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Michel M. Joosten - One of the best experts on this subject based on the ideXlab platform.
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Urinary Potassium Excretion and risk of cardiovascular events
The American journal of clinical nutrition, 2016Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Frank P. Brouwers, Edith J. M. Feskens, Johanna M. Geleijnse, Gerjan Navis, Stephan J. L. Bakker, Michel M. JoostenAbstract:Background: Observational studies on dietary Potassium and risk of cardiovascular disease (CVD) have reported weak-to-modest inverse associations. Long-term prospective studies with multiple 24-h urinary samples for accurate estimation of habitual Potassium intake, however, are scarce. Objective: We examined the association between urinary Potassium Excretion and risk of blood pressure related cardiovascular outcomes. Design: We studied 7795 subjects free of cardiovascular events at baseline in the Prevention of Renal and Vascular End-stage Disease study, a prospective, observational cohort with oversampling of subjects with albuminuria at baseline. Main cardiovascular outcomes were CVD [including ischemic heart disease (IHD), stroke, and vascular interventions], IHD, stroke, and new-onset heart failure (HF). Potassium Excretion was measured in two 24-h urine specimens at the start of the study (1997-1998) and midway through follow-up (2001-2003). Results: Baseline median urinary Potassium Excretion was 70 mmol/24 h (IQR: 56-84 mmol/24 h). During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), a total of 641 CVD, 465 IHD, 172 stroke, and 265 HF events occurred. After adjustment for age and sex, inverse associations were observed between Potassium Excretion and risk [HR per each 26mmol/24-h (1-g/d) increase; 95% CI] of CVD (0.87; 0.78, 0.97) and IHD (0.86; 0.75, 0.97), as well as nonsignificant inverse associations for risk of stroke (0.85; 0.68, 1.06) and HF (0.94; 0.80, 1.10). After further adjustment for body mass index, smoking, alcohol consumption, education, and urinary sodium and magnesium Excretion, urinary Potassium Excretion was not statistically significantly associated with risk (multi variable-adjusted HR per 1-g/d increment; 95% CI) of CVD (0.96; 0.85, 1.09), IHD (0.90; 0.81, 1.04), stroke (1.09; 0.86, 1.39), or HF (0.99; 0.83, 1.18). No associations were observed between the sodium-to-Potassium Excretion ratio and risk of CVD, HID, stroke, or HF. Conclusion: In this cohort with oversampling of subjects with albuminuria at baseline, urinary Potassium Excretion was not independently associated with a lower risk of cardiovascular events.
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urinary Potassium Excretion and risk of developing hypertension the prevention of renal and vascular end stage disease study
Hypertension, 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Gerjan Navis, Stephan J. L. Bakker, Kenneth J Mukamal, Michel M. JoostenAbstract:Previous prospective cohort studies on the association between Potassium intake and risk of hypertension have almost exclusively relied on self-reported dietary data, whereas repeated 24-hour urine Excretions, as estimate of dietary uptake, may provide a more objective and quantitative estimate of this association. Risk of hypertension (defined as blood pressure ≥140/90 mm Hg or initiation of blood pressure-lowering drugs) was prospectively studied in 5511 normotensive subjects aged 28 to 75 years not using blood pressure-lowering drugs at baseline of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Potassium Excretion was measured in two 24-hour urine specimens at baseline (1997-1998) and midway during follow-up (2001-2003). Baseline median Potassium Excretion was 70 mmol/24 h (interquartile range, 57-85 mmol/24 h), which corresponds to a dietary Potassium intake of ≈91 mmol/24 h. During a median follow-up of 7.6 years (interquartile range, 5.0-9.3 years), 1172 subjects developed hypertension. The lowest sex-specific tertile of Potassium Excretion (men: <68 mmol/24 h; women: <58 mmol/24 h) had an increased risk of hypertension after multivariable adjustment (hazard ratio, 1.20; 95% confidence interval, 1.05-1.37), compared with the upper 2 tertiles (Pnonlinearity=0.008). The proportion of hypertension attributable to low Potassium Excretion was 6.2% (95% confidence interval, 1.7%-10.9%). No association was found between the sodium to Potassium Excretion ratio and risk of hypertension after multivariable adjustment. Low urinary Potassium Excretion was associated with an increased risk of developing hypertension. Dietary strategies to increase Potassium intake to the recommended level of 90 mmol/d may have the potential to reduce the incidence of hypertension.
