The Experts below are selected from a list of 207 Experts worldwide ranked by ideXlab platform

Howard V. Wheal - One of the best experts on this subject based on the ideXlab platform.

  • reversal of excitatory Postsynaptic Potential spike potentiation in the ca1 area of the rat hippocampus
    Neuroscience, 1998
    Co-Authors: Christophe Bernard, J Pickering, Howard V. Wheal
    Abstract:

    Abstract In the CA1 area of the hippocampus, low frequency and tetanic conditioning stimuli are known to trigger long-term depression and potentiation of synaptic responses respectively and to produce irreversible excitatory Postsynaptic Potential/spike potentiation, i.e. an increase of the probability of discharge of the neurons. Using simultaneous extracellular recordings in stratum radiatum and stratum pyramidale in the CA1 area of the rat hippocampus, brief application of the K+ channel blocker tetraethylammonium resulted both in long-term potentiation of synaptic responses and in excitatory Postsynaptic Potential/spike potentiation that could be reversed by subsequent low frequency or tetanic stimuli. Excitatory Postsynaptic Potential/spike potentiation and its subsequent reversal by an electrical conditioning stimulus were found to have an N-methyl- d -aspartate receptor-independent component. We conclude that the reversal of excitatory Postsynaptic Potential/spike potentiation can occur and that it does not require the induction of long-term modification of synaptic responses.

  • simultaneous expression of excitatory Postsynaptic Potential spike potentiation and excitatory Postsynaptic Potential spike depression in the hippocampus
    Neuroscience, 1995
    Co-Authors: Christophe Bernard, Howard V. Wheal
    Abstract:

    Abstract Tetanic stimulation of afferents in the stratum radiatum of the CA1 area of the rat hippocampus results in long-term potentiation of excitatory synaptic responses in pyramidal cells. Previous studies have reported a greater increase in the population spike amplitude following the induction of long-term potentiation than could be accounted for by the increase of the slope of the population excitatory Postsynaptic Potential. Two hypotheses have been proposed to explain this phenomenon (called excitatory Postsynaptic Potential/spike potentiation): a modification of the firing threshold and/or a modification of the inhibitory drive. Previous studies have not, however, addressed the question of possible changes in spike threshold in association with long-term depression. This paper examines whether the concomitant long-term potentiation of pharmacologically isolated N -methyl- d -aspartate receptor-mediated excitatory Postsynaptic Potentials, reported previously, is also associated with a change in spike threshold. When the amplitude of the population spike is plotted as a function of the slope of the population excitatory Postsynaptic Potential (excitatory Postsynaptic Potential/spike curve), excitatory Postsynaptic Potential/ spike potentiation (depression) is seen as a shift of the excitatory Postsynaptic Potential/spike curve to the left (right) following a conditioning stimulus. In this study, using kainic acid lesioned hippocampus, we have shown that tetanic stimulation produced excitatory Postsynaptic Potential/spike potentiation of the control synaptic response and excitatory Postsynaptic Potential/spike depression of the isolated N -methyl- d -aspartate receptor-mediated responses.

Christophe Bernard - One of the best experts on this subject based on the ideXlab platform.

  • reversal of excitatory Postsynaptic Potential spike potentiation in the ca1 area of the rat hippocampus
    Neuroscience, 1998
    Co-Authors: Christophe Bernard, J Pickering, Howard V. Wheal
    Abstract:

    Abstract In the CA1 area of the hippocampus, low frequency and tetanic conditioning stimuli are known to trigger long-term depression and potentiation of synaptic responses respectively and to produce irreversible excitatory Postsynaptic Potential/spike potentiation, i.e. an increase of the probability of discharge of the neurons. Using simultaneous extracellular recordings in stratum radiatum and stratum pyramidale in the CA1 area of the rat hippocampus, brief application of the K+ channel blocker tetraethylammonium resulted both in long-term potentiation of synaptic responses and in excitatory Postsynaptic Potential/spike potentiation that could be reversed by subsequent low frequency or tetanic stimuli. Excitatory Postsynaptic Potential/spike potentiation and its subsequent reversal by an electrical conditioning stimulus were found to have an N-methyl- d -aspartate receptor-independent component. We conclude that the reversal of excitatory Postsynaptic Potential/spike potentiation can occur and that it does not require the induction of long-term modification of synaptic responses.

