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N E Skakkebaek - One of the best experts on this subject based on the ideXlab platform.

  • Ultrasonic testicular texture and size in 444 men from the general Population: Correlation to semen quality.
    European Urology, 1993
    Co-Authors: S Lenz, A Giwercman, Elisabeth Carlsen, Elsborg A, Cohr Kh, Jelnes Je, N E Skakkebaek
    Abstract:

    Scrotal ultrasonography was performed in 888 testes of 444 randomly selected men appearing before the medical board prior to military service (Mili group, 287 men, median age 18.8 years), and in employees from an industrial company (Empl group, 157 men, median age 35. 6 years). The ultrasonic volume of each testis was calculated from 3 perpendicular measurements. The ultrasonic texture on sectional planes was scored using a scale from 1 to 5, 1 being very regular, 2 slightly irregular, 3 moderately irregular, 4 very irregular or with bright echogenic points, and 5 with demarcated tumor suspicious areas. Orchidometer measurements were performed in 258 men in Mili group, and semen samples were obtained from 121 men in Empl group

  • ultrasonic testicular texture and size in 444 men from the general Population Correlation to semen quality
    European Urology, 1993
    Co-Authors: S Lenz, A Giwercman, A Elsborg, K H Cohr, J E Jelnes, Elisabeth Carlsen, N E Skakkebaek
    Abstract:

    : Scrotal ultrasonography was performed in 888 testes of 444 randomly selected men appearing before the medical board prior to military service (Mili group, 287 men, median age 18.8 years), and in employees from an industrial company (Empl group, 157 men, median age 35.6 years). The ultrasonic volume of each testis was calculated from 3 perpendicular measurements. The ultrasonic texture on sectional planes was scored using a scale from 1 to 5, 1 being very regular, 2 slightly irregular, 3 moderately irregular, 4 very irregular or with bright echogenic points, and 5 with demarcated tumor suspicious areas. Orchidometer measurements were performed in 258 men in Mili group, and semen samples were obtained from 121 men in Empl group. The ultrasonic volume of the right testis (median 14.1 ml, range 3.0-31.4 ml) was bigger than that of the left testis (median 13.0 ml, range 3.5-35.2). The volume was dependent on age for men under 20 years, but not for men aged 20 years or more. The subgroup of men with a history of cryptorchidism had a smaller average testicular volume (median 10.5 ml) compared with men with normal descent (median 14.1 ml). Ultrasonic volume was positively correlated to the total sperm count in the ejaculate, to sperm penetration in egg white, and to normal sperm morphology. The echo score distribution showed slightly higher scores in Empl for both the right and the left testis. Men in Empl group were older, and it could not be precluded that this difference was due to age.(ABSTRACT TRUNCATED AT 250 WORDS)

Satya P Srivastava - One of the best experts on this subject based on the ideXlab platform.

Richard E Manos - One of the best experts on this subject based on the ideXlab platform.

  • the outcomes of lumbar microdiscectomy in a young active Population Correlation by herniation type and level
    Spine, 2008
    Co-Authors: Christopher B Dewing, Matthew T Provencher, Robert H Riffenburgh, Stewart Kerr, Richard E Manos
    Abstract:

