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Nizar M Mhaidat - One of the best experts on this subject based on the ideXlab platform.
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study of jordanian jojoba simmondsia chinensis liquid wax by gc and gc ms
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M MhaidatAbstract:Context: The oil of Simmondsia chinensis (Link) C.K. Schneid (Simmondsiaceae) has been traditionally used in ethno-medicine because of its unique chemical constituents. Objective: This study determined the Jordanian Jojoba oil components. Fatty acids and sterols profiles were determined by using gas chromatography (GC), while tocopherols profile was determined by using gas chromatography-mass spectrometry (GC/MS). Materials and methods: Jojoba seeds were subjected for hot Extraction by solvent (hexane) in addition to cold Pressing Extraction. Results: The fatty acid α-linolenic acid was in higher percentages within the Jordanian oil than those of Jojoba oil found in other parts of the world. On the other hand, the fatty acids palmitic acid, oleic acid, vaccenic acid, and gondoic acid were in lower percentages within the Jordanian oil. The avenasterol was in higher percentages within the Jordanian oil and the Jordanian Jojoba oil does not contain campesterol or campestanol. In addition, this study found that the major sterols and stanols constituents of the Jordanian Jojoba oil are: sitosterol, campesterol, stigmasterol, cholesterol, avenasterol, and brassicasterol. It was also found that Jojoba oil (hexane extract) contains stigmastadienol while Jojoba oil (cold Pressing extract) does not. Jojoba oil (cold Pressing extract) contains stigmastenol while Jojoba oil (hexane extract) does not. This study showed that the Jordanian Jojoba oil contains α-tocopherol similar to those of Jojoba oil from around the world. Discussion and conclusion: This is a pioneer results regarding Jojoba which is cultivated in Jordan under different environmental conditions.
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STUDY OF JORDANIAN JOJOBA (SIMMONDSIA CHINENSIS) LIQUID WAX BY GC AND GC/MS
European Scientific Journal ESJ, 2014Co-Authors: Hani Al-qizwini, Ekbal Al-khateeb, Nizar M MhaidatAbstract:Context: The oil of Simmondsia chinensis (Link) C.K. Schneid (Simmondsiaceae) has been traditionally used in ethno-medicine because of its unique chemical constituents. Objective: This study determined the Jordanian Jojoba oil components. Fatty acids and sterols profiles were determined by using gas chromatography (GC), while tocopherols profile was determined by using gas chromatography-mass spectrometry (GC/MS). Materials and methods: Jojoba seeds were subjected for hot Extraction by solvent (hexane) in addition to cold Pressing Extraction. Results: The fatty acid α-linolenic acid was in higher percentages within the Jordanian oil than those of Jojoba oil found in other parts of the world. On the other hand, the fatty acids palmitic acid, oleic acid, vaccenic acid, and gondoic acid were in lower percentages within the Jordanian oil. The avenasterol was in higher percentages within the Jordanian oil and the Jordanian Jojoba oil does not contain campesterol or campestanol. In addition, this study found that the major sterols and stanols constituents of the Jordanian Jojoba oil are: sitosterol, campesterol, stigmasterol, cholesterol, avenasterol, and brassicasterol. It was also found that Jojoba oil (hexane extract) contains stigmastadienol while Jojoba oil (cold Pressing extract) does not. Jojoba oil (cold Pressing extract) contains stigmastenol while Jojoba oil (hexane extract) does not. This study showed that the Jordanian Jojoba oil contains α-tocopherol similar to those of Jojoba oil from around the world. Discussion and conclusion: This is a pioneer results regarding Jojoba which is cultivated in Jordan under different environmental conditions.
