The Experts below are selected from a list of 7791 Experts worldwide ranked by ideXlab platform
Philip Demokritou - One of the best experts on this subject based on the ideXlab platform.
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Nanoparticle exposures from nano-enabled toner-based Printing Equipment and human health: state of science and future research needs
Critical reviews in toxicology, 2017Co-Authors: Sandra V. Pirela, John Martin, Dhimiter Bello, Philip DemokritouAbstract:AbstractToner formulations used by laser printers (LP) and photocopiers (PC), collectively called “toner-based Printing Equipment” (TPE), are nano-enabled products (NEP) because they contain several engineered nanomaterials (ENM) that improve toner performance. It has been shown that during consumer use (Printing), these ENM are released in the air, together with other semi-volatile organic nanoparticles, and newly formed gaseous co-pollutants such as volatile organic compounds (VOC). The aim of this review is to detail and analyze physico-chemical and morphological (PCM), as well as the toxicological properties of particulate matter (PM) emissions from TPE. The review covers evolution of science since the early 2000, when this Printing technology first became a subject of public interest, as well as the lagging regulatory framework around it. Important studies that have significantly changed our understanding of these exposures are also highlighted. The review continues with a critical appraisal of the m...
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effects of laser printer emitted engineered nanoparticles on cytotoxicity chemokine expression reactive oxygen species dna methylation and dna damage a comprehensive in vitro analysis in human small airway epithelial cells macrophages and lymphoblast
Environmental Health Perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Xiaoyan Lu, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Effects of Laser Printer–Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymp
Environmental health perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model
Nanotoxicology, 2014Co-Authors: Jennifer D. Sisler, Sandra V. Pirela, Philip Demokritou, Vincent Castranova, Sherri Friend, Mariana T. Farcas, Diane Schwegler-berry, Anna A. Shvedova, Yong QianAbstract:AbstractThe printer is one of the most common office Equipment. Recently, it was reported that toner formulations for Printing Equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during Printing. To date, insufficient research has been performed to understand the potential toxicological properties of printer-emitted particles (PEPs) with several studies using bulk toner particles as test particles. These studies demonstrated the ability of toner particles to cause chronic inflammation and fibrosis in animal models. However, the toxicological implications of inhalation exposures to ENMs emitted from laser Printing Equipment remain largely unknown. The present study investigates the toxicological effects of PEPs using an in vitro alveolar-capillary co-culture model with Human Small Airway Epithelial Cells (SAEC) and Human Microvascular Endothelial Cells (HMVEC). Our data demonstrate that direct exposure of SAEC to low concentrations of PEPs (0.5...
Sandra V. Pirela - One of the best experts on this subject based on the ideXlab platform.
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Nanoparticle exposures from nano-enabled toner-based Printing Equipment and human health: state of science and future research needs
Critical reviews in toxicology, 2017Co-Authors: Sandra V. Pirela, John Martin, Dhimiter Bello, Philip DemokritouAbstract:AbstractToner formulations used by laser printers (LP) and photocopiers (PC), collectively called “toner-based Printing Equipment” (TPE), are nano-enabled products (NEP) because they contain several engineered nanomaterials (ENM) that improve toner performance. It has been shown that during consumer use (Printing), these ENM are released in the air, together with other semi-volatile organic nanoparticles, and newly formed gaseous co-pollutants such as volatile organic compounds (VOC). The aim of this review is to detail and analyze physico-chemical and morphological (PCM), as well as the toxicological properties of particulate matter (PM) emissions from TPE. The review covers evolution of science since the early 2000, when this Printing technology first became a subject of public interest, as well as the lagging regulatory framework around it. Important studies that have significantly changed our understanding of these exposures are also highlighted. The review continues with a critical appraisal of the m...
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effects of laser printer emitted engineered nanoparticles on cytotoxicity chemokine expression reactive oxygen species dna methylation and dna damage a comprehensive in vitro analysis in human small airway epithelial cells macrophages and lymphoblast
Environmental Health Perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Xiaoyan Lu, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Effects of Laser Printer–Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymp
Environmental health perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model
Nanotoxicology, 2014Co-Authors: Jennifer D. Sisler, Sandra V. Pirela, Philip Demokritou, Vincent Castranova, Sherri Friend, Mariana T. Farcas, Diane Schwegler-berry, Anna A. Shvedova, Yong QianAbstract:AbstractThe printer is one of the most common office Equipment. Recently, it was reported that toner formulations for Printing Equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during Printing. To date, insufficient research has been performed to understand the potential toxicological properties of printer-emitted particles (PEPs) with several studies using bulk toner particles as test particles. These studies demonstrated the ability of toner particles to cause chronic inflammation and fibrosis in animal models. However, the toxicological implications of inhalation exposures to ENMs emitted from laser Printing Equipment remain largely unknown. The present study investigates the toxicological effects of PEPs using an in vitro alveolar-capillary co-culture model with Human Small Airway Epithelial Cells (SAEC) and Human Microvascular Endothelial Cells (HMVEC). Our data demonstrate that direct exposure of SAEC to low concentrations of PEPs (0.5...
