Pregnancy Outcome

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Marek Glezerman - One of the best experts on this subject based on the ideXlab platform.

Thomas A. Medsger - One of the best experts on this subject based on the ideXlab platform.

  • Pregnancy Outcome and Anti-Cardiolipin Antibody in Women with Systemic Lupus Erythematosus
    American Journal of Epidemiology, 1993
    Co-Authors: Rosalind Ramsey-goldman, Joan E. Kutzer, Lewis H. Kuller, David S. Guzick, A. Betts Carpenter, Thomas A. Medsger
    Abstract:

    Pregnancies in women with systemic lupus erythematosus are recognized to result in excessive fetal morbidity and mortality. Maternal autoantibody status may explain some of these problems. Anti-cardiolipin antibody has been associated with recurrent Pregnancy losses in some women with lupus, but the risk of these losses has not been defined. At the University of Pittsburgh between January 1, 1979, and December 31, 1989, an unmatched case-control study design was used to determine whether patients with lupus and anti-cardiolipin antibody (81 cases) were at increased risk for adverse Pregnancy Outcomes in comparison with lupus patients without the antibody (174 controls). Cases had 98 of 192 (51%) pregnancies with an adverse Outcome, while controls had 212 of 494 (43%). The odds ratio for having any adverse Pregnancy Outcome was 1.40 (95% confidence interval (CI) 0.98-1.98). When pregnancies were classified according to specific adverse Outcome types, the frequency of late miscarriages (14-20 weeks gestation) in cases and controls was 8% and 3%, respectively. The odds ratio for late miscarriage was 2.94 (95% CI 1.31-6.60). When pregnancies were stratified by birth number and by occurrence of Pregnancy before or after diagnosis, the increased frequency of late miscarriages in cases was noted only in the first Pregnancy when the Pregnancy occurred before recognized disease. Preterm births (before 38 weeks gestation) were increased in cases compared with controls in pregnancies that occurred after diagnosis for second and third pregnancies. If a case had one previous adverse Outcome, the odds ratio for another adverse Outcome was 3.00 (95% CI 1.62-5.57). If a case had two previous adverse Outcomes, the odds ratio for a third adverse Pregnancy Outcome was 4.14 (95% CI 1.62-10.58). Thus, a previous adverse Pregnancy Outcome was the most important risk factor for an adverse Outcome in a subsequent Pregnancy.

Murali Subbaiah - One of the best experts on this subject based on the ideXlab platform.

  • Pregnancy Outcome in Women with Polycystic Ovary Syndrome
    The Journal of Obstetrics and Gynecology of India, 2020
    Co-Authors: Amandeep Mann, Haritha Sagili, Murali Subbaiah
    Abstract:

    Background/Purpose Pregnant women with polycystic ovary syndrome seem to be prone for adverse maternal and perinatal Outcomes, but there is no conclusive evidence. Indian data evaluating the Pregnancy Outcome in women with polycystic ovary syndrome are sparse. This study was proposed to evaluate the Pregnancy Outcome in women with polycystic ovary syndrome. Methods This descriptive study on 135 pregnant women with polycystic ovary syndrome was carried out in a tertiary care hospital in South India from January 2016 to October 2017. Data regarding present Pregnancy, polycystic ovary syndrome and maternal/ perinatal Outcomes were analysed using SPSS version 20. Categorical variables studied were parity, various maternal and perinatal Outcomes. Results The mean age was 26.8 years, 77% had high BMI, and 88% had history of primary infertility. The mean age was 26.8 years, 77% had high BMI, and 88% had history of primary infertility. The proportion of hypertensive disorders of Pregnancy was (17.8%), PROM (18.5%), low APGAR score at 5 min (13%), gestational diabetes (13%), miscarriage (2.2%), preterm delivery (10.4%), caesarean delivery (30.4%), low birth weight babies (2%), macrosomia (0.7%), PPROM (8%), perinatal mortality (2%) and NICU admission (20%). Conclusion The proportion of hypertensive disorders of Pregnancy, PROM, low birth weight babies, low APGAR score at 5 min was found to be higher, but the proportion of GDM, miscarriage, preterm delivery, meconium stained liquor, caesarean delivery, small for gestational age/IUGR, macrosomia, PPROM, perinatal mortality, NICU admission and congenital anomalies was found to be either similar or lower in pregnant women with PCOS in our study to those described in the general pregnant population.