    STUDY DESIGN: Prospective longitudinal clinical study. OBJECTIVE: The purpose of our article was to investigate the clinical outcomes with type and level of disc herniation in a young, active Population undergoing lumbar microdiscectomy. SUMMARY OF BACKGROUND DATA: There are few reported outcomes studies on the relationship between disc herniation level, type of disc herniation, and surgical outcomes of lumbar microdiscectomy in a young, active Population. METHODS: One hundred ninety-seven (197) consecutive single-level lumbar microdiscectomies performed by a single surgeon were prospectively followed over a 3-year period. All patients had failed a period of nonoperative care including physical therapy and/or transforaminal epidural steroid injections. One hundred eighty-three patients (139 males, 44 females) with a mean age of 27.0 years (range 19-46 years) were prospectively followed for a mean of 26 months (range, 12-38 months). Outcomes were assessed using Visual Analog Scale (VAS), Oswestry disability index, patient satisfaction, return to military duty, and need for additional surgery. The type of disc herniation (contained, extruded, or sequestered) and the lumbar level of herniation were also recorded. RESULTS: At final follow-up, 84% (154 of 183) of patients had returned to unrestricted military duty; 16% (29) had been medically discharged. The mean decrease in VAS leg pain score was 4.7 points (from mean preoperative 7.2 to mean postoperative 2.5); 80% (146) reported a decrease of greater than 2 points. The mean Oswestry index improved from 53.6 before surgery to 21.2 at final follow-up. Overall, 85% (156) were satisfied with their surgery. Six patients had recurrent herniations (3%) with 4 of the 6 undergoing additional surgery. Patients with preoperative VAS scores consistent with a preponderance of radicular leg pain versus back pain demonstrated better surgical outcomes in all categories (P < 0.001) When classified by disc herniation type, sequestered discs at all levels demonstrated better Oswestry and VAS scores versus extruded or contained disc herniations. (P < 0.001) Disc herniations at the L5-S1 level had significantly greater improvements in both mean VAS leg and Oswestry outcome scores than disc herniations at the L4-L5 level. (P < 0.001) Preexisting restricted duty status at time of first surgical consultation was associated with poorer outcomes. Smokers had a significantly lower return to full active military duty (P = 0.037). CONCLUSION: Microdiscectomy for symptomatic lumbar disc herniations in young, active patients with a preponderance of leg pain who have failed nonoperative treatment demonstrated a high success rate based on validated outcome measures, patient satisfaction, and return to active duty. Patients with disc herniations at the L5-S1 level had significantly better outcomes than did those at the L4-L5 level. Patients with sequestered or extruded lumbar disc herniations had significantly better outcomes than did those contained herniations. Patients with contained disc herniations, a predominance of back pain, on restricted duty and smoking should be counseled before surgery of the potential for less satisfaction, poorer outcomes scores, and decreased return to duty rates.

  • The outcomes of lumbar microdiscectomy in a young, active Population: Correlation by herniation type and level.
    Spine, 2008
    Co-Authors: Christopher B Dewing, Matthew T Provencher, Robert H Riffenburgh, Stewart Kerr, Richard E Manos
    Abstract:

    Study Design. Prospective longitudinal clinical study. Objective. The purpose of our article was to investigate the clinical outcomes with type and level of disc herniation in a young, active Population undergoing lumbar microdiscectomy. of Background Data. There are few reported outcomes studies on the relationship between disc herniation level, type of disc herniation, and surgical outcomes of lumbar microdiscectomy in a young, active Population. Methods. One hundred ninety-seven (197) consecutive single-level lumbar microdiscectomies performed by a single surgeon were prospectively followed over a 3-year period. All patients had failed a period of nonoperative care including physical therapy and/or transforaminal epidural steroid injections. One hundred eighty-three patients (139 males, 44 females) with a mean age of 27.0 years (range 19-46 years) were prospectively followed for a mean of 26 months (range, 12-38 months). Outcomes were assessed using Visual Analog Scale (VAS), Oswestry disability index, patient satisfaction, return to military duty, and need for additional surgery. The type of disc herniation (contained, extruded, or sequestered) and the lumbar level of herniation were also recorded. Results. At final follow-up, 84% (154 of 183) of patients had returned to unrestricted military duty; 16% (29) had been medically discharged. The mean decrease in VAS leg pain score was 4.7 points (from mean preoperative 7.2 to mean postoperative 2.5); 80% (146) reported a decrease of greater than 2 points. The mean Oswestry index improved from 53.6 before surgery to 21.2 at final follow-up. Overall, 85% (156) were satisfied with their surgery. Six patients had recurrent herniations (3%) with 4 of the 6 undergoing additional surgery. Patients with preoperative VAS scores consistent with a preponderance of radicular leg pain versus back pain demonstrated better surgical outcomes in all categories (P < 0.001) When classified by disc herniation type, sequestered discs at all levels demonstrated better Oswestry and VAS scores versus extruded or contained disc herniations. (P< 0.001) Disc herniations at the L5-S1 level had significantly greater improvements in both mean VAS leg and Oswestry outcome scores than disc herniations at the L4-L5 level. (P< 0.001) Preexisting restricted duty status at time of first surgical consultation was associated with poorer outcomes. Smokers had a significantly lower return to full active military duty (P = 0.037). Conclusion. Microdiscectomy for symptomatic lumbar disc herniations in young, active patients with a preponderance of leg pain who have failed nonoperative treatment demonstrated a high success rate based on validated outcome measures, patient satisfaction, and return to active duty. Patients with disc herniations at the L5-S1 level had significantly better outcomes than did those at the L4-L5 level. Patients with sequestered or extruded lumbar disc herniations had significantly better outcomes than did those contained herniations. Patients with contained disc herniations, a predominance of back pain, on restricted duty and smoking should be counseled before surgery of the potential for less satisfaction, poorer outcomes scores, and decreased return to duty rates.

