The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform

David O Okonkwo - One of the best experts on this subject based on the ideXlab platform.

  • low preoperative serum Prealbumin levels and the postoperative surgical site infection risk in elective spine surgery a consecutive series
    Journal of Neurosurgery, 2018
    Co-Authors: David J Salvetti, Zachary J Tempel, Ezequiel Goldschmidt, Nicole A Colwell, Federico Angriman, David M Panczykowski, Nitin Agarwal, Adam S Kanter, David O Okonkwo
    Abstract:

    OBJECTIVENutritional deficiency negatively affects outcomes in many health conditions. In spine surgery, evidence linking preoperative nutritional deficiency to postoperative surgical site infection (SSI) has been limited to small retrospective studies. Authors of the current study analyzed a large consecutive cohort of patients who had undergone elective spine surgery to determine the relationship between a serum biomarker of nutritional status (preoperative Prealbumin levels) and SSI.METHODSThe authors conducted a retrospective review of the electronic medical charts of patients who had undergone posterior spinal surgeries and whose preoperative Prealbumin level was available. Additional data pertinent to the risk of SSI were also collected. Patients who developed a postoperative SSI were identified, and risk factors for postoperative SSI were analyzed. Nutritional deficiency was defined as a preoperative serum Prealbumin level ≤ 20 mg/dl.RESULTSAmong a consecutive series of 387 patients who met the study criteria for inclusion, the infection rate for those with preoperative Prealbumin ≤ 20 mg/dl was 17.8% (13/73), versus 4.8% (15/314) for those with preoperative Prealbumin > 20 mg/dl. On univariate and multivariate analysis a low preoperative Prealbumin level was a risk factor for postoperative SSI with a crude OR of 4.29 (p < 0.01) and an adjusted OR of 3.28 (p = 0.02). In addition, several previously known risk factors for infection, including diabetes, spinal fusion, and number of operative levels, were significant for the development of an SSI.CONCLUSIONSIn this consecutive series, preoperative Prealbumin levels, a serum biomarker of nutritional status, correlated with the risk of SSI in elective spine surgery. Prehabilitation before spine surgery, including strategies to improve nutritional status in patients with nutritional deficiencies, may increase value and improve spine care.

  • Prealbumin as a serum biomarker of impaired perioperative nutritional status and risk for surgical site infection after spine surgery
    Central European Neurosurgery, 2015
    Co-Authors: Zachary J Tempel, David M Panczykowski, Ramesh Grandhi, Matthew B Maserati, Juan B Ochoa, James M Russavage, David O Okonkwo
    Abstract:

    Introduction Impaired perioperative nutritional status has been shown to be an important predictor of surgical morbidity and is the earliest marker of nutritional deficiency. No study, however, has examined serum Prealbumin as a surrogate marker of nutritional status in patients undergoing spine surgery. Methods We performed a retrospective review of all patients who developed a postoperative deep wound infection after undergoing spine surgery at the University of Pittsburgh Medical Center from January 2008 through December 2011. Demographics, preoperative diagnosis, type of surgery, perioperative serum Prealbumin level, time to infection, number and type of debridement procedures, and length of hospital stay were recorded. Results A total of 83 patients had Prealbumin levels available at the time of presentation of infection. Mean patient age was 56 years, and 71% were women. Surgical treatment for the infection required between 1 and 13 debridements, and 21 (25%) of the 83 patients who had instrumentation placed at the time of the initial surgery required removal of their instrumentation. Inpatient hospitalizations were extended by an average of 13 days. Prealbumin levels were below normal in 82 (99%) of the 83 patients; levels were  Conclusions All patients except one who developed postoperative deep wound infection after spine surgery had serum Prealbumin levels in the malnutrition range at the time of presentation. The current study suggests serum Prealbumin levels may be an inexpensive screening biomarker for nutritional status and risk stratification for postoperative infection after spine surgery.

Jeffrey A Morgan - One of the best experts on this subject based on the ideXlab platform.

