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Marek Isbrandt - One of the best experts on this subject based on the ideXlab platform.
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Effect of Evening Primrose Oil-Based Polyol on the Properties of Rigid Polyurethane⁻Polyisocyanurate Foams for Thermal Insulation.
Polymers, 2018Co-Authors: Joanna Paciorek-sadowska, Marcin Borowicz, Bogusław Czupryński, Marek IsbrandtAbstract:The article presents the results of research on the synthesis of a new biopolyol based on evening Primrose Oil, and its use in the production of rigid polyurethane⁻polyisocyanurate foams intended for thermal insulation. The obtained biopolyol was subjected to analytical, physicochemical, and spectroscopic tests (Fourier transform infrared (FTIR), ¹H NMR, 13C NMR) to confirm its suitability for the synthesis of polyurethane materials. Then, it was used for the partial replacement of the petrochemical polyol in the polyurethane formulation. Obtained rigid polyurethane⁻polyisocyanurate foams are characterized by a lower apparent density, brittleness, water absorption, and thermal conductivity coefficient λ. In addition, foams modified by biopolyols had a higher content of closed cells and higher aging resistance. The results of the conducted research showed that the use of the biopolyol based on evening Primrose Oil may be an alternative to petrochemical polyols. The research presented herein is perfectly consistent with the trends of sustainable development and the philosophy of green chemistry.
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effect of evening Primrose Oil based polyol on the properties of rigid polyurethane polyisocyanurate foams for thermal insulation
Polymers, 2018Co-Authors: Joanna Pacioreksadowska, Marcin Borowicz, Bogusław Czupryński, Marek IsbrandtAbstract:The article presents the results of research on the synthesis of a new biopolyol based on evening Primrose Oil, and its use in the production of rigid polyurethane⁻polyisocyanurate foams intended for thermal insulation. The obtained biopolyol was subjected to analytical, physicochemical, and spectroscopic tests (Fourier transform infrared (FTIR), ¹H NMR, 13C NMR) to confirm its suitability for the synthesis of polyurethane materials. Then, it was used for the partial replacement of the petrochemical polyol in the polyurethane formulation. Obtained rigid polyurethane⁻polyisocyanurate foams are characterized by a lower apparent density, brittleness, water absorption, and thermal conductivity coefficient λ. In addition, foams modified by biopolyols had a higher content of closed cells and higher aging resistance. The results of the conducted research showed that the use of the biopolyol based on evening Primrose Oil may be an alternative to petrochemical polyols. The research presented herein is perfectly consistent with the trends of sustainable development and the philosophy of green chemistry.
Marcin Borowicz - One of the best experts on this subject based on the ideXlab platform.
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Effect of Evening Primrose Oil-Based Polyol on the Properties of Rigid Polyurethane⁻Polyisocyanurate Foams for Thermal Insulation.
Polymers, 2018Co-Authors: Joanna Paciorek-sadowska, Marcin Borowicz, Bogusław Czupryński, Marek IsbrandtAbstract:The article presents the results of research on the synthesis of a new biopolyol based on evening Primrose Oil, and its use in the production of rigid polyurethane⁻polyisocyanurate foams intended for thermal insulation. The obtained biopolyol was subjected to analytical, physicochemical, and spectroscopic tests (Fourier transform infrared (FTIR), ¹H NMR, 13C NMR) to confirm its suitability for the synthesis of polyurethane materials. Then, it was used for the partial replacement of the petrochemical polyol in the polyurethane formulation. Obtained rigid polyurethane⁻polyisocyanurate foams are characterized by a lower apparent density, brittleness, water absorption, and thermal conductivity coefficient λ. In addition, foams modified by biopolyols had a higher content of closed cells and higher aging resistance. The results of the conducted research showed that the use of the biopolyol based on evening Primrose Oil may be an alternative to petrochemical polyols. The research presented herein is perfectly consistent with the trends of sustainable development and the philosophy of green chemistry.
