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M. Julia B.f. Flaminio - One of the best experts on this subject based on the ideXlab platform.
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Fell Pony Syndrome in a Pony in North America
Journal of Veterinary Internal Medicine, 2008Co-Authors: Rachel B. Gardner, Kelsey A. Hart, Tracy Stokol, Thomas J. Divers, M. Julia B.f. FlaminioAbstract:A 5-week-old Fell Pony colt was examined for fever, lethargy, and anemia. The colt had been lethargic for 1 week before examination, had continued to nurse, had a temperature of 104°F (40°C), and was treated with ceftiofur (5 mg/kg IM q12h). Approximately 36 hours before examination, the colt developed watery diarrhea. Blood work performed by the referring veterinarian on the day of admission revealed a PCV of 10%.
Ilyas M Kamboh - One of the best experts on this subject based on the ideXlab platform.
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association analysis of pon2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus
BMC Medical Genetics, 2011Co-Authors: Sudeshna Dasgupta, Yesim F Demirci, Amy S Dressen, Amy H Kao, Elisa Y Rhew, Rosalind Ramseygoldman, Susan Manzi, Candace M Kammerer, Ilyas M KambohAbstract:Low serum paraoxonase (PON) activity is associated with the risk of coronary artery disease, diabetes and systemic lupus erythematosus (SLE). Our prior studies have shown that the PON1/rs662 (p.Gln192Arg), PON1/rs854560 (p.Leu55Met), PON3/rs17884563 and PON3/rs740264 SNPs (single nucleotide polymorphisms) significantly affect serum PON activity. Since PON1, PON2 and PON3 share high degree of structural and functional properties, in this study, we examined the role of PON2 genetic variation on serum PON activity, risk of SLE and SLE-related clinical manifestations in a Caucasian case-control sample. PON2 SNPs were selected from HapMap and SeattleSNPs databases by including at least one tagSNP from each bin defined in these resources. A total of nineteen PON2 SNPs were successfully genotyped in 411 SLE cases and 511 healthy controls using pyrosequencing, restriction fragment length polymorphism (RFLP) or TaqMan allelic discrimination methods. Our pair-wise linkage disequilibrium (LD) analysis, using an r 2 cutoff of 0.7, identified 14 PON2 tagSNPs that captured all 19 PON2 variants in our sample, 12 of which were not in high LD with known PON1 and PON3 SNP modifiers of PON activity. Stepwise regression analysis of PON activity, including the known modifiers, identified five PON2 SNPs [rs6954345 (p.Ser311Cys), rs13306702, rs987539, rs11982486, and rs4729189; P = 0.005 to 2.1 × 10-6] that were significantly associated with PON activity. We found no association of PON2 SNPs with SLE risk but modest associations were observed with lupus nephritis (rs11981433, rs17876205, rs17876183) and immunologic disorder (rs11981433) in SLE patients (P = 0.013 to 0.042). Our data indicate that PON2 genetic variants significantly affect variation in serum PON activity and have modest effects on risk of lupus nephritis and SLE-related immunologic disorder.
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dna polymorphisms in two paraoxonase genes pon1 and pon2 are associated with the risk of coronary heart disease
American Journal of Human Genetics, 1998Co-Authors: Dharambir K Sanghera, Christopher E Aston, Nilmani Saha, Ilyas M KambohAbstract:A common polymorphism at codon 192 in the human paraoxonase (PON) 1 gene has been shown to be associated with increased risk for coronary heart disease (CHD) in Caucasian populations. However, these findings have not been reported consistently in all Caucasian and non-Caucasian populations, suggesting that this is not a functional mutation but may mark a functional mutation present in either PON1 or a nearby gene. Recently, two other PON-like genes, designated "PON2" and "PON3," have been identified, and they are linked with the known PON1 gene on chromosome 7. Identification of additional polymorphisms in the PON-gene cluster may help to locate the functional polymorphism. In this report, we describe the existence of a common polymorphism at codon 311 (Cys-->Ser; PON2*S) in the PON2 gene, as well as its association with CHD alone and in combination with the PON1 codon 192 polymorphism in Asian Indians. The frequency of the PON2*S allele was significantly higher in cases than in controls (.71 vs. .61; P=.016). The age- and sex-adjusted odds ratio (OR) was 2.5 (95% confidence interval s95% CIs=1.8-3.1; P=.0090) for the PON2*S allele carriers. Further stratification of the PON2*S association, on the basis of the presence or absence of the PON1*B allele, showed that the CHD risk associated with the PON2*S allele was confined to PON1*B-allele carriers. Likewise, the PON1*B-allele risk was present only among PON2*S carriers. Age- and sex-adjusted ORs for the PON2*S and PON1*B were 3.6 (95% CI=2.6-4.6; P=.011) and 2.9 (95% CI=2.4-3.5; P=.0002) among the PON1*B and PON2*S carriers, respectively. Our data indicate that both polymorphisms synergistically contribute to the CHD risk in this sample and that this genetic risk is independent of the conventional plasma lipid profile.
Rachel B. Gardner - One of the best experts on this subject based on the ideXlab platform.
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Fell Pony Syndrome in a Pony in North America
Journal of Veterinary Internal Medicine, 2008Co-Authors: Rachel B. Gardner, Kelsey A. Hart, Tracy Stokol, Thomas J. Divers, M. Julia B.f. FlaminioAbstract:A 5-week-old Fell Pony colt was examined for fever, lethargy, and anemia. The colt had been lethargic for 1 week before examination, had continued to nurse, had a temperature of 104°F (40°C), and was treated with ceftiofur (5 mg/kg IM q12h). Approximately 36 hours before examination, the colt developed watery diarrhea. Blood work performed by the referring veterinarian on the day of admission revealed a PCV of 10%.
Thomas J. Divers - One of the best experts on this subject based on the ideXlab platform.
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Fell Pony Syndrome in a Pony in North America
Journal of Veterinary Internal Medicine, 2008Co-Authors: Rachel B. Gardner, Kelsey A. Hart, Tracy Stokol, Thomas J. Divers, M. Julia B.f. FlaminioAbstract:A 5-week-old Fell Pony colt was examined for fever, lethargy, and anemia. The colt had been lethargic for 1 week before examination, had continued to nurse, had a temperature of 104°F (40°C), and was treated with ceftiofur (5 mg/kg IM q12h). Approximately 36 hours before examination, the colt developed watery diarrhea. Blood work performed by the referring veterinarian on the day of admission revealed a PCV of 10%.
Tracy Stokol - One of the best experts on this subject based on the ideXlab platform.
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Fell Pony Syndrome in a Pony in North America
Journal of Veterinary Internal Medicine, 2008Co-Authors: Rachel B. Gardner, Kelsey A. Hart, Tracy Stokol, Thomas J. Divers, M. Julia B.f. FlaminioAbstract:A 5-week-old Fell Pony colt was examined for fever, lethargy, and anemia. The colt had been lethargic for 1 week before examination, had continued to nurse, had a temperature of 104°F (40°C), and was treated with ceftiofur (5 mg/kg IM q12h). Approximately 36 hours before examination, the colt developed watery diarrhea. Blood work performed by the referring veterinarian on the day of admission revealed a PCV of 10%.
