The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform
Fleming Martínez - One of the best experts on this subject based on the ideXlab platform.
-
solubility of sulfamethizole in some Propylene Glycol water mixtures at several temperatures
Fluid Phase Equilibria, 2012Co-Authors: Daniel R. Delgado, Asma Romdhani, Fleming MartínezAbstract:Abstract The solubility of sulfamethizole (SMZ) in Propylene Glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The solubility was maximal in pure Propylene Glycol and very low in pure water at all the temperatures. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data by using the van’t Hoff and Gibbs equations. Thermodynamic quantities of mixing were also calculated by using calorimetric values related to drug fusion process. A nonlinear enthalpy–entropy relationship was observed from a plot of enthalpy vs. Gibbs energy of solution. The plot of Δ soln H ° vs. Δ soln G ° shows two different trends, one with negative slope from pure water up to 0.20 mass fraction of Propylene Glycol and the other one positive beyond this composition up to pure Propylene Glycol. Accordingly, the driving mechanism for SMZ solubility in water-rich mixtures is the entropy, probably due to water-structure loss around the drug non-polar moieties by effect of Propylene Glycol, whereas, above 0.20 mass fraction of Propylene Glycol the driving mechanism is the enthalpy, probably due to SMZ solvation increase by the co-solvent molecules. This behavior is similar to the one exhibited by sulfanilamide and other drugs in the same co-solvent mixtures.
-
Thermodynamics of Sulfanilamide Solubility in Propylene Glycol + Water Mixtures
Latin American Journal of Pharmacy, 2012Co-Authors: Fleming Martínez, Asma Romdhani, Daniel R. DelgadoAbstract:SUMMARY. The solubility of sulfanilamide (SA) in Propylene Glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and mixing were obtained from these solubility data by using the van’t Hoff and Gibbs equations. The solubility was maximal in Propylene Glycol and very low in water at all the temperatures. A non linear enthalpy–entropy relationship was observed from a plot of enthalpy vs. Gibbs energy of solution. The maximum point in plot of ΔsolnH° vs. ΔsolnG° (0.20 mass fraction of Propylene Glycol) separates two different trends, one with negative slope from water up to 0.20 mass fraction of Propylene Glycol and the other one positive beyond this composition up to Propylene Glycol. Accordingly, the driving mechanism for SA solubility in water-rich mixtures is the entropy, probably due to water-structure loss around the drug non-polar moieties by Propylene Glycol, whereas, above 0.20 mass fraction of Propylene Glycol the driving mechanism is the enthalpy, probably due to SA solvation increase by the co-solvent molecules.
-
solution thermodynamics of indomethacin in Propylene Glycol water mixtures
Fluid Phase Equilibria, 2012Co-Authors: Andres R Holguin, Daniel R. Delgado, Gerson A Rodriguez, Diana M Cristancho, Fleming MartínezAbstract:Abstract The equilibrium solubilities of the analgesic drug indomethacin (IMC) in Propylene Glycol + water binary mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all the temperatures studied. A non-linear plot of ΔsolnH° vs. ΔsolnG° with negative slope from pure water up to 0.80 in mass fraction of Propylene Glycol and positive beyond this composition up to neat Propylene Glycol was obtained at the mean temperature, 303.15 K. This behavior is similar to those reported in the literature for this drug in 1,4-dioxane + water and ethanol + water mixtures. Accordingly, the driving mechanism for IMC solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to its better solvation of the drug.
-
Solution thermodynamics of indomethacin in Propylene Glycol + water mixtures
Fluid Phase Equilibria, 2012Co-Authors: Andres R Holguin, Daniel R. Delgado, Gerson A Rodriguez, Diana M Cristancho, Fleming MartínezAbstract:Abstract The equilibrium solubilities of the analgesic drug indomethacin (IMC) in Propylene Glycol + water binary mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all the temperatures studied. A non-linear plot of ΔsolnH° vs. ΔsolnG° with negative slope from pure water up to 0.80 in mass fraction of Propylene Glycol and positive beyond this composition up to neat Propylene Glycol was obtained at the mean temperature, 303.15 K. This behavior is similar to those reported in the literature for this drug in 1,4-dioxane + water and ethanol + water mixtures. Accordingly, the driving mechanism for IMC solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to its better solvation of the drug.
