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Maria Serrano - One of the best experts on this subject based on the ideXlab platform.
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postharvest biology and technology of Pomegranate
Journal of the Science of Food and Agriculture, 2015Co-Authors: Sunil Pareek, Daniel Valero, Maria SerranoAbstract:Pomegranate is a subtropical and tropical fruit of great importance from a health point of view. Despite increasing consumer awareness of the health benefits of Pomegranate, consumption of the fruit is still limited owing to poor postharvest handling, storage recommendations, short shelf life and quality deterioration during transportation, storage and marketing. The occurrence of physiological disorders such as husk scald, splitting and chilling injury is another challenge reducing marketability and consumer acceptance. Recently, notable work on postharvest biology and technology has been done. Pomegranate is highly sensitive to low-oxygen (<5 kPa) atmospheres, chilling injury and decay. One of the major problems associated with Pomegranate fruit is excessive weight loss, which may result in hardening of the husk and browning of the rind and arils. To reduce chilling injury incidence and to extend storability and marketing of Pomegranates, good results were obtained with polyamine, heat, salicylic acid, methyl jasmonate or methyl salicylate treatments prior to cold storage. This article reviews the maturity indices, changes during maturation and ripening, postharvest physiology and technology of Pomegranate fruit as well as the various postharvest treatments for maintaining fruit quality. © 2015 Society of Chemical Industry
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vapor treatments chilling storage and antioxidants in Pomegranates
Processing and Impact on Active Components in Food, 2015Co-Authors: Daniel Valero, Mohammad Sayyari, Seyed Hossein Mirdehghan, Maria SerranoAbstract:Abstract Pomegranate ( Punica granatum L.) is rich in bioactive compounds such as phenolics and anthocyanins with proven antioxidant activity in vitro and in vivo . However, Pomegranates are considered as perishable commodities with severe storability problems due to their sensitivity to developing chilling injury symptoms when they are stored at low temperatures. These symptoms are manifested by skin browning, surface pitting and desiccation and accompanied by increases in electrolyte leakage leading to quality losses and reduced shelf-life. In this chapter, an overview of the chilling injury incidence and its possible minimization throughout appropriate post-harvest treatments is provided, with special emphasis on some innovative tools such as the natural compounds methyl jasmonate and methyl salicylate. These treatments reduced chilling injury and enhanced the content of bioactive compounds and the total antioxidant activity of the arils along storage leading to fruit with enhanced phytochemicals and increased health-beneficial properties to consumers.
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acetyl salicylic acid alleviates chilling injury and maintains nutritive and bioactive compounds and antioxidant activity during postharvest storage of Pomegranates
Postharvest Biology and Technology, 2011Co-Authors: Mohammad Sayyari, Daniel Valero, S Castillo, H M Diazmula, Maria SerranoAbstract:Abstract Pomegranates were treated by dipping with acetyl salicylic acid (ASA) at three concentrations (0.1, 0.5 and 1.0 mM) immediately after harvest and then stored under chilling temperature for 14, 28, 42, 56, 70 and 84 days at 2 °C plus a subsequent period of 4 days at 20 °C. Control fruit exhibited more chilling injury (CI) symptoms (manifested by pitting and browning) than treated fruit during storage, accompanied by increased softening, ion leakage and respiration rate. The ASA treatments were also effective in maintaining higher contents of nutritive (sugars and organic acids) and bioactive compounds (total phenolics and anthocyanins) and total antioxidant activity (TAA), in both hydrophilic (H-TAA) and lipophilic (L-TAA) fractions. These results suggest that ASA could have potential postharvest application for reducing CI, maintain quality and improve the health benefits of Pomegranate fruit consumption by increasing the antioxidant capacity.
