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Benjamin Movsas - One of the best experts on this subject based on the ideXlab platform.
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hypoxic Prostate Muscle po2 ratio predicts for outcome in patients with localized Prostate cancer long term results
2012Co-Authors: A Turaka, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Mark K Buyyounouski, Benjamin MovsasAbstract:Purpose To correlate tumor oxygenation status with long-term biochemical outcome after Prostate brachytherapy. Methods and Materials Custom-made Eppendorf Po 2 microelectrodes were used to obtain Po 2 measurements from the Prostate (P), focused on positive biopsy locations, and normal Muscle tissue (M), as a control. A total of 11,516 measurements were obtained in 57 men with localized Prostate cancer immediately before Prostate brachytherapy was given. The Eppendorf histograms provided the median Po 2 , mean Po 2 , and % 2 ratio on BF. Results With a median follow-up time of 8 years, 12 men had ASTRO BF and 8 had Phoenix BF. On multivariate analysis, P/M Po 2 ratio p = 0.043). Hormonal therapy ( p = 0.015) and P/M Po 2 ratio p = 0.046) emerged as the only independent predictors of the Phoenix BF. Kaplan-Meier freedom from BF for P/M ratio p = 0.03) and for the Phoenix BF was 66% vs. 83% ( p = 0.02). Conclusions Hypoxia in Prostate cancer (low mean P/M Po 2 ratio) significantly predicts for poor long-term biochemical outcome, suggesting that novel hypoxic strategies should be investigated.
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hypoxic Prostate Muscle po2 ratio predicts for biochemical failure in patients with Prostate cancer preliminary findings
2002Co-Authors: Benjamin Movsas, Donald J Chapman, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Corinne C Stobbe, Gerald E Hanks, Alan PollackAbstract:Abstract Objectives To investigate whether low partial pressure of oxygen (Po 2 ) in Prostate cancer (CaP) predicts for biochemical outcome after radiotherapy. We previously reported that hypoxic regions exist in human CaP. Methods Custom-made Eppendorf Po 2 microelectrodes were used to obtain ∼100 Po 2 readings from both pathologically involved regions of the Prostate (as determined by sextant biopsies) and normal Muscle (as an internal control). Fifty-seven patients with localized disease were prospectively studied; all received brachytherapy implants (48 low dose rate and 9 high dose rate) under spinal anesthesia. Nine patients had received prior hormonal therapy. Biochemical failure was defined as two consecutive rises in Prostate-specific antigen level, without a return to baseline. Cox proportional hazards regression analysis was used to evaluate the influence of hypoxia on biochemical control, while adjusting for Prostate-specific antigen, Gleason score, stage, implant type (low dose rate versus high dose rate), perineural invasion, hemoglobin level, use of hormonal therapy, average (mean) of the median Prostate Po 2 , average median Muscle Po 2 , and Prostate/Muscle Po 2 (P/M) ratio. Results With a median follow-up of 19 months (range 4 to 31), 9 patients developed biochemical failure. A threshold analysis of the P/M ratio demonstrated that biochemical control at 2 years differed significantly at a ratio of less than 0.05 versus 0.05 or greater (31% versus 92%, P P = 0.0002). Conclusions To our knowledge, this is the first study to correlate the degree of hypoxia in CaP with treatment outcome after radiotherapy. The P/M Po 2 ratio was the strongest predictor for biochemical control on stepwise multivariate analysis. Longer follow up with more patients is planned to confirm this result.
Alan Pollack - One of the best experts on this subject based on the ideXlab platform.
