The Experts below are selected from a list of 129828 Experts worldwide ranked by ideXlab platform
Anthony A. Nash - One of the best experts on this subject based on the ideXlab platform.
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Immunogenicity of herpes simplex virus type 1 glycoproteins expressed in vaccinia virus recombinants.
Virology, 1990Co-Authors: Barbara Blacklaws, S Krishna, Anthony Charles Minson, Anthony A. NashAbstract:Abstract Vaccinia virus recombinants expressing glycoproteins B (VgB11), D (VgD52), E (gE/7.5 and gE/4B), G (gG-vac), H (gH-vac), and I (gl-vac) of HSV-1 were used to compare the Protective Response to these individual glycoproteins in the mouse. Glycoprotein D induced the best neutralizing antibody titers and the most increased rates of HSV clearance from the ear as well as good protection from the establishment of latent HSV infections in the sensory ganglia. Glycoprotein B also induced good neutralizing antibody titers and as great a protection from the establishment of latency as gD although the rate of virus clearance from the ear was not as great as after immunization with gD. Glycoprotein E induced weak neutralizing antibody but gG, gH, and gl did not show a neutralizing antibody Response. At higher challenge doses of virus (106 PFU HSV-1 in the ear), gE induced a Protective Response by increasing the rate of virus clearance and reducing the acute infection of ganglia as compared to negative control immunized mice. However there was no protection from the establishment of latent infections after immunization with gE. No Protective Response was seen to gG, gH, or gI.
Donna D Zhang - One of the best experts on this subject based on the ideXlab platform.
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a curcumin derivative that inhibits vinyl carbamate induced lung carcinogenesis via activation of the nrf2 Protective Response
Antioxidants & Redox Signaling, 2015Co-Authors: Min Long, Tao Shen, Eli Chapman, Pak Kin Wong, Bo Zhou, J. Chen, Tao Jiang, Donna D ZhangAbstract:Abstract Aims: Lung cancer has a high worldwide morbidity and mortality. The employment of chemopreventive agents is effective to reduce lung cancer. Nuclear factor erythroid 2-related factor 2 (Nrf2) mitigates insults from both exogenous and endogenous sources and thus has been verified as a target for chemoprevention. Curcumin has long been recognized as a chemopreventive agent, but poor bioavailability and weak Nrf2 induction have prohibited clinical application. Thus, we have developed new curcumin derivatives and tested their Nrf2 induction. Results: Based on curcumin, we synthesized curcumin analogs with five carbon linkages and established a structure–activity relationship for Nrf2 induction. Among these derivatives, bis[2-hydroxybenzylidene]acetone (BHBA) was one of the most potent Nrf2 inducers with minimal toxicity and improved pharmacological properties and was thus selected for further investigation. BHBA activated the Nrf2 pathway in the canonical Keap1-Cys151-dependent manner. Furthermore, B...
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a curcumin derivative that inhibits vinyl carbamate induced lung carcinogenesis via activation of the nrf2 Protective Response
Antioxidants & Redox Signaling, 2015Co-Authors: Tao Shen, Min Long, Eli Chapman, Pak Kin Wong, Bo Zhou, J. Chen, Tao Jiang, Dongmei Ren, Donna D ZhangAbstract:Aims: Lung cancer has a high worldwide morbidity and mortality. The employment of chemopreventive agents is effective to reduce lung cancer. Nuclear factor erythroid 2-related factor 2 (Nrf2) mitigates insults from both exogenous and endogenous sources and thus has been verified as a target for chemoprevention. Curcumin has long been recognized as a chemopreventive agent, but poor bioavailability and weak Nrf2 induction have prohibited clinical application. Thus, we have developed new curcumin derivatives and tested their Nrf2 induction. Results: Based on curcumin, we synthesized curcumin analogs with five carbon linkages and established a structure–activity relationship for Nrf2 induction. Among these derivatives, bis[2-hydroxybenzylidene]acetone (BHBA) was one of the most potent Nrf2 inducers with minimal toxicity and improved pharmacological properties and was thus selected for further investigation. BHBA activated the Nrf2 pathway in the canonical Keap1-Cys151-dependent manner. Furthermore, BHBA was able to protect human lung epithelial cells against sodium arsenite [As(III)]-induced cytotoxicity. More importantly, in an in vivo vinyl carbamate-induced lung cancer model in A/J mice, preadministration of BHBA significantly reduced lung adenocarcinoma, while curcumin failed to show any effects even at high doses. Innovation: The curcumin derivative, BHBA, is a potent inducer of Nrf2. It was demonstrated to protect against As(III) toxicity in lung epithelial cells in an Nrf2-dependent manner. Furthermore, compared with curcumin, BHBA displayed improved chemopreventive activities in a carcinogen-induced lung cancer model. Conclusion: Taken together, our results demonstrate that BHBA, a curcumin analog with improved Nrf2-activating and chemopreventive activities both in vitro and in vivo, could be developed into a chemoProtective pharmacological agent. Antioxid. Redox Signal. 23, 651–664.
Tao Shen - One of the best experts on this subject based on the ideXlab platform.