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Urinary Potassium Excretion and Risk of Developing Hypertension The Prevention of Renal and Vascular End-Stage Disease Study
Hypertension (Dallas Tex. : 1979), 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Gerjan Navis, Stephan J. L. Bakker, Kenneth J Mukamal, Michel M. JoostenAbstract:Previous prospective cohort studies on the association between Potassium intake and risk of hypertension have almost exclusively relied on self-reported dietary data, whereas repeated 24-hour urine Excretions, as estimate of dietary uptake, may provide a more objective and quantitative estimate of this association. Risk of hypertension (defined as blood pressure ≥140/90 mm Hg or initiation of blood pressure-lowering drugs) was prospectively studied in 5511 normotensive subjects aged 28 to 75 years not using blood pressure-lowering drugs at baseline of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Potassium Excretion was measured in two 24-hour urine specimens at baseline (1997-1998) and midway during follow-up (2001-2003). Baseline median Potassium Excretion was 70 mmol/24 h (interquartile range, 57-85 mmol/24 h), which corresponds to a dietary Potassium intake of ≈91 mmol/24 h. During a median follow-up of 7.6 years (interquartile range, 5.0-9.3 years), 1172 subjects developed hypertension. The lowest sex-specific tertile of Potassium Excretion (men:
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Abstract MP24: Urinary Potassium Excretion and Risk of Developing Hypertension
Circulation, 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Edith J. M. Feskens, Johanna M. Geleijnse, Gerjan Navis, Stephan J. L. Bakker, Michel M. JoostenAbstract:Background: Potassium supplementation lowers blood pressure (BP) in randomized controlled trials, but the long-term effect of dietary Potassium intake on risk of hypertension has not yet been established. Objective: To examine the association of 24h urinary Excretions of Potassium, reflecting dietary uptake, with risk of hypertension. Methods: We used data from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective, community-based, observational cohort of Dutch men and women aged 28-75 years. Potassium Excretion was measured at baseline (1997-98) and during follow-up (2001-03) in two consecutive 24h urine specimens. Risk of hypertension (defined as BP ≥140/90 mmHg, or initiation of BP-lowering drugs) was studied in 5,511 normotensive subjects not using BP-lowering drugs at baseline. We used Cox proportional hazards regression analysis with time-dependent covariates. Results: Baseline median Potassium Excretion was 72 mmol/24h (Q1-Q3: 57-85 mmol/24h). During a median follow-...
Lyanne M. Kieneker - One of the best experts on this subject based on the ideXlab platform.
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Urinary Potassium Excretion and risk of cardiovascular events
The American journal of clinical nutrition, 2016Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Frank P. Brouwers, Edith J. M. Feskens, Johanna M. Geleijnse, Gerjan Navis, Stephan J. L. Bakker, Michel M. JoostenAbstract:Background: Observational studies on dietary Potassium and risk of cardiovascular disease (CVD) have reported weak-to-modest inverse associations. Long-term prospective studies with multiple 24-h urinary samples for accurate estimation of habitual Potassium intake, however, are scarce. Objective: We examined the association between urinary Potassium Excretion and risk of blood pressure related cardiovascular outcomes. Design: We studied 7795 subjects free of cardiovascular events at baseline in the Prevention of Renal and Vascular End-stage Disease study, a prospective, observational cohort with oversampling of subjects with albuminuria at baseline. Main cardiovascular outcomes were CVD [including ischemic heart disease (IHD), stroke, and vascular interventions], IHD, stroke, and new-onset heart failure (HF). Potassium Excretion was measured in two 24-h urine specimens at the start of the study (1997-1998) and midway through follow-up (2001-2003). Results: Baseline median urinary Potassium Excretion was 70 mmol/24 h (IQR: 56-84 mmol/24 h). During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), a total of 641 CVD, 465 IHD, 172 stroke, and 265 HF events occurred. After adjustment for age and sex, inverse associations were observed between Potassium Excretion and risk [HR per each 26mmol/24-h (1-g/d) increase; 95% CI] of CVD (0.87; 0.78, 0.97) and IHD (0.86; 0.75, 0.97), as well as nonsignificant inverse associations for risk of stroke (0.85; 0.68, 1.06) and HF (0.94; 0.80, 1.10). After further adjustment for body mass index, smoking, alcohol consumption, education, and urinary sodium and magnesium Excretion, urinary Potassium Excretion was not statistically significantly associated with risk (multi variable-adjusted HR per 1-g/d increment; 95% CI) of CVD (0.96; 0.85, 1.09), IHD (0.90; 0.81, 1.04), stroke (1.09; 0.86, 1.39), or HF (0.99; 0.83, 1.18). No associations were observed between the sodium-to-Potassium Excretion ratio and risk of CVD, HID, stroke, or HF. Conclusion: In this cohort with oversampling of subjects with albuminuria at baseline, urinary Potassium Excretion was not independently associated with a lower risk of cardiovascular events.
