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Ali Rashidianirashidabadi - One of the best experts on this subject based on the ideXlab platform.

  • curcumin prevents the structural changes induced in the rats deep cerebellar nuclei by sodium metabisulfite a Preservative Agent
    Asian Pacific Journal of Tropical Medicine, 2014
    Co-Authors: Mohammad Hassan Karimfar, Ali Rashidianirashidabadi, Reza Asadigolshan, Mohammad Amin Abdollahifar, Ali Noorafshan, Aghdas Poostpasand, Saied Karbalaydoust
    Abstract:

    Objective To evaluate the the possible neurotoxic effects of sulfite and the protective potential of curcumin on the deep cerebellar nuclei using stereological methods.

  • curcumin the main part of turmeric prevents learning and memory changes induced by sodium metabisulfite a Preservative Agent in rats
    Experimental Neurobiology, 2013
    Co-Authors: Ali Noorafshan, Reza Asadigolshan, Saied Karbalaydoust, Mohammad Amin Abdollahifar, Ali Rashidianirashidabadi
    Abstract:

    Sodium metabisulfite is used as a disinfectant, antioxidant, and Preservative Agent in the food, beverage, and drug industries. Neurons are highly sensitive to sulfite toxicity. Curcumin is the main part of turmeric and has neuroprotective effects on a variety of nervous system damages. The present study aimed to investigate the possible protective role of curcumin in learning and memory after exposure to sulfite in rats. The rats were divided into five groups receiving distilled water (solvent of the sulfite), olive oil (solvent of the curcumin), sodium metabisulfite (25 mg/kg/day), curcumin (100 mg/kg/day), and sulfite + curcumin. All the animals received daily gavages for 8 weeks. At the end of the 8th week, learning and memory were assessed in a partially-baited eight arm radial maze. The animals treated with sulfite showed fewer correct choices and more reference and working memory errors during the learning phase, at the end of the learning phase, and during the retention testing (p<0.001). The study results demonstrated that sulfite-exposure was associated with impaired learning and memory in rats. Adding curcumin to the rat nutrition plays a protective role in learning and memory after exposure to sulfite.

Ali Noorafshan - One of the best experts on this subject based on the ideXlab platform.

  • curcumin prevents the structural changes induced in the rats deep cerebellar nuclei by sodium metabisulfite a Preservative Agent
    Asian Pacific Journal of Tropical Medicine, 2014
    Co-Authors: Mohammad Hassan Karimfar, Ali Rashidianirashidabadi, Reza Asadigolshan, Mohammad Amin Abdollahifar, Ali Noorafshan, Aghdas Poostpasand, Saied Karbalaydoust
    Abstract:

    Objective To evaluate the the possible neurotoxic effects of sulfite and the protective potential of curcumin on the deep cerebellar nuclei using stereological methods.

  • Curcumin prevents the structural changes induced in the rats' deep cerebellar nuclei by sodium metabisulfite, a Preservative Agent.
    Asian Pacific journal of tropical medicine, 2014
    Co-Authors: Mohammad Hassan Karimfar, Ali Rashidiani-rashidabadi, Mohammad Amin Abdollahifar, Ali Noorafshan, Reza Asadi-golshan, Aghdas Poostpasand, Saied Karbalay-doust
    Abstract:

    To evaluate the the possible neurotoxic effects of sulfite and the protective potential of curcumin on the deep cerebellar nuclei using stereological methods. The rats were randomly divided into five experimental groups (n=6): Group I: distilled water, Group II: Olive oil, Group III: Curcumin (100 mg/kg/day), Group IV: Sodium metabisulfite (25 mg/kg/day), and Group V: Sodium metabisulfite+curcumin. At the end of 56 d, the right cerebellar hemispheres were removed and assigned to stereological studies. The total volume and total neuron number of deep cerebellar nuclei were assessed using Cavalieri and optical disector methods, respectively. The data showed ∼20% and ∼16% decrease was respectively observed in the total volume and the total neuron number of the deep cerebellar nuclei of the sulfite-treated rats in comparison to the distilled water group (P<0.04). However, no significant change was observed in the total volume and neuronal number of the deep cerebellar nuclei in sulfite+curcumin-treated rats and curcumin played a protective role against sulfite. Curcumin or its vehicle (olive oil) did not induce any significant changes. Curcumin, the main part of the turmeric, could prevent the structural changes induced in the deep cerebellar nuclei by sodium metabisulfite, a Preservative Agent, in rats. Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  • sodium metabisulphite a Preservative Agent decreases the heart capillary volume and length and curcumin the main component of curcuma longa cannot protect it
    Folia Biologica, 2014
    Co-Authors: Ali Noorafshan, Reza Asadigolshan, S Monjezi, Saied Karbalaydoust
    Abstract:

