The Experts below are selected from a list of 38538 Experts worldwide ranked by ideXlab platform

Tadeusz Stefaniak - One of the best experts on this subject based on the ideXlab platform.

  • elbow joint position and hand Pressure force Sense under conditions of quick reaction in table tennis players
    Kinesiology, 2021
    Co-Authors: Ziemowit Bańkosz, Tadeusz Stefaniak
    Abstract:

    Joint position Sense and force reproduction are the most commonly used measures of proprioception. It is interesting to measure proprioception in integration of the factors most commonly viewed as most important in table tennis (as it was written above), i.e. speed, in particular – quick reaction. The aim of this study was to evaluate the accuracy of replication of a specific range of motion and force of hand pressing under conditions of limited time. Forty table tennis players and thirty non-athletes participated in the study. Electrogoniometric and dynamometric methods were used in the investigation. The accuracy of replication of pronation and supination movements of the forearm at the elbow joint and force of hand pressing under conditions of limited time (performing the activity as fast as possible in response to the visual signal) were measured. The tests performed in the study revealed that both female and male table tennis players were characterized by a higher level of forearm position Sense during performing the fastest possible pronation and supination movements in most of tasks. Better results of table tennis players than control group suggest that joint position and hand Pressure Sense integrated with quick reaction are important factors in table tennis. The results also indicate opportunities for using this methodology to monitor training.

  • Elbow joint position and hand Pressure force Sense under conditions of quick reaction in table tennis players
    'Faculty of Kinesiology University of Zagreb', 2021
    Co-Authors: Ziemowit Bańkosz, Tadeusz Stefaniak
    Abstract:

    Joint position Sense and force reproduction are the most commonly used measures of proprioception. It is interesting to measure proprioception in integration of the factors most commonly viewed as the most important in table tennis—speed, in particular quick reaction. The aim of this study was to evaluate the accuracy of replication of a specific range of motion and force of hand pressing under conditions of limited time. Forty table tennis players and 30 non-athletes participated in the study. Electrogoniometric and dynamometric methods were used in the investigation. The accuracy of replication of pronation and supination movements of the forearm at the elbow joint and force of hand pressing under conditions of limited time (performing the activity as fast as possible in response to visual signals) were measured. The tests performed in the study revealed that both female and male table tennis players were characterized by a higher level of forearm position Sense during performing the fastest possible pronation and supination movements in most of the tasks. Better results of table tennis players than of the control group suggest that joint position and hand Pressure Sense integrated with quick reaction are important performance factors in table tennis. The results also indicate opportunities for using this methodology to monitor training

Ziemowit Bańkosz - One of the best experts on this subject based on the ideXlab platform.

  • elbow joint position and hand Pressure force Sense under conditions of quick reaction in table tennis players
    Kinesiology, 2021
    Co-Authors: Ziemowit Bańkosz, Tadeusz Stefaniak
    Abstract:

    Joint position Sense and force reproduction are the most commonly used measures of proprioception. It is interesting to measure proprioception in integration of the factors most commonly viewed as most important in table tennis (as it was written above), i.e. speed, in particular – quick reaction. The aim of this study was to evaluate the accuracy of replication of a specific range of motion and force of hand pressing under conditions of limited time. Forty table tennis players and thirty non-athletes participated in the study. Electrogoniometric and dynamometric methods were used in the investigation. The accuracy of replication of pronation and supination movements of the forearm at the elbow joint and force of hand pressing under conditions of limited time (performing the activity as fast as possible in response to the visual signal) were measured. The tests performed in the study revealed that both female and male table tennis players were characterized by a higher level of forearm position Sense during performing the fastest possible pronation and supination movements in most of tasks. Better results of table tennis players than control group suggest that joint position and hand Pressure Sense integrated with quick reaction are important factors in table tennis. The results also indicate opportunities for using this methodology to monitor training.

  • Elbow joint position and hand Pressure force Sense under conditions of quick reaction in table tennis players
    'Faculty of Kinesiology University of Zagreb', 2021
    Co-Authors: Ziemowit Bańkosz, Tadeusz Stefaniak
    Abstract:

    Joint position Sense and force reproduction are the most commonly used measures of proprioception. It is interesting to measure proprioception in integration of the factors most commonly viewed as the most important in table tennis—speed, in particular quick reaction. The aim of this study was to evaluate the accuracy of replication of a specific range of motion and force of hand pressing under conditions of limited time. Forty table tennis players and 30 non-athletes participated in the study. Electrogoniometric and dynamometric methods were used in the investigation. The accuracy of replication of pronation and supination movements of the forearm at the elbow joint and force of hand pressing under conditions of limited time (performing the activity as fast as possible in response to visual signals) were measured. The tests performed in the study revealed that both female and male table tennis players were characterized by a higher level of forearm position Sense during performing the fastest possible pronation and supination movements in most of the tasks. Better results of table tennis players than of the control group suggest that joint position and hand Pressure Sense integrated with quick reaction are important performance factors in table tennis. The results also indicate opportunities for using this methodology to monitor training

Takanori Tanaka - One of the best experts on this subject based on the ideXlab platform.