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urinary Potassium Excretion and risk of developing hypertension the prevention of renal and vascular end stage disease study
Hypertension, 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Gerjan Navis, Stephan J. L. Bakker, Kenneth J Mukamal, Michel M. JoostenAbstract:Previous prospective cohort studies on the association between Potassium intake and risk of hypertension have almost exclusively relied on self-reported dietary data, whereas repeated 24-hour urine Excretions, as estimate of dietary uptake, may provide a more objective and quantitative estimate of this association. Risk of hypertension (defined as blood pressure ≥140/90 mm Hg or initiation of blood pressure-lowering drugs) was prospectively studied in 5511 normotensive subjects aged 28 to 75 years not using blood pressure-lowering drugs at baseline of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Potassium Excretion was measured in two 24-hour urine specimens at baseline (1997-1998) and midway during follow-up (2001-2003). Baseline median Potassium Excretion was 70 mmol/24 h (interquartile range, 57-85 mmol/24 h), which corresponds to a dietary Potassium intake of ≈91 mmol/24 h. During a median follow-up of 7.6 years (interquartile range, 5.0-9.3 years), 1172 subjects developed hypertension. The lowest sex-specific tertile of Potassium Excretion (men: <68 mmol/24 h; women: <58 mmol/24 h) had an increased risk of hypertension after multivariable adjustment (hazard ratio, 1.20; 95% confidence interval, 1.05-1.37), compared with the upper 2 tertiles (Pnonlinearity=0.008). The proportion of hypertension attributable to low Potassium Excretion was 6.2% (95% confidence interval, 1.7%-10.9%). No association was found between the sodium to Potassium Excretion ratio and risk of hypertension after multivariable adjustment. Low urinary Potassium Excretion was associated with an increased risk of developing hypertension. Dietary strategies to increase Potassium intake to the recommended level of 90 mmol/d may have the potential to reduce the incidence of hypertension.
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Urinary Potassium Excretion and Risk of Developing Hypertension The Prevention of Renal and Vascular End-Stage Disease Study
Hypertension (Dallas Tex. : 1979), 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Gerjan Navis, Stephan J. L. Bakker, Kenneth J Mukamal, Michel M. JoostenAbstract:Previous prospective cohort studies on the association between Potassium intake and risk of hypertension have almost exclusively relied on self-reported dietary data, whereas repeated 24-hour urine Excretions, as estimate of dietary uptake, may provide a more objective and quantitative estimate of this association. Risk of hypertension (defined as blood pressure ≥140/90 mm Hg or initiation of blood pressure-lowering drugs) was prospectively studied in 5511 normotensive subjects aged 28 to 75 years not using blood pressure-lowering drugs at baseline of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Potassium Excretion was measured in two 24-hour urine specimens at baseline (1997-1998) and midway during follow-up (2001-2003). Baseline median Potassium Excretion was 70 mmol/24 h (interquartile range, 57-85 mmol/24 h), which corresponds to a dietary Potassium intake of ≈91 mmol/24 h. During a median follow-up of 7.6 years (interquartile range, 5.0-9.3 years), 1172 subjects developed hypertension. The lowest sex-specific tertile of Potassium Excretion (men:
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Abstract MP24: Urinary Potassium Excretion and Risk of Developing Hypertension
Circulation, 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Edith J. M. Feskens, Johanna M. Geleijnse, Gerjan Navis, Stephan J. L. Bakker, Michel M. JoostenAbstract:Background: Potassium supplementation lowers blood pressure (BP) in randomized controlled trials, but the long-term effect of dietary Potassium intake on risk of hypertension has not yet been established. Objective: To examine the association of 24h urinary Excretions of Potassium, reflecting dietary uptake, with risk of hypertension. Methods: We used data from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective, community-based, observational cohort of Dutch men and women aged 28-75 years. Potassium Excretion was measured at baseline (1997-98) and during follow-up (2001-03) in two consecutive 24h urine specimens. Risk of hypertension (defined as BP ≥140/90 mmHg, or initiation of BP-lowering drugs) was studied in 5,511 normotensive subjects not using BP-lowering drugs at baseline. We used Cox proportional hazards regression analysis with time-dependent covariates. Results: Baseline median Potassium Excretion was 72 mmol/24h (Q1-Q3: 57-85 mmol/24h). During a median follow-...