Yong Qian - One of the best experts on this subject based on the ideXlab platform.
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effects of laser printer emitted engineered nanoparticles on cytotoxicity chemokine expression reactive oxygen species dna methylation and dna damage a comprehensive in vitro analysis in human small airway epithelial cells macrophages and lymphoblast
Environmental Health Perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Xiaoyan Lu, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Effects of Laser Printer–Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymp
Environmental health perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model
Nanotoxicology, 2014Co-Authors: Jennifer D. Sisler, Sandra V. Pirela, Philip Demokritou, Vincent Castranova, Sherri Friend, Mariana T. Farcas, Diane Schwegler-berry, Anna A. Shvedova, Yong QianAbstract:AbstractThe printer is one of the most common office Equipment. Recently, it was reported that toner formulations for Printing Equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during Printing. To date, insufficient research has been performed to understand the potential toxicological properties of printer-emitted particles (PEPs) with several studies using bulk toner particles as test particles. These studies demonstrated the ability of toner particles to cause chronic inflammation and fibrosis in animal models. However, the toxicological implications of inhalation exposures to ENMs emitted from laser Printing Equipment remain largely unknown. The present study investigates the toxicological effects of PEPs using an in vitro alveolar-capillary co-culture model with Human Small Airway Epithelial Cells (SAEC) and Human Microvascular Endothelial Cells (HMVEC). Our data demonstrate that direct exposure of SAEC to low concentrations of PEPs (0.5...
Vincent Castranova - One of the best experts on this subject based on the ideXlab platform.
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effects of laser printer emitted engineered nanoparticles on cytotoxicity chemokine expression reactive oxygen species dna methylation and dna damage a comprehensive in vitro analysis in human small airway epithelial cells macrophages and lymphoblast
Environmental Health Perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Xiaoyan Lu, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Effects of Laser Printer–Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymp
Environmental health perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model
Nanotoxicology, 2014Co-Authors: Jennifer D. Sisler, Sandra V. Pirela, Philip Demokritou, Vincent Castranova, Sherri Friend, Mariana T. Farcas, Diane Schwegler-berry, Anna A. Shvedova, Yong QianAbstract:AbstractThe printer is one of the most common office Equipment. Recently, it was reported that toner formulations for Printing Equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during Printing. To date, insufficient research has been performed to understand the potential toxicological properties of printer-emitted particles (PEPs) with several studies using bulk toner particles as test particles. These studies demonstrated the ability of toner particles to cause chronic inflammation and fibrosis in animal models. However, the toxicological implications of inhalation exposures to ENMs emitted from laser Printing Equipment remain largely unknown. The present study investigates the toxicological effects of PEPs using an in vitro alveolar-capillary co-culture model with Human Small Airway Epithelial Cells (SAEC) and Human Microvascular Endothelial Cells (HMVEC). Our data demonstrate that direct exposure of SAEC to low concentrations of PEPs (0.5...
Dhimiter Bello - One of the best experts on this subject based on the ideXlab platform.
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Nanoparticle exposures from nano-enabled toner-based Printing Equipment and human health: state of science and future research needs
Critical reviews in toxicology, 2017Co-Authors: Sandra V. Pirela, John Martin, Dhimiter Bello, Philip DemokritouAbstract:AbstractToner formulations used by laser printers (LP) and photocopiers (PC), collectively called “toner-based Printing Equipment” (TPE), are nano-enabled products (NEP) because they contain several engineered nanomaterials (ENM) that improve toner performance. It has been shown that during consumer use (Printing), these ENM are released in the air, together with other semi-volatile organic nanoparticles, and newly formed gaseous co-pollutants such as volatile organic compounds (VOC). The aim of this review is to detail and analyze physico-chemical and morphological (PCM), as well as the toxicological properties of particulate matter (PM) emissions from TPE. The review covers evolution of science since the early 2000, when this Printing technology first became a subject of public interest, as well as the lagging regulatory framework around it. Important studies that have significantly changed our understanding of these exposures are also highlighted. The review continues with a critical appraisal of the m...
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effects of laser printer emitted engineered nanoparticles on cytotoxicity chemokine expression reactive oxygen species dna methylation and dna damage a comprehensive in vitro analysis in human small airway epithelial cells macrophages and lymphoblast
Environmental Health Perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Xiaoyan Lu, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...
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Effects of Laser Printer–Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymp
Environmental health perspectives, 2015Co-Authors: Sandra V. Pirela, Dhimiter Bello, Isabelle R Miousse, Vincent Castranova, Treye A Thomas, Yong Qian, Lester Kobzik, Igor Koturbash, Philip DemokritouAbstract:BackgroundEngineered nanomaterials (ENMs) incorporated into toner formulations of Printing Equipment become airborne during consumer use. Although information on the complex physicochemical and tox...