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prestorage oxalic acid treatment maintained visual quality bioactive compounds and antioxidant potential of Pomegranate after long term storage at 2 c
Journal of Agricultural and Food Chemistry, 2010Co-Authors: Mohammad Sayyari, Daniel Valero, Mesbah Babalar, Siamak Kalantari, P J Zapata, Maria SerranoAbstract:Oxalic acid at three concentrations (2, 4, and 6 mM) was applied by dipping to Pomegranate fruits of cv. Mollar de Elche, which were then stored for 84 days at 2 °C. Pomegranate is a chilling-sensitive fruit and, thus, control fruits exhibited chilling injury (CI) symptoms after long-term storage at 2 °C that were accompanied by increased respiration rate, weight loss, and electrolyte leakage (EL). The CI symptoms were significantly reduced by oxalic acid treatment, especially for the 6 mM concentration. In addition, control Pomegranates showed significant reduction in the content of total phenolics and ascorbic acid as well as in total antioxidant activity (TAA), in both hydrophilic (H-TAA) and lipophilic (L-TAA) fractions. The application of oxalic acid led to lower losses of total phenolics and significant increase in both ascorbic acid content and H-TAA, whereas L-TAA remained unaffected. Thus, oxalic acid could be a promising postharvest treatment to alleviate CI and increase antioxidant potential.
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reduction of Pomegranate chilling injury during storage after heat treatment role of polyamines
Postharvest Biology and Technology, 2007Co-Authors: Seyed Hossein Mirdehghan, Maria Serrano, P J Zapata, Majid Rahemi, D Martinezromero, Fabian Guillen, J M Valverde, Daniel ValeroAbstract:Abstract Pomegranate fruit (Punica granatum L.) were heat-treated by hot water dip at 45 °C for 4 min, and then stored at 2 °C for 90 days. Fruit immersed in distilled water at 25 °C for 4 min served as controls. Samples were taken every 15 days followed by 3 days at 20 °C. Pomegranates developed chilling injury, manifested as increases in skin browning and electrolyte leakage, which were highly correlated. The severity of damage in control fruit was related to softening and loss of fatty acids with a concomitant reduction in the ratio of unsaturated/saturated fatty acids during storage. These chilling injury symptoms were slightly, but significantly reduced in heat-treated Pomegranates. In addition, the heat treatment induced increases in free putrescine and spermidine during storage, which could have a role in the lower rate of fruit softening and in the diminution of chilling injury severity. These higher polyamine levels as well as maintenance of the unsaturated/saturated fatty acid ratio during storage could account for the maintenance of membrane integrity and fluidity. Thus, heat treatment could induce tolerance mechanism to low temperature through stimulation of polyamine biosynthesis.
Daniel Valero - One of the best experts on this subject based on the ideXlab platform.
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New Approaches to Modeling Methyl Jasmonate Effects on Pomegranate Quality during Postharvest Storage
International Journal of Fruit Science, 2017Co-Authors: Mohammad Sayyari, Fakhreddin Salehi, Daniel ValeroAbstract:ABSTRACTAdaptive neuro fuzzy inference system (ANFIS) and genetic algorithm–artificial neural network (GA-ANN) models were used to predict the effect of methyl jasmonate (at three levels 0, 0.01, and 0.1 mM) and storage time (0, 14, 28, 42, 56, 70, and 84 days) on quality parameters and physiological changes of Pomegranate fruits during storage. Methyl jasmonate reduced chilling injury and improved quality characteristics of Pomegranates during postharvest storage. The GA-ANN and ANFIS were fed with two inputs of methyl jasmonate and storage time. The results showed that GA-ANN predictions agreed with experimental data and the GA-ANN with 14 neurons in one hidden layer can predict physiological changes and quality parameters of Pomegranate (weight loss, pH, chilling injury index, ion leakage, ethylene, respiration, polyphenols, anthocyanins, and total antioxidant activity) with correlation coefficients equal to 0.87. The ANFIS model was trained by a hybrid method and agreement between experimental data an...
