The Experts below are selected from a list of 10014 Experts worldwide ranked by ideXlab platform
Carl L Manthey - One of the best experts on this subject based on the ideXlab platform.
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non peptidic αvβ3 antagonists containing indol 1 yl Propionic Acids
Bioorganic & Medicinal Chemistry Letters, 2005Co-Authors: Kristi A Leonard, Wenxi Pan, Beth M Anaclerio, Joan Gushue, Zihong Guo, Renee L Desjarlais, Marge A Chaikin, Jennifer Lattanze, Carl Crysler, Carl L MantheyAbstract:We describe the synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin α v β 3 . Indol-1-yl Propionic Acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified.
Kristi A Leonard - One of the best experts on this subject based on the ideXlab platform.
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non peptidic αvβ3 antagonists containing indol 1 yl Propionic Acids
Bioorganic & Medicinal Chemistry Letters, 2005Co-Authors: Kristi A Leonard, Wenxi Pan, Beth M Anaclerio, Joan Gushue, Zihong Guo, Renee L Desjarlais, Marge A Chaikin, Jennifer Lattanze, Carl Crysler, Carl L MantheyAbstract:We describe the synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin α v β 3 . Indol-1-yl Propionic Acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified.
V F Larsen - One of the best experts on this subject based on the ideXlab platform.
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degradation of acetic and Propionic Acids in the methane fermentation
Water Research, 1991Co-Authors: A J Mawson, R L Earle, V F LarsenAbstract:Abstract A series of batch digestion experiments was performed to evaluate the effect of elevated acetic acid concentrations on the degradation of Propionic acid and vice versa. Flask digesters were incubated at 37°C with acetic and Propionic Acids added at up to 2000 and 1500 mg 1 −1 , respectively. It was found that increasing the concentration of either acid from low levels reduced the rate of its utilization and that increasing the acetic acid concentration from 1000 to 2000 mg 1 −1 significantly inhibited degradation of Propionic acid added at 500 mg 1 −1 . Good agreement was obtained from fitting the logistic equation to the measured data and between duplicate runs performed within the experiments. The observed inhibition of propionate degradation by acetate confirms several earlier reports of product inhibition in the literature and emphasizes the importance of controlling acid levels in maintaining satisfactory digester operation.
Yinguang Chen - One of the best experts on this subject based on the ideXlab platform.
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effect of solids retention time and temperature on waste activated sludge hydrolysis and short chain fatty Acids accumulation under alkaline conditions in continuous flow reactors
Bioresource Technology, 2009Co-Authors: Leiyu Feng, Yinguang Chen, Hua Wang, Qin WangAbstract:The effects of solids retention time (SRT) and temperature on waste activated sludge (WAS) hydrolysis and short-chain fatty Acids (SCFAs) accumulation were investigated in a series of continuous-flow reactors at pH 10. The experimental results showed that the increase of either SRT or temperature benefited the hydrolysis of WAS and the production of SCFAs. The changes in SRT gave also impact on the percentage of acetic and Propionic Acids in the fermentative SCFAs, but little influence on that of the slightly long-chain SCFAs, such as n-butyric, iso-butyric, n-valeric and iso-valeric Acids. Compared with the control (pH unadjusted) experiment, at SRT of 12 d and temperature of 20 °C the concentration of SCFAs produced at pH 10 increased from 261.2 to 933.5 mg COD/L, and the Propionic acid percentage improved from 11.7 to 16.0%. It can be concluded from this investigation that the efficient continuous production of SCFAs at pH 10 is feasible.
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anaerobic metabolic models for phosphorus and glycogen accumulating organisms with mixed acetic and Propionic Acids as carbon sources
Water Research, 2008Co-Authors: Chao Zhang, Yinguang Chen, Andrew A RandallAbstract:With acetate or propionate as the sole carbon source, anaerobic metabolic models describing phosphorus- and glycogen-accumulating organisms (PAO and GAO) have been developed in the literature. However, comprehensive models are in need for the description of PAO and GAO behaviors with mixed acetic and Propionic Acids as carbon sources since they are the two main volatile fatty Acids (VFA) that coexist in real wastewater. Two metabolic models were proposed to characterize the anaerobic stoichiometry of PAO and GAO, respectively, and two groups of sequencing batch reactors (i.e. 5 PAO-SBRs and 5 GAO-SBRs) with different Propionic to acetic acid ratios were used for the validation of the models. The experimental data indicated that polyhydroxyalkanoates were synthesized via random condensation in GAO cells, whereas the semi-selective/semi-random pathway was used for the integration of acetyl-CoA and propionyl-CoA in PAO cells. When the VFA was pure acetic or Propionic acid, the proposed PAO (or GAO) model reverted back to the reported acetate or propionate PAO (or GAO) model. Results also showed that the energy required for the transportation of 1 C-mol VFA across the membrane of both PAO and GAO cells was independent of the propionate/acetate ratio.
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effect of initial ph control on enhanced biological phosphorus removal from wastewater containing acetic and Propionic Acids
Chemosphere, 2007Co-Authors: Yinguang Chen, Qi ZhouAbstract:In the literature most of the studies on the effect of pH on enhanced biological phosphorous removal were conducted with the acetate wastewater, and the pH was controlled during the entire anaerobic and aerobic stages. This paper investigated the influence of anaerobic initial pH control, which will be more practical than the entire process pH control strategy, on enhanced biological phosphorus removal from wastewater containing acetic and Propionic Acids. Typical pH profile showed that both the initial alkaline and acidic pH tended to neutralize due to the consumption of short-chain fatty acid (SCFA) and intracellular pH regulation by polyphosphate accumulating organisms (PAOs). It was observed that the glycogen degradation and polyhydroxyalkanoates (PHA) accumulation decreased with increasing initial pH, which disagreed with previous reports. In the literature the metabolisms of both glycogen and PHA by PAOs in the acetate wastewater were independent of pH. An anaerobic mechanism model was proposed to explain the intra- and extra-cellular pH buffer nature of PAOs, and to address the reasons for increased polyphosphate degradation and decreased PHA synthesis and glycogen degradation at higher pH. The optimal initial pH for higher soluble ortho-phosphorus (SOP) removal efficiency should be controlled between 6.4 and 7.2. This pH control strategy will be easier to use in practice of wastewater treatment plant.
Jennifer Lattanze - One of the best experts on this subject based on the ideXlab platform.
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non peptidic αvβ3 antagonists containing indol 1 yl Propionic Acids
Bioorganic & Medicinal Chemistry Letters, 2005Co-Authors: Kristi A Leonard, Wenxi Pan, Beth M Anaclerio, Joan Gushue, Zihong Guo, Renee L Desjarlais, Marge A Chaikin, Jennifer Lattanze, Carl Crysler, Carl L MantheyAbstract:We describe the synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin α v β 3 . Indol-1-yl Propionic Acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified.