    Sodium metabisulphite is used as an antioxidant Agent in many pharmaceutical formulations. It is extensively used as a food Preservative and disinfectant. It has been demonstrated that sulphite exposure can affect some organs. Curcumin, the main element of Curcuma longa, has been identified to have multiple protective properties. The present study extends the earlier works to quantitative evaluation of the effects of sulphite and curcumin on the heart structure using stereological methods. In this study, 28 rats were randomly divided into four experimental groups. The rats in groups I to IV received distilled water (group I), sodium metabisulphite (25 mg/ kg/day) (group II), curcumin (100 mg/kg/day) (group III), and sodium metabisulphite+curcumin (group IV), respectively, for 8 weeks. The left ventricle was subjected to stereological methods to estimate the quantitative parameters of the myocardium. A 20 % decrease was observed in the total volume of ventricular tissue in the sulphite-treated animals compared to the distilled water treatment (P < 0.02). Also, the volume and length of the capillaries were reduced by 43 % on average in the sulphite-treated rats in comparison to the distilled water-treated animals (P < 0.02). However, no significant change was seen in the mean and total volume of the myocardium and the cavity and diameter of the capillaries after sulphite ingestion. Treatment with curcumin did not protect the animals against the structural changes of the ventricle. Sulphite, as a Preservative food Agent, reduced the length and volume of the ventricular capillaries and curcumin could not protect them.

  • Curcumin, the Main Part of Turmeric, Prevents Learning and Memory Changes Induced by Sodium Metabisulfite, a Preservative Agent, in Rats
    Experimental Neurobiology, 2013
    Co-Authors: Ali Noorafshan, Mohammad Amin Abdollahifar, Reza Asadi-golshan, Saied Karbalay-doust, Ali Rashidiani-rashidabadi
    Abstract:

    Sodium metabisulfite is used as a disinfectant, antioxidant, and Preservative Agent in the food, beverage, and drug industries. Neurons are highly sensitive to sulfite toxicity. Curcumin is the main part of turmeric and has neuroprotective effects on a variety of nervous system damages. The present study aimed to investigate the possible protective role of curcumin in learning and memory after exposure to sulfite in rats. The rats were divided into five groups receiving distilled water (solvent of the sulfite), olive oil (solvent of the curcumin), sodium metabisulfite (25 mg/kg/day), curcumin (100 mg/kg/day), and sulfite + curcumin. All the animals received daily gavages for 8 weeks. At the end of the 8th week, learning and memory were assessed in a partially-baited eight arm radial maze. The animals treated with sulfite showed fewer correct choices and more reference and working memory errors during the learning phase, at the end of the learning phase, and during the retention testing (p

  • curcumin the main part of turmeric prevents learning and memory changes induced by sodium metabisulfite a Preservative Agent in rats
    Experimental Neurobiology, 2013
    Co-Authors: Ali Noorafshan, Reza Asadigolshan, Saied Karbalaydoust, Mohammad Amin Abdollahifar, Ali Rashidianirashidabadi
    Abstract:

    Sodium metabisulfite is used as a disinfectant, antioxidant, and Preservative Agent in the food, beverage, and drug industries. Neurons are highly sensitive to sulfite toxicity. Curcumin is the main part of turmeric and has neuroprotective effects on a variety of nervous system damages. The present study aimed to investigate the possible protective role of curcumin in learning and memory after exposure to sulfite in rats. The rats were divided into five groups receiving distilled water (solvent of the sulfite), olive oil (solvent of the curcumin), sodium metabisulfite (25 mg/kg/day), curcumin (100 mg/kg/day), and sulfite + curcumin. All the animals received daily gavages for 8 weeks. At the end of the 8th week, learning and memory were assessed in a partially-baited eight arm radial maze. The animals treated with sulfite showed fewer correct choices and more reference and working memory errors during the learning phase, at the end of the learning phase, and during the retention testing (p<0.001). The study results demonstrated that sulfite-exposure was associated with impaired learning and memory in rats. Adding curcumin to the rat nutrition plays a protective role in learning and memory after exposure to sulfite.