  • preoperative Prealbumin level as a predictor of outcomes in patients who underwent left ventricular assist device implantation
    American Journal of Cardiology, 2017
    Co-Authors: Andre C Critsinelis, Chitaru Kurihara, Masashi Kawabori, Tadahisa Sugiura, Andrew B Civitello, Jeffrey A Morgan
    Abstract:

    Malnutrition has been associated with an increased risk of morbidity and mortality in patients who undergo cardiac surgery. However, many measurements of malnutrition have been inadequate prognostic markers. In this study, we sought to determine whether low preoperative serum Prealbumin level was associated with morbidity and mortality in patients who underwent continuous-flow left ventricular assist device (CF-LVAD) implantation. From November 2003 to March 2016, 526 patients with chronic heart failure underwent implantation of a CF-LVAD (HeartMate II, n = 403; HeartWare HVAD, n = 123). Our cohort comprised the 317 CF-LVAD recipients whose records included the preoperative serum Prealbumin level. These patients were divided into 2 groups: those with a normal preoperative serum Prealbumin level (>17 g/dL) and those with hypoPrealbuminemia (≤17 g/dL). These groups were then compared with regard to preoperative demographics, incidence of postoperative complications, long-term survival rate, and cause of death. Kaplan-Meier survival analysis revealed that patients with a low preoperative Prealbumin level had significantly decreased survival rates at 1, 6, 12, and 24 months (p

Chitaru Kurihara - One of the best experts on this subject based on the ideXlab platform.

  • preoperative Prealbumin level as a predictor of outcomes in patients who underwent left ventricular assist device implantation
    American Journal of Cardiology, 2017
    Co-Authors: Andre C Critsinelis, Chitaru Kurihara, Masashi Kawabori, Tadahisa Sugiura, Andrew B Civitello, Jeffrey A Morgan
    Abstract:

    Malnutrition has been associated with an increased risk of morbidity and mortality in patients who undergo cardiac surgery. However, many measurements of malnutrition have been inadequate prognostic markers. In this study, we sought to determine whether low preoperative serum Prealbumin level was associated with morbidity and mortality in patients who underwent continuous-flow left ventricular assist device (CF-LVAD) implantation. From November 2003 to March 2016, 526 patients with chronic heart failure underwent implantation of a CF-LVAD (HeartMate II, n = 403; HeartWare HVAD, n = 123). Our cohort comprised the 317 CF-LVAD recipients whose records included the preoperative serum Prealbumin level. These patients were divided into 2 groups: those with a normal preoperative serum Prealbumin level (>17 g/dL) and those with hypoPrealbuminemia (≤17 g/dL). These groups were then compared with regard to preoperative demographics, incidence of postoperative complications, long-term survival rate, and cause of death. Kaplan-Meier survival analysis revealed that patients with a low preoperative Prealbumin level had significantly decreased survival rates at 1, 6, 12, and 24 months (p

Brun-hansen Hege - One of the best experts on this subject based on the ideXlab platform.

  • Plasma protein fractions in free-living white-tailed eagle (Haliaeetus albicilla) nestlings from Norway
    'Springer Science and Business Media LLC', 2019
    Co-Authors: Flo Jørgen, Løseth, Mari Engvig, Sonne C, Jaspers Veerle, Brun-hansen Hege
    Abstract:

    Background Capillary electrophoresis of plasma proteins has shown great potential as a complementary diagnostic tool for avian species. However, reference intervals for plasma proteins are sparse or lacking for several free-living avian species. The current study reports electrophoretic patterns and concentrations of plasma proteins determined for 70 free-living white-tailed eagle (Haliaeetus albicilla) nestlings from two locations in Norway (Steigen and Smøla) in order to establish reference values for this subpopulation using capillary electrophoresis. The nestlings were between 44 and 87 days of age, and the plasma protein concentrations were investigated for age, sex, year (2015 and 2016) and location differences. To our knowledge, this is the first report of reference intervals of plasma proteins analysed by capillary electrophoresis in free-living white-tailed eagle nestlings. Results The plasma protein concentrations (% of total protein, mean ± SE) were determined for Prealbumin (13.7%, 4.34 ± 0.15 g/L), albumin (46.7%, 14.81 ± 0.24 g/L), α1-globulin (2.4%, 0.74 ± 0.03 g/L), α2-globulin (11.7%, 3.72 ± 0.06 g/L), β-globulin (15.9%, 5.06 ± 0.08 g/L) and γ-globulin (9.6%, 3.05 ± 0.09 g/L). Significant differences were found between the two locations for Prealbumin, α2- and γ-globulins. No significant differences were found between the two sampling years or sexes, and no effect of age was found for any of the plasma proteins. However, Prealbumin levels were several folds higher than previously reported from adults of closely related birds of prey species. There were no other studies on capillary electrophoresis of nestling plasma available for comparison. Conclusion Significant differences were found between sampling locations for Prealbumin, α2- and γ-globulins, which may indicate differences in inflammatory or infectious status between nestlings at the two locations. Sampling year, sex or age had no significant effect on the plasma protein concentrations. These results provide novel data on plasma protein concentrations by capillary electrophoresis and may be useful for evaluation of health status in free-living white-tailed eagle nestlings.publishedVersio