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hypoxic Prostate Muscle po2 ratio predicts for biochemical failure in patients with Prostate cancer preliminary findings
2002Co-Authors: Benjamin Movsas, Donald J Chapman, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Corinne C Stobbe, Gerald E Hanks, Alan PollackAbstract:Abstract Objectives To investigate whether low partial pressure of oxygen (Po 2 ) in Prostate cancer (CaP) predicts for biochemical outcome after radiotherapy. We previously reported that hypoxic regions exist in human CaP. Methods Custom-made Eppendorf Po 2 microelectrodes were used to obtain ∼100 Po 2 readings from both pathologically involved regions of the Prostate (as determined by sextant biopsies) and normal Muscle (as an internal control). Fifty-seven patients with localized disease were prospectively studied; all received brachytherapy implants (48 low dose rate and 9 high dose rate) under spinal anesthesia. Nine patients had received prior hormonal therapy. Biochemical failure was defined as two consecutive rises in Prostate-specific antigen level, without a return to baseline. Cox proportional hazards regression analysis was used to evaluate the influence of hypoxia on biochemical control, while adjusting for Prostate-specific antigen, Gleason score, stage, implant type (low dose rate versus high dose rate), perineural invasion, hemoglobin level, use of hormonal therapy, average (mean) of the median Prostate Po 2 , average median Muscle Po 2 , and Prostate/Muscle Po 2 (P/M) ratio. Results With a median follow-up of 19 months (range 4 to 31), 9 patients developed biochemical failure. A threshold analysis of the P/M ratio demonstrated that biochemical control at 2 years differed significantly at a ratio of less than 0.05 versus 0.05 or greater (31% versus 92%, P P = 0.0002). Conclusions To our knowledge, this is the first study to correlate the degree of hypoxia in CaP with treatment outcome after radiotherapy. The P/M Po 2 ratio was the strongest predictor for biochemical control on stepwise multivariate analysis. Longer follow up with more patients is planned to confirm this result.
Richard E Greenberg - One of the best experts on this subject based on the ideXlab platform.
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hypoxic Prostate Muscle po2 ratio predicts for outcome in patients with localized Prostate cancer long term results
2012Co-Authors: A Turaka, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Mark K Buyyounouski, Benjamin MovsasAbstract:Purpose To correlate tumor oxygenation status with long-term biochemical outcome after Prostate brachytherapy. Methods and Materials Custom-made Eppendorf Po 2 microelectrodes were used to obtain Po 2 measurements from the Prostate (P), focused on positive biopsy locations, and normal Muscle tissue (M), as a control. A total of 11,516 measurements were obtained in 57 men with localized Prostate cancer immediately before Prostate brachytherapy was given. The Eppendorf histograms provided the median Po 2 , mean Po 2 , and % 2 ratio on BF. Results With a median follow-up time of 8 years, 12 men had ASTRO BF and 8 had Phoenix BF. On multivariate analysis, P/M Po 2 ratio p = 0.043). Hormonal therapy ( p = 0.015) and P/M Po 2 ratio p = 0.046) emerged as the only independent predictors of the Phoenix BF. Kaplan-Meier freedom from BF for P/M ratio p = 0.03) and for the Phoenix BF was 66% vs. 83% ( p = 0.02). Conclusions Hypoxia in Prostate cancer (low mean P/M Po 2 ratio) significantly predicts for poor long-term biochemical outcome, suggesting that novel hypoxic strategies should be investigated.
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hypoxic Prostate Muscle po2 ratio predicts for biochemical failure in patients with Prostate cancer preliminary findings
2002Co-Authors: Benjamin Movsas, Donald J Chapman, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Corinne C Stobbe, Gerald E Hanks, Alan PollackAbstract:Abstract Objectives To investigate whether low partial pressure of oxygen (Po 2 ) in Prostate cancer (CaP) predicts for biochemical outcome after radiotherapy. We previously reported that hypoxic regions exist in human CaP. Methods Custom-made Eppendorf Po 2 microelectrodes were used to obtain ∼100 Po 2 readings from both pathologically involved regions of the Prostate (as determined by sextant biopsies) and normal Muscle (as an internal control). Fifty-seven patients with localized disease were prospectively studied; all received brachytherapy implants (48 low dose rate and 9 high dose rate) under spinal anesthesia. Nine patients had received prior hormonal therapy. Biochemical failure was defined as two consecutive rises in Prostate-specific antigen level, without a return to baseline. Cox proportional hazards regression analysis was used to evaluate the influence of hypoxia on biochemical control, while adjusting for Prostate-specific antigen, Gleason score, stage, implant type (low dose rate versus high dose rate), perineural invasion, hemoglobin level, use of hormonal therapy, average (mean) of the median Prostate Po 2 , average median Muscle Po 2 , and Prostate/Muscle Po 2 (P/M) ratio. Results With a median follow-up of 19 months (range 4 to 31), 9 patients developed biochemical failure. A threshold analysis of the P/M ratio demonstrated that biochemical control at 2 years differed significantly at a ratio of less than 0.05 versus 0.05 or greater (31% versus 92%, P P = 0.0002). Conclusions To our knowledge, this is the first study to correlate the degree of hypoxia in CaP with treatment outcome after radiotherapy. The P/M Po 2 ratio was the strongest predictor for biochemical control on stepwise multivariate analysis. Longer follow up with more patients is planned to confirm this result.