  • Pregnancy Outcome in Women with Polycystic Ovary Syndrome
    Journal of obstetrics and gynaecology of India, 2020
    Co-Authors: Amandeep Mann, Haritha Sagili, Murali Subbaiah
    Abstract:

    Pregnant women with polycystic ovary syndrome seem to be prone for adverse maternal and perinatal Outcomes, but there is no conclusive evidence. Indian data evaluating the Pregnancy Outcome in women with polycystic ovary syndrome are sparse. This study was proposed to evaluate the Pregnancy Outcome in women with polycystic ovary syndrome. This descriptive study on 135 pregnant women with polycystic ovary syndrome was carried out in a tertiary care hospital in South India from January 2016 to October 2017. Data regarding present Pregnancy, polycystic ovary syndrome and maternal/ perinatal Outcomes were analysed using SPSS version 20. Categorical variables studied were parity, various maternal and perinatal Outcomes. The mean age was 26.8 years, 77% had high BMI, and 88% had history of primary infertility. The mean age was 26.8 years, 77% had high BMI, and 88% had history of primary infertility. The proportion of hypertensive disorders of Pregnancy was (17.8%), PROM (18.5%), low APGAR score at 5 min (13%), gestational diabetes (13%), miscarriage (2.2%), preterm delivery (10.4%), caesarean delivery (30.4%), low birth weight babies (2%), macrosomia (0.7%), PPROM (8%), perinatal mortality (2%) and NICU admission (20%). The proportion of hypertensive disorders of Pregnancy, PROM, low birth weight babies, low APGAR score at 5 min was found to be higher, but the proportion of GDM, miscarriage, preterm delivery, meconium stained liquor, caesarean delivery, small for gestational age/IUGR, macrosomia, PPROM, perinatal mortality, NICU admission and congenital anomalies was found to be either similar or lower in pregnant women with PCOS in our study to those described in the general pregnant population.

Robert L. Goldenberg - One of the best experts on this subject based on the ideXlab platform.

  • Maternal plasma zinc concentrations and Pregnancy Outcome
    The American journal of clinical nutrition, 2000
    Co-Authors: Tsunenobu Tamura, Robert L. Goldenberg, Kelley E. Johnston, Mary B. Dubard
    Abstract:

    Background There is no consensus in the literature as to whether maternal zinc nutriture is associated with Pregnancy Outcome or fetal growth. Objective We evaluated the associations between plasma zinc concentrations during Pregnancy and various measures of Pregnancy Outcome and neonatal conditions at birth. Design We measured zinc concentrations in plasma samples obtained at a mean of 16 wk of gestation (range: 6-34 wk) from 3448 women who were screened for a trial designed to evaluate the effect of zinc supplementation on fetal growth. Subjects were from low socioeconomic backgrounds and attended a public health clinic for their prenatal care. Plasma zinc concentrations were compared with Pregnancy Outcome, including complications during Pregnancy and delivery, and anthropometric measures and Apgar scores of neonates. Results Plasma zinc concentrations declined as gestation progressed. After plasma zinc concentrations were adjusted for gestational age, they were not significantly associated with any measure of Pregnancy Outcome or neonatal condition. Conclusion We conclude that plasma zinc concentrations during the late first trimester to the early third trimester do not predict Pregnancy Outcomes in women of a low socioeconomic background.

  • Zinc nutriture and Pregnancy Outcome
    Nutrition Research, 1996
    Co-Authors: Tsunenobu Tamura, Robert L. Goldenberg
    Abstract:

    The main purpose of this article is to review the studies describing the relationship between zinc nutriture and Pregnancy Outcome in humans and animals. In addition, we have included a brief description of our recent findings from a randomized trial on the positive effect of zinc supplementation during Pregnancy on birth weight and head circumference of infants. In human studies, the findings in the literature are mostly inconclusive because of inconsistent study conditions, insufficient sample size, or the lack of specific and sensitive test(s) to accurately assess zinc nutriture. Many unanswered questions which require further investigation relating to maternal zinc nutriture and Pregnancy Outcome are discussed.

Nicolas Garrido - One of the best experts on this subject based on the ideXlab platform.

  • value of the sperm chromatin dispersion test in predicting Pregnancy Outcome in intrauterine insemination a blind prospective study
    Human Reproduction, 2006
    Co-Authors: Lourdes Muriel, Marcos Meseguer, Jose Luis Fernandez, J C Alvarez, Jose Remohi, Antonio Pellicer, Nicolas Garrido
    Abstract:

    BACKGROUND: Sperm DNA integrity has been used as a new marker of sperm quality in the prediction of Pregnancy. Nevertheless, no previous study has been performed by analysing the same samples that were employed in assisted reproduction. The main objective of this work was to correlate sperm chromatin dispersion (SCD), measured by the SCD test, with semen parameters and Pregnancy Outcome in intrauterine insemination (IUI). METHODS: A total of 100 semen samples obtained from males of couples undergoing IUI were analysed by the SCD test before and after swim-up, and the results were correlated with semen parameters and Pregnancy Outcome. RESULTS: SCD was negatively correlated with sperm motility in both ejaculated and processed semen. Sperm recovered by swim-up did not show a significant improvement in DNA integrity. No correlation was found between SCD and Pregnancy Outcome in IUI. CONCLUSIONS: DNA dispersion, as measured by the SCD test, is not correlated with Pregnancy Outcome in IUI.