The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Junichi Nomura - One of the best experts on this subject based on the ideXlab platform.
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Thyroid Function and Mood
CNS Drugs, 1994Co-Authors: Junichi NomuraAbstract:The occurrence of mental changes in patients with hyperthyroidism and hypothyroidism is well known. In contrast, the role of thyroid function in patients with depression is still controversial. However, it is certain that some depressed patients have a tendency towards hypothyroidism. Thyroid function should be carefully checked in depressed patients, especially in those who are elderly or in the postpartum period. The thyrotrophin-releasing hormone (TRH; Protirelin) Test is a useful psychoendocrine Test. Thyroid hormones augment the effect of tricyclic antidepressants, and large dosages of these hormones influence the periodic recurrence of mood disorders. Therefore, thyroid hormones can be used as adjunctive therapy in patients with refractory depression. They may also be considered as candidate therapy for the treatment of intractable cycling psychoses.
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Implications for the Treatment of Mood Disorders
1994Co-Authors: Junichi NomuraAbstract:Summary The occurrence of mental changes in patients with hyperthyroidism and hypo thyroidism is well known. In contrast, the role of thyroid function in patients with depression is still controversial. However, it is certain that some depressed patients have a tendency towards hypothyroidism. Thyroid function should be carefully checked in depressed patients, especially in those who are elderly or in the postpartum period. The thyrotrophin-releasing hormone (TRH; Protirelin) Test is a useful psychoendocrine Test. Thyroid hormones augment the effect of tricyclic antidepressants, and large dosages of these hormones influence the periodic recurrence of mood disorders. Therefore, thyroid hormones can be used as adjunctive therapy in patients with refractory depression. They may also be considered as candidate therapy for the treatment of intractable cycling psychoses.
J.p. Macher - One of the best experts on this subject based on the ideXlab platform.
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Circadian variations in response to Protirelin Test in major depressive episode
European Psychiatry, 1991Co-Authors: Fabrice Duval, Marie-claude Mokrani, Marc-antoine Crocq, S Rosenberg, J. Oliveira Castro, S. Valdivieso, J.p. MacherAbstract:SummaryWe studied circadian thyrotropin (TSH) and prolactin (PRL) response to synthetic thyrotropin-releasing-hormone (Protirelin) infusion (200μg IV) at 8 am and 11 pm in 35 drug-free inpatients with DSM III-R Major Depressive Episode and in 22 hospitalized controls. In each group, maximum TSH and PRL responses were lower at 8 am than at 11 pm. The difference between 11 pm-ΔTSH and 8 am-ΔJTSH (ΔΔTSH) was significantly lower in depressed patients compared to controls. No such blunting was observed in PRL responses to Protirelin in depressed patients. In the overall population, TSH response to Protirelin (ie8 am-ΔTSH, 11 pm-ΔTSH,ΔΔTSH) correlated significantly with TSH circadian parameters (iemesor and amplitude). These correlations were also observed with PRL (except forΔΔPRL). TSH mesor and amplitude were lower in depressives than in controls. In contrast, PRL mesor and amplitude were not significantly different between diagnostic groups.ΔΔTSH is thus a chronobiological refinement to the measure of thyroid axis dysfunction in major depression. The blunted TSH response to Protirelin suggests that the TRH receptors of the pituitary thyrotrophs are hyposensitive in major depression.
Fabrice Duval - One of the best experts on this subject based on the ideXlab platform.