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antioxidant and antimicrobial activities of jordanian simmondsia chinensis link c k schneid
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M Mhaidat, Anwar MaraqaAbstract:Context: Various parts of Jojoba plant have been used in ethnomedicine for skin disorders, wound healing and many others. Objective: The purpose was to examine the effect of the total extracts of Jojoba leaves (male & female), testa, seeds and oil on the growth of certain microorganisms in addition to evaluating the antioxidant activity of these extracts. Materials and methods: Plant parts were subjected for hot Extraction by solvents of different polarity (hexane, methanol and ethanol) in addition to cold Pressing Extraction for seed. Furthermore, the active compounds were isolated by preparative thin layer chromatography, followed by identification for simmondsin and three of its derivatives namely Simmondsin-3’-ferulate, 4, 5-Didemethylsimmondsin and 4-Demethylsimmondsin-2’- ferulate, in addition to phenolic compounds, phytosterols, toccopherols and fatty acids. This was accomplished using chemical reagents along with various methods of chromatography and spectral analysis. The evaluation of antioxidant activity of extracts was done by 2, 2-Diphenyl-1-pircryl hydrazyl (DPPH) free radical scavenging method comparing to ascorbic acid activity. Antibacterial and antifungal activities were done using two methods; the agar well diffusion and disc diffusion methods, against (Staphylococcus aureus, Bacillis subtilis, Escherichia coli, Klebsiella pneumonia and Candida albicans). Results: The methanolic extract of testa and ethanolic extracts of both male and female leaves all possess antioxidant activity. Crude extracts do not exhibit antimicrobial activity, neither antibacterial nor antifungal activity. Discussion and conclusion: Plant extracts induced variable degrees of antioxidant activity and proposes its potential as an antioxidant agent for pharmaceutical applications. However, they do not have antimicrobial activity.
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cytotoxic effects of jordanian simmondsia chinensis link c k schneid on different cancer cell lines
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M Mhaidat, Ahmed SaleemAbstract:Context: Different parts of Jojoba (Simmondsia chinensis (Link) C.K. Schneid) from the family Simmondsiaceae have been traditionally used in folklore-medicine for skin disorders, wound healing, tumors and many other uses. Objective: The aim was to examine the effect of the total extracts of Jojoba leaves (male & female), testa, seeds and oil on the growth of various cancer cell lines. Materials and methods: Plant parts were subjected for hot Extraction by solvents of different polarity (hexane, methanol and ethanol), in addition to cold Pressing Extraction of seed. Furthermore, the active compounds were isolated by preparative thin layer chromatography, followed by identification with chemical reagents along with various methods of chromatography and spectral analysis for simmondsin and three of its derivatives namely Simmondsin-3’-ferulate,4,5-Didemethylsimmondsin and 4- Demethylsimmondsin -2’- ferulate. In addition, phenolic compounds, phytosterols, toccopherols and fatty acids were also identified by the same methods. The evaluation of the acute cytotoxic effect of the extracts on human cancer cell lines using human melanoma (MV 3), breast (MCF 7), and colorectal (HCT 116) tumor cell lines, was determined using 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: According the IC50 values, both jojoba oil (hexane extract & cold Pressing extract) and methanolic extract of testa have antitumor activity, more potent than the other parts, against HCT 116, MV 3 cancer cells. Moreover, Jojoba extracts induced a dose-dependent cytotoxicity. Discussion and conclusion: Plant extracts induced variable degrees of cytotoxicity against cancer cell lines due to their active constituents which were observed in different parts of the plant.
Hani Alqizwini - One of the best experts on this subject based on the ideXlab platform.
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study of jordanian jojoba simmondsia chinensis liquid wax by gc and gc ms
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M MhaidatAbstract:Context: The oil of Simmondsia chinensis (Link) C.K. Schneid (Simmondsiaceae) has been traditionally used in ethno-medicine because of its unique chemical constituents. Objective: This study determined the Jordanian Jojoba oil components. Fatty acids and sterols profiles were determined by using gas chromatography (GC), while tocopherols profile was determined by using gas chromatography-mass spectrometry (GC/MS). Materials and methods: Jojoba seeds were subjected for hot Extraction by solvent (hexane) in addition to cold Pressing Extraction. Results: The fatty acid α-linolenic acid was in higher percentages within the Jordanian oil than those of Jojoba oil found in other parts of the world. On the other hand, the fatty acids palmitic acid, oleic acid, vaccenic acid, and gondoic acid were in lower percentages within the Jordanian oil. The avenasterol was in higher percentages within the Jordanian oil and the Jordanian Jojoba oil does not contain campesterol or campestanol. In addition, this study found that the major sterols and stanols constituents of the Jordanian Jojoba oil are: sitosterol, campesterol, stigmasterol, cholesterol, avenasterol, and brassicasterol. It was also found that Jojoba oil (hexane extract) contains stigmastadienol while Jojoba oil (cold Pressing extract) does not. Jojoba oil (cold Pressing extract) contains stigmastenol while Jojoba oil (hexane extract) does not. This study showed that the Jordanian Jojoba oil contains α-tocopherol similar to those of Jojoba oil from around the world. Discussion and conclusion: This is a pioneer results regarding Jojoba which is cultivated in Jordan under different environmental conditions.