Liping Huang - One of the best experts on this subject based on the ideXlab platform.
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spot urine samples compared with 24 h urine samples for estimating changes in urinary sodium and Potassium Excretion in the china salt substitute and stroke study
International Journal of Epidemiology, 2018Co-Authors: Liping Huang, Mark Woodward, Sandrine Stepien, Maoyi Tian, Xuejun Yin, Zhixin Hao, Jixin SunAbstract:Background The capacity of spot urine samples for detecting changes in population sodium and Potassium Excretion is unclear. Methods Changes in urinary sodium and Potassium Excretion, over a 6-month to 2-year interval, were measured from 24-h urine samples and estimated from spot urine samples using several published methods in 3270 Chinese. Additional estimates were made by multiplying individual spot sodium and Potassium concentrations by a single estimated 24-h urine volume derived from external data. Results The measured difference in 24-h urinary Excretion between intervention and control groups was -0.35 g (95% CI: -0.68 to -0.02; P = 0.039) for sodium and 0.66 g (95% CI: 0.52 to 0.80; P 0.10). The estimates were -0.65 g for sodium and 1.11 g for Potassium using individual spot urine concentrations and an externally derived standard urine volume (both P < 0.01). Conclusions The published equations were unable to detect the differences in sodium Excretion measured by 24-h urine samples. A method based upon spot urine electrolyte concentrations and a standard urine volume may offer an alternative approach to measuring differences in sodium and Potassium Excretion between population groups without requiring 24-h urine, but will need further investigation.
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Spot urine samples compared with 24-h urine samples for estimating changes in urinary sodium and Potassium Excretion in the China Salt Substitute and Stroke Study.
International journal of epidemiology, 2018Co-Authors: Liping Huang, Mark Woodward, Sandrine Stepien, Maoyi Tian, Xuejun Yin, Zhixin Hao, Jixin Sun, Bo ZhouAbstract:Background The capacity of spot urine samples for detecting changes in population sodium and Potassium Excretion is unclear. Methods Changes in urinary sodium and Potassium Excretion, over a 6-month to 2-year interval, were measured from 24-h urine samples and estimated from spot urine samples using several published methods in 3270 Chinese. Additional estimates were made by multiplying individual spot sodium and Potassium concentrations by a single estimated 24-h urine volume derived from external data. Results The measured difference in 24-h urinary Excretion between intervention and control groups was -0.35 g (95% CI: -0.68 to -0.02; P = 0.039) for sodium and 0.66 g (95% CI: 0.52 to 0.80; P 0.10). The estimates were -0.65 g for sodium and 1.11 g for Potassium using individual spot urine concentrations and an externally derived standard urine volume (both P
Trang T. Nguyen - One of the best experts on this subject based on the ideXlab platform.
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association of blood pressure with estimates of 24 h urinary sodium and Potassium Excretion from repeated single spot urine samples
Hypertension Research, 2019Co-Authors: Trang T. Nguyen, Katsuyuki Miura, Taichiro Tanaka, Yasuyuki Nakamura, Akira Fujiyoshi, Aya Kadota, Junko Tamaki, Sachiko Tanakamizuno, Toru TakebayashiAbstract:While the association between 24-h urinary sodium and Potassium Excretion with blood pressure is well established, the relationships of these ions to spot urine measurements are unclear. Our purpose is to assess the association between blood pressure and the estimated 24-h sodium and Potassium Excretion from repeated single-spot urine samples. Spot urine and blood pressure were collected annually during a 5-year period from 4360 Japanese workers with ages ranging from 19 to 55 years. Estimates of 24-h sodium and Potassium Excretion were based on Tanaka’s formula. Overall, a single standard deviation increase in the estimated sodium Excretion (36.5 mmol/day) was associated with a 1.3 mmHg higher systolic blood pressure and a 0.8 mmHg higher diastolic blood pressure (P < 0.001). A single standard deviation increase in estimated Potassium Excretion (8.9 mmol/day) was associated with a 1.1 mmHg lower systolic blood pressure and a 0.7 mmHg lower diastolic blood pressure (P < 0.001). As a combined measure of the Excretion of both electrolytes, the estimated 24-h sodium-to-Potassium ratio was positively associated with both blood pressures (P < 0.001). Associations of blood pressure with sodium and the sodium-to-Potassium ratio increased with age and were stronger in men compared to women. Associations with Potassium and the sodium-to-Potassium ratio were stronger in individuals who were overweight. The findings provide evidence for an association between blood pressure and the estimated 24-h sodium and Potassium Excretion from repeated single-spot urine samples. As convenient measures of dietary intake for each electrolyte, repeated spot urine samples may be useful for assessing hypertension risk, especially in men, older individuals, and overweight individuals.
