The Experts below are selected from a list of 672 Experts worldwide ranked by ideXlab platform
Jan Danko - One of the best experts on this subject based on the ideXlab platform.
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Rapidly growing nodular Pseudoangiomatous Stromal Hyperplasia of the breast in an 18-year-old girl.
APMIS : acta pathologica microbiologica et immunologica Scandinavica, 2006Co-Authors: Pavol Zubor, Karol Kajo, Carlos Alberto Dussan, Norbert Szunyogh, Jan DankoAbstract:Pseudoangiomatous Stromal Hyperplasia (PASH) of the breast is a rare benign proliferation of mesenchymal Stromal cells with irregular slit-like formations resembling angiomatous structures. In the majority of cases this lesion is a focal microscopic finding in breast biopsies performed for benign or malignant diseases. It may present in a pure diffuse or nodular form. The exact etiology and pathogenesis of this tumor-like lesion is still unknown, but a proliferative response of myofibroblasts to hormonal stimuli has been postulated. A large 12 x 9 x 3.5 cm rapidly growing nodular form of PASH of the breast in an 18-year-old woman is here described with clinical and histological findings. A possible hormonal etiology was indicated by elevated progesterone (three-fold) and decreased estrogen serum levels. Different diagnostic lesions, such as giant fibroadenoma and low-grade angiosarcoma, are discussed. To the authors' knowledge this is only the fourth case of nodular PASH of the breast reported in the English literature.
Jung Dug Yang - One of the best experts on this subject based on the ideXlab platform.
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Pseudoangiomatous Stromal Hyperplasia Presenting as Rapidly Growing Bilateral Breast Enlargement Refractory to Surgical Excision.
Archives of plastic surgery, 2016Co-Authors: Jeong Woo Lee, Gyu Sik Jung, Jae Bong Kim, Kang Young Choi, Ho Yun Chung, Byung Chae Cho, Ji Young Park, Hye Jung Kim, Ho Yong Park, Jung Dug YangAbstract:Pseudoangiomatous Stromal Hyperplasia (PASH) is a benign proliferative mesenchymal lesion of the breast. PASH presents as a palpable or mammographically detectable mass or is an incidental microscopic finding in up to 23% of breast biopsies. Its pathogenesis is unclear but may involve hormonal factors, as recently postulated. Its clinical, cytological, and radiological characteristics resemble those of other benign tumors, including low-grade angiosarcomas and phyllodes tumors. Because of its uncertain pathogenesis, PASH is usually treated via surgical excision, with post-excision recurrence rates ranging from 7% to 22% [1]. Although several cases of PASH have been recently reported, cases of PASH involving large, rapidly growing lesions refractory to surgical incision are rare [2]. In this study, we report our experience with a case of PASH that presented as rapidly growing bilateral breast enlargement refractory to surgical excision. We also review the pertinent literature, including the clinical and histopathological features, pathogenesis, imaging findings, treatment, and prognosis of PASH.
Alberto G. Ayala - One of the best experts on this subject based on the ideXlab platform.
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Pseudoangiomatous Stromal Hyperplasia of the prostate: report of an unprecedented entity in prostate pathology.
International journal of clinical and experimental pathology, 2018Co-Authors: Alexandra R Rapp, Elizabeth M. Jacobi, Min Jung Jung, Luan D. Truong, Alberto G. AyalaAbstract:Pseudoangiomatous Stromal Hyperplasia is a benign entity of the breast. It is histologically characterized by open, slit-like spaces lined by spindle cells of myofibroblast/fibroblast differentiation in a dense collagenous stroma. Although Pseudoangiomatous Stromal Hyperplasia has been reported in ectopic breast tissue in anogenital mammary-like glands, it has not been previously reported in non-breast tissues. This includes prostatic tissue, which shares similar histology and pathology with the breast. Herein, we report the first case of prostatic Pseudoangiomatous Stromal Hyperplasia based on histological, immunohistochemical, and electron microscopic findings. The patient was a 74-year-old man with a history of benign prostatic Hyperplasia who presented with severe urinary retention and underwent transurethral resection of the prostate. In addition to benign prostatic Hyperplasia, the prostate showed areas of irregular spaces lined occasionally by flattened spindle cells in a background of fibrocollagenous stroma. Immunohistochemically, these cells were diffusely positive for vimentin and negative for CD31, CD34, ERG, pancytokeratin, SMA, and D2-40. Electron microscopic findings also showed some cells with fibroblastic features lining these spaces. Given these findings, we postulated that Pseudoangiomatous Stromal Hyperplasia of the prostate has some cells of fibroblastic lineage. Contrary to its breast counterpart where lining cells demonstrate diffusely and strongly positive staining for CD34 and PR, this prostate case showed negative staining for CD34 and PR. These findings indicate potential differences in the histogenesis of prostatic and breast Pseudoangiomatous Stromal Hyperplasia.
Pavol Zubor - One of the best experts on this subject based on the ideXlab platform.
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Rapidly growing nodular Pseudoangiomatous Stromal Hyperplasia of the breast in an 18-year-old girl.
APMIS : acta pathologica microbiologica et immunologica Scandinavica, 2006Co-Authors: Pavol Zubor, Karol Kajo, Carlos Alberto Dussan, Norbert Szunyogh, Jan DankoAbstract:Pseudoangiomatous Stromal Hyperplasia (PASH) of the breast is a rare benign proliferation of mesenchymal Stromal cells with irregular slit-like formations resembling angiomatous structures. In the majority of cases this lesion is a focal microscopic finding in breast biopsies performed for benign or malignant diseases. It may present in a pure diffuse or nodular form. The exact etiology and pathogenesis of this tumor-like lesion is still unknown, but a proliferative response of myofibroblasts to hormonal stimuli has been postulated. A large 12 x 9 x 3.5 cm rapidly growing nodular form of PASH of the breast in an 18-year-old woman is here described with clinical and histological findings. A possible hormonal etiology was indicated by elevated progesterone (three-fold) and decreased estrogen serum levels. Different diagnostic lesions, such as giant fibroadenoma and low-grade angiosarcoma, are discussed. To the authors' knowledge this is only the fourth case of nodular PASH of the breast reported in the English literature.
Jeong Woo Lee - One of the best experts on this subject based on the ideXlab platform.
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Pseudoangiomatous Stromal Hyperplasia Presenting as Rapidly Growing Bilateral Breast Enlargement Refractory to Surgical Excision.
Archives of plastic surgery, 2016Co-Authors: Jeong Woo Lee, Gyu Sik Jung, Jae Bong Kim, Kang Young Choi, Ho Yun Chung, Byung Chae Cho, Ji Young Park, Hye Jung Kim, Ho Yong Park, Jung Dug YangAbstract:Pseudoangiomatous Stromal Hyperplasia (PASH) is a benign proliferative mesenchymal lesion of the breast. PASH presents as a palpable or mammographically detectable mass or is an incidental microscopic finding in up to 23% of breast biopsies. Its pathogenesis is unclear but may involve hormonal factors, as recently postulated. Its clinical, cytological, and radiological characteristics resemble those of other benign tumors, including low-grade angiosarcomas and phyllodes tumors. Because of its uncertain pathogenesis, PASH is usually treated via surgical excision, with post-excision recurrence rates ranging from 7% to 22% [1]. Although several cases of PASH have been recently reported, cases of PASH involving large, rapidly growing lesions refractory to surgical incision are rare [2]. In this study, we report our experience with a case of PASH that presented as rapidly growing bilateral breast enlargement refractory to surgical excision. We also review the pertinent literature, including the clinical and histopathological features, pathogenesis, imaging findings, treatment, and prognosis of PASH.