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effect of evening Primrose Oil based polyol on the properties of rigid polyurethane polyisocyanurate foams for thermal insulation
Polymers, 2018Co-Authors: Joanna Pacioreksadowska, Marcin Borowicz, Bogusław Czupryński, Marek IsbrandtAbstract:The article presents the results of research on the synthesis of a new biopolyol based on evening Primrose Oil, and its use in the production of rigid polyurethane⁻polyisocyanurate foams intended for thermal insulation. The obtained biopolyol was subjected to analytical, physicochemical, and spectroscopic tests (Fourier transform infrared (FTIR), ¹H NMR, 13C NMR) to confirm its suitability for the synthesis of polyurethane materials. Then, it was used for the partial replacement of the petrochemical polyol in the polyurethane formulation. Obtained rigid polyurethane⁻polyisocyanurate foams are characterized by a lower apparent density, brittleness, water absorption, and thermal conductivity coefficient λ. In addition, foams modified by biopolyols had a higher content of closed cells and higher aging resistance. The results of the conducted research showed that the use of the biopolyol based on evening Primrose Oil may be an alternative to petrochemical polyols. The research presented herein is perfectly consistent with the trends of sustainable development and the philosophy of green chemistry.
Bogusław Czupryński - One of the best experts on this subject based on the ideXlab platform.
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Effect of Evening Primrose Oil-Based Polyol on the Properties of Rigid Polyurethane⁻Polyisocyanurate Foams for Thermal Insulation.
Polymers, 2018Co-Authors: Joanna Paciorek-sadowska, Marcin Borowicz, Bogusław Czupryński, Marek IsbrandtAbstract:The article presents the results of research on the synthesis of a new biopolyol based on evening Primrose Oil, and its use in the production of rigid polyurethane⁻polyisocyanurate foams intended for thermal insulation. The obtained biopolyol was subjected to analytical, physicochemical, and spectroscopic tests (Fourier transform infrared (FTIR), ¹H NMR, 13C NMR) to confirm its suitability for the synthesis of polyurethane materials. Then, it was used for the partial replacement of the petrochemical polyol in the polyurethane formulation. Obtained rigid polyurethane⁻polyisocyanurate foams are characterized by a lower apparent density, brittleness, water absorption, and thermal conductivity coefficient λ. In addition, foams modified by biopolyols had a higher content of closed cells and higher aging resistance. The results of the conducted research showed that the use of the biopolyol based on evening Primrose Oil may be an alternative to petrochemical polyols. The research presented herein is perfectly consistent with the trends of sustainable development and the philosophy of green chemistry.
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effect of evening Primrose Oil based polyol on the properties of rigid polyurethane polyisocyanurate foams for thermal insulation
Polymers, 2018Co-Authors: Joanna Pacioreksadowska, Marcin Borowicz, Bogusław Czupryński, Marek IsbrandtAbstract:The article presents the results of research on the synthesis of a new biopolyol based on evening Primrose Oil, and its use in the production of rigid polyurethane⁻polyisocyanurate foams intended for thermal insulation. The obtained biopolyol was subjected to analytical, physicochemical, and spectroscopic tests (Fourier transform infrared (FTIR), ¹H NMR, 13C NMR) to confirm its suitability for the synthesis of polyurethane materials. Then, it was used for the partial replacement of the petrochemical polyol in the polyurethane formulation. Obtained rigid polyurethane⁻polyisocyanurate foams are characterized by a lower apparent density, brittleness, water absorption, and thermal conductivity coefficient λ. In addition, foams modified by biopolyols had a higher content of closed cells and higher aging resistance. The results of the conducted research showed that the use of the biopolyol based on evening Primrose Oil may be an alternative to petrochemical polyols. The research presented herein is perfectly consistent with the trends of sustainable development and the philosophy of green chemistry.
Dominic Cox - One of the best experts on this subject based on the ideXlab platform.