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antioxidant and antimicrobial activities of jordanian simmondsia chinensis link c k schneid
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M Mhaidat, Anwar MaraqaAbstract:Context: Various parts of Jojoba plant have been used in ethnomedicine for skin disorders, wound healing and many others. Objective: The purpose was to examine the effect of the total extracts of Jojoba leaves (male & female), testa, seeds and oil on the growth of certain microorganisms in addition to evaluating the antioxidant activity of these extracts. Materials and methods: Plant parts were subjected for hot Extraction by solvents of different polarity (hexane, methanol and ethanol) in addition to cold Pressing Extraction for seed. Furthermore, the active compounds were isolated by preparative thin layer chromatography, followed by identification for simmondsin and three of its derivatives namely Simmondsin-3’-ferulate, 4, 5-Didemethylsimmondsin and 4-Demethylsimmondsin-2’- ferulate, in addition to phenolic compounds, phytosterols, toccopherols and fatty acids. This was accomplished using chemical reagents along with various methods of chromatography and spectral analysis. The evaluation of antioxidant activity of extracts was done by 2, 2-Diphenyl-1-pircryl hydrazyl (DPPH) free radical scavenging method comparing to ascorbic acid activity. Antibacterial and antifungal activities were done using two methods; the agar well diffusion and disc diffusion methods, against (Staphylococcus aureus, Bacillis subtilis, Escherichia coli, Klebsiella pneumonia and Candida albicans). Results: The methanolic extract of testa and ethanolic extracts of both male and female leaves all possess antioxidant activity. Crude extracts do not exhibit antimicrobial activity, neither antibacterial nor antifungal activity. Discussion and conclusion: Plant extracts induced variable degrees of antioxidant activity and proposes its potential as an antioxidant agent for pharmaceutical applications. However, they do not have antimicrobial activity.
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cytotoxic effects of jordanian simmondsia chinensis link c k schneid on different cancer cell lines
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M Mhaidat, Ahmed SaleemAbstract:Context: Different parts of Jojoba (Simmondsia chinensis (Link) C.K. Schneid) from the family Simmondsiaceae have been traditionally used in folklore-medicine for skin disorders, wound healing, tumors and many other uses. Objective: The aim was to examine the effect of the total extracts of Jojoba leaves (male & female), testa, seeds and oil on the growth of various cancer cell lines. Materials and methods: Plant parts were subjected for hot Extraction by solvents of different polarity (hexane, methanol and ethanol), in addition to cold Pressing Extraction of seed. Furthermore, the active compounds were isolated by preparative thin layer chromatography, followed by identification with chemical reagents along with various methods of chromatography and spectral analysis for simmondsin and three of its derivatives namely Simmondsin-3’-ferulate,4,5-Didemethylsimmondsin and 4- Demethylsimmondsin -2’- ferulate. In addition, phenolic compounds, phytosterols, toccopherols and fatty acids were also identified by the same methods. The evaluation of the acute cytotoxic effect of the extracts on human cancer cell lines using human melanoma (MV 3), breast (MCF 7), and colorectal (HCT 116) tumor cell lines, was determined using 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: According the IC50 values, both jojoba oil (hexane extract & cold Pressing extract) and methanolic extract of testa have antitumor activity, more potent than the other parts, against HCT 116, MV 3 cancer cells. Moreover, Jojoba extracts induced a dose-dependent cytotoxicity. Discussion and conclusion: Plant extracts induced variable degrees of cytotoxicity against cancer cell lines due to their active constituents which were observed in different parts of the plant.
Severina Pacifico - One of the best experts on this subject based on the ideXlab platform.