S Lenz - One of the best experts on this subject based on the ideXlab platform.

  • Ultrasonic testicular texture and size in 444 men from the general Population: Correlation to semen quality.
    European Urology, 1993
    Co-Authors: S Lenz, A Giwercman, Elisabeth Carlsen, Elsborg A, Cohr Kh, Jelnes Je, N E Skakkebaek
    Abstract:

    Scrotal ultrasonography was performed in 888 testes of 444 randomly selected men appearing before the medical board prior to military service (Mili group, 287 men, median age 18.8 years), and in employees from an industrial company (Empl group, 157 men, median age 35. 6 years). The ultrasonic volume of each testis was calculated from 3 perpendicular measurements. The ultrasonic texture on sectional planes was scored using a scale from 1 to 5, 1 being very regular, 2 slightly irregular, 3 moderately irregular, 4 very irregular or with bright echogenic points, and 5 with demarcated tumor suspicious areas. Orchidometer measurements were performed in 258 men in Mili group, and semen samples were obtained from 121 men in Empl group

  • ultrasonic testicular texture and size in 444 men from the general Population Correlation to semen quality
    European Urology, 1993
    Co-Authors: S Lenz, A Giwercman, A Elsborg, K H Cohr, J E Jelnes, Elisabeth Carlsen, N E Skakkebaek
    Abstract:

    : Scrotal ultrasonography was performed in 888 testes of 444 randomly selected men appearing before the medical board prior to military service (Mili group, 287 men, median age 18.8 years), and in employees from an industrial company (Empl group, 157 men, median age 35.6 years). The ultrasonic volume of each testis was calculated from 3 perpendicular measurements. The ultrasonic texture on sectional planes was scored using a scale from 1 to 5, 1 being very regular, 2 slightly irregular, 3 moderately irregular, 4 very irregular or with bright echogenic points, and 5 with demarcated tumor suspicious areas. Orchidometer measurements were performed in 258 men in Mili group, and semen samples were obtained from 121 men in Empl group. The ultrasonic volume of the right testis (median 14.1 ml, range 3.0-31.4 ml) was bigger than that of the left testis (median 13.0 ml, range 3.5-35.2). The volume was dependent on age for men under 20 years, but not for men aged 20 years or more. The subgroup of men with a history of cryptorchidism had a smaller average testicular volume (median 10.5 ml) compared with men with normal descent (median 14.1 ml). Ultrasonic volume was positively correlated to the total sperm count in the ejaculate, to sperm penetration in egg white, and to normal sperm morphology. The echo score distribution showed slightly higher scores in Empl for both the right and the left testis. Men in Empl group were older, and it could not be precluded that this difference was due to age.(ABSTRACT TRUNCATED AT 250 WORDS)

Dominik Marx - One of the best experts on this subject based on the ideXlab platform.

  • A statistical mechanical theory of proton transport kinetics in hydrogen-bonded networks based on Population Correlation functions with applications to acids and bases
    Journal of Chemical Physics, 2010
    Co-Authors: Mark E Tuckerman, Amalendu Chandra, Dominik Marx
    Abstract:

    Extraction of relaxation times, lifetimes, and rates associated with the transport of topological charge defects in hydrogen-bonded networks from molecular dynamics simulations is a challenge because proton transfer reactions continually change the identity of the defect core. In this paper, we present a statistical mechanical theory that allows these quantities to be computed in an unbiased manner. The theory employs a set of suitably defined indicator or Population functions for locating a defect structure and their associated Correlation functions. These functions are then used to develop a chemical master equation framework from which the rates and lifetimes can be determined. Furthermore, we develop an integral equation formalism for connecting various types of Population Correlation functions and derive an iterative solution to the equation, which is given a graphical interpretation. The chemical master equation framework is applied to the problems of both hydronium and hydroxide transport in bulk w...

  • connecting solvation shell structure to proton transport kinetics in hydrogen bonded networks via Population Correlation functions
    Physical Review Letters, 2007
    Co-Authors: Amalendu Chandra, Mark E Tuckerman, Dominik Marx
    Abstract:

    A theory based on Population Correlation functions is introduced for connecting solvation topologies and microscopic mechanisms to transport kinetics of charge defects in hydrogen-bonded networks. The theory is tested on the hydrated proton by extracting a comprehensive set of relaxation times, lifetimes, and rates from ab initio molecular dynamics simulations and comparing to recent femtosecond experiments. When applied to the controversial case of the hydrated hydroxide ion, the theory predicts that only one out of three proposed transport models is consistent with known experimental data.