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Circadian variations in response to Protirelin Test in major depressive episode
European Psychiatry, 1991Co-Authors: Fabrice Duval, Marie-claude Mokrani, Marc-antoine Crocq, S Rosenberg, J. Oliveira Castro, S. Valdivieso, J.p. MacherAbstract:SummaryWe studied circadian thyrotropin (TSH) and prolactin (PRL) response to synthetic thyrotropin-releasing-hormone (Protirelin) infusion (200μg IV) at 8 am and 11 pm in 35 drug-free inpatients with DSM III-R Major Depressive Episode and in 22 hospitalized controls. In each group, maximum TSH and PRL responses were lower at 8 am than at 11 pm. The difference between 11 pm-ΔTSH and 8 am-ΔJTSH (ΔΔTSH) was significantly lower in depressed patients compared to controls. No such blunting was observed in PRL responses to Protirelin in depressed patients. In the overall population, TSH response to Protirelin (ie8 am-ΔTSH, 11 pm-ΔTSH,ΔΔTSH) correlated significantly with TSH circadian parameters (iemesor and amplitude). These correlations were also observed with PRL (except forΔΔPRL). TSH mesor and amplitude were lower in depressives than in controls. In contrast, PRL mesor and amplitude were not significantly different between diagnostic groups.ΔΔTSH is thus a chronobiological refinement to the measure of thyroid axis dysfunction in major depression. The blunted TSH response to Protirelin suggests that the TRH receptors of the pituitary thyrotrophs are hyposensitive in major depression.
Marie-claude Mokrani - One of the best experts on this subject based on the ideXlab platform.
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Circadian variations in response to Protirelin Test in major depressive episode
European Psychiatry, 1991Co-Authors: Fabrice Duval, Marie-claude Mokrani, Marc-antoine Crocq, S Rosenberg, J. Oliveira Castro, S. Valdivieso, J.p. MacherAbstract:SummaryWe studied circadian thyrotropin (TSH) and prolactin (PRL) response to synthetic thyrotropin-releasing-hormone (Protirelin) infusion (200μg IV) at 8 am and 11 pm in 35 drug-free inpatients with DSM III-R Major Depressive Episode and in 22 hospitalized controls. In each group, maximum TSH and PRL responses were lower at 8 am than at 11 pm. The difference between 11 pm-ΔTSH and 8 am-ΔJTSH (ΔΔTSH) was significantly lower in depressed patients compared to controls. No such blunting was observed in PRL responses to Protirelin in depressed patients. In the overall population, TSH response to Protirelin (ie8 am-ΔTSH, 11 pm-ΔTSH,ΔΔTSH) correlated significantly with TSH circadian parameters (iemesor and amplitude). These correlations were also observed with PRL (except forΔΔPRL). TSH mesor and amplitude were lower in depressives than in controls. In contrast, PRL mesor and amplitude were not significantly different between diagnostic groups.ΔΔTSH is thus a chronobiological refinement to the measure of thyroid axis dysfunction in major depression. The blunted TSH response to Protirelin suggests that the TRH receptors of the pituitary thyrotrophs are hyposensitive in major depression.
Marc-antoine Crocq - One of the best experts on this subject based on the ideXlab platform.
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Circadian variations in response to Protirelin Test in major depressive episode
European Psychiatry, 1991Co-Authors: Fabrice Duval, Marie-claude Mokrani, Marc-antoine Crocq, S Rosenberg, J. Oliveira Castro, S. Valdivieso, J.p. MacherAbstract:SummaryWe studied circadian thyrotropin (TSH) and prolactin (PRL) response to synthetic thyrotropin-releasing-hormone (Protirelin) infusion (200μg IV) at 8 am and 11 pm in 35 drug-free inpatients with DSM III-R Major Depressive Episode and in 22 hospitalized controls. In each group, maximum TSH and PRL responses were lower at 8 am than at 11 pm. The difference between 11 pm-ΔTSH and 8 am-ΔJTSH (ΔΔTSH) was significantly lower in depressed patients compared to controls. No such blunting was observed in PRL responses to Protirelin in depressed patients. In the overall population, TSH response to Protirelin (ie8 am-ΔTSH, 11 pm-ΔTSH,ΔΔTSH) correlated significantly with TSH circadian parameters (iemesor and amplitude). These correlations were also observed with PRL (except forΔΔPRL). TSH mesor and amplitude were lower in depressives than in controls. In contrast, PRL mesor and amplitude were not significantly different between diagnostic groups.ΔΔTSH is thus a chronobiological refinement to the measure of thyroid axis dysfunction in major depression. The blunted TSH response to Protirelin suggests that the TRH receptors of the pituitary thyrotrophs are hyposensitive in major depression.
