The Experts below are selected from a list of 29346 Experts worldwide ranked by ideXlab platform
Malka Hochberg - One of the best experts on this subject based on the ideXlab platform.
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polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non sunscreen protection against uv induced damage in skin cells
Archives of Dermatological Research, 2011Co-Authors: Gennady Rosenblat, Shai Meretski, Joseph Segal, Mark Tarshis, Avi Schroeder, Alexandra Zaninzhorov, Gilead Lion, Arieh Ingber, Malka HochbergAbstract:Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a Protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE2, and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-Protective Agent in UV-induced skin damage.
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polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non sunscreen protection against uv induced damage in skin cells
Archives of Dermatological Research, 2011Co-Authors: Gennady Rosenblat, Shai Meretski, Joseph Segal, Mark Tarshis, Avi Schroeder, Alexandra Zaninzhorov, Gilead Lion, Arieh Ingber, Malka HochbergAbstract:Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a Protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE2, and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-Protective Agent in UV-induced skin damage.
Meichin Yin - One of the best experts on this subject based on the ideXlab platform.
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s ethyl cysteine an amino acid derivative attenuated cisplatin induced nephrotoxicity
Amino Acids, 2020Co-Authors: Hueyliang Kuo, Meichin Mong, Hungchih Chen, Zhihong Wang, Meichin YinAbstract:Renal protection from s-ethyl cysteine (SEC) against cisplatin (CP)-induced inflammatory and oxidative injury was examined. Mice were divided into five groups: normal group, 0.25% SEC group, CP group, 0.125% SEC + CP group, 0.25% SEC + CP group. After 2 weeks supplementation, mice of CP and SEC + CP groups received CP treatment. HE and enhanced renal Nrf2 and HO-1 mRNA expression. These novel findings suggest that dietary SEC via exerting its multiple bio-functions could be considered as a Protective Agent for kidney against CP.
Gupta Sudhiranjan - One of the best experts on this subject based on the ideXlab platform.
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Thymosin Beta 4 Protects Mice from Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy
plos one, 2014Co-Authors: Wei Chuanyu, Kim Il-kwon, Wu Liling, Gupta SudhiranjanAbstract:Pulmonary hypertension (PH) is a progressive vascular disease of pulmonary arteries that impedes ejection of blood by the right ventricle. As a result there is an increase in pulmonary vascular resistance and pulmonary arterial pressure causing right ventricular hypertrophy (RVH) and RV failure. The pathology of PAH involves vascular cell remodeling including pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) proliferation. Current therapies are limited to reverse the vascular remodeling. Investigating a key molecule is required for development of new therapeutic intervention. Thymosin beta-4 (T beta 4) is a ubiquitous G-actin sequestering protein with diverse biological function and promotes wound healing and modulates inflammatory responses. However, it remains unknown whether T beta 4 has any Protective role in PH. The purpose of this study is to evaluate the whether T beta 4 can be used as a vascular-Protective Agent. In monocrotaline (MCT)-induced PH mouse model, we showed that mice treated with T beta 4 significantly attenuated the systolic pressure and RVH, compared to the MCT treated mice. Our data revealed for the first time that T beta 4 selectively targets Notch3-Col 3A-CTGF gene axis in preventing MCT-induced PH and RVH. Our study may provide pre-clinical evidence for T beta 4 and may consider as vasculo-Protective Agent for the treatment of PH induced RVH.Multidisciplinary SciencesSCI(E)PubMed1ARTICLEsgupta@medicine.tamhsc.edu11e110598
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Thymosin beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy
'Public Library of Science (PLoS)', 2014Co-Authors: Wei Chuanyu, Kim Il-kwon, Wu Liling, Gupta SudhiranjanAbstract:Pulmonary hypertension (PH) is a progressive vascular disease of pulmonary arteries that impedes ejection of blood by the right ventricle. As a result there is an increase in pulmonary vascular resistance and pulmonary arterial pressure causing right ventricular hypertrophy (RVH) and RV failure. The pathology of PAH involves vascular cell remodeling including pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) proliferation. Current therapies are limited to reverse the vascular remodeling. Investigating a key molecule is required for development of new therapeutic intervention. Thymosin beta-4 (Tβ4) is a ubiquitous G-actin sequestering protein with diverse biological function and promotes wound healing and modulates inflammatory responses. However, it remains unknown whether Tβ4 has any Protective role in PH. The purpose of this study is to evaluate the whether Tβ4 can be used as a vascular-Protective Agent. In monocrotaline (MCT)-induced PH mouse model, we showed that mice treated with Tβ4 significantly attenuated the systolic pressure and RVH, compared to the MCT treated mice. Our data revealed for the first time that Tβ4 selectively targets Notch3-Col 3A-CTGF gene axis in preventing MCT-induced PH and RVH. Our study may provide pre-clinical evidence for Tβ4 and may consider as vasculo-Protective Agent for the treatment of PH induced RVH.The open access fee for this work was funded through the Texas A&M University Open Access to Knowledge (OAK) Fund
Sudhiranjan Gupta - One of the best experts on this subject based on the ideXlab platform.
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thymosin beta 4 protects mice from monocrotaline induced pulmonary hypertension and right ventricular hypertrophy
PLOS ONE, 2014Co-Authors: Chuanyu Wei, Ilkwon Kim, Sudhiranjan GuptaAbstract:Pulmonary hypertension (PH) is a progressive vascular disease of pulmonary arteries that impedes ejection of blood by the right ventricle. As a result there is an increase in pulmonary vascular resistance and pulmonary arterial pressure causing right ventricular hypertrophy (RVH) and RV failure. The pathology of PAH involves vascular cell remodeling including pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) proliferation. Current therapies are limited to reverse the vascular remodeling. Investigating a key molecule is required for development of new therapeutic intervention. Thymosin beta-4 (Tβ4) is a ubiquitous G-actin sequestering protein with diverse biological function and promotes wound healing and modulates inflammatory responses. However, it remains unknown whether Tβ4 has any Protective role in PH. The purpose of this study is to evaluate the whether Tβ4 can be used as a vascular-Protective Agent. In monocrotaline (MCT)-induced PH mouse model, we showed that mice treated with Tβ4 significantly attenuated the systolic pressure and RVH, compared to the MCT treated mice. Our data revealed for the first time that Tβ4 selectively targets Notch3-Col 3A-CTGF gene axis in preventing MCT-induced PH and RVH. Our study may provide pre-clinical evidence for Tβ4 and may consider as vasculo-Protective Agent for the treatment of PH induced RVH.
Gennady Rosenblat - One of the best experts on this subject based on the ideXlab platform.
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polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non sunscreen protection against uv induced damage in skin cells
Archives of Dermatological Research, 2011Co-Authors: Gennady Rosenblat, Shai Meretski, Joseph Segal, Mark Tarshis, Avi Schroeder, Alexandra Zaninzhorov, Gilead Lion, Arieh Ingber, Malka HochbergAbstract:Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a Protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE2, and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-Protective Agent in UV-induced skin damage.
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polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non sunscreen protection against uv induced damage in skin cells
Archives of Dermatological Research, 2011Co-Authors: Gennady Rosenblat, Shai Meretski, Joseph Segal, Mark Tarshis, Avi Schroeder, Alexandra Zaninzhorov, Gilead Lion, Arieh Ingber, Malka HochbergAbstract:Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a Protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE2, and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-Protective Agent in UV-induced skin damage.
