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Luna, Julio Alberto - One of the best experts on this subject based on the ideXlab platform.
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Progesterone administration in planned reproduction of cattle
Nova Science Publishers, 2017Co-Authors: Helbling, Ignacio Marcelo, Luna, Julio AlbertoAbstract:Cattle constitute one of the most widely used species for animal husbandry. The growing demand for products derived from cattle has led to the development of intensive production systems. These systems require planned breeding of the herd to maintain optimal production Levels. Planned breeding involves estrous cycle control and artificial insemination to assist reproduction. Estrus control is a hormonal treatment that can be performed by following different protocols with the aim of manipulating the reproductive cycle to synchronize estrus in females. Estrus synchronization presents several advantages mainly related to the avoidance of estrus detection and facilitates overall planning, including logistics of artificial insemination, grazing and specific nutrition programs, calving dates, and vaccination schedules. Progesterone plays a major role in estrus cycle control programs. Progesterone Blood Level regulates secretion and patterns of different estrus-inducing hormones and controls follicle and corpus luteum growth and development. Hence, one of the most important step for cycle regulation is the control of Blood Progesterone concentration at required time periods. Typically, the reproductive management strategy includes the administration of an exogenous source of Progesterone to the animal, releasing the hormone at controlled rates to maintain the concentration at supraluteal Levels for a specific period of time. When delivery is disrupted, Progesterone concentration falls below the threshold to subluteal Levels, inducing the beginning of a hormonal-regulated mechanism which will lead to the onset of heat and subsequent ovulation. Several technologies have been developed for Progesterone administration. The most widespread practice is the use of matrices for sustained administration. These matrices are made of polymeric materials and contain the hormone. These polymeric matrices can be manufactured with different geometric shapes and can be placed in different sites of the animal body. Today, intravaginal administration is the main route of administration. Intravaginal devices made of non-biodegradable polymers are the most widely used systems for synchronization purposes. However, some concerns about the nonbiodegradable materials that make up these intravaginal devices and other related inconveniencies promote new research lines. There is a general trend towards simplifying the administration of Progesterone and developing more friendly delivery systems. Strategies include reducing the hormone residue in used devices, reusing devices, the incorporating biodegradable polymeric materials to manufacture the matrices, and simplifying manufacturing processes. In this context, this chapter is intended to point out the importance of both reproduction planning for production animals and the use of Progesterone for estrus cycle control, describing its role, advantages and disadvantages of biodegradable and non-biodegradable delivery devices and future trends in the field of Progesterone delivery.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin
Helbling, Ignacio Marcelo - One of the best experts on this subject based on the ideXlab platform.
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Progesterone administration in planned reproduction of cattle
Nova Science Publishers, 2017Co-Authors: Helbling, Ignacio Marcelo, Luna, Julio AlbertoAbstract:Cattle constitute one of the most widely used species for animal husbandry. The growing demand for products derived from cattle has led to the development of intensive production systems. These systems require planned breeding of the herd to maintain optimal production Levels. Planned breeding involves estrous cycle control and artificial insemination to assist reproduction. Estrus control is a hormonal treatment that can be performed by following different protocols with the aim of manipulating the reproductive cycle to synchronize estrus in females. Estrus synchronization presents several advantages mainly related to the avoidance of estrus detection and facilitates overall planning, including logistics of artificial insemination, grazing and specific nutrition programs, calving dates, and vaccination schedules. Progesterone plays a major role in estrus cycle control programs. Progesterone Blood Level regulates secretion and patterns of different estrus-inducing hormones and controls follicle and corpus luteum growth and development. Hence, one of the most important step for cycle regulation is the control of Blood Progesterone concentration at required time periods. Typically, the reproductive management strategy includes the administration of an exogenous source of Progesterone to the animal, releasing the hormone at controlled rates to maintain the concentration at supraluteal Levels for a specific period of time. When delivery is disrupted, Progesterone concentration falls below the threshold to subluteal Levels, inducing the beginning of a hormonal-regulated mechanism which will lead to the onset of heat and subsequent ovulation. Several technologies have been developed for Progesterone administration. The most widespread practice is the use of matrices for sustained administration. These matrices are made of polymeric materials and contain the hormone. These polymeric matrices can be manufactured with different geometric shapes and can be placed in different sites of the animal body. Today, intravaginal administration is the main route of administration. Intravaginal devices made of non-biodegradable polymers are the most widely used systems for synchronization purposes. However, some concerns about the nonbiodegradable materials that make up these intravaginal devices and other related inconveniencies promote new research lines. There is a general trend towards simplifying the administration of Progesterone and developing more friendly delivery systems. Strategies include reducing the hormone residue in used devices, reusing devices, the incorporating biodegradable polymeric materials to manufacture the matrices, and simplifying manufacturing processes. In this context, this chapter is intended to point out the importance of both reproduction planning for production animals and the use of Progesterone for estrus cycle control, describing its role, advantages and disadvantages of biodegradable and non-biodegradable delivery devices and future trends in the field of Progesterone delivery.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin
Niar Abdellatif - One of the best experts on this subject based on the ideXlab platform.
