The Experts below are selected from a list of 840 Experts worldwide ranked by ideXlab platform
Lestariningtyas Ariek - One of the best experts on this subject based on the ideXlab platform.
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KESESUAIAN PEMERIKSAAN REFLEKS-REFLEKS PRIMITIF DAN TES MUNCHEN UNTUK PENILAIAN PERKEMBANGAN MOTORIK BAYI (THE COMPATIBILITY BETWEEN Primitive Reflexes AND MUNCHEN TEST FOR THE ASSESSMENT OF INFANT MOVEMENT GROWTH)
2004Co-Authors: Lestariningtyas AriekAbstract:Background : Primitive Reflexes represent the complex automatic movement pattern mediated by brain stem, found in normal growth and underlying the infant growth. Objective : To study whether there are compatibility to Primitive Reflexes by domain motor Munchen test as assessment of growth of infant motor Method : Cross sectional study, 68 infants in healthy infant clinic of Dr.Kariadi Hospital in Semarang. Munchen and Primitive Reflexes test are performed, including motor domain Munchen test, there are crawl ability, sit, walk, grasp and Primitive Reflexes of STNR, ATNR, Moro, TLS, PSR, Stepping reflex, SRHB, SRBB and also grasp Reflexes Result : From 68 infant performed Munchen test 36 normal, 32 abnormal, had a compatibility to motor domain crawl by STNR (p
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KESESUAIAN PEMERIKSAAN REFLEKS-REFLEKS PRIMITIF DAN TES MUNCHEN UNTUK PENILAIAN PERKEMBANGAN MOTORIK BAYI (THE COMPATIBILITY BETWEEN Primitive Reflexes AND MUNCHEN TEST FOR THE ASSESSMENT OF INFANT MOVEMENT GROWTH)
2004Co-Authors: Lestariningtyas AriekAbstract:Background : Primitive Reflexes represent the complex automatic movement pattern mediated by brain stem, found in normal growth and underlying the infant growth. Objective : To study whether there are compatibility to Primitive Reflexes by domain motor Munchen test as assessment of growth of infant motor Method : Cross sectional study, 68 infants in healthy infant clinic of Dr.Kariadi Hospital in Semarang. Munchen and Primitive Reflexes test are performed, including motor domain Munchen test, there are crawl ability, sit, walk, grasp and Primitive Reflexes of STNR, ATNR, Moro, TLS, PSR, Stepping reflex, SRHB, SRBB and also grasp Reflexes Result : From 68 infant performed Munchen test 36 normal, 32 abnormal, had a compatibility to motor domain crawl by STNR ($0,05, kappa value 0,612), sit by ATNR ($0,05, kappa value 0,563), TLS ($0,05, kappa value 0,457 ), Moro ($0,05, kappa value 0,404), walk by PSR ($0,05, kappa value 0,501), stepping reflex ($0,05, kappa value 0,462), SRHB ($0,05, kappa value 0,539) and SRBB (p
Robert W. Hamill - One of the best experts on this subject based on the ideXlab platform.
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glasgow coma scale and the neurologic examination
2016Co-Authors: Curtis G. Benesch, Keith D. Mcdaniel, Christopher Cox, Robert W. HamillAbstract:Results: When compared with patients in the Clinical Dementia Rating stages 3 and 4, patients with a stage 5 scored significantly lower on the Glasgow Coma Scale, with the discriminating subscales being verbal and motor responses. Primitive Reflexes, myoclonus, and dyskinesia were increasingly prevalent in the more terminal stages. Cognitive screening assessments did not discriminate between groups. Conclusions: Rudimentary neurologic functions can be readily assessed and, when viewed together with the Glasgow Coma Scale, may circumvent the "floor effect" frequently encountered when using the currently available cognitive and functional scales and, thereby, better define patients with end-stage Alzheimer's disease.
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End-Stage Alzheimer's Disease: Glasgow Coma Scale and the Neurologic Examination
JAMA Neurology, 1995Co-Authors: Curtis G. Benesch, Keith D. Mcdaniel, Robert W. HamillAbstract:Objective: To characterize the cognitive and neurologic features of patients with end-stage Alzheimer's disease using a standard neurologic examination and the Glasgow Coma Scale. Design: Case series. Setting: Local community nursing homes. Patients: Forty patients with Alzheimer's disease were drawn from previously enrolled subjects in the Rochester Alzheimer's Disease Project with Clinical Dementia Rating scores of 3, 4, or 5. Main Outcome Measures: Scores on the Glasgow Coma Scale and cognitive screening examinations and the prevalence of neurologic manifestations such as Primitive Reflexes and extrapyramidal signs were compared across the Clinical Dementia Rating groups. Results: When compared with patients in the Clinical Dementia Rating stages 3 and 4, patients with a stage 5 scored significantly lower on the Glasgow Coma Scale, with the discriminating subscales being verbal and motor responses. Primitive Reflexes, myoclonus, and dyskinesia were increasingly prevalent in the more terminal stages. Cognitive screening assessments did not discriminate between groups. Conclusions: Rudimentary neurologic functions can be readily assessed and, when viewed together with the Glasgow Coma Scale, may circumvent the "floor effect" frequently encountered when using the currently available cognitive and functional scales and, thereby, better define patients with end-stage Alzheimer's disease.
Curtis G. Benesch - One of the best experts on this subject based on the ideXlab platform.
