The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform
Georges Tocco - One of the best experts on this subject based on the ideXlab platform.
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the dual response of Protein Kinase Fyn to neural trauma early induction in neurons and delayed induction in reactive astrocytes
Experimental Neurology, 2004Co-Authors: Jong Tai Chun, Marianna Crispino, Georges ToccoAbstract:Abstract In the developing central nervous system, a src -related Protein–tyrosine Kinase Fyn participates in the myelination process, neuronal growth, and cytoskeletal organization. In adults, Fyn has been implicated in learning and memory formation. To test if Fyn expression is modulated by neuronal activity, we performed quantitative in situ hybridization (ISH) using brain sections of the adult rats that had undergone either kainic acid (KA)-induced seizures or neuronal deafferentation (entorhinal cortex lesion, ECL). In the KA model, a few hours after seizure activities, Fyn mRNA was elevated in the dentate gyrus (DG) (+45%), cerebral cortex layer III (+35%), and piriform cortex (+25%). Conversely, Fyn mRNA consistently decreased in the hippocampal neurons after transection of the major axonal inputs from the entorhinal cortex. Although Fyn expression in the brain has been allegedly limited to neurons and oligodendrocytes, we provide in this study the first evidence that Fyn mRNA is highly expressed in the astrocytes involved in reactive gliosis. In the KA model, the occurrence of Fyn -overexpressing astrocytes increased with the progress of neuronal damage in the CA1 and CA3 regions of the hippocampus. In contrast, Fyn -overexpressing astrocytes were not observed in the granular cell layer of dentate gyrus (DG), where neurons were not damaged. Likewise, in the ECL model, the most drastic change in Fyn mRNA expression took place at the reactive astrocytes near the stab wound sites, where Fyn mRNA levels were doubled 4–10 d after the lesion. Collectively, our data suggest that (i) an early induction of Fyn mRNA in neurons is linked to neuronal activity, and (ii) the delayed induction of Fyn mRNA in reactive astrocytes near the damaged cells may play novel signaling roles during glial response.
Jong Tai Chun - One of the best experts on this subject based on the ideXlab platform.
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the dual response of Protein Kinase Fyn to neural trauma early induction in neurons and delayed induction in reactive astrocytes
Experimental Neurology, 2004Co-Authors: Jong Tai Chun, Marianna Crispino, Georges ToccoAbstract:Abstract In the developing central nervous system, a src -related Protein–tyrosine Kinase Fyn participates in the myelination process, neuronal growth, and cytoskeletal organization. In adults, Fyn has been implicated in learning and memory formation. To test if Fyn expression is modulated by neuronal activity, we performed quantitative in situ hybridization (ISH) using brain sections of the adult rats that had undergone either kainic acid (KA)-induced seizures or neuronal deafferentation (entorhinal cortex lesion, ECL). In the KA model, a few hours after seizure activities, Fyn mRNA was elevated in the dentate gyrus (DG) (+45%), cerebral cortex layer III (+35%), and piriform cortex (+25%). Conversely, Fyn mRNA consistently decreased in the hippocampal neurons after transection of the major axonal inputs from the entorhinal cortex. Although Fyn expression in the brain has been allegedly limited to neurons and oligodendrocytes, we provide in this study the first evidence that Fyn mRNA is highly expressed in the astrocytes involved in reactive gliosis. In the KA model, the occurrence of Fyn -overexpressing astrocytes increased with the progress of neuronal damage in the CA1 and CA3 regions of the hippocampus. In contrast, Fyn -overexpressing astrocytes were not observed in the granular cell layer of dentate gyrus (DG), where neurons were not damaged. Likewise, in the ECL model, the most drastic change in Fyn mRNA expression took place at the reactive astrocytes near the stab wound sites, where Fyn mRNA levels were doubled 4–10 d after the lesion. Collectively, our data suggest that (i) an early induction of Fyn mRNA in neurons is linked to neuronal activity, and (ii) the delayed induction of Fyn mRNA in reactive astrocytes near the damaged cells may play novel signaling roles during glial response.
Marianna Crispino - One of the best experts on this subject based on the ideXlab platform.
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the dual response of Protein Kinase Fyn to neural trauma early induction in neurons and delayed induction in reactive astrocytes
Experimental Neurology, 2004Co-Authors: Jong Tai Chun, Marianna Crispino, Georges ToccoAbstract:Abstract In the developing central nervous system, a src -related Protein–tyrosine Kinase Fyn participates in the myelination process, neuronal growth, and cytoskeletal organization. In adults, Fyn has been implicated in learning and memory formation. To test if Fyn expression is modulated by neuronal activity, we performed quantitative in situ hybridization (ISH) using brain sections of the adult rats that had undergone either kainic acid (KA)-induced seizures or neuronal deafferentation (entorhinal cortex lesion, ECL). In the KA model, a few hours after seizure activities, Fyn mRNA was elevated in the dentate gyrus (DG) (+45%), cerebral cortex layer III (+35%), and piriform cortex (+25%). Conversely, Fyn mRNA consistently decreased in the hippocampal neurons after transection of the major axonal inputs from the entorhinal cortex. Although Fyn expression in the brain has been allegedly limited to neurons and oligodendrocytes, we provide in this study the first evidence that Fyn mRNA is highly expressed in the astrocytes involved in reactive gliosis. In the KA model, the occurrence of Fyn -overexpressing astrocytes increased with the progress of neuronal damage in the CA1 and CA3 regions of the hippocampus. In contrast, Fyn -overexpressing astrocytes were not observed in the granular cell layer of dentate gyrus (DG), where neurons were not damaged. Likewise, in the ECL model, the most drastic change in Fyn mRNA expression took place at the reactive astrocytes near the stab wound sites, where Fyn mRNA levels were doubled 4–10 d after the lesion. Collectively, our data suggest that (i) an early induction of Fyn mRNA in neurons is linked to neuronal activity, and (ii) the delayed induction of Fyn mRNA in reactive astrocytes near the damaged cells may play novel signaling roles during glial response.
Helmut Prof Dr Schafer - One of the best experts on this subject based on the ideXlab platform.
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use of modulators of signal transduction via the Protein Kinase Fyn in the treatment of tumor diseases
2002Co-Authors: Bernd Berwanger, Holger Christiansen, Martin Eilers, Oliver Hartmann, Helmut Prof Dr SchaferAbstract:The present invention describes the use of modulators of signal transduction via the Protein Kinase Fyn (such. As Rho-Kinase inhibitors or inhibitors of Protein Kinase CSK) for the treatment of tumor diseases, especially for the therapy of neuroblastoma.
Bernd Berwanger - One of the best experts on this subject based on the ideXlab platform.
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use of modulators of signal transduction via the Protein Kinase Fyn in the treatment of tumor diseases
2002Co-Authors: Bernd Berwanger, Holger Christiansen, Martin Eilers, Oliver Hartmann, Helmut Prof Dr SchaferAbstract:The present invention describes the use of modulators of signal transduction via the Protein Kinase Fyn (such. As Rho-Kinase inhibitors or inhibitors of Protein Kinase CSK) for the treatment of tumor diseases, especially for the therapy of neuroblastoma.