Mohammad Amin Abdollahifar - One of the best experts on this subject based on the ideXlab platform.

  • curcumin prevents the structural changes induced in the rats deep cerebellar nuclei by sodium metabisulfite a Preservative Agent
    Asian Pacific Journal of Tropical Medicine, 2014
    Co-Authors: Mohammad Hassan Karimfar, Ali Rashidianirashidabadi, Reza Asadigolshan, Mohammad Amin Abdollahifar, Ali Noorafshan, Aghdas Poostpasand, Saied Karbalaydoust
    Abstract:

    Objective To evaluate the the possible neurotoxic effects of sulfite and the protective potential of curcumin on the deep cerebellar nuclei using stereological methods.

  • Curcumin prevents the structural changes induced in the rats' deep cerebellar nuclei by sodium metabisulfite, a Preservative Agent.
    Asian Pacific journal of tropical medicine, 2014
    Co-Authors: Mohammad Hassan Karimfar, Ali Rashidiani-rashidabadi, Mohammad Amin Abdollahifar, Ali Noorafshan, Reza Asadi-golshan, Aghdas Poostpasand, Saied Karbalay-doust
    Abstract:

    To evaluate the the possible neurotoxic effects of sulfite and the protective potential of curcumin on the deep cerebellar nuclei using stereological methods. The rats were randomly divided into five experimental groups (n=6): Group I: distilled water, Group II: Olive oil, Group III: Curcumin (100 mg/kg/day), Group IV: Sodium metabisulfite (25 mg/kg/day), and Group V: Sodium metabisulfite+curcumin. At the end of 56 d, the right cerebellar hemispheres were removed and assigned to stereological studies. The total volume and total neuron number of deep cerebellar nuclei were assessed using Cavalieri and optical disector methods, respectively. The data showed ∼20% and ∼16% decrease was respectively observed in the total volume and the total neuron number of the deep cerebellar nuclei of the sulfite-treated rats in comparison to the distilled water group (P<0.04). However, no significant change was observed in the total volume and neuronal number of the deep cerebellar nuclei in sulfite+curcumin-treated rats and curcumin played a protective role against sulfite. Curcumin or its vehicle (olive oil) did not induce any significant changes. Curcumin, the main part of the turmeric, could prevent the structural changes induced in the deep cerebellar nuclei by sodium metabisulfite, a Preservative Agent, in rats. Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  • Curcumin, the Main Part of Turmeric, Prevents Learning and Memory Changes Induced by Sodium Metabisulfite, a Preservative Agent, in Rats
    Experimental Neurobiology, 2013
    Co-Authors: Ali Noorafshan, Mohammad Amin Abdollahifar, Reza Asadi-golshan, Saied Karbalay-doust, Ali Rashidiani-rashidabadi
    Abstract:

    Sodium metabisulfite is used as a disinfectant, antioxidant, and Preservative Agent in the food, beverage, and drug industries. Neurons are highly sensitive to sulfite toxicity. Curcumin is the main part of turmeric and has neuroprotective effects on a variety of nervous system damages. The present study aimed to investigate the possible protective role of curcumin in learning and memory after exposure to sulfite in rats. The rats were divided into five groups receiving distilled water (solvent of the sulfite), olive oil (solvent of the curcumin), sodium metabisulfite (25 mg/kg/day), curcumin (100 mg/kg/day), and sulfite + curcumin. All the animals received daily gavages for 8 weeks. At the end of the 8th week, learning and memory were assessed in a partially-baited eight arm radial maze. The animals treated with sulfite showed fewer correct choices and more reference and working memory errors during the learning phase, at the end of the learning phase, and during the retention testing (p

  • curcumin the main part of turmeric prevents learning and memory changes induced by sodium metabisulfite a Preservative Agent in rats
    Experimental Neurobiology, 2013
    Co-Authors: Ali Noorafshan, Reza Asadigolshan, Saied Karbalaydoust, Mohammad Amin Abdollahifar, Ali Rashidianirashidabadi
    Abstract:

