The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform

E. Mannarino - One of the best experts on this subject based on the ideXlab platform.

  • Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease
    European Journal of Clinical Pharmacology, 1991
    Co-Authors: G. Ciuffetti, Laura Santambrogio, M. Mercuri, R. Lombardini, R. Paltriccia, G. Lupattelli, E. Mannarino
    Abstract:

    The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow Positive-Pressure System), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen Pressure (P_tcO_2) during treadmill exercise to stress leg circulation was also measured. Leucocyte-derived free radicals were generated during peripheral ischaemia. Pentoxifylline inhibited their generation, blocked the release of reactive oxygen metabolites, and reduced impairment of the filterability rate of unfractionated leucocytes. The improvements were accompanied by significant shortening of the half-time of recovery of transcutaneous oxygen Pressure, indicating that ischaemic damage had been contained.

Elmo Mannarino - One of the best experts on this subject based on the ideXlab platform.

  • Effects of Iloprost on Blood Rheology and Tissue Perfusion in Patients with Intermittent Claudication: Results of a Double-blind Placebo-controlled Study
    International Journal of Angiology, 2002
    Co-Authors: Giovanni Ciuffetti, Leonella Pasqualini, Rita Lombardini, Matteo Pirro, Marco Cardile, Elmo Mannarino
    Abstract:

    The effects of an infusion of a single dose of Iloprost (from 0.5 up to a maximum of 2 ng/kg/min for six hours) in patients with stage II peripheral vascular disease (PVD) on blood rheology and tissue perfusion were determined in a double-blind placebo-controlled study using repeated treadmill exercise test to stress leg circulation. Blood viscosity (BV) at low shear, soluble P-selectin levels (expression of platelet activation), unfractioned leukocyte and erythrocyte filterability rates (using a constant-flow Positive-Pressure System), plasma fibrinogen concentration, haematocrit, leukocyte and platelet counts were measured in two matched groups of 8 PVD patients before and after treatment. Transcutaneous oxygen Pressure (TcPO2) during controlled ischaemia was also measured. Controlled peripheral ischaemia generated an impaired haemorheological profile. Iloprost reduced the impairments in BV and the filterability rates of unfractioned leukocytes, inhibited platelet activation and improved erythrocyte deformability. These improvements were associated with significant shortening of the TcPO2 half recovery time, indicating that ischaemic damage had been contained.

  • Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease : results of a double-blind placebo-controlled study
    European Journal of Clinical Pharmacology, 1991
    Co-Authors: Giovanni Ciuffetti, Michele Mercuri, Rita Lombardini, Ott C, Graziana Lupattelli, Rita Paltriccia, Laura Santambrogio, Elmo Mannarino
    Abstract:

    The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow Positive-Pressure System), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen Pressure (PtcO2) during treadmill exercise to stress leg circulation was also measured.

  • WHOLE-BLOOD FILTERABILITY IN SUDDEN DEAFNESS
    Laryngoscope, 1991
    Co-Authors: Giovanni Ciuffetti, Elmo Mannarino, Rita Lombardini, Alessandro Scardazza, Giovanni Serafini, Costantino Simoncelli
    Abstract:

    Sixteen patients with sudden deafness (SD), diagnosed on the basis of a battery of audiometric tests, but with no other medical or surgical pathology requiring drug treatment, underwent monitoring of their hemorheological profiles to see whether disturbances in the microcirculation could be linked to SD. Plasma viscosity, the filterabilities, (using a low-shear Positive Pressure System) through 5-microns-diameter pore Nuclepore filters, of whole blood and red and unfractionated white cells were monitored in 16 SD patients and 32 controls matched for age, sex and socioeconomic status. Whole blood filterability and the filterability of the red blood cells were significantly impaired in the SD patients, which suggests that alterations in the microcirculation are linked, in some way, to sudden deafness.