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a curcumin derivative that inhibits vinyl carbamate induced lung carcinogenesis via activation of the nrf2 Protective Response
Antioxidants & Redox Signaling, 2015Co-Authors: Min Long, Tao Shen, Eli Chapman, Pak Kin Wong, Bo Zhou, J. Chen, Tao Jiang, Donna D ZhangAbstract:Abstract Aims: Lung cancer has a high worldwide morbidity and mortality. The employment of chemopreventive agents is effective to reduce lung cancer. Nuclear factor erythroid 2-related factor 2 (Nrf2) mitigates insults from both exogenous and endogenous sources and thus has been verified as a target for chemoprevention. Curcumin has long been recognized as a chemopreventive agent, but poor bioavailability and weak Nrf2 induction have prohibited clinical application. Thus, we have developed new curcumin derivatives and tested their Nrf2 induction. Results: Based on curcumin, we synthesized curcumin analogs with five carbon linkages and established a structure–activity relationship for Nrf2 induction. Among these derivatives, bis[2-hydroxybenzylidene]acetone (BHBA) was one of the most potent Nrf2 inducers with minimal toxicity and improved pharmacological properties and was thus selected for further investigation. BHBA activated the Nrf2 pathway in the canonical Keap1-Cys151-dependent manner. Furthermore, B...
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a curcumin derivative that inhibits vinyl carbamate induced lung carcinogenesis via activation of the nrf2 Protective Response
Antioxidants & Redox Signaling, 2015Co-Authors: Tao Shen, Min Long, Eli Chapman, Pak Kin Wong, Bo Zhou, J. Chen, Tao Jiang, Dongmei Ren, Donna D ZhangAbstract:Aims: Lung cancer has a high worldwide morbidity and mortality. The employment of chemopreventive agents is effective to reduce lung cancer. Nuclear factor erythroid 2-related factor 2 (Nrf2) mitigates insults from both exogenous and endogenous sources and thus has been verified as a target for chemoprevention. Curcumin has long been recognized as a chemopreventive agent, but poor bioavailability and weak Nrf2 induction have prohibited clinical application. Thus, we have developed new curcumin derivatives and tested their Nrf2 induction. Results: Based on curcumin, we synthesized curcumin analogs with five carbon linkages and established a structure–activity relationship for Nrf2 induction. Among these derivatives, bis[2-hydroxybenzylidene]acetone (BHBA) was one of the most potent Nrf2 inducers with minimal toxicity and improved pharmacological properties and was thus selected for further investigation. BHBA activated the Nrf2 pathway in the canonical Keap1-Cys151-dependent manner. Furthermore, BHBA was able to protect human lung epithelial cells against sodium arsenite [As(III)]-induced cytotoxicity. More importantly, in an in vivo vinyl carbamate-induced lung cancer model in A/J mice, preadministration of BHBA significantly reduced lung adenocarcinoma, while curcumin failed to show any effects even at high doses. Innovation: The curcumin derivative, BHBA, is a potent inducer of Nrf2. It was demonstrated to protect against As(III) toxicity in lung epithelial cells in an Nrf2-dependent manner. Furthermore, compared with curcumin, BHBA displayed improved chemopreventive activities in a carcinogen-induced lung cancer model. Conclusion: Taken together, our results demonstrate that BHBA, a curcumin analog with improved Nrf2-activating and chemopreventive activities both in vitro and in vivo, could be developed into a chemoProtective pharmacological agent. Antioxid. Redox Signal. 23, 651–664.
Barbara Blacklaws - One of the best experts on this subject based on the ideXlab platform.
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Immunogenicity of herpes simplex virus type 1 glycoproteins expressed in vaccinia virus recombinants.
Virology, 1990Co-Authors: Barbara Blacklaws, S Krishna, Anthony Charles Minson, Anthony A. NashAbstract:Abstract Vaccinia virus recombinants expressing glycoproteins B (VgB11), D (VgD52), E (gE/7.5 and gE/4B), G (gG-vac), H (gH-vac), and I (gl-vac) of HSV-1 were used to compare the Protective Response to these individual glycoproteins in the mouse. Glycoprotein D induced the best neutralizing antibody titers and the most increased rates of HSV clearance from the ear as well as good protection from the establishment of latent HSV infections in the sensory ganglia. Glycoprotein B also induced good neutralizing antibody titers and as great a protection from the establishment of latency as gD although the rate of virus clearance from the ear was not as great as after immunization with gD. Glycoprotein E induced weak neutralizing antibody but gG, gH, and gl did not show a neutralizing antibody Response. At higher challenge doses of virus (106 PFU HSV-1 in the ear), gE induced a Protective Response by increasing the rate of virus clearance and reducing the acute infection of ganglia as compared to negative control immunized mice. However there was no protection from the establishment of latent infections after immunization with gE. No Protective Response was seen to gG, gH, or gI.
Anna K Overby - One of the best experts on this subject based on the ideXlab platform.
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Fast type I interferon Response protects astrocytes from flavivirus infection and virus-induced cytopathic effects
Journal of Neuroinflammation, 2016Co-Authors: Richard Lindqvist, Jonathan D. Gilthorpe, Andrea Kroger, Silke Wolfel, Filip Mundt, Nelson O. Gekara, Anna K OverbyAbstract:Background Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon Response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this Protective Response are not defined.