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Can agronomic practices and cold-Pressing Extraction parameters affect phenols and polyphenols content in hempseed oils?
Industrial Crops and Products, 2019Co-Authors: Salvatore Faugno, Simona Piccolella, M. Sannino, Luigia Principio, Giuseppina Crescente, Gian Maria Baldi, Nunzio Fiorentino, Severina PacificoAbstract:Abstract Hemp seed oil is an extraordinary dietary source of polyunsaturated fatty acids (PUFAs), to huge health benefits are related. PUFAs abundance could indeed contribute the oil turning rancid and deteriorating through oxidation. Thus, antioxidant compounds, characteristic of hemp seed matrix, should be more favorably extract to hopefully safeguard the oil stability. Moreover, antioxidants ability to counteract the onset of oxidative stress-related diseases could be employed to further enhance hemp seed oil functional value. In this context, phenols and polyphenols, which are poorly explored in hempseed oil so far, are thoroughly investigated by untargeted UHPLC-HRMS and MS/MS techniques in seed oils from Cannabis sativa L. cv USO31. Data recorded highlighted that hemp seed oil could contain, as minor constituents, saccharides, phenol compounds (some of them never described before - e.g. tyrosol hexoside, caffeoyl tartaric acid isomers), as well as flavonoids, of which glycosides of flavonols quercetin, kaempferol and isorhamnetin were the most representative. Glucuronide derivatives were also present. Multivariate principal-component analysis (PCA) highlighted that agronomic practices (e.g. plant density/m2, use of fertilizers) and cold-Pressing Extraction parameters (e.g. temperature, nozzle size) massively affected the relative content of each compounds’ class. Hemp seeds from soils, which did not undergo pre-seeding fertilization, and with 60 plant/m2crop density, ensured the highest production of phenols and polyphenols, whereas their abundance could be compromised when the plant density was halved.
Nicola Verdone - One of the best experts on this subject based on the ideXlab platform.
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Process optimisation in sunflower oil Extraction by supercritical CO2
Chemical Engineering Science, 2002Co-Authors: Marco Bravi, Roberto Bubbico, F. Manna, Nicola VerdoneAbstract:Abstract A continuous process for the Extraction of sunflower oil using supercritical CO 2 , featuring multiple extractors, one oil separator and three cascaded CO 2 recovery vessels operating at different pressures, was devised and studied. For every single equipment of the plant making up the process a mathematical model was built. Experimental tests—consisting in measurements of oil solubility in supercritical CO 2 —were carried out in a laboratory-scale apparatus to characterise the behaviour of sunflower oil in the separation from the supercritical fluid. The mathematical model of the whole process was coded in the commercial gPROMS process modelling environment where both its simulation and optimisation—this latter assuming the overall oil production cost as the objective function—were carried out. The process- and economics-related results are discussed and compared with those obtained with traditional and cold-Pressing Extraction.
Ekbal Alkhateeb - One of the best experts on this subject based on the ideXlab platform.
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study of jordanian jojoba simmondsia chinensis liquid wax by gc and gc ms
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M MhaidatAbstract:Context: The oil of Simmondsia chinensis (Link) C.K. Schneid (Simmondsiaceae) has been traditionally used in ethno-medicine because of its unique chemical constituents. Objective: This study determined the Jordanian Jojoba oil components. Fatty acids and sterols profiles were determined by using gas chromatography (GC), while tocopherols profile was determined by using gas chromatography-mass spectrometry (GC/MS). Materials and methods: Jojoba seeds were subjected for hot Extraction by solvent (hexane) in addition to cold Pressing Extraction. Results: The fatty acid α-linolenic acid was in higher percentages within the Jordanian oil than those of Jojoba oil found in other parts of the world. On the other hand, the fatty acids palmitic acid, oleic acid, vaccenic acid, and gondoic acid were in lower percentages within the Jordanian oil. The avenasterol was in higher percentages within the Jordanian oil and the Jordanian Jojoba oil does not contain campesterol or campestanol. In addition, this study found that the major sterols and stanols constituents of the Jordanian Jojoba oil are: sitosterol, campesterol, stigmasterol, cholesterol, avenasterol, and brassicasterol. It was also found that Jojoba oil (hexane extract) contains stigmastadienol while Jojoba oil (cold Pressing extract) does not. Jojoba oil (cold Pressing extract) contains stigmastenol while Jojoba oil (hexane extract) does not. This study showed that the Jordanian Jojoba oil contains α-tocopherol similar to those of Jojoba oil from around the world. Discussion and conclusion: This is a pioneer results regarding Jojoba which is cultivated in Jordan under different environmental conditions.