    Sodium metabisulfite is used as a disinfectant, antioxidant, and Preservative Agent in the food, beverage, and drug industries. Neurons are highly sensitive to sulfite toxicity. Curcumin is the main part of turmeric and has neuroprotective effects on a variety of nervous system damages. The present study aimed to investigate the possible protective role of curcumin in learning and memory after exposure to sulfite in rats. The rats were divided into five groups receiving distilled water (solvent of the sulfite), olive oil (solvent of the curcumin), sodium metabisulfite (25 mg/kg/day), curcumin (100 mg/kg/day), and sulfite + curcumin. All the animals received daily gavages for 8 weeks. At the end of the 8th week, learning and memory were assessed in a partially-baited eight arm radial maze. The animals treated with sulfite showed fewer correct choices and more reference and working memory errors during the learning phase, at the end of the learning phase, and during the retention testing (p<0.001). The study results demonstrated that sulfite-exposure was associated with impaired learning and memory in rats. Adding curcumin to the rat nutrition plays a protective role in learning and memory after exposure to sulfite.

Saied Karbalaydoust - One of the best experts on this subject based on the ideXlab platform.

  • curcumin prevents the structural changes induced in the rats deep cerebellar nuclei by sodium metabisulfite a Preservative Agent
    Asian Pacific Journal of Tropical Medicine, 2014
    Co-Authors: Mohammad Hassan Karimfar, Ali Rashidianirashidabadi, Reza Asadigolshan, Mohammad Amin Abdollahifar, Ali Noorafshan, Aghdas Poostpasand, Saied Karbalaydoust
    Abstract:

    Objective To evaluate the the possible neurotoxic effects of sulfite and the protective potential of curcumin on the deep cerebellar nuclei using stereological methods.

  • sodium metabisulphite a Preservative Agent decreases the heart capillary volume and length and curcumin the main component of curcuma longa cannot protect it
    Folia Biologica, 2014
    Co-Authors: Ali Noorafshan, Reza Asadigolshan, S Monjezi, Saied Karbalaydoust
    Abstract:

    Sodium metabisulphite is used as an antioxidant Agent in many pharmaceutical formulations. It is extensively used as a food Preservative and disinfectant. It has been demonstrated that sulphite exposure can affect some organs. Curcumin, the main element of Curcuma longa, has been identified to have multiple protective properties. The present study extends the earlier works to quantitative evaluation of the effects of sulphite and curcumin on the heart structure using stereological methods. In this study, 28 rats were randomly divided into four experimental groups. The rats in groups I to IV received distilled water (group I), sodium metabisulphite (25 mg/ kg/day) (group II), curcumin (100 mg/kg/day) (group III), and sodium metabisulphite+curcumin (group IV), respectively, for 8 weeks. The left ventricle was subjected to stereological methods to estimate the quantitative parameters of the myocardium. A 20 % decrease was observed in the total volume of ventricular tissue in the sulphite-treated animals compared to the distilled water treatment (P < 0.02). Also, the volume and length of the capillaries were reduced by 43 % on average in the sulphite-treated rats in comparison to the distilled water-treated animals (P < 0.02). However, no significant change was seen in the mean and total volume of the myocardium and the cavity and diameter of the capillaries after sulphite ingestion. Treatment with curcumin did not protect the animals against the structural changes of the ventricle. Sulphite, as a Preservative food Agent, reduced the length and volume of the ventricular capillaries and curcumin could not protect them.

  • curcumin the main part of turmeric prevents learning and memory changes induced by sodium metabisulfite a Preservative Agent in rats
    Experimental Neurobiology, 2013
    Co-Authors: Ali Noorafshan, Reza Asadigolshan, Saied Karbalaydoust, Mohammad Amin Abdollahifar, Ali Rashidianirashidabadi
    Abstract:

    Sodium metabisulfite is used as a disinfectant, antioxidant, and Preservative Agent in the food, beverage, and drug industries. Neurons are highly sensitive to sulfite toxicity. Curcumin is the main part of turmeric and has neuroprotective effects on a variety of nervous system damages. The present study aimed to investigate the possible protective role of curcumin in learning and memory after exposure to sulfite in rats. The rats were divided into five groups receiving distilled water (solvent of the sulfite), olive oil (solvent of the curcumin), sodium metabisulfite (25 mg/kg/day), curcumin (100 mg/kg/day), and sulfite + curcumin. All the animals received daily gavages for 8 weeks. At the end of the 8th week, learning and memory were assessed in a partially-baited eight arm radial maze. The animals treated with sulfite showed fewer correct choices and more reference and working memory errors during the learning phase, at the end of the learning phase, and during the retention testing (p<0.001). The study results demonstrated that sulfite-exposure was associated with impaired learning and memory in rats. Adding curcumin to the rat nutrition plays a protective role in learning and memory after exposure to sulfite.

