The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Raul Hinojosa - One of the best experts on this subject based on the ideXlab platform.
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Cochlear nucleus neuron analysis in individuals with Presbycusis.
The Laryngoscope, 2011Co-Authors: Raul Hinojosa, Erik G NelsonAbstract:Objectives/Hypothesis: The aim of this study was to analyze the cochlear nucleus neuron population in individuals with normal hearing and Presbycusis. Study Design: Retrospective study of archival human temporal bone and brain stem tissues. Methods: Using strict inclusion criteria, the temporal bones and cochlear nuclei from six normal hearing individuals and four individuals with Presbycusis were selected for analysis. The spiral ganglion cell population, the cochlear nucleus neuron population, and the cell body size of the neurons were quantified in these cases. Results: A relationship was not observed between age and the spiral ganglion cell population in the normal hearing group. Presbycusis subjects exhibited a reduced spiral ganglion cell population. The mean cochlear nucleus neuron population was observed to be significantly higher in the Presbycusis group (mean ± standard deviation: 114,170 ± 10,570) compared to the normal hearing group (91,470 ± 9,510) (P = .019). This difference was predominantly the result of greater multipolar and granule cell neuron populations. Only the fusiform neuron type exhibited a significantly different mean cell body cross-sectional area between the normal hearing group (242 ± 27) and the Presbycusis group (300 ± 37) (P = .033). Conclusions: This investigation is the first time, to our knowledge, that the populations of the eight neuron types in the cochlear nucleus have been quantified in both normal hearing individuals and individuals with Presbycusis. The data support the concept that Presbycusis is not an effect of aging alone but instead may be a condition that predisposes one to hearing loss with advancing age and is characterized by a congenitally elevated cochlear nucleus neuron population. Laryngoscope, 121:2641–2648, 2011
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Presbycusis a human temporal bone study of individuals with flat audiometric patterns of hearing loss using a new method to quantify stria vascularis volume
Laryngoscope, 2010Co-Authors: Erik G Nelson, Raul HinojosaAbstract:Objective: The purpose of this study was to determine the prevalence of stria vascularis atrophy in individuals with Presbycusis and flat audiometric patterns of hearing loss. Individuals with Presbycusis have historically been categorized by the shape of their audiograms, and flat audiometric thresholds have been reported to be associated with atrophy of the stria vascularis. Stria vascularis volume was not measured in these studies. Study Design: Retrospective case review. Methods: Archival human temporal bones from individuals with Presbycusis were selected on the basis of strict audiometric criteria for flat audiometric thresholds. Six temporal bones that met these criteria were identified and compared with 10 temporal bones in individuals with normal hearing. A unique quantitative method was developed to measure the stria vascularis volume in these temporal bones. The hair cell and spiral ganglion cell populations also were quantitatively evaluated. Results: Only one of the six individuals with Presbycusis and flat audiometric thresholds had significant atrophy of the stria vascularis. This individual with stria vascularis atrophy also had reduced inner hair cell, outer hair cell, and ganglion cell populations. Three of the individuals with Presbycusis had spiral ganglion cell loss, three individuals had inner hair cell loss, and all six individuals had outer hair cell loss. Conclusions: The results of this investigation suggest that individuals with Presbycusis and flat audiometric patterns of hearing loss infrequently have stria vascularis atrophy. Outer hair cell loss alone or in combination with inner hair cell or ganglion cell loss may be the cause of flat audiometric thresholds in individuals with Presbycusis.
