The Experts below are selected from a list of 49800 Experts worldwide ranked by ideXlab platform
Andreas Witt - One of the best experts on this subject based on the ideXlab platform.
-
Distribution of Sensory Nerve endings around the human sinus tarsi: a cadaver study.
Journal of Anatomy, 2014Co-Authors: Susanne Rein, Suzanne Manthey, Hans Zwipp, Andreas WittAbstract:: The aim of this study was to analyse the pattern of Sensory Nerve endings and blood vessels around the sinus tarsi. The superficial and deep parts of the fat pads at the inferior extensor retinaculum (IER) as well as the subtalar joint capsule inside the sinus tarsi from 13 cadaver feet were dissected. The distribution of the Sensory Nerve endings and blood vessels were analysed in the resected specimens as the number per cm(2) after staining with haematoxylin-eosin, S100 protein, low-affinity neurotrophin receptor p75, and protein gene product 9.5 using the classification of Freeman and Wyke. Free Nerve endings were the predominant Sensory ending (P
-
Distribution of Sensory Nerve endings around the human sinus tarsi: a cadaver study.
Journal of Anatomy, 2014Co-Authors: Susanne Rein, Suzanne Manthey, Hans Zwipp, Andreas WittAbstract:The aim of this study was to analyse the pattern of Sensory Nerve endings and blood vessels around the sinus tarsi. The superficial and deep parts of the fat pads at the inferior extensor retinaculum (IER) as well as the subtalar joint capsule inside the sinus tarsi from 13 cadaver feet were dissected. The distribution of the Sensory Nerve endings and blood vessels were analysed in the resected specimens as the number per cm(2) after staining with haematoxylin-eosin, S100 protein, low-affinity neurotrophin receptor p75, and protein gene product 9.5 using the classification of Freeman and Wyke. Free Nerve endings were the predominant Sensory ending (P
Susan E. Mackinnon - One of the best experts on this subject based on the ideXlab platform.
-
the impact of motor and Sensory Nerve architecture on Nerve regeneration
Experimental Neurology, 2008Co-Authors: Arash Moradzadeh, Gregory H. Borschel, Janina P. Luciano, Elizabeth L. Whitlock, Ayato Hayashi, Daniel A. Hunter, Susan E. MackinnonAbstract:Sensory Nerve autografting is the standard of care for injuries resulting in a Nerve gap. Recent work demonstrates superior regeneration with motor Nerve grafts. Improved regeneration with motor grafting may be a result of the Nerve's Schwann cell basal lamina tube size. Motor Nerves have larger SC basal lamina tubes, which may allow more Nerve fibers to cross a Nerve graft repair. Architecture may partially explain the suboptimal clinical results seen with Sensory Nerve grafting techniques. To define the role of Nerve architecture, we evaluated regeneration through acellular motor and Sensory Nerve grafts. Thirty-six Lewis rats underwent tibial Nerve repairs with 5 mm double-cable motor or triple-cable Sensory Nerve isografts. Grafts were harvested and acellularized in University of Wisconsin solution. Control animals received fresh motor or Sensory cable isografts. Nerves were harvested after 4 weeks and histomorphometry was performed. In 6 animals per group from the fresh motor and Sensory cable graft groups, weekly walking tracks and wet muscle mass ratios were performed at 7 weeks. Histomorphometry revealed more robust Nerve regeneration in both acellular and cellular motor grafts. Sensory groups showed poor regeneration with significantly decreased percent Nerve, fiber count, and density (p<0.05). Walking tracks revealed a trend toward improved functional recovery in the motor group. Gastrocnemius wet muscle mass ratios show a significantly greater muscle mass recovery in the motor group (p<0.05). Nerve architecture (size of SC basal lamina tubes) plays an important role in Nerve regeneration in a mixed Nerve gap model.