  • Physical exercise and blood flow properties.
    British Journal of Sports Medicine, 1990
    Co-Authors: Giovanni Ciuffetti, Michele Mercuri, Rita Lombardini, U Milia, Elmo Mannarino
    Abstract:

    In 46 executive level managers at risk for cardiovascular disease, whole blood filterability through five micron pore Nuclepore filters was monitored using a constant flow Positive Pressure System before and after treadmill exercise and compared to our laboratory standard. Our results show regular exercise compensates not only for the potential damage risk factors represent but also for the physical stress provoked by vigorous exercise.

  • Reactive oxygen metabolites in peripheral arterial occlusive disease.
    Vasa-european Journal of Vascular Medicine, 1990
    Co-Authors: Giovanni Ciuffetti, Elmo Mannarino, Michele Mercuri, Leonella Pasqualini, Rita Lombardini, Ott C, Graziana Lupattelli, Rita Paltriccia
    Abstract:

    Plasma oxydant activity (marker of reactive oxygen metabolites) and the unfractionated leucocyte filterability rate (determined through 5 micron pore diameter Nuclepore filters, using a Positive Pressure System) were monitored in 15 stage II peripheral vascular disease (PVD) patients before and after ischaemia was induced by treadmill exercise (12° slope/2 km/hour)

Giovanni Ciuffetti - One of the best experts on this subject based on the ideXlab platform.

  • Effects of Iloprost on Blood Rheology and Tissue Perfusion in Patients with Intermittent Claudication: Results of a Double-blind Placebo-controlled Study
    International Journal of Angiology, 2002
    Co-Authors: Giovanni Ciuffetti, Leonella Pasqualini, Rita Lombardini, Matteo Pirro, Marco Cardile, Elmo Mannarino
    Abstract:

    The effects of an infusion of a single dose of Iloprost (from 0.5 up to a maximum of 2 ng/kg/min for six hours) in patients with stage II peripheral vascular disease (PVD) on blood rheology and tissue perfusion were determined in a double-blind placebo-controlled study using repeated treadmill exercise test to stress leg circulation. Blood viscosity (BV) at low shear, soluble P-selectin levels (expression of platelet activation), unfractioned leukocyte and erythrocyte filterability rates (using a constant-flow Positive-Pressure System), plasma fibrinogen concentration, haematocrit, leukocyte and platelet counts were measured in two matched groups of 8 PVD patients before and after treatment. Transcutaneous oxygen Pressure (TcPO2) during controlled ischaemia was also measured. Controlled peripheral ischaemia generated an impaired haemorheological profile. Iloprost reduced the impairments in BV and the filterability rates of unfractioned leukocytes, inhibited platelet activation and improved erythrocyte deformability. These improvements were associated with significant shortening of the TcPO2 half recovery time, indicating that ischaemic damage had been contained.

  • Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease : results of a double-blind placebo-controlled study
    European Journal of Clinical Pharmacology, 1991
    Co-Authors: Giovanni Ciuffetti, Michele Mercuri, Rita Lombardini, Ott C, Graziana Lupattelli, Rita Paltriccia, Laura Santambrogio, Elmo Mannarino
    Abstract:

    The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow Positive-Pressure System), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen Pressure (PtcO2) during treadmill exercise to stress leg circulation was also measured.

  • WHOLE-BLOOD FILTERABILITY IN SUDDEN DEAFNESS
    Laryngoscope, 1991
    Co-Authors: Giovanni Ciuffetti, Elmo Mannarino, Rita Lombardini, Alessandro Scardazza, Giovanni Serafini, Costantino Simoncelli
    Abstract:

    Sixteen patients with sudden deafness (SD), diagnosed on the basis of a battery of audiometric tests, but with no other medical or surgical pathology requiring drug treatment, underwent monitoring of their hemorheological profiles to see whether disturbances in the microcirculation could be linked to SD. Plasma viscosity, the filterabilities, (using a low-shear Positive Pressure System) through 5-microns-diameter pore Nuclepore filters, of whole blood and red and unfractionated white cells were monitored in 16 SD patients and 32 controls matched for age, sex and socioeconomic status. Whole blood filterability and the filterability of the red blood cells were significantly impaired in the SD patients, which suggests that alterations in the microcirculation are linked, in some way, to sudden deafness.