  • Plasma protein fractions in free-living white-tailed eagle (Haliaeetus albicilla) nestlings from Norway
    2019
    Co-Authors: Flo Jørgen, Løseth, Mari Engvig, Sonne C, Jaspers Veerle, Brun-hansen Hege
    Abstract:

    Background Capillary electrophoresis of plasma proteins has shown great potential as a complementary diagnostic tool for avian species. However, reference intervals for plasma proteins are sparse or lacking for several free-living avian species. The current study reports electrophoretic patterns and concentrations of plasma proteins determined for 70 free-living white-tailed eagle (Haliaeetus albicilla) nestlings from two locations in Norway (Steigen and Smøla) in order to establish reference values for this subpopulation using capillary electrophoresis. The nestlings were between 44 and 87 days of age, and the plasma protein concentrations were investigated for age, sex, year (2015 and 2016) and location differences. To our knowledge, this is the first report of reference intervals of plasma proteins analysed by capillary electrophoresis in free-living white-tailed eagle nestlings. Results The plasma protein concentrations (% of total protein, mean ± SE) were determined for Prealbumin (13.7%, 4.34 ± 0.15 g/L), albumin (46.7%, 14.81 ± 0.24 g/L), α1-globulin (2.4%, 0.74 ± 0.03 g/L), α2-globulin (11.7%, 3.72 ± 0.06 g/L), β-globulin (15.9%, 5.06 ± 0.08 g/L) and γ-globulin (9.6%, 3.05 ± 0.09 g/L). Significant differences were found between the two locations for Prealbumin, α2- and γ-globulins. No significant differences were found between the two sampling years or sexes, and no effect of age was found for any of the plasma proteins. However, Prealbumin levels were several folds higher than previously reported from adults of closely related birds of prey species. There were no other studies on capillary electrophoresis of nestling plasma available for comparison. Conclusion Significant differences were found between sampling locations for Prealbumin, α2- and γ-globulins, which may indicate differences in inflammatory or infectious status between nestlings at the two locations. Sampling year, sex or age had no significant effect on the plasma protein concentrations. These results provide novel data on plasma protein concentrations by capillary electrophoresis and may be useful for evaluation of health status in free-living white-tailed eagle nestlings

Andre C Critsinelis - One of the best experts on this subject based on the ideXlab platform.

  • preoperative Prealbumin level as a predictor of outcomes in patients who underwent left ventricular assist device implantation
    American Journal of Cardiology, 2017
    Co-Authors: Andre C Critsinelis, Chitaru Kurihara, Masashi Kawabori, Tadahisa Sugiura, Andrew B Civitello, Jeffrey A Morgan
    Abstract:

    Malnutrition has been associated with an increased risk of morbidity and mortality in patients who undergo cardiac surgery. However, many measurements of malnutrition have been inadequate prognostic markers. In this study, we sought to determine whether low preoperative serum Prealbumin level was associated with morbidity and mortality in patients who underwent continuous-flow left ventricular assist device (CF-LVAD) implantation. From November 2003 to March 2016, 526 patients with chronic heart failure underwent implantation of a CF-LVAD (HeartMate II, n = 403; HeartWare HVAD, n = 123). Our cohort comprised the 317 CF-LVAD recipients whose records included the preoperative serum Prealbumin level. These patients were divided into 2 groups: those with a normal preoperative serum Prealbumin level (>17 g/dL) and those with hypoPrealbuminemia (≤17 g/dL). These groups were then compared with regard to preoperative demographics, incidence of postoperative complications, long-term survival rate, and cause of death. Kaplan-Meier survival analysis revealed that patients with a low preoperative Prealbumin level had significantly decreased survival rates at 1, 6, 12, and 24 months (p