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postharvest biology and technology of Pomegranate
Journal of the Science of Food and Agriculture, 2015Co-Authors: Sunil Pareek, Daniel Valero, Maria SerranoAbstract:Pomegranate is a subtropical and tropical fruit of great importance from a health point of view. Despite increasing consumer awareness of the health benefits of Pomegranate, consumption of the fruit is still limited owing to poor postharvest handling, storage recommendations, short shelf life and quality deterioration during transportation, storage and marketing. The occurrence of physiological disorders such as husk scald, splitting and chilling injury is another challenge reducing marketability and consumer acceptance. Recently, notable work on postharvest biology and technology has been done. Pomegranate is highly sensitive to low-oxygen (<5 kPa) atmospheres, chilling injury and decay. One of the major problems associated with Pomegranate fruit is excessive weight loss, which may result in hardening of the husk and browning of the rind and arils. To reduce chilling injury incidence and to extend storability and marketing of Pomegranates, good results were obtained with polyamine, heat, salicylic acid, methyl jasmonate or methyl salicylate treatments prior to cold storage. This article reviews the maturity indices, changes during maturation and ripening, postharvest physiology and technology of Pomegranate fruit as well as the various postharvest treatments for maintaining fruit quality. © 2015 Society of Chemical Industry
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vapor treatments chilling storage and antioxidants in Pomegranates
Processing and Impact on Active Components in Food, 2015Co-Authors: Daniel Valero, Mohammad Sayyari, Seyed Hossein Mirdehghan, Maria SerranoAbstract:Abstract Pomegranate ( Punica granatum L.) is rich in bioactive compounds such as phenolics and anthocyanins with proven antioxidant activity in vitro and in vivo . However, Pomegranates are considered as perishable commodities with severe storability problems due to their sensitivity to developing chilling injury symptoms when they are stored at low temperatures. These symptoms are manifested by skin browning, surface pitting and desiccation and accompanied by increases in electrolyte leakage leading to quality losses and reduced shelf-life. In this chapter, an overview of the chilling injury incidence and its possible minimization throughout appropriate post-harvest treatments is provided, with special emphasis on some innovative tools such as the natural compounds methyl jasmonate and methyl salicylate. These treatments reduced chilling injury and enhanced the content of bioactive compounds and the total antioxidant activity of the arils along storage leading to fruit with enhanced phytochemicals and increased health-beneficial properties to consumers.
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acetyl salicylic acid alleviates chilling injury and maintains nutritive and bioactive compounds and antioxidant activity during postharvest storage of Pomegranates
Postharvest Biology and Technology, 2011Co-Authors: Mohammad Sayyari, Daniel Valero, S Castillo, H M Diazmula, Maria SerranoAbstract:Abstract Pomegranates were treated by dipping with acetyl salicylic acid (ASA) at three concentrations (0.1, 0.5 and 1.0 mM) immediately after harvest and then stored under chilling temperature for 14, 28, 42, 56, 70 and 84 days at 2 °C plus a subsequent period of 4 days at 20 °C. Control fruit exhibited more chilling injury (CI) symptoms (manifested by pitting and browning) than treated fruit during storage, accompanied by increased softening, ion leakage and respiration rate. The ASA treatments were also effective in maintaining higher contents of nutritive (sugars and organic acids) and bioactive compounds (total phenolics and anthocyanins) and total antioxidant activity (TAA), in both hydrophilic (H-TAA) and lipophilic (L-TAA) fractions. These results suggest that ASA could have potential postharvest application for reducing CI, maintain quality and improve the health benefits of Pomegranate fruit consumption by increasing the antioxidant capacity.
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prestorage oxalic acid treatment maintained visual quality bioactive compounds and antioxidant potential of Pomegranate after long term storage at 2 c
Journal of Agricultural and Food Chemistry, 2010Co-Authors: Mohammad Sayyari, Daniel Valero, Mesbah Babalar, Siamak Kalantari, P J Zapata, Maria SerranoAbstract:Oxalic acid at three concentrations (2, 4, and 6 mM) was applied by dipping to Pomegranate fruits of cv. Mollar de Elche, which were then stored for 84 days at 2 °C. Pomegranate is a chilling-sensitive fruit and, thus, control fruits exhibited chilling injury (CI) symptoms after long-term storage at 2 °C that were accompanied by increased respiration rate, weight loss, and electrolyte leakage (EL). The CI symptoms were significantly reduced by oxalic acid treatment, especially for the 6 mM concentration. In addition, control Pomegranates showed significant reduction in the content of total phenolics and ascorbic acid as well as in total antioxidant activity (TAA), in both hydrophilic (H-TAA) and lipophilic (L-TAA) fractions. The application of oxalic acid led to lower losses of total phenolics and significant increase in both ascorbic acid content and H-TAA, whereas L-TAA remained unaffected. Thus, oxalic acid could be a promising postharvest treatment to alleviate CI and increase antioxidant potential.
