Wingfield, Abbie E Smithryan
    Abstract:

    Background During exercise, the demand for oxygen and energy substrates is elevated in active skeletal muscle. Supplements with high nitrate and polyphenol content have been shown to increase nitric oxide production and enhance exercise efficiency. The current randomized, double-blind, placebo-controlled, crossover study aimed to investigate the acute effects of Pomegranate Extract on blood flow, vessel diameter, and exercise performance in active individuals.

  • effects of Pomegranate Extract on blood flow and running time to exhaustion
    Applied Physiology Nutrition and Metabolism, 2014
    Co-Authors: Eric T Trexler, Abbie E Smithryan, Malia N Melvin, Erica J Roelofs, Hailee L Wingfield
    Abstract:

    Recent research has shown that dietary nitrate has favorable effects on blood flow and exercise performance. The purpose of this randomized, double-blind, placebo-controlled crossover study was to investigate the acute effects of Pomegranate Extract on blood flow, vessel diameter, and exercise performance in active individuals. Nineteen men and women (mean ± SD: age, 22.2 ± 2.2 years; height, 174.8 ± 10.7 cm; body mass, 71.9 ± 13.5 kg) were randomly assigned to a placebo (PL) or Pomegranate Extract (PE) group. Participants performed a maximal oxygen consumption treadmill test to determine peak velocity (PV). Participants returned after 24–48 h and ingested either PL or PE. Brachial artery blood flow was assessed using ultrasound at baseline and 30 min post-ingestion (30minPI). Three treadmill runs to exhaustion were performed at 90%, 100%, and 110% PV. Blood flow was assessed immediately after each exercise bout and 30 min postexercise (30minPEx). After a 7–10 day washout, participants repeated the same p...

Eric T Trexler - One of the best experts on this subject based on the ideXlab platform.

  • effects of Pomegranate Extract on blood flow and vessel diameter after high intensity exercise in young healthy adults
    European Journal of Sport Science, 2017
    Co-Authors: Erica J Roelofs, Eric T Trexler, Abbie E Smithryan, Katie R. Hirsch, Meredith G. Mock
    Abstract:

    AbstractThe effects of Pomegranate Extract (PE) supplementation were evaluated on high-intensity exercise performance, blood flow, vessel diameter, oxygen saturation (SPO2), heart rate (HR), and blood pressure (BP). In a randomized, crossover design, nineteen recreationally resistance-trained participants were randomly assigned to PE (1000 mg) or placebo (PL), which were consumed 30 min prior to a repeated sprint ability (RSA) test and repetitions to fatigue (RTF) on bench and leg press. The RSA consisted of ten six-second sprints on a friction-loaded cycle ergometer with 30 s recovery. Brachial artery blood flow and vessel diameter were assessed by ultrasound. Blood flow, vessel diameter, SPO2, HR, and BP were assessed at baseline, 30 min post ingestion, immediately post exercise (IPost), and 30 min post exercise (30minPost). With PE, blood flow significantly increased IPost RSA (mean difference = 18.49 mL min−1; P < .05), and IPost and 30minPost RTF (P < .05) according to confidence intervals (CI). Vess...

  • Effects of Pomegranate Extract on blood flow and vessel diameter after high-intensity exercise in young, healthy adults.
    European journal of sport science, 2016
    Co-Authors: Erica J Roelofs, Eric T Trexler, Katie R. Hirsch, Abbie E. Smith-ryan, Meredith G. Mock
    Abstract:

    AbstractThe effects of Pomegranate Extract (PE) supplementation were evaluated on high-intensity exercise performance, blood flow, vessel diameter, oxygen saturation (SPO2), heart rate (HR), and blood pressure (BP). In a randomized, crossover design, nineteen recreationally resistance-trained participants were randomly assigned to PE (1000 mg) or placebo (PL), which were consumed 30 min prior to a repeated sprint ability (RSA) test and repetitions to fatigue (RTF) on bench and leg press. The RSA consisted of ten six-second sprints on a friction-loaded cycle ergometer with 30 s recovery. Brachial artery blood flow and vessel diameter were assessed by ultrasound. Blood flow, vessel diameter, SPO2, HR, and BP were assessed at baseline, 30 min post ingestion, immediately post exercise (IPost), and 30 min post exercise (30minPost). With PE, blood flow significantly increased IPost RSA (mean difference = 18.49 mL min−1; P 

  • The effects of Pomegranate Extract on anaerobic exercise performance & cardiovascular responses.
    Journal of The International Society of Sports Nutrition, 2015
    Co-Authors: Erica J Roelofs, Eric T Trexler, Katie R. Hirsch, Meredith G. Mock, Abbie E. Smith-ryan
    Abstract:

    Background During exercise, there is an increased demand for oxygen. Increasing blood flow may provide an ergogenic effect. Dietary nitrate supplementation, such as Pomegranate Extract (PE), has been linked to reduced vascular resistance, enhanced vasodilation, and increased blood flow to possibly improve exercise efficiency. The purpose of this study was to evaluate the effects of acute PE supplementation on anaerobic exercise, flow mediated dilation (FMD), oxygen saturation (SP02), heart rate (HR), and blood pressure (BP).

  • the effects of Pomegranate Extract on blood flow vessel diameter and exercise tolerance
    Journal of The International Society of Sports Nutrition, 2014
    Co-Authors: Malia N Melvin, Eric T Trexler, Erica J Roelofs, Hailee L Wingfield, Abbie E Smithryan
    Abstract:

    Background During exercise, the demand for oxygen and energy substrates is elevated in active skeletal muscle. Supplements with high nitrate and polyphenol content have been shown to increase nitric oxide production and enhance exercise efficiency. The current randomized, double-blind, placebo-controlled, crossover study aimed to investigate the acute effects of Pomegranate Extract on blood flow, vessel diameter, and exercise performance in active individuals.

  • effects of Pomegranate Extract on blood flow and running time to exhaustion
    Applied Physiology Nutrition and Metabolism, 2014
    Co-Authors: Eric T Trexler, Abbie E Smithryan, Malia N Melvin, Erica J Roelofs, Hailee L Wingfield
    Abstract:

    Recent research has shown that dietary nitrate has favorable effects on blood flow and exercise performance. The purpose of this randomized, double-blind, placebo-controlled crossover study was to investigate the acute effects of Pomegranate Extract on blood flow, vessel diameter, and exercise performance in active individuals. Nineteen men and women (mean ± SD: age, 22.2 ± 2.2 years; height, 174.8 ± 10.7 cm; body mass, 71.9 ± 13.5 kg) were randomly assigned to a placebo (PL) or Pomegranate Extract (PE) group. Participants performed a maximal oxygen consumption treadmill test to determine peak velocity (PV). Participants returned after 24–48 h and ingested either PL or PE. Brachial artery blood flow was assessed using ultrasound at baseline and 30 min post-ingestion (30minPI). Three treadmill runs to exhaustion were performed at 90%, 100%, and 110% PV. Blood flow was assessed immediately after each exercise bout and 30 min postexercise (30minPEx). After a 7–10 day washout, participants repeated the same p...