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the effects of evening Primrose Oil on nerve function and capillarization in streptozotocin diabetic rats modulation by the cyclo oxygenase inhibitor flurbiprofen
British Journal of Pharmacology, 1993Co-Authors: Norman E. Cameron, Mary A. Cotter, K. C. Dines, S. Robertson, Dominic CoxAbstract:1 The aims of this study were first, to examine whether deficits in nerve conduction in streptozotocin-diabetic rats could be reversed by a 10% dietary supplement of evening Primrose Oil. Second, to determine the time-course of reversal, and third, to assess whether the effects could be blocked by the cylco-oxygenase inhibitor flurbiprofen (5 mg kg−1 day−1). 2 One-month diabetes produced 20% and 15% deficits in sciatic motor and saphenous sensory conduction velocity respectively, which were maintained over 2 months diabetes. 3 The effect of 1-month evening Primrose Oil treatment on abnormalities caused by an initial month of untreated diabetes was examined. Motor and sensory nerve conduction velocity were restored to the non-diabetic level. 4 Resistance to hypoxic conduction failure was investigated for sciatic nerve trunk in vitro. The 80% conduction failure times were 29% and 55% prolonged by 1- and 2-month diabetes respectively. Evening Primrose Oil did not reverse the increased hypoxic resistance following 1-month untreated diabetes. 5 Sciatic nerve endoneurial capillary density was not significantly affected by diabetes, but was 16% increased in diabetic rats with reversal by evening Primrose Oil treatment for 1 month compared to 2-month untreated diabetes. 6 Serial motor conduction velocity measurement after 3-month untreated diabetes revealed complete normalization by evening Primrose Oil within 4 days. Cessation of treatment resulted in a rapid decline in conduction velocity over 24 h. 7 In a preventive study of 2-month duration, 6 groups of rats were used. These comprised non-diabetic controls, diabetic rats, and evening Primrose Oil-treated diabetic rats, both with and without flurbiprofen treatment. Flurbiprofen had no significant effect in non-diabetic rats, but produced an 11% worsening of motor conduction velocity and a 21% reduction of sciatic capillary density in diabetic rats. Evening Primrose Oil prevented the decreases in conduction velocity and increased hypoxic resistance with diabetes, and caused a 23% increase in capillary density. Flurbiprofen completely blocked the effect of evening Primrose Oil on conduction velocity, resistance to hypoxia, and capillarization. 8 Six main conclusions were reached. First, evening Primrose Oil rapidly reverses conduction deficits in diabetic rats. Second, the effects of treatment may be very short-lived, suggesting a primary metabolic action. Third, evening Primrose Oil cannot reverse established changes in hypoxic resistance over 1-month treatment. Fourth, long-term treatment causes angiogenesis, suggesting a vascular action. Fifth, products of cyclo-oxygenase-mediated metabolism are necessary for maintaining vasa nervorum integrity in diabetic rats. Sixth, evening Primrose Oil probably acts by providing substrate for vasodilator prostanoid synthesis by vasa nervorum.
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The effects of evening Primrose Oil on nerve function and capillarization in streptozotocin‐diabetic rats: modulation by the cyclo‐oxygenase inhibitor flurbiprofen
British Journal of Pharmacology, 1993Co-Authors: Norman E. Cameron, Mary A. Cotter, K. C. Dines, S. Robertson, Dominic CoxAbstract:1 The aims of this study were first, to examine whether deficits in nerve conduction in streptozotocin-diabetic rats could be reversed by a 10% dietary supplement of evening Primrose Oil. Second, to determine the time-course of reversal, and third, to assess whether the effects could be blocked by the cylco-oxygenase inhibitor flurbiprofen (5 mg kg−1 day−1). 2 One-month diabetes produced 20% and 15% deficits in sciatic motor and saphenous sensory conduction velocity respectively, which were maintained over 2 months diabetes. 3 The effect of 1-month evening Primrose Oil treatment on abnormalities caused by an initial month of untreated diabetes was examined. Motor and sensory nerve conduction velocity were restored to the non-diabetic level. 4 Resistance to hypoxic conduction failure was investigated for sciatic nerve trunk in vitro. The 80% conduction failure times were 29% and 55% prolonged by 1- and 2-month diabetes respectively. Evening Primrose Oil did not reverse the increased hypoxic resistance following 1-month untreated diabetes. 5 Sciatic nerve endoneurial capillary density was not significantly affected by diabetes, but was 16% increased in diabetic rats with reversal by evening Primrose Oil treatment for 1 month compared to 2-month untreated diabetes. 6 Serial motor conduction velocity measurement after 3-month untreated diabetes revealed complete normalization by evening Primrose Oil within 4 days. Cessation of treatment resulted in a rapid decline in conduction velocity over 24 h. 7 In a preventive study of 2-month duration, 6 groups of rats were used. These comprised non-diabetic controls, diabetic rats, and evening Primrose Oil-treated diabetic rats, both with and without flurbiprofen treatment. Flurbiprofen had no significant effect in non-diabetic rats, but produced an 11% worsening of motor conduction velocity and a 21% reduction of sciatic capillary density in diabetic rats. Evening Primrose Oil prevented the decreases in conduction velocity and increased hypoxic resistance with diabetes, and caused a 23% increase in capillary density. Flurbiprofen completely blocked the effect of evening Primrose Oil on conduction velocity, resistance to hypoxia, and capillarization. 8 Six main conclusions were reached. First, evening Primrose Oil rapidly reverses conduction deficits in diabetic rats. Second, the effects of treatment may be very short-lived, suggesting a primary metabolic action. Third, evening Primrose Oil cannot reverse established changes in hypoxic resistance over 1-month treatment. Fourth, long-term treatment causes angiogenesis, suggesting a vascular action. Fifth, products of cyclo-oxygenase-mediated metabolism are necessary for maintaining vasa nervorum integrity in diabetic rats. Sixth, evening Primrose Oil probably acts by providing substrate for vasodilator prostanoid synthesis by vasa nervorum.
