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W Bloise - One of the best experts on this subject based on the ideXlab platform.

  • 10 GnRH AGONIST THERAPY IN TRUE PRECOCIUS PUBERTY SECONDARY TO HYPOTHALAMIC HAMARTOMA (IHH)
    Pediatric Research, 1994
    Co-Authors: S Domenice, A C Latronico, B B Mendonca, I J P Arnhold, W Bloise
    Abstract:

    Hypothalamic hamartomas, are benigns tumors of central nervous system, related to Development of the true Sexual Precocious puberty, have been more frecuently diagnosed due to improvement of the radiologic technology (computed tomography and MRI scanning). We studied two children with Precocious Sexual Development (Case 1: boy, onset the Development of public hair and growth of the penis at 6 months of age; Case 2: girl with breast Development and menarche at 6 months. In both patients hypothalamic hamartomas were demonstrated by MRI (Case 2) and CT and MRI (case 1). At the first evaluation we observed enlargenment of the penis (8,0 cm) and a testicular diameter of 2,5 cm in case 1; and b reast stage Tanner II in case 2. Both had a pubertal response to the GnRH stimulation test (100 mg IV), LH 51,4 and 28.3 mUI/ml, respectively and normal levels of DHEAS for age. The children were treated with GnRH analog depot (D-Trp6-GnRH) in dosage of 1.5 mg IM every month for 36 and 18 months respectively. Gonadotropin secretion was inhibited with use of GnRH analog. Physical signs of puberty did not progress futher, without menstrual periods and with height velocity remained between normal range. Laboratory data showed normalization of testosterone level in case 1 (144,5 to 15 ng/dl). We conclude that GnRH analog therapy is efficient in patients with true Precocious puberty secondary to hyphotalamic hamartoma.

Alvin Chung Man Leung - One of the best experts on this subject based on the ideXlab platform.

  • serum bioactive follicle stimulating hormone levels in girls with Precocious Sexual Development
    The Journal of Clinical Endocrinology and Metabolism, 1990
    Co-Authors: Christina Yan Wang, C Q Zhong, Alvin Chung Man Leung
    Abstract:

    We studied the serum immunoreactive (immuno) and bioactive (bio) FSH concentrations in 16 prepubertal children (1.3–9 yr old), 6 girls with premature thelarche (0.8–2 yr old), and 9 girls with central Precocious puberty (2.5–9.3 yr old). The serum bio-FSH was measured by the granulosa cell aromatase bioassay. The basal serum bio-FSH levels were not significantly different in patients with central Precocious puberty (6.4 ± 1.5 IU/L), premature thelarche (7.5 ± 0.5 IU/L), and prepubertal controls (4.4 ± 0.7 IU/L). However, the peak responses of both serum immuno- and bio-FSH levels to iv GnRH were higher in patients with premature thelarche (immuno-FSH, 29.3 ± 2.3 IU/L; bio-FSH, 100.7 ± 12.2 IU/L) than in those with central Precocious puberty [immuno-FSH, 17.5 ± 3.1 IU/L (p < 0.05); bio-FSH, 42.4 ± 9.8 IU/L (p < 0.01)]. This suggests that in children with premature thelarche, there is a predominant immuno- as well as bio-FSH response to GnRH. After 12 months of GnRH agonist therapy, both serum immunoand bio...

S Domenice - One of the best experts on this subject based on the ideXlab platform.

  • 10 GnRH AGONIST THERAPY IN TRUE PRECOCIUS PUBERTY SECONDARY TO HYPOTHALAMIC HAMARTOMA (IHH)
    Pediatric Research, 1994
    Co-Authors: S Domenice, A C Latronico, B B Mendonca, I J P Arnhold, W Bloise
    Abstract:

    Hypothalamic hamartomas, are benigns tumors of central nervous system, related to Development of the true Sexual Precocious puberty, have been more frecuently diagnosed due to improvement of the radiologic technology (computed tomography and MRI scanning). We studied two children with Precocious Sexual Development (Case 1: boy, onset the Development of public hair and growth of the penis at 6 months of age; Case 2: girl with breast Development and menarche at 6 months. In both patients hypothalamic hamartomas were demonstrated by MRI (Case 2) and CT and MRI (case 1). At the first evaluation we observed enlargenment of the penis (8,0 cm) and a testicular diameter of 2,5 cm in case 1; and b reast stage Tanner II in case 2. Both had a pubertal response to the GnRH stimulation test (100 mg IV), LH 51,4 and 28.3 mUI/ml, respectively and normal levels of DHEAS for age. The children were treated with GnRH analog depot (D-Trp6-GnRH) in dosage of 1.5 mg IM every month for 36 and 18 months respectively. Gonadotropin secretion was inhibited with use of GnRH analog. Physical signs of puberty did not progress futher, without menstrual periods and with height velocity remained between normal range. Laboratory data showed normalization of testosterone level in case 1 (144,5 to 15 ng/dl). We conclude that GnRH analog therapy is efficient in patients with true Precocious puberty secondary to hyphotalamic hamartoma.

Christina Yan Wang - One of the best experts on this subject based on the ideXlab platform.