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glasgow coma scale and the neurologic examination
2016Co-Authors: Curtis G. Benesch, Keith D. Mcdaniel, Christopher Cox, Robert W. HamillAbstract:Results: When compared with patients in the Clinical Dementia Rating stages 3 and 4, patients with a stage 5 scored significantly lower on the Glasgow Coma Scale, with the discriminating subscales being verbal and motor responses. Primitive Reflexes, myoclonus, and dyskinesia were increasingly prevalent in the more terminal stages. Cognitive screening assessments did not discriminate between groups. Conclusions: Rudimentary neurologic functions can be readily assessed and, when viewed together with the Glasgow Coma Scale, may circumvent the "floor effect" frequently encountered when using the currently available cognitive and functional scales and, thereby, better define patients with end-stage Alzheimer's disease.
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End-Stage Alzheimer's Disease: Glasgow Coma Scale and the Neurologic Examination
JAMA Neurology, 1995Co-Authors: Curtis G. Benesch, Keith D. Mcdaniel, Robert W. HamillAbstract:Objective: To characterize the cognitive and neurologic features of patients with end-stage Alzheimer's disease using a standard neurologic examination and the Glasgow Coma Scale. Design: Case series. Setting: Local community nursing homes. Patients: Forty patients with Alzheimer's disease were drawn from previously enrolled subjects in the Rochester Alzheimer's Disease Project with Clinical Dementia Rating scores of 3, 4, or 5. Main Outcome Measures: Scores on the Glasgow Coma Scale and cognitive screening examinations and the prevalence of neurologic manifestations such as Primitive Reflexes and extrapyramidal signs were compared across the Clinical Dementia Rating groups. Results: When compared with patients in the Clinical Dementia Rating stages 3 and 4, patients with a stage 5 scored significantly lower on the Glasgow Coma Scale, with the discriminating subscales being verbal and motor responses. Primitive Reflexes, myoclonus, and dyskinesia were increasingly prevalent in the more terminal stages. Cognitive screening assessments did not discriminate between groups. Conclusions: Rudimentary neurologic functions can be readily assessed and, when viewed together with the Glasgow Coma Scale, may circumvent the "floor effect" frequently encountered when using the currently available cognitive and functional scales and, thereby, better define patients with end-stage Alzheimer's disease.
Roberto Monastero - One of the best experts on this subject based on the ideXlab platform.
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Isolated, subtle, neurological abnormalities in neurologically and cognitively healthy aging subjects
Journal of Neurology, 2015Co-Authors: Cecilia Camarda, Rosolino Camarda, Iacopo Battaglini, Cesare Gagliardo, Paola Torelli, Roberto MonasteroAbstract:The aim of this study is to describe the frequency of isolated, subtle, neurological abnormalities (ISNAs) in a large population of neurologically and cognitively healthy subjects and to compare ISNAs to various types of MRI-detected cerebrovascular lesions and subcortical brain atrophy in different age classes. 907 subjects were selected from a large, prospective hospital-based study. At baseline neurological examination, 17 ISNAs were selected. Primitive Reflexes were the most common ISNAs (35.8 %), while dysphagia was the most rarely encountered (0.3 %). Measures of small vessel disease, i.e., deep and subcortical white matter hyperintensity and lacunar infarcts as well as subcortical atrophy, were variously associated with ISNAs. In the adult group, the ISNAs were associated with hypertriglyceridemia, TIA, and subcortical lacunar infarcts, while in the elderly–old group they were associated with arterial hypertension, subcortical white matter hyperintensity, and subcortical atrophy. An increased risk of ISNAs was associated with lacunae and white matter hyperintensity in the parietal region. This study shows that white matter hyperintensity, lacunae, and subcortical atrophy are associated with an increased risk of ISNAs in cognitively and neurologically healthy aging subjects. ISNAs are not benign signs. Therefore, adults and elderly people presenting with ISNAs should have access to accurate history and diagnosis to prevent progression of small vessel disease and future neurological and cognitive disabilities.
John C Van Swieten - One of the best experts on this subject based on the ideXlab platform.
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Symmetrical Corticobasal Syndrome Caused by a Novel c.314dup Progranulin Mutation
Journal of Molecular Neuroscience, 2011Co-Authors: Elise G P Dopper, Wang Zheng Chiu, Inge Koning, Rick Van Minkelen, Matthew C. Baker, Harro Seelaar, Annemieke J M Rozemuller, Rosa Rademakers, John C Van SwietenAbstract:Corticobasal syndrome (CBS) is characterised by asymmetrical parkinsonism and cognitive impairment. The underlying pathology varies between corticobasal degeneration, progressive supranuclear palsy, Alzheimer’s disease, Creutzfeldt–Jakob disease and frontotemporal lobar degeneration sometimes in association with GRN mutations. A 61-year-old male underwent neurological examination, neuropsychological assessment, MRI, and HMPAO-SPECT at our medical centre. After his death at the age of 63, brain autopsy, genetic screening and mRNA expression analysis were performed. The patient presented with slow progressive walking disabilities, non-fluent language problems, behavioural changes and forgetfulness. His family history was negative. He had Primitive Reflexes, rigidity of his arms and postural instability. Later in the disease course he developed dystonia of his left leg, pathological crying, mutism and dysphagia. Neuropsychological assessment revealed prominent ideomotor and ideational apraxia, executive dysfunction, non-fluent aphasia and memory deficits. Neuroimaging showed symmetrical predominant frontoparietal atrophy and hypoperfusion. Frontotemporal lobar degeneration (FTLD)-TDP type 3 pathology was found at autopsy. GRN sequencing revealed a novel frameshift mutation c.314dup, p.Cys105fs and GRN mRNA levels showed a 50% decrease. We found a novel GRN mutation in a patient with an atypical (CBS) presentation with symmetric neuroimaging findings. GRN mutations are an important cause of CBS associated with FTLD-TDP type 3 pathology, sometimes in sporadic cases. Screening for GRN mutations should also be considered in CBS patients without a positive family history.