Gilles J Guillemin - One of the best experts on this subject based on the ideXlab platform.
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consumption of Pomegranates improves synaptic function in a transgenic mice model of alzheimer s disease
Oncotarget, 2016Co-Authors: Nady Braidy, Musthafa Mohamed Essa, Samir Aladawi, Anne Poljak, Subash Selvaraju, Thamilarasan Manivasagm, Arokiasamy Justin Thenmozhi, Lezanne Ooi, Perminder S Sachdev, Gilles J GuilleminAbstract:// Nady Braidy 1,* , Musthafa Mohamed Essa 2,3,* , Anne Poljak 1,4 , Subash Selvaraju 2,3 , Samir Al-Adawi 2,4 , Thamilarasan Manivasagm 5 , Arokiasamy Justin Thenmozhi 5 , Lezanne Ooi 6 , Perminder Sachdev 1,7 and Gilles J. Guillemin 8 1 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia 2 Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al Khoudh, Oman 3 Ageing and Dementia Research Group, Sultan Qaboos University, Al Khoudh, Oman 4 College of Medicine and Health Sciences, Sultan Qaboos University, Al Khoudh, Oman 5 Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, India 6 Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia 7 Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia 8 Neuroinflammation Group, MND and Neurodegenerative Diseases Research Centre, Macquarie University, NSW, Australia * These authors have contributed equally to this work Correspondence to: Gilles J. Guillemin, email: // Musthafa Mohamed Essa, email: // Keywords : Pomegranates; synapse; inflammation; amyloid beta protein; amyloid precursor protein; Gerotarget Received : April 04, 2016 Accepted : June 17, 2016 Published : July 28, 2016 Abstract Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by extracellular plaques containing abnormal Amyloid Beta (Aβ) aggregates, intracellular neurofibrillary tangles containing hyperphosphorylated tau protein, microglia-dominated neuroinflammation, and impairments in synaptic plasticity underlying cognitive deficits. Therapeutic strategies for the treatment of AD are currently limited. In this study, we investigated the effects of dietary supplementation of 4% Pomegranate extract to a standard chow diet on neuroinflammation, and synaptic plasticity in APPsw/Tg2576 mice brain. Treatment with a custom mixed diet (pellets) containing 4% Pomegranate for 15 months ameliorated the loss of synaptic structure proteins, namely PSD-95, Munc18-1, and SNAP25, synaptophysin, phosphorylation of Calcium/Calmodulin Dependent Protein Kinase IIα (p-CaMKIIα/ CaMKIIα), and phosphorylation of Cyclic AMP-Response Element Binding Protein (pCREB/CREB), inhibited neuroinflammatory activity, and enhanced autophagy, and activation of the phophoinositide-3-kinase-Akt-mammalian target of rapamycin signaling pathway. These neuroprotective effects were associated with reduced β-site cleavage of Amyloid Precursor Protein in APPsw/Tg2576 mice. Therefore, long-term supplementation with Pomegranates can attenuate AD pathology by reducing inflammation, and altering APP-dependent processes.