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Presbycusis a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature
Laryngoscope, 2006Co-Authors: Erik G Nelson, Raul HinojosaAbstract:Objective: The purpose of this retrospective case review was to identify patterns of cochlear element degeneration in individuals with Presbycusis exhibiting downward sloping audiometric patterns of hearing loss and to correlate these findings with those reported in the literature to clarify conflicting concepts regarding the association between hearing loss and morphologic abnormalities. Methods: Archival human temporal bones from individuals with Presbycusis were selected on the basis of strict audiometric criteria for downward-sloping audiometric thresholds. Twenty-one temporal bones that met these criteria were identified and compared with 10 temporal bones from individuals with normal hearing. The stria vascularis volumes, spiral ganglion cell populations, inner hair cells, and outer hair cells were quantitatively evaluated. The relationship between the severity of hearing loss and the degeneration of cochlear elements was analyzed using univariate linear regression models. Results: Outer hair cell loss and ganglion cell loss was observed in all individuals with Presbycusis. Inner hair cell loss was observed in 18 of the 21 individuals with Presbycusis and stria vascularis loss was observed in 10 of the 21 individuals with Presbycusis. The extent of degeneration of all four of the cochlear elements evaluated was highly associated with the severity of hearing loss based on audiometric thresholds at 8,000 Hz and the pure-tone average at 500, 1,000, and 2,000 Hz. The extent of ganglion cell degeneration was associated with the slope of the audiogram. Conclusions: Individuals with downward-sloping audiometric patterns of Presbycusis exhibit degeneration of the stria vascularis, spiral ganglion cells, inner hair cells, and outer hair cells that is associated with the severity of hearing loss. This association has not been previously reported in studies that did not use quantitative methodologies for evaluating the cochlear elements and strict audiometric criteria for selecting cases.
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mitochondrial dna deletions associated with aging and possibly Presbycusis a human archival temporal bone study
American Journal of Otology, 1997Co-Authors: Uma Bai, Raul Hinojosa, Michael D Seidman, Wayne S QuirkAbstract:Hypothesis: We attempted to determine if the common mitochondrial DNA aging deletion is also associated with Presbycusis. Background: Presbycusis is the most common cause of deafness in adults in the United States, affecting approximately 40% of the population older than 75 years of age. The ability to identify a gene(s) or a specific genetic deficit(s) associated with Presbycusis has significant clinical importance. Methods: The current study examined mitochondrial DNA (mtDNA) from cochlear sections of 34 human temporal bones: 17 with normal hearing and 17 with Presbycusis. DNA was extracted from celloidin-embedded temporal bone sections; and specific oligonucleotide primers were designed to amplify the cytochrome b gene and a 4,977 base pair (bp) deletion of the mtDNA. Polymerase chain reaction (PCR) was used to amplify the base pair products that correspond to targeted gene regions, and sequencing was used to verify the products. Results: Fourteen of the 17 patients with hearing loss showed the 4,977 bp deletion and this deletion was present in only eight of the 17 human specimens with normal audiograms. The cytochrome b gene was amplified from all specimens. Conclusions: The current study demonstrates the presence of a 4,977 bp deletion in human mitochondrial DNA genome that is associated with aging and with some forms of Presbycusis. These results, coupled with previous animal studies, suggest that this 4,977 deletion may be associated with Presbycusis.
Robert D Frisina - One of the best experts on this subject based on the ideXlab platform.
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higher serum aldosterone correlates with lower hearing thresholds a possible protective hormone against Presbycusis
Hearing Research, 2005Co-Authors: Sherif F Tadros, Susan T Frisina, Frances Mapes, Robert D FrisinaAbstract:Abstract Aldosterone hormone is a mineralocorticoid secreted by adrenal gland cortex and controls serum sodium (Na + ) and potassium (K + ) levels. Aldosterone has a stimulatory effect on expression of sodium–potassium ATPase (Na, K-ATPase) and sodium–potassium–chloride cotransporter (NKCC) in cell membranes. In the present investigation, the relation between serum aldosterone levels and age-related hearing loss (Presbycusis) and the correlation between these levels versus the degree of Presbycusis in humans were examined. Serum aldosterone concentrations were compared between normal hearing and presbycusic groups. Pure-tone audiometry, transient evoked otoacoustic emissions (TEOAE), hearing in noise test (HINT) and gap detection were tested for each subject and compared to the serum aldosterone levels. A highly significant difference between groups in serum aldosterone concentrations was found ( p = 0.0003, t = 3.95, df = 45). Highly significant correlations between pure-tone thresholds in both right and left ears, and HINT scores versus serum aldosterone levels were also discovered. On the contrary, no significant correlations were seen in the case of TEOAEs and gap detection. We conclude that aldosterone hormone may have a protective effect on hearing in old age. This effect is more peripheral than central, appearing to affect inner hair cells more than outer hair cells.
