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D. Shearer - One of the best experts on this subject based on the ideXlab platform.
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p 41 Psychogenic Alopecia by fur plucking in a family of seal point siamese cats three cases
Veterinary Dermatology, 2004Co-Authors: K. E. Loft, D. ShearerAbstract:Three seal-point Siamese cats (phenotype = SIA n), from the same line of breeding, displayed fur-plucking of the dorsum. Feline Psychogenic Alopecia is an anxiety neurosis. In these cats, fur-plucking is an excessive grooming behaviour leading to fur hyperpigmentation. The first case was a 3-year-old intact female that had been fur-plucking from 6 months of age. She was the offspring of the mating of a lilac-point male (SIA a) and a SIA n female. The cat was treated with depomedrol and Viacutan® without effect. The second case was a 3-year-old castrated male that had been fur-plucking from 9 months of age. He was treated with megestrol acetate with moderate effect. The third case was a 1-year-old intact female that had been fur-plucking from 6 months of age and was the offspring of the first case and a male chocolate point (SIA b). She was treated with depomedrol and Viacutan® without effect. None of the littermates with other phenotypes (4 SIA a) had dermatological complaints. All affected cats underwent a full evaluation including dermatophyte testing (negative), ectoparasite tests (negative) and intradermal tests (negative). An 8-week food elimination trial followed by a 3-week challenge had no effect. Histopathology revealed a mild mononuclear superficial perivascular dermatitis and perifolliculitis. There were no morphological hair or hair follicle abnormalities. A diagnosis of feline Psychogenic Alopecia was made on the basis of exclusion. The finding of feline Psychogenic Alopecia in three closely related cats suggests that the disorder may be hereditary or have an inherited component. Funding: Kruuse A/S Denmark.
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P‐41 Psychogenic Alopecia by fur‐plucking in a family of seal‐point Siamese cats: three cases
Veterinary Dermatology, 2004Co-Authors: K. E. Loft, D. ShearerAbstract:Three seal-point Siamese cats (phenotype = SIA n), from the same line of breeding, displayed fur-plucking of the dorsum. Feline Psychogenic Alopecia is an anxiety neurosis. In these cats, fur-plucking is an excessive grooming behaviour leading to fur hyperpigmentation. The first case was a 3-year-old intact female that had been fur-plucking from 6 months of age. She was the offspring of the mating of a lilac-point male (SIA a) and a SIA n female. The cat was treated with depomedrol and Viacutan® without effect. The second case was a 3-year-old castrated male that had been fur-plucking from 9 months of age. He was treated with megestrol acetate with moderate effect. The third case was a 1-year-old intact female that had been fur-plucking from 6 months of age and was the offspring of the first case and a male chocolate point (SIA b). She was treated with depomedrol and Viacutan® without effect. None of the littermates with other phenotypes (4 SIA a) had dermatological complaints. All affected cats underwent a full evaluation including dermatophyte testing (negative), ectoparasite tests (negative) and intradermal tests (negative). An 8-week food elimination trial followed by a 3-week challenge had no effect. Histopathology revealed a mild mononuclear superficial perivascular dermatitis and perifolliculitis. There were no morphological hair or hair follicle abnormalities. A diagnosis of feline Psychogenic Alopecia was made on the basis of exclusion. The finding of feline Psychogenic Alopecia in three closely related cats suggests that the disorder may be hereditary or have an inherited component. Funding: Kruuse A/S Denmark.