-
The Impact of Motor and Sensory Nerve Architecture on Nerve Regeneration
Experimental neurology, 2008Co-Authors: Arash Moradzadeh, Gregory H. Borschel, Janina P. Luciano, Elizabeth L. Whitlock, Ayato Hayashi, Daniel A. Hunter, Susan E. MackinnonAbstract:Sensory Nerve autografting is the standard of care for injuries resulting in a Nerve gap. Recent work demonstrates superior regeneration with motor Nerve grafts. Improved regeneration with motor grafting may be a result of the Nerve's Schwann cell basal lamina tube size. Motor Nerves have larger SC basal lamina tubes, which may allow more Nerve fibers to cross a Nerve graft repair. Architecture may partially explain the suboptimal clinical results seen with Sensory Nerve grafting techniques. To define the role of Nerve architecture, we evaluated regeneration through acellular motor and Sensory Nerve grafts. Thirty-six Lewis rats underwent tibial Nerve repairs with 5 mm double-cable motor or triple-cable Sensory Nerve isografts. Grafts were harvested and acellularized in University of Wisconsin solution. Control animals received fresh motor or Sensory cable isografts. Nerves were harvested after 4 weeks and histomorphometry was performed. In 6 animals per group from the fresh motor and Sensory cable graft groups, weekly walking tracks and wet muscle mass ratios were performed at 7 weeks. Histomorphometry revealed more robust Nerve regeneration in both acellular and cellular motor grafts. Sensory groups showed poor regeneration with significantly decreased percent Nerve, fiber count, and density (p
-
Reinnervation of distal Sensory Nerve environments by regenerating Sensory axons
Neuroscience, 1992Co-Authors: Susan E. Mackinnon, A.l. DellonAbstract:Abstract This study investigated the specificity of Sensory Nerve regeneration in a primate model. In adult cynomolgus monkeys, the femoral Nerve was explored in the groin and two Sensory branches identified. A Sensory branch was sectioned and introduced into the proximal channel of a Y-shaped silicone chamber. This proximal Sensory Nerve stump was given distal choices of distal Sensory Nerve graft or distal Sensory Nerve which was intact to the distal Sensory cutaneous receptors. After eight months, histological analysis confirmed axonal growth directed towards both the distal Nerve graft and the distal Nerve intact to the distal cutaneous receptors. However, the number of Nerve fibres directed towards the distal Nerve was significantly greater than the number of Nerve fibres directed towards the Nerve graft ( P These results suggest that while both distal Nerve graft and distal intact Nerve act as specific targets to regenerating proximal primate Nerve, the presence of an intact distal end-organ positively enhances Sensory regeneration.
Susanne Rein - One of the best experts on this subject based on the ideXlab platform.
-
Distribution of Sensory Nerve endings around the human sinus tarsi: a cadaver study.
Journal of Anatomy, 2014Co-Authors: Susanne Rein, Suzanne Manthey, Hans Zwipp, Andreas WittAbstract:: The aim of this study was to analyse the pattern of Sensory Nerve endings and blood vessels around the sinus tarsi. The superficial and deep parts of the fat pads at the inferior extensor retinaculum (IER) as well as the subtalar joint capsule inside the sinus tarsi from 13 cadaver feet were dissected. The distribution of the Sensory Nerve endings and blood vessels were analysed in the resected specimens as the number per cm(2) after staining with haematoxylin-eosin, S100 protein, low-affinity neurotrophin receptor p75, and protein gene product 9.5 using the classification of Freeman and Wyke. Free Nerve endings were the predominant Sensory ending (P
-
Distribution of Sensory Nerve endings around the human sinus tarsi: a cadaver study.
Journal of Anatomy, 2014Co-Authors: Susanne Rein, Suzanne Manthey, Hans Zwipp, Andreas WittAbstract:The aim of this study was to analyse the pattern of Sensory Nerve endings and blood vessels around the sinus tarsi. The superficial and deep parts of the fat pads at the inferior extensor retinaculum (IER) as well as the subtalar joint capsule inside the sinus tarsi from 13 cadaver feet were dissected. The distribution of the Sensory Nerve endings and blood vessels were analysed in the resected specimens as the number per cm(2) after staining with haematoxylin-eosin, S100 protein, low-affinity neurotrophin receptor p75, and protein gene product 9.5 using the classification of Freeman and Wyke. Free Nerve endings were the predominant Sensory ending (P
Rajna Ogrin - One of the best experts on this subject based on the ideXlab platform.
-
The use of Sensory Nerve stimulation and compression bandaging to improve Sensory Nerve function and healing of chronic venous leg ulcers
Current aging science, 2009Co-Authors: Rajna Ogrin, Peteris Darzins, Zeinab KhalilAbstract:Low frequency transcutaneous Sensory Nerve stimulation (LF-SNS) [International Patent PCT/AU2004/001079:“Nerve function and tissue healing” (Khalil, Z.)] improves Sensory Nerve function and accelerates wound healing of older animals. Intervention: Double blind, placebo controlled randomised trial of LF-SNS for 5 minutes, twice daily for up to 12 weeks, on healing of chronic venous leg ulcers in older people. Four layer compression bandaging was the standard therapy. Outcome measures (methods): Wound healing and the rate of epithelialisation (calculated from serial wound area estimation), microvascular blood flow (measured using LASER Doppler flowmetry), transcutaneous oxygen tension (measured using a transcutaneous oxygen monitor, TCM Radiometer). Sensory Nerve activity (assessed via measuring electrical cutaneous perception threshold using the Neurometer®CPT and the flare response to 5% capsaicin (a selective activator of C fibres). Participants: 14 older people with chronic venous ulcers randomly allocated to active (mean age 74.8±2.3 years) and 15 to Sham Nerve stimulation (mean age 76.5±2.6 years). Results: Microvascular blood flow improved in all participants. A high proportion of wounds healed (∼ 60%). There were trends for better C-fibre function and faster healing rates in the Active group (1.1±0.3 cm2/wk) compared to the Sham group (0.6±0.2 cm2/wk) but failed to reach statistical significance due to the small sample size. Conclusions: The improvement in microvascular blood flow in both groups was an unexpected finding that has not previously been described. Most likely this was due to the four layer compression bandaging provided to all participants. Improved microvascular blood flow may be a significant contributor to wound healing. The observed trends to increased healing rates and improvements in C-fibre function in the actively stimulated group compared to the sham group warrant further studies of LF-SNS as an adjunct therapy for chronic venous leg ulcers. An exploration of the possibility that LFSNS induced-improvement in C-fibre function could protect against future ulceration is also warranted.
