The Experts below are selected from a list of 206517 Experts worldwide ranked by ideXlab platform
Jinghong Li - One of the best experts on this subject based on the ideXlab platform.
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Nanomaterials in carbohydrate biosensors
Trends in Analytical Chemistry, 2014Co-Authors: Yangzhong Wang, Ke Qu, Xiangqun Zeng, Longhua Tang, Eric Moore, Z. Z. Li, Jinghong LiAbstract:Abstract Nanomaterials have received much attention for their fascinating catalytic activity, large surface area, and excellent photonic and electronic features. These characteristic properties have been used to improve the sensitivity and the specificity of biosensors. This article reviews Nanomaterials, including metal nanoparticles (NPs), carbon materials, quantum dots, magnetic NPs and silicon NPs, and evaluates their different functions when applied to the construction of carbohydrate biosensors. Furthermore, we discuss specialized Nanomaterials, e.g., photo-to-electron conversion Nanomaterials, upconverting NPs, composite Nanomaterials and nanopores. Finally, we present applications of nanomaterial-based carbohydrate biosensors, including profiling of carbohydrate-lectin interaction, cancer-cell and pathogen detection, and glycosylation analysis.
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Nanomaterials in carbohydrate biosensors
TrAC - Trends in Analytical Chemistry, 2014Co-Authors: Yangzhong Wang, Ke Qu, Yixiong Liu, Zhaolong Li, Xiangqun Zeng, Longhua Tang, Eric Moore, Jinghong LiAbstract:Nanomaterials have received much attention for their fascinating catalytic activity, large surface area, and excellent photonic and electronic features. These characteristic properties have been used to improve the sensitivity and the specificity of biosensors. This article reviews Nanomaterials, including metal nanoparticles (NPs), carbon materials, quantum dots, magnetic NPs and silicon NPs, and evaluates their different functions when applied to the construction of carbohydrate biosensors. Furthermore, we discuss specialized Nanomaterials, e.g., photo-to-electron conversion Nanomaterials, upconverting NPs, composite Nanomaterials and nanopores. Finally, we present applications of nanomaterial-based carbohydrate biosensors, including profiling of carbohydrate-lectin interaction, cancer-cell and pathogen detection, and glycosylation analysis. © 2014 Elsevier Ltd.
Eric M.v. Hoek - One of the best experts on this subject based on the ideXlab platform.
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a review of the antibacterial effects of silver Nanomaterials and potential implications for human health and the environment
Journal of Nanoparticle Research, 2010Co-Authors: Catalina Marambiojones, Eric M.v. HoekAbstract:Here, we present a review of the antibacterial effects of silver Nanomaterials, including proposed antibacterial mechanisms and possible toxicity to higher organisms. For purpose of this review, silver Nanomaterials include silver nanoparticles, stabilized silver salts, silver–dendrimer, polymer and metal oxide composites, and silver-impregnated zeolite and activated carbon materials. While there is some evidence that silver nanoparticles can directly damage bacteria cell membranes, silver Nanomaterials appear to exert bacteriocidal activity predominantly through release of silver ions followed (individually or in combination) by increased membrane permeability, loss of the proton motive force, inducing de-energization of the cells and efflux of phosphate, leakage of cellular content, and disruption DNA replication. Eukaryotic cells could be similarly impacted by most of these mechanisms and, indeed, a small but growing body of literature supports this concern. Most antimicrobial studies are performed in simple aquatic media or cell culture media without proper characterization of silver nanomaterial stability (aggregation, dissolution, and re-precipitation). Silver nanoparticle stability is governed by particle size, shape, and capping agents as well as solution pH, ionic strength, specific ions and ligands, and organic macromolecules—all of which influence silver nanoparticle stability and bioavailability. Although none of the studies reviewed definitively proved any immediate impacts to human health or the environment by a silver nanomaterial containing product, the entirety of the science reviewed suggests some caution and further research are warranted given the already widespread and rapidly growing use of silver Nanomaterials.