-
Solution Thermodynamics and Preferential Solvation of Meloxicam in Propylene Glycol + Water Mixtures
Journal of Solution Chemistry, 2011Co-Authors: Andres R Holguin, Fleming Martínez, Daniel R. Delgado, Yizhak MarcusAbstract:The equilibrium solubilities of the analgesic drug meloxicam (MEL) in Propylene Glycol + water mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all temperatures studied. A nonlinear plot of Δ_soln H ° versus Δ_soln G ° gave a negative slope from pure water up to 0.80 mass fraction of Propylene Glycol and a positive slope above this composition up to neat Propylene Glycol, at the mean temperature 303.15 K. Accordingly, the driving mechanism for MEL solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around nonpolar moieties of the drug, while for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to better solvation of the drug. The preferential solvation of MEL by the components of the solvent was estimated by means of the inverse Kirkwood-Buff integral method, showing rather small preferential solvation of MEL by Propylene Glycol at all compositions.
Daniel R. Delgado - One of the best experts on this subject based on the ideXlab platform.
-
solubility of sulfamethizole in some Propylene Glycol water mixtures at several temperatures
Fluid Phase Equilibria, 2012Co-Authors: Daniel R. Delgado, Asma Romdhani, Fleming MartínezAbstract:Abstract The solubility of sulfamethizole (SMZ) in Propylene Glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The solubility was maximal in pure Propylene Glycol and very low in pure water at all the temperatures. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data by using the van’t Hoff and Gibbs equations. Thermodynamic quantities of mixing were also calculated by using calorimetric values related to drug fusion process. A nonlinear enthalpy–entropy relationship was observed from a plot of enthalpy vs. Gibbs energy of solution. The plot of Δ soln H ° vs. Δ soln G ° shows two different trends, one with negative slope from pure water up to 0.20 mass fraction of Propylene Glycol and the other one positive beyond this composition up to pure Propylene Glycol. Accordingly, the driving mechanism for SMZ solubility in water-rich mixtures is the entropy, probably due to water-structure loss around the drug non-polar moieties by effect of Propylene Glycol, whereas, above 0.20 mass fraction of Propylene Glycol the driving mechanism is the enthalpy, probably due to SMZ solvation increase by the co-solvent molecules. This behavior is similar to the one exhibited by sulfanilamide and other drugs in the same co-solvent mixtures.
-
Thermodynamics of Sulfanilamide Solubility in Propylene Glycol + Water Mixtures
Latin American Journal of Pharmacy, 2012Co-Authors: Fleming Martínez, Asma Romdhani, Daniel R. DelgadoAbstract:SUMMARY. The solubility of sulfanilamide (SA) in Propylene Glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and mixing were obtained from these solubility data by using the van’t Hoff and Gibbs equations. The solubility was maximal in Propylene Glycol and very low in water at all the temperatures. A non linear enthalpy–entropy relationship was observed from a plot of enthalpy vs. Gibbs energy of solution. The maximum point in plot of ΔsolnH° vs. ΔsolnG° (0.20 mass fraction of Propylene Glycol) separates two different trends, one with negative slope from water up to 0.20 mass fraction of Propylene Glycol and the other one positive beyond this composition up to Propylene Glycol. Accordingly, the driving mechanism for SA solubility in water-rich mixtures is the entropy, probably due to water-structure loss around the drug non-polar moieties by Propylene Glycol, whereas, above 0.20 mass fraction of Propylene Glycol the driving mechanism is the enthalpy, probably due to SA solvation increase by the co-solvent molecules.
-
solution thermodynamics of indomethacin in Propylene Glycol water mixtures
Fluid Phase Equilibria, 2012Co-Authors: Andres R Holguin, Daniel R. Delgado, Gerson A Rodriguez, Diana M Cristancho, Fleming MartínezAbstract:Abstract The equilibrium solubilities of the analgesic drug indomethacin (IMC) in Propylene Glycol + water binary mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all the temperatures studied. A non-linear plot of ΔsolnH° vs. ΔsolnG° with negative slope from pure water up to 0.80 in mass fraction of Propylene Glycol and positive beyond this composition up to neat Propylene Glycol was obtained at the mean temperature, 303.15 K. This behavior is similar to those reported in the literature for this drug in 1,4-dioxane + water and ethanol + water mixtures. Accordingly, the driving mechanism for IMC solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to its better solvation of the drug.
-
Solution thermodynamics of indomethacin in Propylene Glycol + water mixtures
Fluid Phase Equilibria, 2012Co-Authors: Andres R Holguin, Daniel R. Delgado, Gerson A Rodriguez, Diana M Cristancho, Fleming MartínezAbstract:Abstract The equilibrium solubilities of the analgesic drug indomethacin (IMC) in Propylene Glycol + water binary mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all the temperatures studied. A non-linear plot of ΔsolnH° vs. ΔsolnG° with negative slope from pure water up to 0.80 in mass fraction of Propylene Glycol and positive beyond this composition up to neat Propylene Glycol was obtained at the mean temperature, 303.15 K. This behavior is similar to those reported in the literature for this drug in 1,4-dioxane + water and ethanol + water mixtures. Accordingly, the driving mechanism for IMC solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to its better solvation of the drug.