  • serum bioactive follicle stimulating hormone levels in girls with Precocious Sexual Development
    The Journal of Clinical Endocrinology and Metabolism, 1990
    Co-Authors: Christina Yan Wang, C Q Zhong, Alvin Chung Man Leung
    Abstract:

    We studied the serum immunoreactive (immuno) and bioactive (bio) FSH concentrations in 16 prepubertal children (1.3–9 yr old), 6 girls with premature thelarche (0.8–2 yr old), and 9 girls with central Precocious puberty (2.5–9.3 yr old). The serum bio-FSH was measured by the granulosa cell aromatase bioassay. The basal serum bio-FSH levels were not significantly different in patients with central Precocious puberty (6.4 ± 1.5 IU/L), premature thelarche (7.5 ± 0.5 IU/L), and prepubertal controls (4.4 ± 0.7 IU/L). However, the peak responses of both serum immuno- and bio-FSH levels to iv GnRH were higher in patients with premature thelarche (immuno-FSH, 29.3 ± 2.3 IU/L; bio-FSH, 100.7 ± 12.2 IU/L) than in those with central Precocious puberty [immuno-FSH, 17.5 ± 3.1 IU/L (p < 0.05); bio-FSH, 42.4 ± 9.8 IU/L (p < 0.01)]. This suggests that in children with premature thelarche, there is a predominant immuno- as well as bio-FSH response to GnRH. After 12 months of GnRH agonist therapy, both serum immunoand bio...

Mario Georgenascimento - One of the best experts on this subject based on the ideXlab platform.

  • differential Precocious Sexual Development of proctoeces lintoni digenea fellodistomidae in three sympatric species of keyhole limpets fissurella spp may affect transmission to the final host
    Journal of Parasitology, 2001
    Co-Authors: Luis Balboa, Mario Georgenascimento, Patricio F Ojeda
    Abstract:

    The prevalence, abundance, and Developmental status of the digenetic trematode Proctoeces lintoni Siddiqui et Cable 1960 were compared in 3 species of keyhole limpets Fissurella. A total of 197 limpets was collected at Caleta Chome, south-central Chile. Fissurella picta and F. costata had the highest prevalence of infection, whereas F. picta showed the greatest abundance of parasites, which increased with host shell length. However, the frequency of P. lintoni specimens with eggs in the uterus was greatest in F. costata. These results suggest that an increased rate of Development of a parasite in the intermediate host may shorten the residence time necessary for maturation in the final host. Thus, faster Development of the parasite in F. costata suggests the possibility that the parasites transmitted through this host species have shorter maturation times in clingfishes than individuals transmitted via other limpet species.

  • differential Precocious Sexual Development of proctoeces lintoni digenea fellodistomidae in three sympatric species of keyhole limpets fissurella spp may
    2001
    Co-Authors: Luis Balboa, Mario Georgenascimento, Patricio F Ojedat, Catdlica De Chile
    Abstract:

    The prevalence, abundance, and Developmental status of the digenetic trematode Proctoeces lintoni Siddiqui et Cable 1960 were compared in 3 species of keyhole limpets Fissurella. A total of 197 limpets was collected at Caleta Chome, south-central Chile. Fissurella picta and F. costata had the highest prevalence of infection, whereas F. picta showed the greatest abundance of parasites, which increased with host shell length. However, the frequency of P. lintoni specimens with eggs in the uterus was greatest in F. costata. These results suggest that an increased rate of Development of a parasite in the intermediate host may shorten the residence time necessary for maturation in the final host. Thus, faster Development of the parasite in F. costata sug- gests the possibility that the parasites transmitted through this host spe- cies have shorter maturation times in clingfishes than individuals trans- mitted via other limpet species. ABSTRACT: The prevalence, abundance, and Developmental status of the digenetic trematode Proctoeces lintoni Siddiqui et Cable 1960 were compared in 3 species of keyhole limpets Fissurella. A total of 197 limpets was collected at Caleta Chome, south-central Chile. Fissurella picta and F. costata had the highest prevalence of infection, whereas F. picta showed the greatest abundance of parasites, which increased with host shell length. However, the frequency of P. lintoni specimens with eggs in the uterus was greatest in F. costata. These results suggest that an increased rate of Development of a parasite in the intermediate host may shorten the residence time necessary for maturation in the final host. Thus, faster Development of the parasite in F. costata sug- gests the possibility that the parasites transmitted through this host spe- cies have shorter maturation times in clingfishes than individuals trans- mitted via other limpet species. The taxonomic status of species in Proctoeces is confusing because of the variability of characters used for discrimination (Stunkard and Uzmann, 1959; Bray and Gibson, 1980; Bray, 1983). George-Nasci- mento and Quiroga (1983) described Proctoeces humboldti (Digenea: Fellodistomidae) in limpets Fissurella spp. (Mollusca: Archaeogastro- poda) along the coast of Chile. Later, Oliva (1984) described P. chilen- sis from the clingfish Syciases sanguineus (Pisces: Gobiesocidae). Sub- sequently, Oliva and Zegers (1988) compared Proctoeces specimens collected from a few limpet and clingfishes, and concluded that forms