-
The effect of Sensory Nerve stimulation on Sensory Nerve function in people with peripheral neuropathy associated with diabetes.
Neurological research, 2007Co-Authors: Zeinab Khalil, Rajna Ogrin, Peteris DarzinsAbstract:Abstract Objective: To assess the effect of Sensory Nerve stimulation in older people with peripheral neuropathy associated with diabetes (DPN). Materials and methods: A randomized, placebo controlled, double blind trial was used to assess the effect of 12 weeks of low frequency Sensory Nerve stimulation (LF-SNS) in the lower limb [International Patent Application No. PCT/AU2004/001079: 'Nerve function and tissue healing' (Z. Khalil)]. Response to capsaicin, basal microvascular blood flow, electric cutaneous threshold and oxygen tension were assessed pre- and post-treatment and between limbs. Participants: People 55 years of age or older diagnosed with DPN: 35 active and 31 placebo participants. Results: Between groups comparisons: no significant differences occurred between stimulation groups. Within subject comparisons: in the active LF-SNS group, comparing stimulated to contralateral legs, there were significant increases in size of capsaicin flare [t(1,33)=3.65, p
-
Use of the Sensory Nerve stimulator to accelerate healing of a venous leg ulcer with Sensory Nerve dysfunction: a case study
International wound journal, 2005Co-Authors: Rajna Ogrin, Peteris Darzins, Zainab KhalilAbstract:A new therapy using Sensory Nerve stimulation [International Patent Application Number PCT/AU2004/001079: "Nerve function and tissue healing" (Khalil, Z)] has been developed in our vascular physiology laboratory. This treatment has been found to improve the deficient Sensory Nerve function and associated deficient wound healing of older persons to levels seen in young people. An 82-year-old man with a small but persistent venous leg ulcer for 18 months, despite apparently appropriate wound dressings and compression therapy, was seen in a specialist wound management service. The patient's Sensory and microvascular function was assessed in great detail using the vascular physiology laboratory techniques, and he was provided the Sensory Nerve stimulation therapy in addition to conventional therapy. His wound healed after 4 weeks. We report the case here. Prior to Nerve stimulation therapy, cutaneous sensation, microvascular blood flow and oxygen tension were found to be reduced near the ulcer when compared with the opposite, non ulcerated leg. After therapy, oxygen tension and microvascular blood flow had improved. This case provides further evidence that Sensory Nerve stimulation therapy at the stipulated parameters improves wound healing. The observation that Sensory Nerve function improved provides support for the notion that improvement in healing is mediated by improved Nerve function.
Zainab Khalil - One of the best experts on this subject based on the ideXlab platform.
-
Use of the Sensory Nerve stimulator to accelerate healing of a venous leg ulcer with Sensory Nerve dysfunction: a case study
International wound journal, 2005Co-Authors: Rajna Ogrin, Peteris Darzins, Zainab KhalilAbstract:A new therapy using Sensory Nerve stimulation [International Patent Application Number PCT/AU2004/001079: "Nerve function and tissue healing" (Khalil, Z)] has been developed in our vascular physiology laboratory. This treatment has been found to improve the deficient Sensory Nerve function and associated deficient wound healing of older persons to levels seen in young people. An 82-year-old man with a small but persistent venous leg ulcer for 18 months, despite apparently appropriate wound dressings and compression therapy, was seen in a specialist wound management service. The patient's Sensory and microvascular function was assessed in great detail using the vascular physiology laboratory techniques, and he was provided the Sensory Nerve stimulation therapy in addition to conventional therapy. His wound healed after 4 weeks. We report the case here. Prior to Nerve stimulation therapy, cutaneous sensation, microvascular blood flow and oxygen tension were found to be reduced near the ulcer when compared with the opposite, non ulcerated leg. After therapy, oxygen tension and microvascular blood flow had improved. This case provides further evidence that Sensory Nerve stimulation therapy at the stipulated parameters improves wound healing. The observation that Sensory Nerve function improved provides support for the notion that improvement in healing is mediated by improved Nerve function.