-
Solution Thermodynamics and Preferential Solvation of Meloxicam in Propylene Glycol + Water Mixtures
Journal of Solution Chemistry, 2011Co-Authors: Andres R Holguin, Fleming Martínez, Daniel R. Delgado, Yizhak MarcusAbstract:The equilibrium solubilities of the analgesic drug meloxicam (MEL) in Propylene Glycol + water mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all temperatures studied. A nonlinear plot of Δ_soln H ° versus Δ_soln G ° gave a negative slope from pure water up to 0.80 mass fraction of Propylene Glycol and a positive slope above this composition up to neat Propylene Glycol, at the mean temperature 303.15 K. Accordingly, the driving mechanism for MEL solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around nonpolar moieties of the drug, while for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to better solvation of the drug. The preferential solvation of MEL by the components of the solvent was estimated by means of the inverse Kirkwood-Buff integral method, showing rather small preferential solvation of MEL by Propylene Glycol at all compositions.
Andres R Holguin - One of the best experts on this subject based on the ideXlab platform.
-
solution thermodynamics of indomethacin in Propylene Glycol water mixtures
Fluid Phase Equilibria, 2012Co-Authors: Andres R Holguin, Daniel R. Delgado, Gerson A Rodriguez, Diana M Cristancho, Fleming MartínezAbstract:Abstract The equilibrium solubilities of the analgesic drug indomethacin (IMC) in Propylene Glycol + water binary mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all the temperatures studied. A non-linear plot of ΔsolnH° vs. ΔsolnG° with negative slope from pure water up to 0.80 in mass fraction of Propylene Glycol and positive beyond this composition up to neat Propylene Glycol was obtained at the mean temperature, 303.15 K. This behavior is similar to those reported in the literature for this drug in 1,4-dioxane + water and ethanol + water mixtures. Accordingly, the driving mechanism for IMC solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to its better solvation of the drug.
-
Solution thermodynamics of indomethacin in Propylene Glycol + water mixtures
Fluid Phase Equilibria, 2012Co-Authors: Andres R Holguin, Daniel R. Delgado, Gerson A Rodriguez, Diana M Cristancho, Fleming MartínezAbstract:Abstract The equilibrium solubilities of the analgesic drug indomethacin (IMC) in Propylene Glycol + water binary mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all the temperatures studied. A non-linear plot of ΔsolnH° vs. ΔsolnG° with negative slope from pure water up to 0.80 in mass fraction of Propylene Glycol and positive beyond this composition up to neat Propylene Glycol was obtained at the mean temperature, 303.15 K. This behavior is similar to those reported in the literature for this drug in 1,4-dioxane + water and ethanol + water mixtures. Accordingly, the driving mechanism for IMC solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to its better solvation of the drug.
-
Solution Thermodynamics and Preferential Solvation of Meloxicam in Propylene Glycol + Water Mixtures
Journal of Solution Chemistry, 2011Co-Authors: Andres R Holguin, Fleming Martínez, Daniel R. Delgado, Yizhak MarcusAbstract:The equilibrium solubilities of the analgesic drug meloxicam (MEL) in Propylene Glycol + water mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all temperatures studied. A nonlinear plot of Δ_soln H ° versus Δ_soln G ° gave a negative slope from pure water up to 0.80 mass fraction of Propylene Glycol and a positive slope above this composition up to neat Propylene Glycol, at the mean temperature 303.15 K. Accordingly, the driving mechanism for MEL solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around nonpolar moieties of the drug, while for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to better solvation of the drug. The preferential solvation of MEL by the components of the solvent was estimated by means of the inverse Kirkwood-Buff integral method, showing rather small preferential solvation of MEL by Propylene Glycol at all compositions.
-
solution thermodynamics and preferential solvation of meloxicam in Propylene Glycol water mixtures
Journal of Solution Chemistry, 2011Co-Authors: Andres R Holguin, Fleming Martínez, Daniel R. Delgado, Yizhak MarcusAbstract:The equilibrium solubilities of the analgesic drug meloxicam (MEL) in Propylene Glycol + water mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat Propylene Glycol and very low in pure water at all temperatures studied. A nonlinear plot of ΔsolnH° versus ΔsolnG° gave a negative slope from pure water up to 0.80 mass fraction of Propylene Glycol and a positive slope above this composition up to neat Propylene Glycol, at the mean temperature 303.15 K. Accordingly, the driving mechanism for MEL solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around nonpolar moieties of the drug, while for the Propylene Glycol-rich mixtures it was the enthalpy, probably due to better solvation of the drug. The preferential solvation of MEL by the components of the solvent was estimated by means of the inverse Kirkwood-Buff integral method, showing rather small preferential solvation of MEL by Propylene Glycol at all compositions.
