The Experts below are selected from a list of 37062 Experts worldwide ranked by ideXlab platform
Jason Y Park - One of the best experts on this subject based on the ideXlab platform.
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Precision Medicine in Gastrointestinal Pathology
Archives of pathology & laboratory medicine, 2016Co-Authors: David H Wang, Jason Y ParkAbstract:-Precision Medicine is the promise of individualized therapy and management of patients based on their personal biology. There are now multiple global initiatives to perform whole-genome sequencing on millions of individuals. In the United States, an early program was the Million Veteran Program, and a more recent proposal in 2015 by the president of the United States is the Precision Medicine Initiative. To implement Precision Medicine in routine oncology care, genetic variants present in tumors need to be matched with effective clinical therapeutics. When we focus on the current state of Precision Medicine for gastrointestinal malignancies, it becomes apparent that there is a mixed history of success and failure. -To present the current state of Precision Medicine using gastrointestinal oncology as a model. We will present currently available targeted therapeutics, promising new findings in clinical genomic oncology, remaining quality issues in genomic testing, and emerging oncology clinical trial designs. -Review of the literature including clinical genomic studies on gastrointestinal malignancies, clinical oncology trials on therapeutics targeted to molecular alterations, and emerging clinical oncology study designs. -Translating our ability to sequence thousands of genes into meaningful improvements in patient survival will be the challenge for the next decade.
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Precision Medicine in Gastrointestinal Pathology
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: David H Wang, Jason Y ParkAbstract:Context.—Precision Medicine is the promise of individualized therapy and management of patients based on their personal biology. There are now multiple global initiatives to perform whole-genome se...
David H Wang - One of the best experts on this subject based on the ideXlab platform.
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Precision Medicine in Gastrointestinal Pathology
Archives of pathology & laboratory medicine, 2016Co-Authors: David H Wang, Jason Y ParkAbstract:-Precision Medicine is the promise of individualized therapy and management of patients based on their personal biology. There are now multiple global initiatives to perform whole-genome sequencing on millions of individuals. In the United States, an early program was the Million Veteran Program, and a more recent proposal in 2015 by the president of the United States is the Precision Medicine Initiative. To implement Precision Medicine in routine oncology care, genetic variants present in tumors need to be matched with effective clinical therapeutics. When we focus on the current state of Precision Medicine for gastrointestinal malignancies, it becomes apparent that there is a mixed history of success and failure. -To present the current state of Precision Medicine using gastrointestinal oncology as a model. We will present currently available targeted therapeutics, promising new findings in clinical genomic oncology, remaining quality issues in genomic testing, and emerging oncology clinical trial designs. -Review of the literature including clinical genomic studies on gastrointestinal malignancies, clinical oncology trials on therapeutics targeted to molecular alterations, and emerging clinical oncology study designs. -Translating our ability to sequence thousands of genes into meaningful improvements in patient survival will be the challenge for the next decade.
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Precision Medicine in Gastrointestinal Pathology
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: David H Wang, Jason Y ParkAbstract:Context.—Precision Medicine is the promise of individualized therapy and management of patients based on their personal biology. There are now multiple global initiatives to perform whole-genome se...
Joseph Loscalzo - One of the best experts on this subject based on the ideXlab platform.
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Precision Medicine in cardiology
Nature Reviews Cardiology, 2016Co-Authors: Elliott M Antman, Joseph LoscalzoAbstract:Both the cardiovascular research and clinical communities are ideally positioned to develop and implement Precision Medicine to achieve more effective prevention and treatment. This Review highlights the advances in modern bioMedicine that make possible the Precision Medicine era, provides current examples of the use of this approach in the cardiovascular field, and defines the goals and barriers to implementation of a Precision Medicine system.