Norman E. Cameron - One of the best experts on this subject based on the ideXlab platform.
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Nerve function in galactosaemic rats: effects of evening Primrose Oil and doxazosin
European Journal of Pharmacology, 1995Co-Authors: K. C. Dines, Mary A. Cotter, Norman E. CameronAbstract:Rats were fed for 6 weeks with a 40% galactose diet to chronically stimulate the polyol pathway. Sciatic motor and saphenous sensory nerve conduction velocity deficits of 22% and 14% respectively developed. Treatment with evening Primrose Oil or doxazosin from galactosaemia induction partially (approximately 60%) prevented the development of reduced motor and sensory conduction, the former treatment being more successful than the latter. Sciatic nerve resistance to hypoxic conduction failure was 49% increased by galactosaemia. This abnormality was 27% and 43% prevented by doxazosin and evening Primrose Oil respectively. Galactosaemic sciatic nerves had a 10% increase in water content and endoneurial capillary density was 24% reduced. While neither treatment affected water content, both caused angiogenesis, elevating capillary density by approximately 16%. The data support the hypothesis that, as in experimental diabetes mellitus, the main effect of polyol pathway activation on peripheral nerve function occurs indirectly via a neurovascular action.
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the effects of evening Primrose Oil on nerve function and capillarization in streptozotocin diabetic rats modulation by the cyclo oxygenase inhibitor flurbiprofen
British Journal of Pharmacology, 1993Co-Authors: Norman E. Cameron, Mary A. Cotter, K. C. Dines, S. Robertson, Dominic CoxAbstract:1 The aims of this study were first, to examine whether deficits in nerve conduction in streptozotocin-diabetic rats could be reversed by a 10% dietary supplement of evening Primrose Oil. Second, to determine the time-course of reversal, and third, to assess whether the effects could be blocked by the cylco-oxygenase inhibitor flurbiprofen (5 mg kg−1 day−1). 2 One-month diabetes produced 20% and 15% deficits in sciatic motor and saphenous sensory conduction velocity respectively, which were maintained over 2 months diabetes. 3 The effect of 1-month evening Primrose Oil treatment on abnormalities caused by an initial month of untreated diabetes was examined. Motor and sensory nerve conduction velocity were restored to the non-diabetic level. 4 Resistance to hypoxic conduction failure was investigated for sciatic nerve trunk in vitro. The 80% conduction failure times were 29% and 55% prolonged by 1- and 2-month diabetes respectively. Evening Primrose Oil did not reverse the increased hypoxic resistance following 1-month untreated diabetes. 5 Sciatic nerve endoneurial capillary density was not significantly affected by diabetes, but was 16% increased in diabetic rats with reversal by evening Primrose Oil treatment for 1 month compared to 2-month untreated diabetes. 6 Serial motor conduction velocity measurement after 3-month untreated diabetes revealed complete normalization by evening Primrose Oil within 4 days. Cessation of treatment resulted in a rapid decline in conduction velocity over 24 h. 7 In a preventive study of 2-month duration, 6 groups of rats were used. These comprised non-diabetic controls, diabetic rats, and evening Primrose Oil-treated diabetic rats, both with and without flurbiprofen treatment. Flurbiprofen had no significant effect in non-diabetic rats, but produced an 11% worsening of motor conduction velocity and a 21% reduction of sciatic capillary density in diabetic rats. Evening Primrose Oil prevented the decreases in conduction velocity and increased hypoxic resistance with diabetes, and caused a 23% increase in capillary density. Flurbiprofen completely blocked the effect of evening Primrose Oil on conduction velocity, resistance to hypoxia, and capillarization. 8 Six main conclusions were reached. First, evening Primrose Oil rapidly reverses conduction deficits in diabetic rats. Second, the effects of treatment may be very short-lived, suggesting a primary metabolic action. Third, evening Primrose Oil cannot reverse established changes in hypoxic resistance over 1-month treatment. Fourth, long-term treatment causes angiogenesis, suggesting a vascular action. Fifth, products of cyclo-oxygenase-mediated metabolism are necessary for maintaining vasa nervorum integrity in diabetic rats. Sixth, evening Primrose Oil probably acts by providing substrate for vasodilator prostanoid synthesis by vasa nervorum.