Erik G Nelson - One of the best experts on this subject based on the ideXlab platform.
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age related change in vestibular ganglion cell populations in individuals with Presbycusis and normal hearing
Otology & Neurotology, 2017Co-Authors: Michael B Gluth, Erik G NelsonAbstract:Hypothesis We sought to establish that the decline of vestibular ganglion cell counts uniquely correlates with spiral ganglion cell counts, cochlear hair cell counts, and hearing phenotype in individuals with Presbycusis. Background The relationship between aging in the vestibular system and aging in the cochlea is a topic of ongoing investigation. Histopathologic age-related changes the vestibular system may mirror what is seen in the cochlea, but correlations with hearing phenotype and the impact of Presbycusis are not well understood. Methods Vestibular ganglion cells, spiral ganglion cells, and cochlear hair cells were counted in specimens from individuals with Presbycusis and normal hearing. These were taken from within a large collection of processed human temporal bones. Correlations between histopathology and hearing phenotype were investigated. Results Vestibular ganglion cell counts were positively correlated with spiral ganglion cell counts and cochlear hair cell counts and were negatively correlated with hearing phenotype. There was no statistical evidence on linear regression to suggest that the relationship between age and cell populations differed significantly according to whether Presbycusis was present or not. Superior vestibular ganglion cells were more negatively correlated with age than inferior ganglion cells. No difference in vestibular ganglion cells was noted based on sex. Conclusion Vestibular ganglion cell counts progressively deteriorate with age, and this loss correlates closely with changes in the cochlea, as well as hearing phenotype. However, these correlations do not appear to be unique in individuals with Presbycusis as compared with those with normal hearing.
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Cochlear nucleus neuron analysis in individuals with Presbycusis.
The Laryngoscope, 2011Co-Authors: Raul Hinojosa, Erik G NelsonAbstract:Objectives/Hypothesis: The aim of this study was to analyze the cochlear nucleus neuron population in individuals with normal hearing and Presbycusis. Study Design: Retrospective study of archival human temporal bone and brain stem tissues. Methods: Using strict inclusion criteria, the temporal bones and cochlear nuclei from six normal hearing individuals and four individuals with Presbycusis were selected for analysis. The spiral ganglion cell population, the cochlear nucleus neuron population, and the cell body size of the neurons were quantified in these cases. Results: A relationship was not observed between age and the spiral ganglion cell population in the normal hearing group. Presbycusis subjects exhibited a reduced spiral ganglion cell population. The mean cochlear nucleus neuron population was observed to be significantly higher in the Presbycusis group (mean ± standard deviation: 114,170 ± 10,570) compared to the normal hearing group (91,470 ± 9,510) (P = .019). This difference was predominantly the result of greater multipolar and granule cell neuron populations. Only the fusiform neuron type exhibited a significantly different mean cell body cross-sectional area between the normal hearing group (242 ± 27) and the Presbycusis group (300 ± 37) (P = .033). Conclusions: This investigation is the first time, to our knowledge, that the populations of the eight neuron types in the cochlear nucleus have been quantified in both normal hearing individuals and individuals with Presbycusis. The data support the concept that Presbycusis is not an effect of aging alone but instead may be a condition that predisposes one to hearing loss with advancing age and is characterized by a congenitally elevated cochlear nucleus neuron population. Laryngoscope, 121:2641–2648, 2011
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Presbycusis a human temporal bone study of individuals with flat audiometric patterns of hearing loss using a new method to quantify stria vascularis volume
Laryngoscope, 2010Co-Authors: Erik G Nelson, Raul HinojosaAbstract:Objective: The purpose of this study was to determine the prevalence of stria vascularis atrophy in individuals with Presbycusis and flat audiometric patterns of hearing loss. Individuals with Presbycusis have historically been categorized by the shape of their audiograms, and flat audiometric thresholds have been reported to be associated with atrophy of the stria vascularis. Stria vascularis volume was not measured in these studies. Study Design: Retrospective case review. Methods: Archival human temporal bones from individuals with Presbycusis were selected on the basis of strict audiometric criteria for flat audiometric thresholds. Six temporal bones that met these criteria were identified and compared with 10 temporal bones in individuals with normal hearing. A unique