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antioxidant and antimicrobial activities of jordanian simmondsia chinensis link c k schneid
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M Mhaidat, Anwar MaraqaAbstract:Context: Various parts of Jojoba plant have been used in ethnomedicine for skin disorders, wound healing and many others. Objective: The purpose was to examine the effect of the total extracts of Jojoba leaves (male & female), testa, seeds and oil on the growth of certain microorganisms in addition to evaluating the antioxidant activity of these extracts. Materials and methods: Plant parts were subjected for hot Extraction by solvents of different polarity (hexane, methanol and ethanol) in addition to cold Pressing Extraction for seed. Furthermore, the active compounds were isolated by preparative thin layer chromatography, followed by identification for simmondsin and three of its derivatives namely Simmondsin-3’-ferulate, 4, 5-Didemethylsimmondsin and 4-Demethylsimmondsin-2’- ferulate, in addition to phenolic compounds, phytosterols, toccopherols and fatty acids. This was accomplished using chemical reagents along with various methods of chromatography and spectral analysis. The evaluation of antioxidant activity of extracts was done by 2, 2-Diphenyl-1-pircryl hydrazyl (DPPH) free radical scavenging method comparing to ascorbic acid activity. Antibacterial and antifungal activities were done using two methods; the agar well diffusion and disc diffusion methods, against (Staphylococcus aureus, Bacillis subtilis, Escherichia coli, Klebsiella pneumonia and Candida albicans). Results: The methanolic extract of testa and ethanolic extracts of both male and female leaves all possess antioxidant activity. Crude extracts do not exhibit antimicrobial activity, neither antibacterial nor antifungal activity. Discussion and conclusion: Plant extracts induced variable degrees of antioxidant activity and proposes its potential as an antioxidant agent for pharmaceutical applications. However, they do not have antimicrobial activity.
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cytotoxic effects of jordanian simmondsia chinensis link c k schneid on different cancer cell lines
European Scientific Journal ESJ, 2014Co-Authors: Hani Alqizwini, Ekbal Alkhateeb, Nizar M Mhaidat, Ahmed SaleemAbstract:Context: Different parts of Jojoba (Simmondsia chinensis (Link) C.K. Schneid) from the family Simmondsiaceae have been traditionally used in folklore-medicine for skin disorders, wound healing, tumors and many other uses. Objective: The aim was to examine the effect of the total extracts of Jojoba leaves (male & female), testa, seeds and oil on the growth of various cancer cell lines. Materials and methods: Plant parts were subjected for hot Extraction by solvents of different polarity (hexane, methanol and ethanol), in addition to cold Pressing Extraction of seed. Furthermore, the active compounds were isolated by preparative thin layer chromatography, followed by identification with chemical reagents along with various methods of chromatography and spectral analysis for simmondsin and three of its derivatives namely Simmondsin-3’-ferulate,4,5-Didemethylsimmondsin and 4- Demethylsimmondsin -2’- ferulate. In addition, phenolic compounds, phytosterols, toccopherols and fatty acids were also identified by the same methods. The evaluation of the acute cytotoxic effect of the extracts on human cancer cell lines using human melanoma (MV 3), breast (MCF 7), and colorectal (HCT 116) tumor cell lines, was determined using 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: According the IC50 values, both jojoba oil (hexane extract & cold Pressing extract) and methanolic extract of testa have antitumor activity, more potent than the other parts, against HCT 116, MV 3 cancer cells. Moreover, Jojoba extracts induced a dose-dependent cytotoxicity. Discussion and conclusion: Plant extracts induced variable degrees of cytotoxicity against cancer cell lines due to their active constituents which were observed in different parts of the plant.