K. E. Loft - One of the best experts on this subject based on the ideXlab platform.
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p 41 Psychogenic Alopecia by fur plucking in a family of seal point siamese cats three cases
Veterinary Dermatology, 2004Co-Authors: K. E. Loft, D. ShearerAbstract:Three seal-point Siamese cats (phenotype = SIA n), from the same line of breeding, displayed fur-plucking of the dorsum. Feline Psychogenic Alopecia is an anxiety neurosis. In these cats, fur-plucking is an excessive grooming behaviour leading to fur hyperpigmentation. The first case was a 3-year-old intact female that had been fur-plucking from 6 months of age. She was the offspring of the mating of a lilac-point male (SIA a) and a SIA n female. The cat was treated with depomedrol and Viacutan® without effect. The second case was a 3-year-old castrated male that had been fur-plucking from 9 months of age. He was treated with megestrol acetate with moderate effect. The third case was a 1-year-old intact female that had been fur-plucking from 6 months of age and was the offspring of the first case and a male chocolate point (SIA b). She was treated with depomedrol and Viacutan® without effect. None of the littermates with other phenotypes (4 SIA a) had dermatological complaints. All affected cats underwent a full evaluation including dermatophyte testing (negative), ectoparasite tests (negative) and intradermal tests (negative). An 8-week food elimination trial followed by a 3-week challenge had no effect. Histopathology revealed a mild mononuclear superficial perivascular dermatitis and perifolliculitis. There were no morphological hair or hair follicle abnormalities. A diagnosis of feline Psychogenic Alopecia was made on the basis of exclusion. The finding of feline Psychogenic Alopecia in three closely related cats suggests that the disorder may be hereditary or have an inherited component. Funding: Kruuse A/S Denmark.
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P‐41 Psychogenic Alopecia by fur‐plucking in a family of seal‐point Siamese cats: three cases
Veterinary Dermatology, 2004Co-Authors: K. E. Loft, D. ShearerAbstract:Three seal-point Siamese cats (phenotype = SIA n), from the same line of breeding, displayed fur-plucking of the dorsum. Feline Psychogenic Alopecia is an anxiety neurosis. In these cats, fur-plucking is an excessive grooming behaviour leading to fur hyperpigmentation. The first case was a 3-year-old intact female that had been fur-plucking from 6 months of age. She was the offspring of the mating of a lilac-point male (SIA a) and a SIA n female. The cat was treated with depomedrol and Viacutan® without effect. The second case was a 3-year-old castrated male that had been fur-plucking from 9 months of age. He was treated with megestrol acetate with moderate effect. The third case was a 1-year-old intact female that had been fur-plucking from 6 months of age and was the offspring of the first case and a male chocolate point (SIA b). She was treated with depomedrol and Viacutan® without effect. None of the littermates with other phenotypes (4 SIA a) had dermatological complaints. All affected cats underwent a full evaluation including dermatophyte testing (negative), ectoparasite tests (negative) and intradermal tests (negative). An 8-week food elimination trial followed by a 3-week challenge had no effect. Histopathology revealed a mild mononuclear superficial perivascular dermatitis and perifolliculitis. There were no morphological hair or hair follicle abnormalities. A diagnosis of feline Psychogenic Alopecia was made on the basis of exclusion. The finding of feline Psychogenic Alopecia in three closely related cats suggests that the disorder may be hereditary or have an inherited component. Funding: Kruuse A/S Denmark.
Joseph A Bernstein - One of the best experts on this subject based on the ideXlab platform.
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Psychogenic Alopecia in rhesus macaques presenting as focally extensive Alopecia of the distal limb.
Comparative Medicine, 2011Co-Authors: Joshua A. Kramer, Joe H. Simmons, Keith G. Mansfield, Joseph A BernsteinAbstract:Alopecia is a major concern in rhesus macaque (Macaca mulatta) colonies from both a regulatory and colony-health perspective and is currently a focus of research.3,4,6,10,12,18,26,31,32 Numerous causes have been reported, including inflammatory,2,19,25,27 allergic,18,21 genetic,1 nutritional,8,24,28,33 infectious,15 and idiopathic13 etiologies. Despite this information, a default diagnosis of Psychogenic self-inflicted Alopecia often is reached in the absence of an evidence-based diagnostic approach. Experience in comparative veterinary and human dermatology indicates that there is no single cause of Alopecia. Because Alopecia can be either a primary or secondary lesion in dermatology, veterinarians and regulatory authorities should have a full understanding of the breadth of diseases that can lead to Alopecia and to pursue a systematic dermatologic diagnostic plan to direct appropriate treatment. Focally extensive Alopecia affecting the distal limbs (Figure 1) is a common clinical pattern in the colony we describe here. Generally, these macaques have irregularly shaped patches of hair loss on their forearms or lower legs (or both) that is not necessarily associated with diffuse Alopecia on other anatomic sites. This clinical pattern is quite distinct from the generalized Alopecia seen in other macaques. Figure 1. Clinical appearance of distal limb Alopecia, with a well circumscribed area of hair loss without underlying skin inflammation. Herein, we describe the clinical and pathologic evaluations of rhesus macaques with this specific pattern of Alopecia. Locally extensive, noninflammatory Alopecia is the only presenting clinical sign in these animals. On the basis of exclusion of other differential diagnoses, we conclude that Psychogenic Alopecia is the presumptive cause.
