The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

Ronald D Mann - One of the best experts on this subject based on the ideXlab platform.

  • an instructive example of a long latency adverse drug reaction sclerosing peritonitis due to Practolol
    Pharmacoepidemiology and Drug Safety, 2007
    Co-Authors: Ronald D Mann
    Abstract:

    Objective By examination of the original Yellow Card data to determine the duration of the latent period of the sclerosing peritonitis which formed part of the oculomucocutaneous syndrome that was associated with Practolol, the beta-adrenergic receptor blocking agent that was withdrawn from clinical usage in the UK in December 1975 in response to reports of the syndrome. Method Relevant drug analysis prints (DAPs) for Practolol were obtained from the Medicines and Healthcare Products Regulatory Agency (MHRA) and, by application to the Interim Committee on Yellow Card data, copies were obtained of the anonymised Yellow Card reports for all the 201 cases of sclerosing peritonitis that were reported in patients treated with Practolol. These data were used to determine the latent period of this iatrogenic adverse drug reaction. Results It was shown that no other cause than Practolol operated in all or a majority of the cases of sclerosing peritonitis and the suspected adverse reaction could properly be attributed to the drug. The latent period (the time period between the drug start date and the reaction start date) of the sclerosing peritonitis associated with Practolol averaged 201 weeks (range 26–606 weeks; standard deviation 130 weeks). Conclusion The latent period of the sclerosing peritonitis that formed part of the Practolol oculomucocutaneous syndrome averaged about 4 years and had a range of from 0.5 to over 11.5 years. The Yellow Card Scheme could detect this ultra long-latency adverse reaction. Copyright © 2007 John Wiley & Sons, Ltd.

Longdi Li - One of the best experts on this subject based on the ideXlab platform.

  • room temperature phosphorimetric determination of Practolol with dansyl chloride labeling
    Spectroscopy and Spectral Analysis, 1998
    Co-Authors: Aijun Tong, Yalan Wu, Longdi Li
    Abstract:

    : Dansyl Chloride (DNS-Cl) was used as a phosphorescent labeling agent for the determination of Practolol. The derivative was formed by refluxing Practolol-ethyl acetate solution with the solid DNS-Cl in the presence of potassium carbonate anhydride. Room-temperature phosphorescent (RTP) properties of the derivative were studied by a micelle-stabilized room-temperature phosphorescence (MS-RTP) method. Phosphorescence lifetimes of Practolol-DNS and the DNS-Cl were found to be 0.791 and 0.408ms, respectively. By applying the derivative MS-RTP technique, Practolol could be quantitatively determined without previous separation process. Detection limit of Practolol with the proposed method was 0.19 microg/mL.

Aijun Tong - One of the best experts on this subject based on the ideXlab platform.

  • room temperature phosphorimetric determination of Practolol with dansyl chloride labeling
    Spectroscopy and Spectral Analysis, 1998
    Co-Authors: Aijun Tong, Yalan Wu, Longdi Li
    Abstract:

    : Dansyl Chloride (DNS-Cl) was used as a phosphorescent labeling agent for the determination of Practolol. The derivative was formed by refluxing Practolol-ethyl acetate solution with the solid DNS-Cl in the presence of potassium carbonate anhydride. Room-temperature phosphorescent (RTP) properties of the derivative were studied by a micelle-stabilized room-temperature phosphorescence (MS-RTP) method. Phosphorescence lifetimes of Practolol-DNS and the DNS-Cl were found to be 0.791 and 0.408ms, respectively. By applying the derivative MS-RTP technique, Practolol could be quantitatively determined without previous separation process. Detection limit of Practolol with the proposed method was 0.19 microg/mL.

Yalan Wu - One of the best experts on this subject based on the ideXlab platform.

  • room temperature phosphorimetric determination of Practolol with dansyl chloride labeling
    Spectroscopy and Spectral Analysis, 1998
    Co-Authors: Aijun Tong, Yalan Wu, Longdi Li
    Abstract:

    : Dansyl Chloride (DNS-Cl) was used as a phosphorescent labeling agent for the determination of Practolol. The derivative was formed by refluxing Practolol-ethyl acetate solution with the solid DNS-Cl in the presence of potassium carbonate anhydride. Room-temperature phosphorescent (RTP) properties of the derivative were studied by a micelle-stabilized room-temperature phosphorescence (MS-RTP) method. Phosphorescence lifetimes of Practolol-DNS and the DNS-Cl were found to be 0.791 and 0.408ms, respectively. By applying the derivative MS-RTP technique, Practolol could be quantitatively determined without previous separation process. Detection limit of Practolol with the proposed method was 0.19 microg/mL.