The Experts below are selected from a list of 12003 Experts worldwide ranked by ideXlab platform
Yanbing Zhang - One of the best experts on this subject based on the ideXlab platform.
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design and antiproliferative evaluation of novel Sulfanilamide derivatives as potential tubulin polymerization inhibitors
Molecules, 2017Co-Authors: Jifeng Liu, Ruohan Zhao, Saiyang Zhang, Yanbing ZhangAbstract:A series of Sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, MCF-7 and PC-3). The detailed structure-activity relationships for these Sulfanilamide-1,2,3-triazole hybrids were investigated. All these Sulfanilamide-1,2,3-triazole hybrids exhibited moderate to potent activity against all cell lines. In particular 4-methyl-N-((1-(3-phenoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide (11f) showed the most potent inhibitory effect against PC-3 cells, with an IC50 value of 4.08 μM. Furthermore, the tubulin polymerization inhibitory activity in vitro of compound 11f was 2.41 μM. These Sulfanilamide hybrids might serve as bioactive fragments for developing more potent antiproliferative agents.
Sanela Savić - One of the best experts on this subject based on the ideXlab platform.
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Sulfanilamide in solution and liposome vesicles; in vitro release and UV-stability studies
Elsevier, 2017Co-Authors: Sanja Petrović, Ana Tačić, Vesna Nikolić, Saša Savić, Ljubiša Nikolić, Sanela SavićAbstract:The main goal of this study was to develop a liposome formulation with Sulfanilamide and to investigate the liposomes impact on its release and stability to the UV-A/UV-B and UV-C irradiation. Liposome dispersions with incorporated Sulfanilamide were prepared by thin-film hydration method and liposomes role to the Sulfanilamide release was investigated by using a dialysis method. Comparatively, Sulfanilamide in phosphate buffer solution was subject to release study as well to the UV irradiation providing for the possibilities of kinetics analysis. In vitro drug release study demonstrated that 20% of Sulfanilamide was released from liposomes within 1 h that is approximately twice as slower as in the case of dissolved Sulfanilamide in phosphate buffer solution. The kinetic release process can be described by Korsmeyer–Peppas model and according to the value of diffusion release exponent it can be concluded that drug release mechanism is based on the phenomenon of diffusion. The Sulfanilamide degradation in phosphate buffer solution and liposomes is related to the formation of UV-induced degradation products that are identified by UHPLC/MS analysis as: sulfanilic acid, aniline and benzidine. The UV-induced Sulfanilamide degradation in the phosphate buffer solution and liposome vesicles fits the first- order kinetic model. The degradation rate constants are dependent on the involved UV photons energy input as well as Sulfanilamide microenvironment. Liposome microenvironment provides better irradiation Sulfanilamide stability. The obtained results suggest that liposomes might be promising carriers for delayed Sulfanilamide delivery and may serve as a basis for further research. Keywords: Sulfanilamide, Liposomes, Stability, Irradiation, Degradation, Releas
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Sulfanilamide in solution and liposome vesicles; in vitro release and UV-stability studies.
Saudi Pharmaceutical Journal, 2017Co-Authors: Sanja Petrović, Ana Tačić, Vesna Nikolić, Saša Savić, Ljubiša Nikolić, Sanela SavićAbstract:Abstract The main goal of this study was to develop a liposome formulation with Sulfanilamide and to investigate the liposomes impact on its release and stability to the UV-A/UV-B and UV-C irradiation. Liposome dispersions with incorporated Sulfanilamide were prepared by thin-film hydration method and liposomes role to the Sulfanilamide release was investigated by using a dialysis method. Comparatively, Sulfanilamide in phosphate buffer solution was subject to release study as well to the UV irradiation providing for the possibilities of kinetics analysis. In vitro drug release study demonstrated that 20% of Sulfanilamide was released from liposomes within 1 h that is approximately twice as slower as in the case of dissolved Sulfanilamide in phosphate buffer solution. The kinetic release process can be described by Korsmeyer–Peppas model and according to the value of diffusion release exponent it can be concluded that drug release mechanism is based on the phenomenon of diffusion. The Sulfanilamide degradation in phosphate buffer solution and liposomes is related to the formation of UV-induced degradation products that are identified by UHPLC/MS analysis as: sulfanilic acid, aniline and benzidine. The UV-induced Sulfanilamide degradation in the phosphate buffer solution and liposome vesicles fits the first- order kinetic model. The degradation rate constants are dependent on the involved UV photons energy input as well as Sulfanilamide microenvironment. Liposome microenvironment provides better irradiation Sulfanilamide stability. The obtained results suggest that liposomes might be promising carriers for delayed Sulfanilamide delivery and may serve as a basis for further research.