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long term 15 mo dietary supplementation with Pomegranates from oman attenuates cognitive and behavioral deficits in a transgenic mice model of alzheimer s disease
Nutrition, 2015Co-Authors: Selvaraju Subash, Nady Braidy, Musthafa Mohamed Essa, Al Buraiki Zayana, Vaishnav Ragini, Samir Aladawi, Abdullah Alasmi, Gilles J GuilleminAbstract:Abstract Objective Transgenic (Tg) mice, which possess an amyloid precursor protein (APP) gene mutation, develop extracellular amyloid β (Aβ) deposition in the brain, and severe memory and behavioral deficits with age. These mice serve as an important animal model for testing the efficacy of novel drug candidates for the treatment and management of symptoms of Alzheimer's disease (AD). Several reports have suggested that oxidative stress is the underlying cause of Aβ neurotoxicity in AD. Pomegranates contain very high levels of antioxidants and several medicinal properties that may be useful for improving quality of life in individuals with AD. The aim of this study was to investigate the effect of dietary supplementation of Omani Pomegranate extract on memory, anxiety, and learning skills in an AD mouse model possessing the double Swedish APP mutation (APPsw/Tg2576). Methods The experimental groups of APP-Tg mice from the age of 4 mo were fed a custom mixed diet (pellets) containing 4% Pomegranate. We assessed spatial memory and learning ability, psychomotor coordination, and anxiety-related behavior in Tg and wild-type mice at the age of 4 to 5 mo and 18 to 19 mo using the Morris water maze test, rotarod performance test, elevated plus-maze test, and open field test. Results APPsw/Tg2576 mice that were fed a standard chow diet without Pomegranates showed significant memory deficits, increased anxiety-related behavior, and severe impairment in spatial learning ability, position discrimination learning ability, and motor coordination compared with the wild-type mice on the same diet, at the age of 18 to 19 mo. In contrast, APPsw/Tg2576 mice that were fed a diet containing 4% Pomegranates showed significant improvements in memory, learning, locomotor function, as well as reduction in anxiety, compared with APPsw/Tg2576 mice fed the standard chow diet. Conclusion Our results suggest that dietary supplementation with Pomegranates may slow the progression of cognitive and behavioral impairments in AD.
Robert Mansel - One of the best experts on this subject based on the ideXlab platform.
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Chemopreventive and adjuvant therapeutic potential of Pomegranate (Punica granatum) for human breast cancer
Breast Cancer Research and Treatment, 2002Co-Authors: Rajendra Mehta, Weiping Yu, Ishak Neeman, Talia Livney, Akiva Amichay, Donald Poirier, Paul Nicholls, Andrew Kirby, Wenguo Jiang, Robert ManselAbstract:Fresh organically grown Pomegranates ( Punica granatum L.) of the Wonderful cultivar were processed into three components: fermented juice, aqueous pericarp extract and cold-pressed or supercritical CO_2-extracted seed oil. Exposure to additional solvents yielded polyphenol-rich fractions (‘polyphenols’) from each of the three components. Their actions, and of the crude whole oil and crude fermented and unfermented juice concentrate, were assessed in vitro for possible chemopreventive or adjuvant therapeutic potential in human breast cancer. The ability to effect a blockade of endogenous active estrogen biosynthesis was shown by polyphenols from fermented juice, pericarp, and oil, which inhibited aromatase activity by 60–80%. Fermented juice and pericarp polyphenols, and whole seed oil, inhibited 17-β-hydroxysteroid dehydrogenase Type 1 from 34 to 79%, at concentrations ranging from 100 to 1,000 μg/ml according to seed oil ≫ fermented juice polyphenols > pericarp polyphenols. In a yeast estrogen screen (YES) lyophilized fresh Pomegranate juice effected a 55% inhibition of the estrogenic activity of 17-β-estradiol; whereas the lyophilized juice by itself displayed only minimal estrogenic action. Inhibition of cell lines by fermented juice and pericarp polyphenols was according to estrogen-dependent (MCF-7) ≫ estrogen- independent (MB-MDA-231) > normal human breast epithelial cells (MCF-10A). In both MCF-7 and MB-MDA-231 cells, fermented Pomegranate juice polyphenols consistently showed about twice the anti-proliferative effect as fresh Pomegranate juice polyphenols. Pomegranate seed oil effected 90% inhibition of proliferation of MCF-7 at 100 μg/ml medium, 75% inhibition of invasion of MCF-7 across a Matrigel membrane at 10 μg/ml, and 54% apoptosis in MDA-MB-435 estrogen receptor negative metastatic human breast cancer cells at 50 μg/ml. In a %% murine mammary gland organ culture, fermented juice polyphenols effected 47% inhibition of cancerous lesion formation induced by the carcinogen 7,12-dimethylbenz[ a ]anthracene (DMBA). The findings suggest that clinical trials to further assess chemopreventive and adjuvant therapeutic applications of Pomegranate in human breast cancer may be warranted.