quantitative method was developed to measure the stria vascularis volume in these temporal bones. The hair cell and spiral ganglion cell populations also were quantitatively evaluated. Results: Only one of the six individuals with Presbycusis and flat audiometric thresholds had significant atrophy of the stria vascularis. This individual with stria vascularis atrophy also had reduced inner hair cell, outer hair cell, and ganglion cell populations. Three of the individuals with Presbycusis had spiral ganglion cell loss, three individuals had inner hair cell loss, and all six individuals had outer hair cell loss. Conclusions: The results of this investigation suggest that individuals with Presbycusis and flat audiometric patterns of hearing loss infrequently have stria vascularis atrophy. Outer hair cell loss alone or in combination with inner hair cell or ganglion cell loss may be the cause of flat audiometric thresholds in individuals with Presbycusis.
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Presbycusis a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature
Laryngoscope, 2006Co-Authors: Erik G Nelson, Raul HinojosaAbstract:Objective: The purpose of this retrospective case review was to identify patterns of cochlear element degeneration in individuals with Presbycusis exhibiting downward sloping audiometric patterns of hearing loss and to correlate these findings with those reported in the literature to clarify conflicting concepts regarding the association between hearing loss and morphologic abnormalities. Methods: Archival human temporal bones from individuals with Presbycusis were selected on the basis of strict audiometric criteria for downward-sloping audiometric thresholds. Twenty-one temporal bones that met these criteria were identified and compared with 10 temporal bones from individuals with normal hearing. The stria vascularis volumes, spiral ganglion cell populations, inner hair cells, and outer hair cells were quantitatively evaluated. The relationship between the severity of hearing loss and the degeneration of cochlear elements was analyzed using univariate linear regression models. Results: Outer hair cell loss and ganglion cell loss was observed in all individuals with Presbycusis. Inner hair cell loss was observed in 18 of the 21 individuals with Presbycusis and stria vascularis loss was observed in 10 of the 21 individuals with Presbycusis. The extent of degeneration of all four of the cochlear elements evaluated was highly associated with the severity of hearing loss based on audiometric thresholds at 8,000 Hz and the pure-tone average at 500, 1,000, and 2,000 Hz. The extent of ganglion cell degeneration was associated with the slope of the audiogram. Conclusions: Individuals with downward-sloping audiometric patterns of Presbycusis exhibit degeneration of the stria vascularis, spiral ganglion cells, inner hair cells, and outer hair cells that is associated with the severity of hearing loss. This association has not been previously reported in studies that did not use quantitative methodologies for evaluating the cochlear elements and strict audiometric criteria for selecting cases.
Haiying Sun - One of the best experts on this subject based on the ideXlab platform.
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correlation between mitochondrial dna 4977 bp deletion and Presbycusis a system review and meta analysis
Medicine, 2019Co-Authors: Haiying Sun, Jie Yuan, Baoai Han, Tao Zhou, Tian Wang, Xiuping YangAbstract:OBJECTIVE Researchers have evaluated the associations between mitochondrial DNA (mtDNA) 4977 bp deletion and Presbycusis. This study aimed to assess the differences of mtDNA 4977 bp deletion between Presbycusis patients and controls by conducting a meta-analysis of published studies. METHODS Databases, including PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched to collect case-control studies on the correlation between mitochondrial DNA 4977 bp deletion and Presbycusis. The research findings of related articles were collected according to the inclusion criteria. Pooled odds ratios (ORs) and corresponding confidence intervals (CIs) were calculated. Meanwhile, subgroup analysis was performed to examine the source of heterogeneity. Revman 5.3 and Stata 12.0 software were used for data synthesis. RESULTS Eight English and Chinese studies were included in the meta-analysis, the results of which showed that mitochondrial DNA 4977 bp deletion could increase the risk of Presbycusis (OR = 8.16, 95% CI: 3.51-18.99), and the difference was statistically significant (P <. 01). Analysis of the polled OR showed the incidence of mtDNA 4977 bp deletion was 8.50 times higher in Asians with Presbycusis than in the control group. And the OR in the studies of occidentals was 7.24. Sample source analysis was also performed with the sample source divided by temporal bone source and other sources (hair and blood). The OR was 4.18 and 22.36 for the temporal bone and other sources, respectively. CONCLUSION Mitochondrial DNA 4977 bp deletion could increase the risk of Presbycusis.