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Clinical Determination of Bromocriptine 2.5 mg (Parlodel ® ) Induced Ovulation in Atlas Shepherd Bitch
Journal of Veterinary Science & Technology, 2018Co-Authors: Slimani Khaled Mabrouk, Niar AbdellatifAbstract:Eight atlas shepherd bitch tow years old and weighing between 14 and 16 kg have received a heat induction treatment with bromocriptine (Parlodel® 2.5 mg Breakable tablet Box of 30 tablets). The dosage adapted for the dog was 1.25 mg/15 kg body weight per day for a heat induction. The heats were followed from the 5th day of proestrus and during estrus to the canine clinical pathology of veterinary institute Ibn Khaldoun University of Tiaret between January 2014 and January 2015. For the diagnosis of ovulation the vaginal smears and ultrasound of the ovaries were combined with the proportioning of Progesterone. No structural anomaly of ovaries and no genital infection were observed on clinical examination. The aim of this study is: To answer the question: Can Bromocriptine treatment induce ovulatory heat? All bitches (8/8) showed vulvar loss between day 21 and day 40 of Bromocriptine treatment. 89% (7/8) bitches exhibited a significant positive chronological evolution between the Progesterone Blood Level and eosinophilic index and diameter of ovaries in. The ovarian diameter in 100% (8/8) bitches was 19 +/- 2.07 mm at the moment of ovulation.
Slimani Khaled Mabrouk - One of the best experts on this subject based on the ideXlab platform.
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Clinical Determination of Bromocriptine 2.5 mg (Parlodel ® ) Induced Ovulation in Atlas Shepherd Bitch
Journal of Veterinary Science & Technology, 2018Co-Authors: Slimani Khaled Mabrouk, Niar AbdellatifAbstract:Eight atlas shepherd bitch tow years old and weighing between 14 and 16 kg have received a heat induction treatment with bromocriptine (Parlodel® 2.5 mg Breakable tablet Box of 30 tablets). The dosage adapted for the dog was 1.25 mg/15 kg body weight per day for a heat induction. The heats were followed from the 5th day of proestrus and during estrus to the canine clinical pathology of veterinary institute Ibn Khaldoun University of Tiaret between January 2014 and January 2015. For the diagnosis of ovulation the vaginal smears and ultrasound of the ovaries were combined with the proportioning of Progesterone. No structural anomaly of ovaries and no genital infection were observed on clinical examination. The aim of this study is: To answer the question: Can Bromocriptine treatment induce ovulatory heat? All bitches (8/8) showed vulvar loss between day 21 and day 40 of Bromocriptine treatment. 89% (7/8) bitches exhibited a significant positive chronological evolution between the Progesterone Blood Level and eosinophilic index and diameter of ovaries in. The ovarian diameter in 100% (8/8) bitches was 19 +/- 2.07 mm at the moment of ovulation.
Abbas Tafakhori - One of the best experts on this subject based on the ideXlab platform.
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Melatonin as a Potential Prophylactic Therapy for Menstrual-Related Migraine Headache: A Randomized Clinical Trial
Archives of Neuroscience, 2020Co-Authors: Elham Mohammadyahya, Payam Sarraf, Nina Javadian, Mamak Shariat, Sama Bitarafan, Abbas TafakhoriAbstract:Background: Migraine is a common disabling and chronic neurological disorder affecting women aged 25 - 55 with a considerably higher frequency. It has been shown that migraine attack rates change according to the hormonal changes during the menstrual cycle. A study showed that reduced Progesterone Levels, especially during the end days of the luteal phase and menstruation, are associated with increased episodes of attacks in more than half of the migraine patients. Moreover, another study suggested that the melatonin Level changes are positively correlated with the Progesterone Blood Level. Previous studies indicated that the Level of nocturnal urinary melatonin is lower in patients with menstrual-related migraine than in healthy subjects. Objectives: Considering the potential role of melatonin in the circadian system and its relationship with gonadal steroid Blood Level changes in patients, we aimed to investigate the therapeutic efficacy of melatonin in patients with menstrual-related migraines. Methods: An open-label randomized clinical trial was conducted (IR code: IRCT20121110011424N4). Patients with menstrual-related migraine referring to the Neurology Clinic of Imam Khomeini Hospital were evaluated and randomly assigned to either naproxen (250 mg every 12 hours) or melatonin (3 mg, half an hour before sleep) treatment groups. At the end of the first and third menstrual bleeding phases, the patients were assessed by a migraine diary, Visual Analog scale (VAS) for pain, and the Berlin questionnaire. Results: The study evaluated 56 patients (26 in the melatonin arm and 30 in the naproxen arm). Attack days (P < 0.001) and the headache severity (P < 0.001) improved in both groups compared to baseline. A significant difference was found between the melatonin and naproxen treatment groups in sedative and analgesic drug use (P < 0.05). Also, melatonin significantly changed the snoring rate and post-sleep tiredness compared to baseline (P < 0.05 and P < 0.05, respectively) whereas no improvement was observed in the naproxen treatment group concerning the sleep quality. Conclusions: We showed the beneficial role of melatonin in reducing the attack frequency and severity in migraine patients with menstrual-related headaches. Preventive therapy with melatonin also showed a significant reduction in the number of sedative drug use during attacks and improved the patients’ sleep quality when compared to naproxen.