The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
Alessandra Urbani - One of the best experts on this subject based on the ideXlab platform.
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Trauma Decreases Leucine Enkephalin Hydrolysis in Human Plasma
2016Co-Authors: Reto Babst, Lucilla Bongiorno, Mario Marini, Giorgio L. Roda, Giulio Spagnoli, Alessandra UrbaniAbstract:Plasma hydrolysis of leucine enkephalin was evaluated, to-gether with several cellular immune parameters, in a homoge-neous group of human subjects who had undergone severe trauma (Proximal Femur Fracture); data obtained were compared with those obtained in an age-matched control group. In the experimental group, immediately after hospitalization, sub-strate hydrolysis was reduced with respect both to the control subjects and the same patients 4 weeks after the trauma. Chromatographic separation of the enzymes active on leu-enkephalin showed that the reduction of substrate hydrolysis is mainly attributable to the decrease in the activity of enkephalin-degrading enzymes, principally of aminopeptidases, per se, whereas the role of the low-molecular-weight plasma inhibitors is only minor. In the same subjects, several of the immunolog
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trauma decreases leucine enkephalin hydrolysis in human plasma
Journal of Pharmacology and Experimental Therapeutics, 1999Co-Authors: Reto Babst, Lucilla Bongiorno, Mario Marini, Giulio Spagnoli, L. Giorgio Roda, Alessandra UrbaniAbstract:Plasma hydrolysis of leucine enkephalin was evaluated, together with several cellular immune parameters, in a homogeneous group of human subjects who had undergone severe trauma (Proximal Femur Fracture); data obtained were compared with those obtained in an age-matched control group. In the experimental group, immediately after hospitalization, substrate hydrolysis was reduced with respect both to the control subjects and the same patients 4 weeks after the trauma. Chromatographic separation of the enzymes active on leu-enkephalin showed that the reduction of substrate hydrolysis is mainly attributable to the decrease in the activity of enkephalin-degrading enzymes, principally of aminopeptidases, per se, whereas the role of the low-molecular-weight plasma inhibitors is only minor. In the same subjects, several of the immunological parameters measured underwent modifications that may be considered stress related. However, the absence of a quantitative relationship between reduction in hydrolysis and modifications of immune parameters does not support the hypothesis of a direct relationship between these two sets of data.
Alessandro Masse - One of the best experts on this subject based on the ideXlab platform.
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does lesser trochanter implication affect hip flexion strength in Proximal Femur Fracture
European Journal of Trauma and Emergency Surgery, 2015Co-Authors: Alessandro Aprato, Lo R Baido, Enrico Grosso, Ronald Matteotti, Alessandro Crosio, Alessandro MasseAbstract:Purpose In pertrochanteric and intertrochanteric femoral Fractures, the avulsion of the lesser trochanter by the pull of the iliopsoas muscle is not uncommon. This fragment is not commonly fixed because the avulsion of the lesser is tough to not influence the clinical outcome but up to date there is no evidence to support this statement. The aim of this study is to evaluate if lesser trochanter implication affects psoas muscle strength in Proximal Femur Fracture.
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does lesser trochanter implication affect hip flexion strength in Proximal Femur Fracture
European Journal of Trauma and Emergency Surgery, 2015Co-Authors: Alessandro Aprato, Lo R Baido, Enrico Grosso, Ronald Matteotti, Alessandro Crosio, Alessandro MasseAbstract:In pertrochanteric and intertrochanteric femoral Fractures, the avulsion of the lesser trochanter by the pull of the iliopsoas muscle is not uncommon. This fragment is not commonly fixed because the avulsion of the lesser is tough to not influence the clinical outcome but up to date there is no evidence to support this statement. The aim of this study is to evaluate if lesser trochanter implication affects psoas muscle strength in Proximal Femur Fracture. Patients with a consolidated intertrochanteric or pertrochanteric Fracture associated or not with lesser trochanter Fracture were enrolled, respectively, in group A and group B. Criteria of inclusion were the achievement of an anatomic reduction with gamma nail and a complete consolidation of the Fracture. Criteria of exclusion were a follow-up shorter than 6 months and age over 65 years old at surgery. Patients were retrospectively reviewed for the purpose of this study. Range of motion, modified Harris Hip Score (mHHS), flexion strength with hip in neutral position, at 90° of flexion and in “figure four” position were evaluated on injured and healthy side. On the pre-operative X-rays, the vertical displacement of the lesser trochanter was calculated. Groups A and B showed no significant difference in age and follow-up. No statistical difference between the two groups was found in range of motion, mean mHHS, hip flexion strength at 90° of hip flexion. Lesser trochanter Fracture group showed a significantly reduced strength in flexion with hip in neutral flexion (mean difference between two groups was 18.5 kgf). Lesser trochanter displacement showed a significant correlation with strength at 90° of flexion. Our results showed that lesser trochanter implication may result in decreased hip flexion strength. Lesser trochanter displacement is directly correlated with flexion strength. Further studies will be necessary to understand if lesser trochanter fixation may be a good solution for those patients.