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Association of blood pressure with estimates of 24-h urinary sodium and Potassium Excretion from repeated single-spot urine samples
Hypertension research : official journal of the Japanese Society of Hypertension, 2018Co-Authors: Trang T. Nguyen, Katsuyuki Miura, Sachiko Tanaka-mizuno, Taichiro Tanaka, Yasuyuki Nakamura, Akira Fujiyoshi, Aya Kadota, Junko Tamaki, Toru Takebayashi, Tomonori OkamuraAbstract:While the association between 24-h urinary sodium and Potassium Excretion with blood pressure is well established, the relationships of these ions to spot urine measurements are unclear. Our purpose is to assess the association between blood pressure and the estimated 24-h sodium and Potassium Excretion from repeated single-spot urine samples. Spot urine and blood pressure were collected annually during a 5-year period from 4360 Japanese workers with ages ranging from 19 to 55 years. Estimates of 24-h sodium and Potassium Excretion were based on Tanaka’s formula. Overall, a single standard deviation increase in the estimated sodium Excretion (36.5 mmol/day) was associated with a 1.3 mmHg higher systolic blood pressure and a 0.8 mmHg higher diastolic blood pressure (P
Stephan J. L. Bakker - One of the best experts on this subject based on the ideXlab platform.
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Urinary Potassium Excretion and risk of cardiovascular events
The American journal of clinical nutrition, 2016Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Frank P. Brouwers, Edith J. M. Feskens, Johanna M. Geleijnse, Gerjan Navis, Stephan J. L. Bakker, Michel M. JoostenAbstract:Background: Observational studies on dietary Potassium and risk of cardiovascular disease (CVD) have reported weak-to-modest inverse associations. Long-term prospective studies with multiple 24-h urinary samples for accurate estimation of habitual Potassium intake, however, are scarce. Objective: We examined the association between urinary Potassium Excretion and risk of blood pressure related cardiovascular outcomes. Design: We studied 7795 subjects free of cardiovascular events at baseline in the Prevention of Renal and Vascular End-stage Disease study, a prospective, observational cohort with oversampling of subjects with albuminuria at baseline. Main cardiovascular outcomes were CVD [including ischemic heart disease (IHD), stroke, and vascular interventions], IHD, stroke, and new-onset heart failure (HF). Potassium Excretion was measured in two 24-h urine specimens at the start of the study (1997-1998) and midway through follow-up (2001-2003). Results: Baseline median urinary Potassium Excretion was 70 mmol/24 h (IQR: 56-84 mmol/24 h). During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), a total of 641 CVD, 465 IHD, 172 stroke, and 265 HF events occurred. After adjustment for age and sex, inverse associations were observed between Potassium Excretion and risk [HR per each 26mmol/24-h (1-g/d) increase; 95% CI] of CVD (0.87; 0.78, 0.97) and IHD (0.86; 0.75, 0.97), as well as nonsignificant inverse associations for risk of stroke (0.85; 0.68, 1.06) and HF (0.94; 0.80, 1.10). After further adjustment for body mass index, smoking, alcohol consumption, education, and urinary sodium and magnesium Excretion, urinary Potassium Excretion was not statistically significantly associated with risk (multi variable-adjusted HR per 1-g/d increment; 95% CI) of CVD (0.96; 0.85, 1.09), IHD (0.90; 0.81, 1.04), stroke (1.09; 0.86, 1.39), or HF (0.99; 0.83, 1.18). No associations were observed between the sodium-to-Potassium Excretion ratio and risk of CVD, HID, stroke, or HF. Conclusion: In this cohort with oversampling of subjects with albuminuria at baseline, urinary Potassium Excretion was not independently associated with a lower risk of cardiovascular events.