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age related changes in mitochondrial antioxidant enzyme trx2 and txnip trx2 ask1 signal pathways in the auditory cortex of a mimetic aging rat model changes to trx2 in the auditory cortex
FEBS Journal, 2015Co-Authors: Haiying Sun, Xueyan Zhao, Yi Zhong, Lingling Zeng, Xubo Chen, Jie Yuan, Yu Sun, Wen Kong, Weijia KongAbstract:Age-associated degeneration in the central auditory system, which is defined as central Presbycusis, can impair sound localization and speech perception. Research has shown that oxidative stress plays a central role in the pathological process of central Presbycusis. Thioredoxin 2 (Trx2), one member of thioredoxin family, plays a key role in regulating the homeostasis of cellular reactive oxygen species and anti-apoptosis. The purpose of this study was to explore the association between Trx2 and the phenotype of central Presbycusis using a mimetic aging animal model induced by long-term exposure to d-galactose (d-Gal). We also explored changes in thioredoxin-interacting protein (TXNIP), apoptosis signal regulating kinase 1 (ASK1) and phosphorylated ASK1 (p-ASK1) expression, as well as the Trx2–TXNIP/Trx2–ASK1 binding complex in the auditory cortex of mimetic aging rats. Our results demonstrate that, compared with control groups, the levels of Trx2 and Trx2–ASK1 binding complex were significantly reduced, whereas TXNIP, ASK1 p-ASK1 expression, and Trx2–TXNIP binding complex were significantly increased in the auditory cortex of the mimetic aging groups. Our results indicated that changes in Trx2 and the TXNIP–Trx2–ASK1 signal pathway may participate in the pathogenesis of central Presbycusis.
Paul H. Delano - One of the best experts on this subject based on the ideXlab platform.
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neural links between facial emotion recognition and cognitive impairment in Presbycusis
International Journal of Geriatric Psychiatry, 2021Co-Authors: Chama Belkhiria, Paul H. Delano, Rodrigo C. Vergara, Melissa Martinez, Carolina DelgadoAbstract:OBJECTIVES Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound hearing loss, probably reflecting common neural changes. Here, we aim to study the association between brain structures and FER impairment in mild to moderate age-related hearing loss participants. METHODS We evaluated FER in a cross-sectional cohort of 111 Chilean nondemented elderly participants. They were assessed for FER in seven different categories using 35 facial stimuli. We collected pure-tone average (PTA) audiometric thresholds, cognitive and neuropsychiatric assessments, and morphometric brain imaging using a 3-Tesla MRI. RESULTS According to PTA threshold levels, participants were classified as controls (≤25 dB, n = 56) or Presbycusis (>25 dB, n = 55), with an average PTA of 17.08 ± 4.8 dB HL and 36.27 ± 9.5 dB HL respectively. Poorer total FER score was correlated with worse hearing thresholds (r = -0.23, p < 0.05) in participants with Presbycusis. Multiple regression models explained 57 % of the variability of FER in Presbycusis and 10% in controls. In both groups, the main determinant of FER was cognitive performance. In the brain structure of Presbycusis participants, FER was correlated with the atrophy of the right insula, right hippocampus, bilateral cingulate cortex and multiple areas of the temporal cortex. In controls, FER was only associated with bilateral middle temporal cortex volume. CONCLUSIONS FER impairment in Presbycusis is distinctively associated with atrophy of neural structures engaged in the perceptual and conceptual level of face emotion processing.