Reto Babst - One of the best experts on this subject based on the ideXlab platform.
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Trauma Decreases Leucine Enkephalin Hydrolysis in Human Plasma
2016Co-Authors: Reto Babst, Lucilla Bongiorno, Mario Marini, Giorgio L. Roda, Giulio Spagnoli, Alessandra UrbaniAbstract:Plasma hydrolysis of leucine enkephalin was evaluated, to-gether with several cellular immune parameters, in a homoge-neous group of human subjects who had undergone severe trauma (Proximal Femur Fracture); data obtained were compared with those obtained in an age-matched control group. In the experimental group, immediately after hospitalization, sub-strate hydrolysis was reduced with respect both to the control subjects and the same patients 4 weeks after the trauma. Chromatographic separation of the enzymes active on leu-enkephalin showed that the reduction of substrate hydrolysis is mainly attributable to the decrease in the activity of enkephalin-degrading enzymes, principally of aminopeptidases, per se, whereas the role of the low-molecular-weight plasma inhibitors is only minor. In the same subjects, several of the immunolog
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trauma decreases leucine enkephalin hydrolysis in human plasma
Journal of Pharmacology and Experimental Therapeutics, 1999Co-Authors: Reto Babst, Lucilla Bongiorno, Mario Marini, Giulio Spagnoli, L. Giorgio Roda, Alessandra UrbaniAbstract:Plasma hydrolysis of leucine enkephalin was evaluated, together with several cellular immune parameters, in a homogeneous group of human subjects who had undergone severe trauma (Proximal Femur Fracture); data obtained were compared with those obtained in an age-matched control group. In the experimental group, immediately after hospitalization, substrate hydrolysis was reduced with respect both to the control subjects and the same patients 4 weeks after the trauma. Chromatographic separation of the enzymes active on leu-enkephalin showed that the reduction of substrate hydrolysis is mainly attributable to the decrease in the activity of enkephalin-degrading enzymes, principally of aminopeptidases, per se, whereas the role of the low-molecular-weight plasma inhibitors is only minor. In the same subjects, several of the immunological parameters measured underwent modifications that may be considered stress related. However, the absence of a quantitative relationship between reduction in hydrolysis and modifications of immune parameters does not support the hypothesis of a direct relationship between these two sets of data.
Daniel Prietoalhambra - One of the best experts on this subject based on the ideXlab platform.
