The Experts below are selected from a list of 9657 Experts worldwide ranked by ideXlab platform
James W. Limperos - One of the best experts on this subject based on the ideXlab platform.
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Making sense of 3-D printing: Creating a map of additive manufacturing products and services
Additive Manufacturing, 2014Co-Authors: Brett P. Conner, Ashley N. Martof, Lauren M. Rodomsky, Caitlyn M. Rodomsky, Dakesha C. Jordan, Guha P. Manogharan, James W. LimperosAbstract:Given the attention around additive manufacturing (AM), organizations want to know if their products should be fabricated using AM. To facilitate product development decisions, a reference system is shown describing the key attributes of a product from a manufacturability stand-point: complexity, customization, and Production Volume. Complexity and customization scales enable the grouping of products into regions of the map with common levels of the three attributes. A geometric complexity factor developed for cast parts is modified for a more general application. Parts with varying geometric complexity are then analyzed and mapped into regions of the complexity, customization, and Production Volume model. A discrete set of customization levels are also introduced. Implications for product development and manufacturing business approaches are discussed.
Ronald Rogers - One of the best experts on this subject based on the ideXlab platform.
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HPV Chemical Tests Threaten Small Producers: High costs of testing high-Production-Volume chemicals worry smaller firms
Chemical & Engineering News, 1999Co-Authors: Ronald RogersAbstract:Many small and midsized specialty and custom chemical companies are concerned about the economic and competitive impact of the industry's voluntary program to test high-Production-Volume (HPV) chemicals. Industry experts say that unless changes are made to the program, companies may be forced to quit certain HPV businesses. HPV chemicals are those manufactured in or imported into the U.S. in Volumes of 1 million lb or more per year. The HPV program was set in motion late last year when the Environmental Protection Agency, with the support of the Chemical Manufacturers Association (CMA) and the Environmental Defense Fund, issued an unprecedented challenge to 900 companies in the chemical industry. They announced the HPV Challenge Program, calling for importers and manufacturers of HPV chemicals to volunteer to sponsor—conduct or fund—environmental and health testing for 2,800 HPV chemicals and to make the data available to the public by 2004 (C&EN, Nov. 2,1998, page 19). As of March 15, ...
A. Benson - One of the best experts on this subject based on the ideXlab platform.
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High Production Volume (HPV) Chemicals
Encyclopedia of Toxicology, 2020Co-Authors: S. Nikfar, A.f. Behboudi, J. Van Der Kolk, A. BensonAbstract:Chemicals produced and/or imported in high Volumes are called high Production Volume (HPV) chemicals. HPV chemicals have been identified by governments, industry, and environmental organizations. These chemicals are generally produced in quantities of more than 454 000 kg (1 million pounds) per year (United States) or 100 000 kg (2.2 million pounds) per year (Organisation for Economic Cooperation and Development (OECD) and European Union) and are thought to have a higher potential for human or environmental exposure due to their HPVs. The OECD has developed a voluntary program to accelerate the collection of a standard base set of toxicological and environmental information for these HPV chemicals. The United States has developed national programs to collect, assess, and publish relevant information on the hazards and risks of HPV chemicals. The European Union has chosen a different approach for HPVs in its Registration, Evaluation and Authorization of Chemicals regulation.
P. Brooker - One of the best experts on this subject based on the ideXlab platform.
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HPV : A new era in data-gathering for high Production Volume chemicals
Chimica Oggi-chemistry Today, 1999Co-Authors: P. BrookerAbstract:The next five years will see the gathering of health and environmental data on most if not all of the high Production Volume (HPV) chemicals used today.
Herbert S. Rosenkranz - One of the best experts on this subject based on the ideXlab platform.
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The High Production Volume Chemical Challenge Program : The Rodent LD50 and its Possible Replacement.
Atla-alternatives To Laboratory Animals, 2020Co-Authors: Herbert S. Rosenkranz, Albert R. CunninghamAbstract:The High Production Volume Chemical Challenge Program provides an opportunity to re-examine the usefulness and informational value of tests currently used to obtain preliminary hazard identification data. With a view to assessing the mechanistic information provided by the rodent LD50 test and to ascertain the possibility of replacing it with other more acceptable assays, we used a recently developed approach to determine the relationship of the LD50 assay to other toxicological protocols. Our analyses indicate that, of the assays examined, the LD50 was significantly related to toxicity in cultured cells and to binding at the Ah receptor.
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Estimating the extent of the health hazard posed by high-Production Volume chemicals.
Environmental Health Perspectives, 2001Co-Authors: Albert R. Cunningham, Herbert S. RosenkranzAbstract:We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-Production Volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals.
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The high Production Volume chemical challenge program: the relevance of the in vivo micronucleus assay.
Regulatory Toxicology and Pharmacology, 2000Co-Authors: Herbert S. Rosenkranz, Albert R. CunninghamAbstract:The in vivo rodent bone marrow micronucleus assay (Mnt) has assumed a pivotal role in screening strategies for the identification of substances potentially carcinogenic to humans. The analysis of the results of the current international 5-year effort to provide toxicological data for high Production Volume chemicals will play a crucial role in developing future strategies for identifying health hazards. As part of that program, consideration is being given to accepting either in vitro genotoxicity data or results of the Mnt. The present analyses indicate that for hazard identification purposes that, in fact, in vitro genotoxicity test results, such as those derived from the Salmonella mutagenicity assay, may be an acceptable alternative.