Peter J Reilly - One of the best experts on this subject based on the ideXlab platform.
-
ruminal fermentation of Propylene Glycol and glycerol
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Steven Trabue, Kenwood Scoggin, Siska Tjandrakusuma, Mark A Rasmussen, Peter J ReillyAbstract:Bovine rumen fluid was fermented anaerobically with 25 mM R-Propylene Glycol, S-Propylene Glycol, or glycerol added. After 24 h, all of the Propylene Glycol enantiomers and approximately 80% of the glycerol were metabolized. Acetate, propionate, butyrate, valerate, and caproate concentrations, in decreasing order, all increased with incubation time. Addition of any of the three substrates somewhat decreased acetate formation, while addition of either Propylene Glycol increased propionate formation but decreased that of butyrate. R- and S-Propylene Glycol did not differ significantly in either their rates of disappearance or the products formed when they were added to the fermentation medium. Fermentations of rumen fluid containing Propylene Glycol emitted the sulfur-containing gases 1-propanethiol, 1-(methylthio)propane, methylthiirane, 2,4-dimethylthiophene, 1-(methylthio)-1-propanethiol, dipropyl disulfide, 1-(propylthio)-1-propanethiol, dipropyl trisulfide, 3,5-diethyl-1,2,4-trithiolane, 2-ethyl-1,3-dithiane, and 2,4,6-triethyl-1,3,5-trithiane. Metabolic pathways that yield each of these gases are proposed. The sulfur-containing gases produced during Propylene Glycol fermentation in the rumen may contribute to the toxic effects seen in cattle when high doses are administered for therapeutic purposes.
Asma Romdhani - One of the best experts on this subject based on the ideXlab platform.
-
solubility of sulfamethizole in some Propylene Glycol water mixtures at several temperatures
Fluid Phase Equilibria, 2012Co-Authors: Daniel R. Delgado, Asma Romdhani, Fleming MartínezAbstract:Abstract The solubility of sulfamethizole (SMZ) in Propylene Glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The solubility was maximal in pure Propylene Glycol and very low in pure water at all the temperatures. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data by using the van’t Hoff and Gibbs equations. Thermodynamic quantities of mixing were also calculated by using calorimetric values related to drug fusion process. A nonlinear enthalpy–entropy relationship was observed from a plot of enthalpy vs. Gibbs energy of solution. The plot of Δ soln H ° vs. Δ soln G ° shows two different trends, one with negative slope from pure water up to 0.20 mass fraction of Propylene Glycol and the other one positive beyond this composition up to pure Propylene Glycol. Accordingly, the driving mechanism for SMZ solubility in water-rich mixtures is the entropy, probably due to water-structure loss around the drug non-polar moieties by effect of Propylene Glycol, whereas, above 0.20 mass fraction of Propylene Glycol the driving mechanism is the enthalpy, probably due to SMZ solvation increase by the co-solvent molecules. This behavior is similar to the one exhibited by sulfanilamide and other drugs in the same co-solvent mixtures.
-
Thermodynamics of Sulfanilamide Solubility in Propylene Glycol + Water Mixtures
Latin American Journal of Pharmacy, 2012Co-Authors: Fleming Martínez, Asma Romdhani, Daniel R. DelgadoAbstract:SUMMARY. The solubility of sulfanilamide (SA) in Propylene Glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and mixing were obtained from these solubility data by using the van’t Hoff and Gibbs equations. The solubility was maximal in Propylene Glycol and very low in water at all the temperatures. A non linear enthalpy–entropy relationship was observed from a plot of enthalpy vs. Gibbs energy of solution. The maximum point in plot of ΔsolnH° vs. ΔsolnG° (0.20 mass fraction of Propylene Glycol) separates two different trends, one with negative slope from water up to 0.20 mass fraction of Propylene Glycol and the other one positive beyond this composition up to Propylene Glycol. Accordingly, the driving mechanism for SA solubility in water-rich mixtures is the entropy, probably due to water-structure loss around the drug non-polar moieties by Propylene Glycol, whereas, above 0.20 mass fraction of Propylene Glycol the driving mechanism is the enthalpy, probably due to SA solvation increase by the co-solvent molecules.