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in hospital care complications and 4 month mortality following a hip or Proximal Femur Fracture the spanish registry of osteoporotic Femur Fractures prospective cohort study
Archives of Osteoporosis, 2018Co-Authors: Daniel Prietoalhambra, Carlen Reyes, Miguel Sanz Sainz, Jesus Gonzalezmacias, Luis Gracia Delgado, Cristina Alonso Bouzon, Sarah Mills Ganan, Damian Mifsut MiedesAbstract:We have characterised 997 hip Fracture patients from a representative 45 Spanish hospitals, and followed them up prospectively for up to 4 months. Despite suboptimal surgical delays (average 59.1 hours), in-hospital mortality was lower than in Northern European cohorts. The secondary Fracture prevention gap is unacceptably high at 85%. To characterise inpatient care, complications, and 4-month mortality following a hip or Proximal Femur Fracture in Spain. Design: prospective cohort study. Consecutive sample of patients ≥ 50 years old admitted in a representative 45 hospitals for a hip or Proximal Femur fragility Fracture, from June 2014 to June 2016 and followed up for 4 months post-Fracture. Patient characteristics, site of Fracture, in-patient care (including secondary Fracture prevention) and complications, and 4-month mortality are described. A total of 997 subjects (765 women) of mean (standard deviation) age 83.6 (8.4) years were included. Previous history of Fracture/s (36.9%) and falls (43%) were common, and 10-year FRAX-estimated major and hip Fracture risks were 15.2% (9.0%) and 8.5% (7.6%) respectively. Inter-trochanteric (44.6%) and displaced intra-capsular (28.0%) were the most common Fracture sites, and fixation with short intramedullary nail (38.6%) with spinal anaesthesia (75.5%) the most common procedures. Surgery and rehabilitation were initiated within a mean 59.1 (56.7) and 61.9 (55.1) hours respectively, and average length of stay was 11.5 (9.3) days. Antithrombotic and antibiotic prophylaxis were given to 99.8% and 98.2% respectively, whilst only 12.4% received secondary Fracture prevention at discharge. Common complications included delirium (36.1 %) and kidney failure (14.1%), with in-hospital and 4-month mortality of 2.1% and 11% respectively. Despite suboptimal surgical delay, post-hip Fracture mortality is low in Spanish hospitals. The secondary Fracture prevention gap is unacceptably high at > 85%, in spite of virtually universal anti-thrombotic and antibiotic prophylaxis.
Alessandro Aprato - One of the best experts on this subject based on the ideXlab platform.
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does lesser trochanter implication affect hip flexion strength in Proximal Femur Fracture
European Journal of Trauma and Emergency Surgery, 2015Co-Authors: Alessandro Aprato, Lo R Baido, Enrico Grosso, Ronald Matteotti, Alessandro Crosio, Alessandro MasseAbstract:Purpose In pertrochanteric and intertrochanteric femoral Fractures, the avulsion of the lesser trochanter by the pull of the iliopsoas muscle is not uncommon. This fragment is not commonly fixed because the avulsion of the lesser is tough to not influence the clinical outcome but up to date there is no evidence to support this statement. The aim of this study is to evaluate if lesser trochanter implication affects psoas muscle strength in Proximal Femur Fracture.
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does lesser trochanter implication affect hip flexion strength in Proximal Femur Fracture
European Journal of Trauma and Emergency Surgery, 2015Co-Authors: Alessandro Aprato, Lo R Baido, Enrico Grosso, Ronald Matteotti, Alessandro Crosio, Alessandro MasseAbstract:In pertrochanteric and intertrochanteric femoral Fractures, the avulsion of the lesser trochanter by the pull of the iliopsoas muscle is not uncommon. This fragment is not commonly fixed because the avulsion of the lesser is tough to not influence the clinical outcome but up to date there is no evidence to support this statement. The aim of this study is to evaluate if lesser trochanter implication affects psoas muscle strength in Proximal Femur Fracture. Patients with a consolidated intertrochanteric or pertrochanteric Fracture associated or not with lesser trochanter Fracture were enrolled, respectively, in group A and group B. Criteria of inclusion were the achievement of an anatomic reduction with gamma nail and a complete consolidation of the Fracture. Criteria of exclusion were a follow-up shorter than 6 months and age over 65 years old at surgery. Patients were retrospectively reviewed for the purpose of this study. Range of motion, modified Harris Hip Score (mHHS), flexion strength with hip in neutral position, at 90° of flexion and in “figure four” position were evaluated on injured and healthy side. On the pre-operative X-rays, the vertical displacement of the lesser trochanter was calculated. Groups A and B showed no significant difference in age and follow-up. No statistical difference between the two groups was found in range of motion, mean mHHS, hip flexion strength at 90° of hip flexion. Lesser trochanter Fracture group showed a significantly reduced strength in flexion with hip in neutral flexion (mean difference between two groups was 18.5 kgf). Lesser trochanter displacement showed a significant correlation with strength at 90° of flexion. Our results showed that lesser trochanter implication may result in decreased hip flexion strength. Lesser trochanter displacement is directly correlated with flexion strength. Further studies will be necessary to understand if lesser trochanter fixation may be a good solution for those patients.