Eric M Horwitz - One of the best experts on this subject based on the ideXlab platform.
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hypoxic Prostate Muscle po2 ratio predicts for outcome in patients with localized Prostate cancer long term results
2012Co-Authors: A Turaka, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Mark K Buyyounouski, Benjamin MovsasAbstract:Purpose To correlate tumor oxygenation status with long-term biochemical outcome after Prostate brachytherapy. Methods and Materials Custom-made Eppendorf Po 2 microelectrodes were used to obtain Po 2 measurements from the Prostate (P), focused on positive biopsy locations, and normal Muscle tissue (M), as a control. A total of 11,516 measurements were obtained in 57 men with localized Prostate cancer immediately before Prostate brachytherapy was given. The Eppendorf histograms provided the median Po 2 , mean Po 2 , and % 2 ratio on BF. Results With a median follow-up time of 8 years, 12 men had ASTRO BF and 8 had Phoenix BF. On multivariate analysis, P/M Po 2 ratio p = 0.043). Hormonal therapy ( p = 0.015) and P/M Po 2 ratio p = 0.046) emerged as the only independent predictors of the Phoenix BF. Kaplan-Meier freedom from BF for P/M ratio p = 0.03) and for the Phoenix BF was 66% vs. 83% ( p = 0.02). Conclusions Hypoxia in Prostate cancer (low mean P/M Po 2 ratio) significantly predicts for poor long-term biochemical outcome, suggesting that novel hypoxic strategies should be investigated.
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hypoxic Prostate Muscle po2 ratio predicts for biochemical failure in patients with Prostate cancer preliminary findings
2002Co-Authors: Benjamin Movsas, Donald J Chapman, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Corinne C Stobbe, Gerald E Hanks, Alan PollackAbstract:Abstract Objectives To investigate whether low partial pressure of oxygen (Po 2 ) in Prostate cancer (CaP) predicts for biochemical outcome after radiotherapy. We previously reported that hypoxic regions exist in human CaP. Methods Custom-made Eppendorf Po 2 microelectrodes were used to obtain ∼100 Po 2 readings from both pathologically involved regions of the Prostate (as determined by sextant biopsies) and normal Muscle (as an internal control). Fifty-seven patients with localized disease were prospectively studied; all received brachytherapy implants (48 low dose rate and 9 high dose rate) under spinal anesthesia. Nine patients had received prior hormonal therapy. Biochemical failure was defined as two consecutive rises in Prostate-specific antigen level, without a return to baseline. Cox proportional hazards regression analysis was used to evaluate the influence of hypoxia on biochemical control, while adjusting for Prostate-specific antigen, Gleason score, stage, implant type (low dose rate versus high dose rate), perineural invasion, hemoglobin level, use of hormonal therapy, average (mean) of the median Prostate Po 2 , average median Muscle Po 2 , and Prostate/Muscle Po 2 (P/M) ratio. Results With a median follow-up of 19 months (range 4 to 31), 9 patients developed biochemical failure. A threshold analysis of the P/M ratio demonstrated that biochemical control at 2 years differed significantly at a ratio of less than 0.05 versus 0.05 or greater (31% versus 92%, P P = 0.0002). Conclusions To our knowledge, this is the first study to correlate the degree of hypoxia in CaP with treatment outcome after radiotherapy. The P/M Po 2 ratio was the strongest predictor for biochemical control on stepwise multivariate analysis. Longer follow up with more patients is planned to confirm this result.