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The effects of evening Primrose Oil on nerve function and capillarization in streptozotocin‐diabetic rats: modulation by the cyclo‐oxygenase inhibitor flurbiprofen
British Journal of Pharmacology, 1993Co-Authors: Norman E. Cameron, Mary A. Cotter, K. C. Dines, S. Robertson, Dominic CoxAbstract:1 The aims of this study were first, to examine whether deficits in nerve conduction in streptozotocin-diabetic rats could be reversed by a 10% dietary supplement of evening Primrose Oil. Second, to determine the time-course of reversal, and third, to assess whether the effects could be blocked by the cylco-oxygenase inhibitor flurbiprofen (5 mg kg−1 day−1). 2 One-month diabetes produced 20% and 15% deficits in sciatic motor and saphenous sensory conduction velocity respectively, which were maintained over 2 months diabetes. 3 The effect of 1-month evening Primrose Oil treatment on abnormalities caused by an initial month of untreated diabetes was examined. Motor and sensory nerve conduction velocity were restored to the non-diabetic level. 4 Resistance to hypoxic conduction failure was investigated for sciatic nerve trunk in vitro. The 80% conduction failure times were 29% and 55% prolonged by 1- and 2-month diabetes respectively. Evening Primrose Oil did not reverse the increased hypoxic resistance following 1-month untreated diabetes. 5 Sciatic nerve endoneurial capillary density was not significantly affected by diabetes, but was 16% increased in diabetic rats with reversal by evening Primrose Oil treatment for 1 month compared to 2-month untreated diabetes. 6 Serial motor conduction velocity measurement after 3-month untreated diabetes revealed complete normalization by evening Primrose Oil within 4 days. Cessation of treatment resulted in a rapid decline in conduction velocity over 24 h. 7 In a preventive study of 2-month duration, 6 groups of rats were used. These comprised non-diabetic controls, diabetic rats, and evening Primrose Oil-treated diabetic rats, both with and without flurbiprofen treatment. Flurbiprofen had no significant effect in non-diabetic rats, but produced an 11% worsening of motor conduction velocity and a 21% reduction of sciatic capillary density in diabetic rats. Evening Primrose Oil prevented the decreases in conduction velocity and increased hypoxic resistance with diabetes, and caused a 23% increase in capillary density. Flurbiprofen completely blocked the effect of evening Primrose Oil on conduction velocity, resistance to hypoxia, and capillarization. 8 Six main conclusions were reached. First, evening Primrose Oil rapidly reverses conduction deficits in diabetic rats. Second, the effects of treatment may be very short-lived, suggesting a primary metabolic action. Third, evening Primrose Oil cannot reverse established changes in hypoxic resistance over 1-month treatment. Fourth, long-term treatment causes angiogenesis, suggesting a vascular action. Fifth, products of cyclo-oxygenase-mediated metabolism are necessary for maintaining vasa nervorum integrity in diabetic rats. Sixth, evening Primrose Oil probably acts by providing substrate for vasodilator prostanoid synthesis by vasa nervorum.