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urinary Potassium Excretion and risk of developing hypertension the prevention of renal and vascular end stage disease study
Hypertension, 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Gerjan Navis, Stephan J. L. Bakker, Kenneth J Mukamal, Michel M. JoostenAbstract:Previous prospective cohort studies on the association between Potassium intake and risk of hypertension have almost exclusively relied on self-reported dietary data, whereas repeated 24-hour urine Excretions, as estimate of dietary uptake, may provide a more objective and quantitative estimate of this association. Risk of hypertension (defined as blood pressure ≥140/90 mm Hg or initiation of blood pressure-lowering drugs) was prospectively studied in 5511 normotensive subjects aged 28 to 75 years not using blood pressure-lowering drugs at baseline of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Potassium Excretion was measured in two 24-hour urine specimens at baseline (1997-1998) and midway during follow-up (2001-2003). Baseline median Potassium Excretion was 70 mmol/24 h (interquartile range, 57-85 mmol/24 h), which corresponds to a dietary Potassium intake of ≈91 mmol/24 h. During a median follow-up of 7.6 years (interquartile range, 5.0-9.3 years), 1172 subjects developed hypertension. The lowest sex-specific tertile of Potassium Excretion (men: <68 mmol/24 h; women: <58 mmol/24 h) had an increased risk of hypertension after multivariable adjustment (hazard ratio, 1.20; 95% confidence interval, 1.05-1.37), compared with the upper 2 tertiles (Pnonlinearity=0.008). The proportion of hypertension attributable to low Potassium Excretion was 6.2% (95% confidence interval, 1.7%-10.9%). No association was found between the sodium to Potassium Excretion ratio and risk of hypertension after multivariable adjustment. Low urinary Potassium Excretion was associated with an increased risk of developing hypertension. Dietary strategies to increase Potassium intake to the recommended level of 90 mmol/d may have the potential to reduce the incidence of hypertension.
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Urinary Potassium Excretion and Risk of Developing Hypertension The Prevention of Renal and Vascular End-Stage Disease Study
Hypertension (Dallas Tex. : 1979), 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Rudolf A. De Boer, Gerjan Navis, Stephan J. L. Bakker, Kenneth J Mukamal, Michel M. JoostenAbstract:Previous prospective cohort studies on the association between Potassium intake and risk of hypertension have almost exclusively relied on self-reported dietary data, whereas repeated 24-hour urine Excretions, as estimate of dietary uptake, may provide a more objective and quantitative estimate of this association. Risk of hypertension (defined as blood pressure ≥140/90 mm Hg or initiation of blood pressure-lowering drugs) was prospectively studied in 5511 normotensive subjects aged 28 to 75 years not using blood pressure-lowering drugs at baseline of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Potassium Excretion was measured in two 24-hour urine specimens at baseline (1997-1998) and midway during follow-up (2001-2003). Baseline median Potassium Excretion was 70 mmol/24 h (interquartile range, 57-85 mmol/24 h), which corresponds to a dietary Potassium intake of ≈91 mmol/24 h. During a median follow-up of 7.6 years (interquartile range, 5.0-9.3 years), 1172 subjects developed hypertension. The lowest sex-specific tertile of Potassium Excretion (men:
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Abstract MP24: Urinary Potassium Excretion and Risk of Developing Hypertension
Circulation, 2014Co-Authors: Lyanne M. Kieneker, Ron T. Gansevoort, Edith J. M. Feskens, Johanna M. Geleijnse, Gerjan Navis, Stephan J. L. Bakker, Michel M. JoostenAbstract:Background: Potassium supplementation lowers blood pressure (BP) in randomized controlled trials, but the long-term effect of dietary Potassium intake on risk of hypertension has not yet been established. Objective: To examine the association of 24h urinary Excretions of Potassium, reflecting dietary uptake, with risk of hypertension. Methods: We used data from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective, community-based, observational cohort of Dutch men and women aged 28-75 years. Potassium Excretion was measured at baseline (1997-98) and during follow-up (2001-03) in two consecutive 24h urine specimens. Risk of hypertension (defined as BP ≥140/90 mmHg, or initiation of BP-lowering drugs) was studied in 5,511 normotensive subjects not using BP-lowering drugs at baseline. We used Cox proportional hazards regression analysis with time-dependent covariates. Results: Baseline median Potassium Excretion was 72 mmol/24h (Q1-Q3: 57-85 mmol/24h). During a median follow-...