Bernstein, Joseph A - One of the best experts on this subject based on the ideXlab platform.
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Psychogenic Alopecia in Rhesus Macaques Presenting as Focally Extensive Alopecia of the Distal Limb
American Association for Laboratory Animal Science, 1Co-Authors: Kramer, Joshua A, Mansfield, Keith G, Simmons, Joe H, Bernstein, Joseph AAbstract:Focally extensive Alopecia affecting the distal limbs is a common clinical finding in rhesus macaque (Macaca mulatta) colonies and is both a regulatory and colony-health concern. We performed diagnostic examinations including physical exams, bloodwork, skin scrapes, surface cytology, and surface bacterial–fungal cultures on 17 rhesus macaques with this presentation of Alopecia. Skin biopsies from alopecic skin obtained from each macaque were compared with those of normal skin from the same animal. Immunohistochemistry and metachromatic staining for inflammatory cells were performed to compare alopecic and normal skin. In addition, we compared these biopsies with those previously obtained from macaques with generalized Alopecia and dermal inflammatory infiltrates consistent with cutaneous hypersensitivity disorders and with those from animals with normal haircoats. Bacterial and fungal cultures, skin scrapes, surface cytology, and bloodwork were unremarkable. Affected skin showed only mild histologic alteration, with rare evidence of trichomalacia and follicular loss. Numbers of mast cells and CD3+ lymphocytes did not differ between alopecic and normally haired skin from the same animal. The number of mast cells in alopecic skin from animals in the current cohort was significantly lower than that in skin of animals previously diagnosed with a cutaneous hypersensitivity disorder. Numbers of both mast cells and CD3+ lymphocytes in alopecic skin from the current cohort were similar to those from biopsies of animals with normal haircoats. Together, the clinical findings and pathology are consistent with a Psychogenic origin for this pattern of Alopecia in rhesus macaques
Joshua A. Kramer - One of the best experts on this subject based on the ideXlab platform.
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Psychogenic Alopecia in rhesus macaques presenting as focally extensive Alopecia of the distal limb.
Comparative Medicine, 2011Co-Authors: Joshua A. Kramer, Joe H. Simmons, Keith G. Mansfield, Joseph A BernsteinAbstract:Alopecia is a major concern in rhesus macaque (Macaca mulatta) colonies from both a regulatory and colony-health perspective and is currently a focus of research.3,4,6,10,12,18,26,31,32 Numerous causes have been reported, including inflammatory,2,19,25,27 allergic,18,21 genetic,1 nutritional,8,24,28,33 infectious,15 and idiopathic13 etiologies. Despite this information, a default diagnosis of Psychogenic self-inflicted Alopecia often is reached in the absence of an evidence-based diagnostic approach. Experience in comparative veterinary and human dermatology indicates that there is no single cause of Alopecia. Because Alopecia can be either a primary or secondary lesion in dermatology, veterinarians and regulatory authorities should have a full understanding of the breadth of diseases that can lead to Alopecia and to pursue a systematic dermatologic diagnostic plan to direct appropriate treatment. Focally extensive Alopecia affecting the distal limbs (Figure 1) is a common clinical pattern in the colony we describe here. Generally, these macaques have irregularly shaped patches of hair loss on their forearms or lower legs (or both) that is not necessarily associated with diffuse Alopecia on other anatomic sites. This clinical pattern is quite distinct from the generalized Alopecia seen in other macaques. Figure 1. Clinical appearance of distal limb Alopecia, with a well circumscribed area of hair loss without underlying skin inflammation. Herein, we describe the clinical and pathologic evaluations of rhesus macaques with this specific pattern of Alopecia. Locally extensive, noninflammatory Alopecia is the only presenting clinical sign in these animals. On the basis of exclusion of other differential diagnoses, we conclude that Psychogenic Alopecia is the presumptive cause.