  • Effects of Ticlopidine on the Neurologic Outcome and the Hemorheologic Pattern in the Postacute Phase of Ischemic Stroke: A Pilot Study:
    Angiology, 1990
    Co-Authors: Giovanni Ciuffetti, Michele Mercuri, Rita Lombardini, Rita Paltriccia, Giovanni Aisa, Cristiana Neri, Umberto Senin
    Abstract:

    This double-blind pilot study observed the effects of a twenty-one day oral ticlopidine treatment (250 mg/twice daily) on the neurologic outcome and the hemorheologic pattern of 15 patients and 15 placebo-treated controls. Patients and controls (age range sixty-six to eighty-six years) were included in the study within twelve hours of the onset of ischemic stroke, confirmed clinically and by computerized tomography. Scores on Hachinski's Scale and the following he morheologic parameters were monitored weekly for twenty-one days: fibrino gen levels, the whole blood, unfractionated white and red blood cell filterability rates (through 5-micron-pore-diameter filters using a constant-flow Positive- Pressure System), and the leukocyte count and activation (by microscopic obser vation). The results showed treatment with ticlopidine improved the neurologic outcome (Hachinski's Score +36%, p < 0.03) slightly but significantly (p < 0.001) increased the average values of the whole blood (+ 19%) and red cell (+ 17%)...

  • Physical exercise and blood flow properties.
    British Journal of Sports Medicine, 1990
    Co-Authors: Giovanni Ciuffetti, Michele Mercuri, Rita Lombardini, U Milia, Elmo Mannarino
    Abstract:

    In 46 executive level managers at risk for cardiovascular disease, whole blood filterability through five micron pore Nuclepore filters was monitored using a constant flow Positive Pressure System before and after treadmill exercise and compared to our laboratory standard. Our results show regular exercise compensates not only for the potential damage risk factors represent but also for the physical stress provoked by vigorous exercise.

Laura Santambrogio - One of the best experts on this subject based on the ideXlab platform.

  • Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease : results of a double-blind placebo-controlled study
    European Journal of Clinical Pharmacology, 1991
    Co-Authors: Giovanni Ciuffetti, Michele Mercuri, Rita Lombardini, Ott C, Graziana Lupattelli, Rita Paltriccia, Laura Santambrogio, Elmo Mannarino
    Abstract:

    The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow Positive-Pressure System), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen Pressure (PtcO2) during treadmill exercise to stress leg circulation was also measured.

  • Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease
    European Journal of Clinical Pharmacology, 1991
    Co-Authors: G. Ciuffetti, Laura Santambrogio, M. Mercuri, R. Lombardini, R. Paltriccia, G. Lupattelli, E. Mannarino
    Abstract:

    The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow Positive-Pressure System), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen Pressure (P_tcO_2) during treadmill exercise to stress leg circulation was also measured. Leucocyte-derived free radicals were generated during peripheral ischaemia. Pentoxifylline inhibited their generation, blocked the release of reactive oxygen metabolites, and reduced impairment of the filterability rate of unfractionated leucocytes. The improvements were accompanied by significant shortening of the half-time of recovery of transcutaneous oxygen Pressure, indicating that ischaemic damage had been contained.

G. Ciuffetti - One of the best experts on this subject based on the ideXlab platform.

  • Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease
    European Journal of Clinical Pharmacology, 1991
    Co-Authors: G. Ciuffetti, Laura Santambrogio, M. Mercuri, R. Lombardini, R. Paltriccia, G. Lupattelli, E. Mannarino
    Abstract:

    The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow Positive-Pressure System), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen Pressure (P_tcO_2) during treadmill exercise to stress leg circulation was also measured. Leucocyte-derived free radicals were generated during peripheral ischaemia. Pentoxifylline inhibited their generation, blocked the release of reactive oxygen metabolites, and reduced impairment of the filterability rate of unfractionated leucocytes. The improvements were accompanied by significant shortening of the half-time of recovery of transcutaneous oxygen Pressure, indicating that ischaemic damage had been contained.