Jifeng Liu - One of the best experts on this subject based on the ideXlab platform.
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design and antiproliferative evaluation of novel Sulfanilamide derivatives as potential tubulin polymerization inhibitors
Molecules, 2017Co-Authors: Jifeng Liu, Ruohan Zhao, Saiyang Zhang, Yanbing ZhangAbstract:A series of Sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, MCF-7 and PC-3). The detailed structure-activity relationships for these Sulfanilamide-1,2,3-triazole hybrids were investigated. All these Sulfanilamide-1,2,3-triazole hybrids exhibited moderate to potent activity against all cell lines. In particular 4-methyl-N-((1-(3-phenoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide (11f) showed the most potent inhibitory effect against PC-3 cells, with an IC50 value of 4.08 μM. Furthermore, the tubulin polymerization inhibitory activity in vitro of compound 11f was 2.41 μM. These Sulfanilamide hybrids might serve as bioactive fragments for developing more potent antiproliferative agents.
Ana Tačić - One of the best experts on this subject based on the ideXlab platform.
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Sulfanilamide in solution and liposome vesicles; in vitro release and UV-stability studies.
Saudi Pharmaceutical Journal, 2017Co-Authors: Sanja Petrović, Ana Tačić, Vesna Nikolić, Saša Savić, Ljubiša Nikolić, Sanela SavićAbstract:Abstract The main goal of this study was to develop a liposome formulation with Sulfanilamide and to investigate the liposomes impact on its release and stability to the UV-A/UV-B and UV-C irradiation. Liposome dispersions with incorporated Sulfanilamide were prepared by thin-film hydration method and liposomes role to the Sulfanilamide release was investigated by using a dialysis method. Comparatively, Sulfanilamide in phosphate buffer solution was subject to release study as well to the UV irradiation providing for the possibilities of kinetics analysis. In vitro drug release study demonstrated that 20% of Sulfanilamide was released from liposomes within 1 h that is approximately twice as slower as in the case of dissolved Sulfanilamide in phosphate buffer solution. The kinetic release process can be described by Korsmeyer–Peppas model and according to the value of diffusion release exponent it can be concluded that drug release mechanism is based on the phenomenon of diffusion. The Sulfanilamide degradation in phosphate buffer solution and liposomes is related to the formation of UV-induced degradation products that are identified by UHPLC/MS analysis as: sulfanilic acid, aniline and benzidine. The UV-induced Sulfanilamide degradation in the phosphate buffer solution and liposome vesicles fits the first- order kinetic model. The degradation rate constants are dependent on the involved UV photons energy input as well as Sulfanilamide microenvironment. Liposome microenvironment provides better irradiation Sulfanilamide stability. The obtained results suggest that liposomes might be promising carriers for delayed Sulfanilamide delivery and may serve as a basis for further research.