  • simultaneous expression of excitatory Postsynaptic Potential spike potentiation and excitatory Postsynaptic Potential spike depression in the hippocampus
    Neuroscience, 1995
    Co-Authors: Christophe Bernard, Howard V. Wheal
    Abstract:

    Abstract Tetanic stimulation of afferents in the stratum radiatum of the CA1 area of the rat hippocampus results in long-term potentiation of excitatory synaptic responses in pyramidal cells. Previous studies have reported a greater increase in the population spike amplitude following the induction of long-term potentiation than could be accounted for by the increase of the slope of the population excitatory Postsynaptic Potential. Two hypotheses have been proposed to explain this phenomenon (called excitatory Postsynaptic Potential/spike potentiation): a modification of the firing threshold and/or a modification of the inhibitory drive. Previous studies have not, however, addressed the question of possible changes in spike threshold in association with long-term depression. This paper examines whether the concomitant long-term potentiation of pharmacologically isolated N -methyl- d -aspartate receptor-mediated excitatory Postsynaptic Potentials, reported previously, is also associated with a change in spike threshold. When the amplitude of the population spike is plotted as a function of the slope of the population excitatory Postsynaptic Potential (excitatory Postsynaptic Potential/spike curve), excitatory Postsynaptic Potential/ spike potentiation (depression) is seen as a shift of the excitatory Postsynaptic Potential/spike curve to the left (right) following a conditioning stimulus. In this study, using kainic acid lesioned hippocampus, we have shown that tetanic stimulation produced excitatory Postsynaptic Potential/spike potentiation of the control synaptic response and excitatory Postsynaptic Potential/spike depression of the isolated N -methyl- d -aspartate receptor-mediated responses.

Mo Ning - One of the best experts on this subject based on the ideXlab platform.

  • effect of he ne laser on fast excitatory Postsynaptic Potential f epsp of neurons in the isolated rat superior cervical ganglia
    Chinese Journal of Medical Physics, 2003
    Co-Authors: Mo Ning
    Abstract:

    The effects of He-Ne laser with wavelength 632.8 nm on fast excitatory Postsynaptic Potential(f-EPSP) of neurons in isolated rat superior cervical ganglia were investigated by means of intracellular recording techniques. The neurons with stable f-EPSP were irradiated by power densities of 1 mW/cm2-5 mW/cnr, pulse frequency of 1 Hz laser. The results were as follows:(1) the effect is different with various power density and time; irradiated by the 2mW/cm2 laser, the membrane conductance and the amplitude of the f-EPSP could augment (P0.05) and even caused action Potential(AP) at the end of the first two minute; the membrane conductance and the f-EPSP could descend and lasted for 3 to 10 minutes later; but the 5 mW/cnr laser irradiation could depress the f-EPSP for the irradiating times. (2)with 2mW/cnr power density, He-Ne laser clearly promote the integration of neurons. The results indicated that there were the second-order phases in the interaction of He-Ne laser with neurons; first, the initial short-time promotive effect; second, the late long-time effect of inhibition. The mechanism of the effect He-Ne laser on f-EPSP of postganglionic neurons may be the photobiology effects of low power laser.

  • effect of helium neon laser on fast excitatory Postsynaptic Potential f epsp of neurons in the isolated rat superior cervical ganglia
    Laser Tissue Interaction XIII: Photochemical Photothermal and Photomechanical, 2002
    Co-Authors: Mo Hua, He Ping, Mo Ning
    Abstract:

    Single electrical stimulation of the cervical sympathetic trunk elicits in the ganglion cells an excitatory Postsynaptic Potential (EPSP) or multiple EPSPs of varying latencies, among which a fast excitatory Postsynaptic Potential (f-EPSP) is the main type of ganglionic transmission in the sympathetic neurons. In previous work, we studied the effects of Helium-Neon laser with wavelength 632.8 nm on membrane conductance of neurons with stable f- EPSP in isolated rat superior cervical ganglia. The aim of this study is to further measure the effect of Helium-Neon Laser with wavelength 632.8 nm on fast excitatory Postsynaptic Potential of postganglionic neurons in the isolated rate superior cervical ganglia by means of intracellular recording techniques. The neurons with fast excitatory Postsynaptic Potential were irradiated by different power densities (1 and 5 mW/cm2), pulse frequency of 1 Hz laser. Irradiated by the 2 mW/cm2 laser, the amplitude of the f-EPSP could augment (P<0.05) and even caused action Potential (AP) at the end of the first 1-2 minute, the F-EPSP could descend and lasted for 3- 8 minutes later.© (2002) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

Tanya D. Ivanova - One of the best experts on this subject based on the ideXlab platform.

Dominique Debanne - One of the best experts on this subject based on the ideXlab platform.

  • Bidirectional plasticity of excitatory Postsynaptic Potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 2002
    Co-Authors: Gaël Daoudal, Yasuhiro Hanada, Dominique Debanne
    Abstract:

    Integration of synaptic excitation to generate an action Potential (excitatory Postsynaptic Potential-spike coupling or E-S coupling) determines the neuronal output. Bidirectional synaptic plasticity is well established in the hippocampus, but whether active synaptic integration can display potentiation and depression remains unclear. We show here that synaptic depression is associated with an N-methyl-d-aspartate receptor-dependent and long-lasting depression of E-S coupling. E-S depression is input-specific and is expressed in the presence of γ-aminobutyric acid type A and B receptor antagonists. In single neurons, E-S depression is observed without modification of Postsynaptic passive properties. We conclude that a decrease in intrinsic excitability underlies E-S depression and is synergic with glutamatergic long-term depression.