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Precision Medicine in cardiology
Nature reviews. Cardiology, 2016Co-Authors: Elliott M Antman, Joseph LoscalzoAbstract:The cardiovascular research and clinical communities are ideally positioned to address the epidemic of noncommunicable causes of death, as well as advance our understanding of human health and disease, through the development and implementation of Precision Medicine. New tools will be needed for describing the cardiovascular health status of individuals and populations, including 'omic' data, exposome and social determinants of health, the microbiome, behaviours and motivations, patient-generated data, and the array of data in electronic medical records. Cardiovascular specialists can build on their experience and use Precision Medicine to facilitate discovery science and improve the efficiency of clinical research, with the goal of providing more precise information to improve the health of individuals and populations. Overcoming the barriers to implementing Precision Medicine will require addressing a range of technical and sociopolitical issues. Health care under Precision Medicine will become a more integrated, dynamic system, in which patients are no longer a passive entity on whom measurements are made, but instead are central stakeholders who contribute data and participate actively in shared decision-making. Many traditionally defined diseases have common mechanisms; therefore, elimination of a siloed approach to Medicine will ultimately pave the path to the creation of a universal Precision Medicine environment.
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Opportunities for the Cardiovascular Community in the Precision Medicine Initiative
Circulation, 2016Co-Authors: Svati H. Shah, Joseph Loscalzo, Geoffrey S. Ginsburg, Donna K. Arnett, Steven R. Houser, Calum A. Macrae, Seema Mital, Jennifer L. HallAbstract:The Precision Medicine Initiative recently announced by President Barack Obama seeks to move the field of Precision Medicine more rapidly into clinical care. Precision Medicine revolves around the concept of integrating individual-level data including genomics, biomarkers, lifestyle and other environmental factors, wearable device physiological data, and information from electronic health records to ultimately provide better clinical care to individual patients. The Precision Medicine Initiative as currently structured will primarily fund efforts in cancer genomics with longer-term goals of advancing Precision Medicine to all areas of health, and will be supported through creation of a 1 million person cohort study across the United States. This focused effort on Precision Medicine provides scientists, clinicians, and patients within the cardiovascular community an opportunity to work together boldly to advance clinical care; the community needs to be aware and engaged in the process as it progresses. This article provides a framework for potential involvement of the cardiovascular community in the Precision Medicine Initiative, while highlighting significant challenges for its successful implementation.
Jennifer L. Hall - One of the best experts on this subject based on the ideXlab platform.
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Opportunities for the Cardiovascular Community in the Precision Medicine Initiative
Circulation, 2016Co-Authors: Svati H. Shah, Joseph Loscalzo, Geoffrey S. Ginsburg, Donna K. Arnett, Steven R. Houser, Calum A. Macrae, Seema Mital, Jennifer L. HallAbstract:The Precision Medicine Initiative recently announced by President Barack Obama seeks to move the field of Precision Medicine more rapidly into clinical care. Precision Medicine revolves around the concept of integrating individual-level data including genomics, biomarkers, lifestyle and other environmental factors, wearable device physiological data, and information from electronic health records to ultimately provide better clinical care to individual patients. The Precision Medicine Initiative as currently structured will primarily fund efforts in cancer genomics with longer-term goals of advancing Precision Medicine to all areas of health, and will be supported through creation of a 1 million person cohort study across the United States. This focused effort on Precision Medicine provides scientists, clinicians, and patients within the cardiovascular community an opportunity to work together boldly to advance clinical care; the community needs to be aware and engaged in the process as it progresses. This article provides a framework for potential involvement of the cardiovascular community in the Precision Medicine Initiative, while highlighting significant challenges for its successful implementation.
Michael J. Joyner - One of the best experts on this subject based on the ideXlab platform.
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Precision Medicine, Cardiovascular Disease and Hunting Elephants
Progress in cardiovascular diseases, 2016Co-Authors: Michael J. JoynerAbstract:Precision Medicine postulates improved prediction, prevention, diagnosis and treatment of disease based on patient specific factors especially DNA sequence (i.e., gene) variants. Ideas related to Precision Medicine stem from the much anticipated "genetic revolution in Medicine" arising seamlessly from the human genome project (HGP). In this essay I deconstruct the concept of Precision Medicine and raise questions about the validity of the paradigm in general and its application to cardiovascular disease. Thus far Precision Medicine has underperformed based on the vision promulgated by enthusiasts. While niche successes for Precision Medicine are likely, the promises of broad based transformation should be viewed with skepticism. Open discussion and debate related to Precision Medicine are urgently needed to avoid misapplication of resources, hype, iatrogenic interventions, and distraction from established approaches with ongoing utility. Failure to engage in such debate will lead to negative unintended consequences from a revolution that might never come.