Alexandra L Hanlon - One of the best experts on this subject based on the ideXlab platform.
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hypoxic Prostate Muscle po2 ratio predicts for outcome in patients with localized Prostate cancer long term results
2012Co-Authors: A Turaka, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Mark K Buyyounouski, Benjamin MovsasAbstract:Purpose To correlate tumor oxygenation status with long-term biochemical outcome after Prostate brachytherapy. Methods and Materials Custom-made Eppendorf Po 2 microelectrodes were used to obtain Po 2 measurements from the Prostate (P), focused on positive biopsy locations, and normal Muscle tissue (M), as a control. A total of 11,516 measurements were obtained in 57 men with localized Prostate cancer immediately before Prostate brachytherapy was given. The Eppendorf histograms provided the median Po 2 , mean Po 2 , and % 2 ratio on BF. Results With a median follow-up time of 8 years, 12 men had ASTRO BF and 8 had Phoenix BF. On multivariate analysis, P/M Po 2 ratio p = 0.043). Hormonal therapy ( p = 0.015) and P/M Po 2 ratio p = 0.046) emerged as the only independent predictors of the Phoenix BF. Kaplan-Meier freedom from BF for P/M ratio p = 0.03) and for the Phoenix BF was 66% vs. 83% ( p = 0.02). Conclusions Hypoxia in Prostate cancer (low mean P/M Po 2 ratio) significantly predicts for poor long-term biochemical outcome, suggesting that novel hypoxic strategies should be investigated.
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hypoxic Prostate Muscle po2 ratio predicts for biochemical failure in patients with Prostate cancer preliminary findings
2002Co-Authors: Benjamin Movsas, Donald J Chapman, Alexandra L Hanlon, Eric M Horwitz, Richard E Greenberg, Corinne C Stobbe, Gerald E Hanks, Alan PollackAbstract:Abstract Objectives To investigate whether low partial pressure of oxygen (Po 2 ) in Prostate cancer (CaP) predicts for biochemical outcome after radiotherapy. We previously reported that hypoxic regions exist in human CaP. Methods Custom-made Eppendorf Po 2 microelectrodes were used to obtain ∼100 Po 2 readings from both pathologically involved regions of the Prostate (as determined by sextant biopsies) and normal Muscle (as an internal control). Fifty-seven patients with localized disease were prospectively studied; all received brachytherapy implants (48 low dose rate and 9 high dose rate) under spinal anesthesia. Nine patients had received prior hormonal therapy. Biochemical failure was defined as two consecutive rises in Prostate-specific antigen level, without a return to baseline. Cox proportional hazards regression analysis was used to evaluate the influence of hypoxia on biochemical control, while adjusting for Prostate-specific antigen, Gleason score, stage, implant type (low dose rate versus high dose rate), perineural invasion, hemoglobin level, use of hormonal therapy, average (mean) of the median Prostate Po 2 , average median Muscle Po 2 , and Prostate/Muscle Po 2 (P/M) ratio. Results With a median follow-up of 19 months (range 4 to 31), 9 patients developed biochemical failure. A threshold analysis of the P/M ratio demonstrated that biochemical control at 2 years differed significantly at a ratio of less than 0.05 versus 0.05 or greater (31% versus 92%, P P = 0.0002). Conclusions To our knowledge, this is the first study to correlate the degree of hypoxia in CaP with treatment outcome after radiotherapy. The P/M Po 2 ratio was the strongest predictor for biochemical control on stepwise multivariate analysis. Longer follow up with more patients is planned to confirm this result.