  • an open label single dose parallel group dose increasing study comparing the pharmacokinetics and tolerability of pilsicainide hydrochloride in healthy korean and japanese male subjects
    Clinical Therapeutics, 2009
    Co-Authors: Bohyung Kim, Jungryul Kim, Kyoung Soo Lim, Jaewoo Kim, Kyupyo Kim, Jang Hee Hong, Injin Jang, Sanggoo Shin, Takanori Tanaka
    Abstract:

    Abstract Background: Pilsicainide hydrochloride is a class IC antiarrhythmic agent used for the treatment of supraventricular and ventricular arrhythmias. Objective: The objective of this study was to compare the pharmacokinetics and tolerability of pilsicainide in healthy Korean and Japanese male volunteers to satisfy regulatory requirements for marketing pilsicainide in the Republic of Korea. Methods: This was an open-label, single-dose, parallel-group, dose-increasing study. It was simultaneously conducted in healthy Korean and Japanese volunteers from September 2005 through May 2006; pilsicainide was approved for use in the Republic of Korea in 2007. Subjects for the 100-mg group were enrolled after the performance of tolerability evaluations in the 50-mg dose group. Serial blood and urine samples were collected up to 24 hours after dosing, and drug concentrations in plasma and urine were determined by high-performance liquid chromatography. Tolerability was evaluated by monitoring adverse events (AEs), clinical laboratory parameters, and results of 12-lead electrocardiograms (ECGs). Results: Sixteen healthy Korean male subjects (mean [SD] age, 24.5 [4.2] years; weight, 71.8 [5.5] kg; height, 176.6 [6.3] cm) and 16 healthy male Japanese subjects (age, 24.7 [4.9] years; weight, 60.2 [4.4] kg; height, 171.9 [6.4] cm) were enrolled in the study. Values for AUC and C max of pilsicainide increased proportionally with dose escalation in all subjects. Pilsicainide reached C max 0.5 to 1.5 hours after dosing in both the Korean and Japanese subjects. The mean (SD) dose-normalized values for C max for the Korean and Japanese subjects were 9.4 (1.9) and 9.2 (1.6) ng/mL/mg, respectively. The mean (SD) dose-normalized values for AUC 0-∞ were 56.0 (8.0) ng · h/mL/mg in the Korean subjects and 53.8 (8.1) ng · h/mL/mg in the Japanese subjects. None of these findings were statistically significant. A total of 9 AEs occurred in 7 of the 16 Korean subjects; they included dizziness, feeling of being hot, somnolence, and atrioventricular block. All of the AEs were mild in severity and were considered possibly related to pilsicainide. Two of the 16 Japanese subjects had a total of 4 AEs. All of the AEs occurred in the subjects treated with 50 mg. Of the 2 subjects with AEs, 1 subject had a decrease in blood Pressure, a Sense of discomfort, and PR-interval prolongation on ECG, while the other developed a premature ventricular contraction (PVC). The PR-interval prolongation and PVC were determined to be possibly related to pilsicainide, and these were mild in severity. The other AEs (ie, decreased blood Pressure, Sense of discomfort) were moderate in severity. Conclusions: The results of this study suggest that the pharmacokinetic profile of pilsicainide was not significantly different between these healthy Korean and Japanese male volunteers. A single dose (50 or 100 mg) of pilsicainide was well tolerated in both ethnic groups.

Bohyung Kim - One of the best experts on this subject based on the ideXlab platform.

  • an open label single dose parallel group dose increasing study comparing the pharmacokinetics and tolerability of pilsicainide hydrochloride in healthy korean and japanese male subjects
    Clinical Therapeutics, 2009
    Co-Authors: Bohyung Kim, Jungryul Kim, Kyoung Soo Lim, Jaewoo Kim, Kyupyo Kim, Jang Hee Hong, Injin Jang, Sanggoo Shin, Takanori Tanaka
    Abstract:

    Abstract Background: Pilsicainide hydrochloride is a class IC antiarrhythmic agent used for the treatment of supraventricular and ventricular arrhythmias. Objective: The objective of this study was to compare the pharmacokinetics and tolerability of pilsicainide in healthy Korean and Japanese male volunteers to satisfy regulatory requirements for marketing pilsicainide in the Republic of Korea. Methods: This was an open-label, single-dose, parallel-group, dose-increasing study. It was simultaneously conducted in healthy Korean and Japanese volunteers from September 2005 through May 2006; pilsicainide was approved for use in the Republic of Korea in 2007. Subjects for the 100-mg group were enrolled after the performance of tolerability evaluations in the 50-mg dose group. Serial blood and urine samples were collected up to 24 hours after dosing, and drug concentrations in plasma and urine were determined by high-performance liquid chromatography. Tolerability was evaluated by monitoring adverse events (AEs), clinical laboratory parameters, and results of 12-lead electrocardiograms (ECGs). Results: Sixteen healthy Korean male subjects (mean [SD] age, 24.5 [4.2] years; weight, 71.8 [5.5] kg; height, 176.6 [6.3] cm) and 16 healthy male Japanese subjects (age, 24.7 [4.9] years; weight, 60.2 [4.4] kg; height, 171.9 [6.4] cm) were enrolled in the study. Values for AUC and C max of pilsicainide increased proportionally with dose escalation in all subjects. Pilsicainide reached C max 0.5 to 1.5 hours after dosing in both the Korean and Japanese subjects. The mean (SD) dose-normalized values for C max for the Korean and Japanese subjects were 9.4 (1.9) and 9.2 (1.6) ng/mL/mg, respectively. The mean (SD) dose-normalized values for AUC 0-∞ were 56.0 (8.0) ng · h/mL/mg in the Korean subjects and 53.8 (8.1) ng · h/mL/mg in the Japanese subjects. None of these findings were statistically significant. A total of 9 AEs occurred in 7 of the 16 Korean subjects; they included dizziness, feeling of being hot, somnolence, and atrioventricular block. All of the AEs were mild in severity and were considered possibly related to pilsicainide. Two of the 16 Japanese subjects had a total of 4 AEs. All of the AEs occurred in the subjects treated with 50 mg. Of the 2 subjects with AEs, 1 subject had a decrease in blood Pressure, a Sense of discomfort, and PR-interval prolongation on ECG, while the other developed a premature ventricular contraction (PVC). The PR-interval prolongation and PVC were determined to be possibly related to pilsicainide, and these were mild in severity. The other AEs (ie, decreased blood Pressure, Sense of discomfort) were moderate in severity. Conclusions: The results of this study suggest that the pharmacokinetic profile of pilsicainide was not significantly different between these healthy Korean and Japanese male volunteers. A single dose (50 or 100 mg) of pilsicainide was well tolerated in both ethnic groups.

Kyupyo Kim - One of the best experts on this subject based on the ideXlab platform.

  • an open label single dose parallel group dose increasing study comparing the pharmacokinetics and tolerability of pilsicainide hydrochloride in healthy korean and japanese male subjects
    Clinical Therapeutics, 2009
    Co-Authors: Bohyung Kim, Jungryul Kim, Kyoung Soo Lim, Jaewoo Kim, Kyupyo Kim, Jang Hee Hong, Injin Jang, Sanggoo Shin, Takanori Tanaka
    Abstract:

    Abstract Background: Pilsicainide hydrochloride is a class IC antiarrhythmic agent used for the treatment of supraventricular and ventricular arrhythmias. Objective: The objective of this study was to compare the pharmacokinetics and tolerability of pilsicainide in healthy Korean and Japanese male volunteers to satisfy regulatory requirements for marketing pilsicainide in the Republic of Korea. Methods: This was an open-label, single-dose, parallel-group, dose-increasing study. It was simultaneously conducted in healthy Korean and Japanese volunteers from September 2005 through May 2006; pilsicainide was approved for use in the Republic of Korea in 2007. Subjects for the 100-mg group were enrolled after the performance of tolerability evaluations in the 50-mg dose group. Serial blood and urine samples were collected up to 24 hours after dosing, and drug concentrations in plasma and urine were determined by high-performance liquid chromatography. Tolerability was evaluated by monitoring adverse events (AEs), clinical laboratory parameters, and results of 12-lead electrocardiograms (ECGs). Results: Sixteen healthy Korean male subjects (mean [SD] age, 24.5 [4.2] years; weight, 71.8 [5.5] kg; height, 176.6 [6.3] cm) and 16 healthy male Japanese subjects (age, 24.7 [4.9] years; weight, 60.2 [4.4] kg; height, 171.9 [6.4] cm) were enrolled in the study. Values for AUC and C max of pilsicainide increased proportionally with dose escalation in all subjects. Pilsicainide reached C max 0.5 to 1.5 hours after dosing in both the Korean and Japanese subjects. The mean (SD) dose-normalized values for C max for the Korean and Japanese subjects were 9.4 (1.9) and 9.2 (1.6) ng/mL/mg, respectively. The mean (SD) dose-normalized values for AUC 0-∞ were 56.0 (8.0) ng · h/mL/mg in the Korean subjects and 53.8 (8.1) ng · h/mL/mg in the Japanese subjects. None of these findings were statistically significant. A total of 9 AEs occurred in 7 of the 16 Korean subjects; they included dizziness, feeling of being hot, somnolence, and atrioventricular block. All of the AEs were mild in severity and were considered possibly related to pilsicainide. Two of the 16 Japanese subjects had a total of 4 AEs. All of the AEs occurred in the subjects treated with 50 mg. Of the 2 subjects with AEs, 1 subject had a decrease in blood Pressure, a Sense of discomfort, and PR-interval prolongation on ECG, while the other developed a premature ventricular contraction (PVC). The PR-interval prolongation and PVC were determined to be possibly related to pilsicainide, and these were mild in severity. The other AEs (ie, decreased blood Pressure, Sense of discomfort) were moderate in severity. Conclusions: The results of this study suggest that the pharmacokinetic profile of pilsicainide was not significantly different between these healthy Korean and Japanese male volunteers. A single dose (50 or 100 mg) of pilsicainide was well tolerated in both ethnic groups.