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Understanding biophysicochemical interactions at the nano-bio interface
Nature Materials, 2009Co-Authors: Andre E. Nel, Darrell Velegol, Tian Xia, Fred Klaessig, Eric M.v. Hoek, Ponisseril Somasundaran, Lutz Madler, Vincent Castranova, Mike ThompsonAbstract:Rapid growth in nanotechnology is increasing the likelihood of engineered Nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of Nanomaterials.
Taihong Wang - One of the best experts on this subject based on the ideXlab platform.
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Nanomaterials for electrochemical non enzymatic glucose biosensors
RSC Advances, 2013Co-Authors: Peng Si, Youju Huang, Taihong WangAbstract:This review overviews the recent development of Nanomaterials for the application of electrochemical non-enzymatic glucose biosensors. The electrocatalytic mechanism and glucose sensing performance of a variety of nanostructured materials including metallic nanoparticles, metal oxides, metal complexes, alloys and carbon Nanomaterials are discussed. The merits and shortfalls of each nanomaterial as electrocatalyst for non-enzymatic biosensing are evaluated and the prospects of non-enzymatic glucose biosensors are presented.
Jianbin Zheng - One of the best experts on this subject based on the ideXlab platform.
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Recent progress in electrochemical sensing of cardiac troponin by using nanomaterial-induced signal amplification
Microchimica Acta, 2017Co-Authors: Qinglin Sheng, Xiujuan Qiao, Ming Zhou, Jianbin ZhengAbstract:Cardiac troponin (cTn) is a specific and sensitive biomarker for diagnosis of myocardial injury. Hence, numerous kinds of biosensors for cTn have been reported. Electrochemical methods possess inherent advantages over other kinds of sensors because they are specific, sensitive, and simple. By combining the advantages of electrochemical biosensors with those of Nanomaterials, some interesting electrochemical biosensor for cTn can be obtained where the Nanomaterials trigger substantial signal amplification. This review (with 101 refs.) summarizes the state of the art in electrochemical biosensing of cTn based on the use of Nanomaterials. Following an introduction into the field, the use of Nanomaterials in electrochemical sensing is briefly discussed. A next section covers strategies for signal amplification by using Nanomaterials, with subsections on the use of nanowires, nanotubes, graphenes, and various other nanoparticles. The article concludes with a discussion of the prospects of nanomaterial-based signal amplification and on future research directions. Graphical abstractIllustration of electrochemical biosensing of cardiac troponin (cTn) with various kinds of Nanomaterials, including nanowires, nanotubes, graphene and nanoparticles, as the signal amplification modules.
Benoit Nemery - One of the best experts on this subject based on the ideXlab platform.
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Do Nanomedicines Require Novel Safety Assessments to Ensure their Safety for Long-Term Human Use?
Drug Safety, 2009Co-Authors: Peter Hoet, Barbara Legiest, Jorina Geys, Benoit NemeryAbstract:Nanomaterials have different chemical, physical and biological characteristics than larger materials of the same chemical composition. These differences give nanotechnology a double identity: their use implies novel and interesting medical and/or industrial applications but also potential danger for human and environmental health. Here, we briefly review the most important types of Nanomaterials, the difficulties in assessing safety or toxicity, and describe existing test protocols used in nanomaterial safety evaluation. In general, the big challenge of nanotechnology, particularly for nanomedicine (nanobioengineering), is to understand which nano-specific characteristics interact with particular biological systems and functions in order to optimize the therapeutic potential and reduce the undesired responses. The evaluation of the safety of medicinal Nanomaterials, especially for long-term application, is an important challenge for the near future. At present, it is still too early to predict, on the basis of the characteristics of the nanomaterial, a possible biological response because no reliable database exists. Therefore, a case-by-case approach for hazard identification is still required, so it is difficult to establish a risk assessment framework.