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chemopreventive and adjuvant therapeutic potential of Pomegranate punica granatum for human breast cancer
Breast Cancer Research and Treatment, 2002Co-Authors: Nam Deuk Kim, Ishak Neeman, Talia Livney, Akiva Amichay, Donald Poirier, Wenguo Jiang, Rajendra G Mehta, P J Nicholls, Andrew James Kirby, Robert ManselAbstract:Fresh organically grown Pomegranates (Punica granatum L.) of the Wonderful cultivar were processed into three components: fermented juice, aqueous pericarp extract and cold-pressed or supercritical CO2-extracted seed oil. Exposure to additional solvents yielded polyphenol-rich fractions ('polyphenols') from each of the three components. Their actions, and of the crude whole oil and crude fermented and unfermented juice concentrate, were assessed in vitro for possible chemopreventive or adjuvant therapeutic potential in human breast cancer. The ability to effect a blockade of endogenous active estrogen biosynthesis was shown by polyphenols from fermented juice, pericarp, and oil, which inhibited aromatase activity by 60-80%. Fermented juice and pericarp polyphenols, and whole seed oil, inhibited 17-beta-hydroxysteroid dehydrogenase Type 1 from 34 to 79%, at concentrations ranging from 100 to 1,000 microg/ml according to seed oil >> fermented juice polyphenols > pericarp polyphenols. In a yeast estrogen screen (YES) lyophilized fresh Pomegranate juice effected a 55% inhibition of the estrogenic activity of 17-beta-estradiol; whereas the lyophilized juice by itself displayed only minimal estrogenic action. Inhibition of cell lines by fermented juice and pericarp polyphenols was according to estrogen-dependent (MCF-7) >> estrogen-independent (MB-MDA-231) > normal human breast epithelial cells (MCF-10A). In both MCF-7 and MB-MDA-231 cells, fermented Pomegranate juice polyphenols consistently showed about twice the anti-proliferative effect as fresh Pomegranate juice polyphenols. Pomegranate seed oil effected 90% inhibition of proliferation of MCF-7 at 100 microg/ml medium, 75% inhibition of invasion of MCF-7 across a Matrigel membrane at 10 microg/ml, and 54% apoptosis in MDA-MB-435 estrogen receptor negative metastatic human breast cancer cells at 50 microg/ml. In a murine mammary gland organ culture, fermented juice polyphenols effected 47% inhibition of cancerous lesion formation induced by the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). The findings suggest that clinical trials to further assess chemopreventive and adjuvant therapeutic applications of Pomegranate in human breast cancer may be warranted.
Bijan Kavoosi - One of the best experts on this subject based on the ideXlab platform.
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Methyl Jasmonate Foliar Spray Substantially Enhances the Productivity, Quality and Phytochemical Contents of Pomegranate Fruit
Journal of Plant Growth Regulation, 2019Co-Authors: Mohammadreza Asghari, Mohammad Merrikhi, Bijan KavoosiAbstract:As an alternative to chemicals, the use of phytohormones and growth regulators is considered as a novel method of enhancing the yield, quality parameters and nutritional capacity of fruit crops. Physiological responses and changes in quality attributes, yield, and phytochemicals of Pomegranate fruits in response to foliar spray with different concentrations of methyl jasmonate (MeJA) at different growth and development stages were studied. MeJA in a concentration dependent manner, from 0.1 to 0.5 mM, substantially increased fruit total antioxidant and phenylalanine ammonialyase activities, total phenolics, ellagic acid, punicalagin, and tannic acid contents, sweetness, total soluble solids, whole fruit, aril and peel weights, firmness and juice content at harvest. MeJA substantially decreased fruit respiration rate and titratable acidity. Compared to the control, fruits from the trees treated with 0.5 mM MeJA showed 133% increase in aril weight, 141.4% increase in peel weight, 101% increase in fruit weight, and 24.7% increase in juice content ( p ≤ 0.01). As a novel finding, the results showed that multiple spray of Pomegranate trees and fruits with 0.5 mM MeJA is as an effective and practical strategy to enhance the yield, quality, and phytochemical contents of Pomegranates.
