The Experts below are selected from a list of 157614 Experts worldwide ranked by ideXlab platform
Hong Jiang - One of the best experts on this subject based on the ideXlab platform.
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metabolomic study of raw and processed atractylodes macrocephala koidz by lc ms
Journal of Pharmaceutical and Biomedical Analysis, 2014Co-Authors: Guoshun Shan, Liangxiao Zhang, Qimiao Zhao, Hongbin Xiao, Rongjie Zhuo, Gang Xu, Hong JiangAbstract:Abstract Bai-Zhu, the dried rhizome of Atractylodes macrocephala Koidz (AMK), is widely used as a tonic herbal in eastern Asia. It is commonly used as prepared slices in clinic by stir-frying with wheat bran (processed AMK). In the theories of traditional Chinese medicine (TCM), Bai-Zhu possesses significantly different therapeutic effects before and after Processing. However, the molecular mechanics of this Processing is still unknown. In this paper, the strategy of metabolomics was employed to investigate the changes of chemical constituents in Atractylodes macrocephala Koidz after Processing. Meanwhile, the cell activity test variation of processed and unprocessed medicine was used to interpret the Processing Mechanism of AMK. Using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC–QTOF/MS) with the method of multivariate statistic analyses including principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA), atractylenolide I, atractylenolide II, atractylenolide III, atractylenolide VI, 7-hydroxycoumarin, 8-β-methoxy atractylenolide I and Selina-4 (14), 7 (11)-dien-8-one were rapidly explored as the potential chemical markers of raw and processed AMK, respectively. Furthermore, it could be speculated that the Processing Mechanism of AMK was to increase the content of atractylenolide III which could strengthen the effect on gastrointestinal function.
Guoshun Shan - One of the best experts on this subject based on the ideXlab platform.
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determination of orcinol glucoside by lc ms in curculigo orchioides and its application to a pharmacokinetic study
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy, 2019Co-Authors: Bonan Liu, Xiaohang Ren, Guoshun Shan, Tianzhu JiaAbstract:Abstract This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-Processing Mechanism.
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metabolomic study of raw and processed atractylodes macrocephala koidz by lc ms
Journal of Pharmaceutical and Biomedical Analysis, 2014Co-Authors: Guoshun Shan, Liangxiao Zhang, Qimiao Zhao, Hongbin Xiao, Rongjie Zhuo, Gang Xu, Hong JiangAbstract:Abstract Bai-Zhu, the dried rhizome of Atractylodes macrocephala Koidz (AMK), is widely used as a tonic herbal in eastern Asia. It is commonly used as prepared slices in clinic by stir-frying with wheat bran (processed AMK). In the theories of traditional Chinese medicine (TCM), Bai-Zhu possesses significantly different therapeutic effects before and after Processing. However, the molecular mechanics of this Processing is still unknown. In this paper, the strategy of metabolomics was employed to investigate the changes of chemical constituents in Atractylodes macrocephala Koidz after Processing. Meanwhile, the cell activity test variation of processed and unprocessed medicine was used to interpret the Processing Mechanism of AMK. Using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC–QTOF/MS) with the method of multivariate statistic analyses including principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA), atractylenolide I, atractylenolide II, atractylenolide III, atractylenolide VI, 7-hydroxycoumarin, 8-β-methoxy atractylenolide I and Selina-4 (14), 7 (11)-dien-8-one were rapidly explored as the potential chemical markers of raw and processed AMK, respectively. Furthermore, it could be speculated that the Processing Mechanism of AMK was to increase the content of atractylenolide III which could strengthen the effect on gastrointestinal function.
Gang Xu - One of the best experts on this subject based on the ideXlab platform.