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Sulfanilamide in solution and liposome vesicles; in vitro release and UV-stability studies
Elsevier, 2017Co-Authors: Sanja Petrović, Ana Tačić, Vesna Nikolić, Saša Savić, Ljubiša Nikolić, Sanela SavićAbstract:The main goal of this study was to develop a liposome formulation with Sulfanilamide and to investigate the liposomes impact on its release and stability to the UV-A/UV-B and UV-C irradiation. Liposome dispersions with incorporated Sulfanilamide were prepared by thin-film hydration method and liposomes role to the Sulfanilamide release was investigated by using a dialysis method. Comparatively, Sulfanilamide in phosphate buffer solution was subject to release study as well to the UV irradiation providing for the possibilities of kinetics analysis. In vitro drug release study demonstrated that 20% of Sulfanilamide was released from liposomes within 1 h that is approximately twice as slower as in the case of dissolved Sulfanilamide in phosphate buffer solution. The kinetic release process can be described by Korsmeyer–Peppas model and according to the value of diffusion release exponent it can be concluded that drug release mechanism is based on the phenomenon of diffusion. The Sulfanilamide degradation in phosphate buffer solution and liposomes is related to the formation of UV-induced degradation products that are identified by UHPLC/MS analysis as: sulfanilic acid, aniline and benzidine. The UV-induced Sulfanilamide degradation in the phosphate buffer solution and liposome vesicles fits the first- order kinetic model. The degradation rate constants are dependent on the involved UV photons energy input as well as Sulfanilamide microenvironment. Liposome microenvironment provides better irradiation Sulfanilamide stability. The obtained results suggest that liposomes might be promising carriers for delayed Sulfanilamide delivery and may serve as a basis for further research. Keywords: Sulfanilamide, Liposomes, Stability, Irradiation, Degradation, Releas
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Inclusion complexes of Sulfanilamide with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014Co-Authors: Ana Tačić, Ivan Savić, Vesna Nikolić, Ivana Savić, Snežana Ilić-stojanović, Dušica Ilić, Slobodan Petrović, Mirjana Popsavin, Agnes KaporAbstract:Sulfanilamide belongs to the group of drugs that have a bacteriostatic effect on different pathogenic microorganisms. This activity originates from the competitive antagonism with p -aminobenzoic acid, which is an integral part of folic acid. The safe use of Sulfanilamide is limited due to poor solubility in the aqueous medium. Therefore, the aim of this paper is the synthesis of Sulfanilamide, as well as preparing and structural characterization of its inclusion complexes with cyclodextrins. The crude Sulfanilamide was obtained in the synthesis between acetanilide and chlorosulfonic acid according to the standard procedure. The synthesized Sulfanilamide was recrystallized from water in order to obtain the satisfactory purity of the substance. Sufanilamide was complexed with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin by the co-precipitation method. A molecular encapsulation of Sulfanilamide was confirmed by using FTIR, ^1H-NMR, XRD and DSC methods. Phase-solubility techniques were used to assess the formation of the inclusion complex between Sulfanilamide and cyclodextrins. The photostability of Sulfanilamide and its inclusion complexes was estimated by UVB irradiation in a photochemical reactor by applying the UV–Vis method. Based on the UV–Vis analysis, Sulfanilamide:2-hydroxypropyl-β-cyclodextrin complex was presented as more photostable than Sulfanilamide:β-cyclodextrin complex and Sulfanilamide. The obtained results enable the potential use of these inclusion complexes for the preparation of oral formulations due to the enhanced solubility of Sulfanilamide.
Lihong Wang - One of the best experts on this subject based on the ideXlab platform.
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molecularly imprinted polymer graphene oxide modified glassy carbon electrode for selective detection of Sulfanilamide
Progress in Natural Science: Materials International, 2017Co-Authors: Xiaobing Wei, Lihong WangAbstract:Abstract A novel sensitive electrochemical sensor based on a glassy carbon electrode (GCE) modified with molecularly imprinted polymer (MIP) and grapheme oxide (GO) was developed. The MIP/GO material was prepared by precipitation polymerization in the presence of Sulfanilamide as template molecule. The MIP/GO based electrochemical sensor was characterized using scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV). The results indicated that the sensor exhibited good affinity and excellent electrochemical response for Sulfanilamide. Under optimized conditions, the oxidation peak current intensity of Sulfanilamide showed two linear dynamic ranges from 10 to 1000 ng mL −1 , and the standard deviation was less than 5% using SWV method. The sensor displays good stability, reproducibility, and high sensitivity. It can be further applied to quantify Sulfanilamide in milk.
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Molecularly imprinted polymer/graphene oxide modified glassy carbon electrode for selective detection of Sulfanilamide
Elsevier, 2017Co-Authors: Xiaobing Wei, Lihong WangAbstract:A novel sensitive electrochemical sensor based on a glassy carbon electrode (GCE) modified with molecularly imprinted polymer (MIP) and grapheme oxide (GO) was developed. The MIP/GO material was prepared by precipitation polymerization in the presence of Sulfanilamide as template molecule. The MIP/GO based electrochemical sensor was characterized using scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV). The results indicated that the sensor exhibited good affinity and excellent electrochemical response for Sulfanilamide. Under optimized conditions, the oxidation peak current intensity of Sulfanilamide showed two linear dynamic ranges from 10 to 1000 ng mL−1, and the standard deviation was less than 5% using SWV method. The sensor displays good stability, reproducibility, and high sensitivity. It can be further applied to quantify Sulfanilamide in milk