Reza Asadigolshan - One of the best experts on this subject based on the ideXlab platform.

  • curcumin prevents the structural changes induced in the rats deep cerebellar nuclei by sodium metabisulfite a Preservative Agent
    Asian Pacific Journal of Tropical Medicine, 2014
    Co-Authors: Mohammad Hassan Karimfar, Ali Rashidianirashidabadi, Reza Asadigolshan, Mohammad Amin Abdollahifar, Ali Noorafshan, Aghdas Poostpasand, Saied Karbalaydoust
    Abstract:

    Objective To evaluate the the possible neurotoxic effects of sulfite and the protective potential of curcumin on the deep cerebellar nuclei using stereological methods.

  • sodium metabisulphite a Preservative Agent decreases the heart capillary volume and length and curcumin the main component of curcuma longa cannot protect it
    Folia Biologica, 2014
    Co-Authors: Ali Noorafshan, Reza Asadigolshan, S Monjezi, Saied Karbalaydoust
    Abstract:

    Sodium metabisulphite is used as an antioxidant Agent in many pharmaceutical formulations. It is extensively used as a food Preservative and disinfectant. It has been demonstrated that sulphite exposure can affect some organs. Curcumin, the main element of Curcuma longa, has been identified to have multiple protective properties. The present study extends the earlier works to quantitative evaluation of the effects of sulphite and curcumin on the heart structure using stereological methods. In this study, 28 rats were randomly divided into four experimental groups. The rats in groups I to IV received distilled water (group I), sodium metabisulphite (25 mg/ kg/day) (group II), curcumin (100 mg/kg/day) (group III), and sodium metabisulphite+curcumin (group IV), respectively, for 8 weeks. The left ventricle was subjected to stereological methods to estimate the quantitative parameters of the myocardium. A 20 % decrease was observed in the total volume of ventricular tissue in the sulphite-treated animals compared to the distilled water treatment (P < 0.02). Also, the volume and length of the capillaries were reduced by 43 % on average in the sulphite-treated rats in comparison to the distilled water-treated animals (P < 0.02). However, no significant change was seen in the mean and total volume of the myocardium and the cavity and diameter of the capillaries after sulphite ingestion. Treatment with curcumin did not protect the animals against the structural changes of the ventricle. Sulphite, as a Preservative food Agent, reduced the length and volume of the ventricular capillaries and curcumin could not protect them.

  • curcumin the main part of turmeric prevents learning and memory changes induced by sodium metabisulfite a Preservative Agent in rats
    Experimental Neurobiology, 2013
    Co-Authors: Ali Noorafshan, Reza Asadigolshan, Saied Karbalaydoust, Mohammad Amin Abdollahifar, Ali Rashidianirashidabadi
    Abstract:

    Sodium metabisulfite is used as a disinfectant, antioxidant, and Preservative Agent in the food, beverage, and drug industries. Neurons are highly sensitive to sulfite toxicity. Curcumin is the main part of turmeric and has neuroprotective effects on a variety of nervous system damages. The present study aimed to investigate the possible protective role of curcumin in learning and memory after exposure to sulfite in rats. The rats were divided into five groups receiving distilled water (solvent of the sulfite), olive oil (solvent of the curcumin), sodium metabisulfite (25 mg/kg/day), curcumin (100 mg/kg/day), and sulfite + curcumin. All the animals received daily gavages for 8 weeks. At the end of the 8th week, learning and memory were assessed in a partially-baited eight arm radial maze. The animals treated with sulfite showed fewer correct choices and more reference and working memory errors during the learning phase, at the end of the learning phase, and during the retention testing (p<0.001). The study results demonstrated that sulfite-exposure was associated with impaired learning and memory in rats. Adding curcumin to the rat nutrition plays a protective role in learning and memory after exposure to sulfite.