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metabolomic study of raw and processed atractylodes macrocephala koidz by lc ms
Journal of Pharmaceutical and Biomedical Analysis, 2014Co-Authors: Guoshun Shan, Liangxiao Zhang, Qimiao Zhao, Hongbin Xiao, Rongjie Zhuo, Gang Xu, Hong JiangAbstract:Abstract Bai-Zhu, the dried rhizome of Atractylodes macrocephala Koidz (AMK), is widely used as a tonic herbal in eastern Asia. It is commonly used as prepared slices in clinic by stir-frying with wheat bran (processed AMK). In the theories of traditional Chinese medicine (TCM), Bai-Zhu possesses significantly different therapeutic effects before and after Processing. However, the molecular mechanics of this Processing is still unknown. In this paper, the strategy of metabolomics was employed to investigate the changes of chemical constituents in Atractylodes macrocephala Koidz after Processing. Meanwhile, the cell activity test variation of processed and unprocessed medicine was used to interpret the Processing Mechanism of AMK. Using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC–QTOF/MS) with the method of multivariate statistic analyses including principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA), atractylenolide I, atractylenolide II, atractylenolide III, atractylenolide VI, 7-hydroxycoumarin, 8-β-methoxy atractylenolide I and Selina-4 (14), 7 (11)-dien-8-one were rapidly explored as the potential chemical markers of raw and processed AMK, respectively. Furthermore, it could be speculated that the Processing Mechanism of AMK was to increase the content of atractylenolide III which could strengthen the effect on gastrointestinal function.
Rongjie Zhuo - One of the best experts on this subject based on the ideXlab platform.
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metabolomic study of raw and processed atractylodes macrocephala koidz by lc ms
Journal of Pharmaceutical and Biomedical Analysis, 2014Co-Authors: Guoshun Shan, Liangxiao Zhang, Qimiao Zhao, Hongbin Xiao, Rongjie Zhuo, Gang Xu, Hong JiangAbstract:Abstract Bai-Zhu, the dried rhizome of Atractylodes macrocephala Koidz (AMK), is widely used as a tonic herbal in eastern Asia. It is commonly used as prepared slices in clinic by stir-frying with wheat bran (processed AMK). In the theories of traditional Chinese medicine (TCM), Bai-Zhu possesses significantly different therapeutic effects before and after Processing. However, the molecular mechanics of this Processing is still unknown. In this paper, the strategy of metabolomics was employed to investigate the changes of chemical constituents in Atractylodes macrocephala Koidz after Processing. Meanwhile, the cell activity test variation of processed and unprocessed medicine was used to interpret the Processing Mechanism of AMK. Using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC–QTOF/MS) with the method of multivariate statistic analyses including principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA), atractylenolide I, atractylenolide II, atractylenolide III, atractylenolide VI, 7-hydroxycoumarin, 8-β-methoxy atractylenolide I and Selina-4 (14), 7 (11)-dien-8-one were rapidly explored as the potential chemical markers of raw and processed AMK, respectively. Furthermore, it could be speculated that the Processing Mechanism of AMK was to increase the content of atractylenolide III which could strengthen the effect on gastrointestinal function.
Hongbin Xiao - One of the best experts on this subject based on the ideXlab platform.
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metabolomic study of raw and processed atractylodes macrocephala koidz by lc ms
Journal of Pharmaceutical and Biomedical Analysis, 2014Co-Authors: Guoshun Shan, Liangxiao Zhang, Qimiao Zhao, Hongbin Xiao, Rongjie Zhuo, Gang Xu, Hong JiangAbstract:Abstract Bai-Zhu, the dried rhizome of Atractylodes macrocephala Koidz (AMK), is widely used as a tonic herbal in eastern Asia. It is commonly used as prepared slices in clinic by stir-frying with wheat bran (processed AMK). In the theories of traditional Chinese medicine (TCM), Bai-Zhu possesses significantly different therapeutic effects before and after Processing. However, the molecular mechanics of this Processing is still unknown. In this paper, the strategy of metabolomics was employed to investigate the changes of chemical constituents in Atractylodes macrocephala Koidz after Processing. Meanwhile, the cell activity test variation of processed and unprocessed medicine was used to interpret the Processing Mechanism of AMK. Using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC–QTOF/MS) with the method of multivariate statistic analyses including principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA), atractylenolide I, atractylenolide II, atractylenolide III, atractylenolide VI, 7-hydroxycoumarin, 8-β-methoxy atractylenolide I and Selina-4 (14), 7 (11)-dien-8-one were rapidly explored as the potential chemical markers of raw and processed AMK, respectively. Furthermore, it could be speculated that the Processing Mechanism of AMK was to increase the content of atractylenolide III which could strengthen the effect on gastrointestinal function.