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Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis.
Frontiers in aging neuroscience, 2020Co-Authors: Chama Belkhiria, Paul H. Delano, Rodrigo C. Vergara, Simón San Martín, Alexis Leiva, Melissa Martinez, Bruno Marcenaro, Maricarmen Andrade, Carolina DelgadoAbstract:Hearing loss is an important risk factor for dementia. However, the mechanisms that relate these disorders are still unknown. As a proxy of this relationship, we studied the structural brain changes associated with functional impairment in activities of daily living in subjects with age related hearing loss, or Presbycusis. One hundred eleven independent, non-demented subjects older than 65 years recruited in the ANDES cohort were evaluated using a combined approach including (i) audiological tests: hearing thresholds and cochlear function measured by pure tone averages and the distortion product otoacoustic emissions respectively; (ii) behavioral variables: cognitive, neuropsychiatric, and functional impairment in activities of daily living measured by validated questionnaires; and (iii) structural brain imaging-assessed by magnetic resonance imaging at 3 Tesla. The mean age of the recruited subjects (69 females) was 73.95 ± 5.47 years (mean ± SD) with an average educational level of 9.44 ± 4.2 years of schooling. According to the audiometric hearing thresholds and presence of otoacoustic emissions, we studied three groups: controls with normal hearing (n = 36), Presbycusis with preserved cochlear function (n = 33), and Presbycusis with cochlear dysfunction (n = 38). We found a significant association (R2D = 0.17) between the number of detected otoacoustic emissions and apathy symptoms. The Presbycusis with cochlear dysfunction group had worse performance than controls in global cognition, language and executive functions, and severe apathy symptoms than the other groups. The neuropsychiatric symptoms and language deficits were the main determinants of functional impairment in both groups of subjects with Presbycusis. Atrophy of insula, amygdala, and other temporal areas were related with functional impairment, apathy, and language deficits in the Presbycusis with cochlear dysfunction group. We conclude that (i) the neuropsychiatric symptoms had a major effect on functional loss in subjects with Presbycusis, (ii) cochlear dysfunction is relevant for the association between hearing loss and behavioral impairment, and (iii) atrophy of the insula and amygdala among other temporal areas are related with hearing loss and behavioral impairment.
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Music Training and Education Slow the Deterioration of Music Perception Produced by Presbycusis in the Elderly
Frontiers in aging neuroscience, 2017Co-Authors: Felipe N. Moreno-gómez, Guillermo Véliz, Marcos Rojas, Cristián Martínez, Rubén Olmedo, Felipe Panussis, Alexies Dagnino-subiabre, Carolina Delgado, Paul H. DelanoAbstract:The perception of music depends on the normal function of the peripheral and central auditory system. Aged subjects without hearing loss have altered music perception, including pitch and temporal features. Presbycusis or age-related hearing loss is a frequent condition in elderly people, produced by neurodegenerative processes that affect the cochlear receptor cells and brain circuits involved in auditory perception. Clinically, Presbycusis patients have bilateral high-frequency hearing loss and deteriorated speech intelligibility. Music impairments in Presbycusis subjects can be attributed to the normal aging processes and to Presbycusis neuropathological changes. However, whether Presbycusis further impairs music perception remains controversial. Here, we developed a computerized version of the Montreal battery of evaluation of amusia (MBEA) and assessed music perception in 175 Chilean adults aged between 18 and 90 years without hearing complaints and in symptomatic Presbycusis patients. We give normative data for MBEA performance in a Latin-American population, showing age and educational effects. In addition, we found that symptomatic Presbycusis was the most relevant factor determining global MBEA accuracy in aged subjects. Moreover, we show that melodic impairments in Presbycusis individuals were diminished by music training, while the performance in temporal tasks were affected by the educational level and music training. We conclude that music training and education are important factors as they can slow the deterioration of music perception produced by age-related hearing loss.