The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Eliathamby Ambikairajah - One of the best experts on this subject based on the ideXlab platform.
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spectro temporal analysis of speech affected by depression and Psychomotor Retardation
International Conference on Acoustics Speech and Signal Processing, 2013Co-Authors: Nicholas Cummins, Julien Epps, Eliathamby AmbikairajahAbstract:To enhance current diagnostic methods used when assessing a depressed individual, an objective screening mechanism, ideally based on non-intrusive behavioral signals, is needed. Given the clinical description of depression speech as `dull, monotonous and flat' and promising previous results from spectral features, we hypothesize that the effects of depression on speech are embedded in spectro-temporal events. To test this hypothesis we explore different methodologies, based on the modulation spectrum, for extracting long-term spectro-temporal information from speech and assess their suitability as a clinical marker of depression. Results indicate that: depressive speech information is captured in the modulation spectrum, long-term spectro-temporal information is important in depressed speech identification and there are potential differences in the effects that depression and Psychomotor Retardation have on speech production mechanisms.
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ICASSP - Spectro-temporal analysis of speech affected by depression and Psychomotor Retardation
2013 IEEE International Conference on Acoustics Speech and Signal Processing, 2013Co-Authors: Nicholas Cummins, Julien Epps, Eliathamby AmbikairajahAbstract:To enhance current diagnostic methods used when assessing a depressed individual, an objective screening mechanism, ideally based on non-intrusive behavioral signals, is needed. Given the clinical description of depression speech as `dull, monotonous and flat' and promising previous results from spectral features, we hypothesize that the effects of depression on speech are embedded in spectro-temporal events. To test this hypothesis we explore different methodologies, based on the modulation spectrum, for extracting long-term spectro-temporal information from speech and assess their suitability as a clinical marker of depression. Results indicate that: depressive speech information is captured in the modulation spectrum, long-term spectro-temporal information is important in depressed speech identification and there are potential differences in the effects that depression and Psychomotor Retardation have on speech production mechanisms.
Peretz Lavie - One of the best experts on this subject based on the ideXlab platform.
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Melatonin treatment in an institutionalised child with Psychomotor Retardation and an irregular sleep–wake pattern
Archives of disease in childhood, 1998Co-Authors: G. Pillar, A Etzioni, E Shahar, Peretz LavieAbstract:An institutionalised 13 year old girl with Psychomotor Retardation suffered from an irregular sleep-wake pattern. Multiple measurements of urinary sulphatoxymelatonin (aMT6) concentrations were abnormally low, without any significant day-night differences. Administration of exogenous melatonin (3 mg) at 18:00 resulted in increased nocturnal urinary aMT6 concentrations and improvements in her sleep-wake pattern. Melatonin may help disabled children suffering from sleep disorders.
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melatonin treatment in an institutionalised child with Psychomotor Retardation and an irregular sleep wake pattern
Archives of Disease in Childhood, 1998Co-Authors: G. Pillar, A Etzioni, E Shahar, Peretz LavieAbstract:An institutionalised 13 year old girl with Psychomotor Retardation suffered from an irregular sleep-wake pattern. Multiple measurements of urinary sulphatoxymelatonin (aMT6) concentrations were abnormally low, without any significant day-night differences. Administration of exogenous melatonin (3 mg) at 18:00 resulted in increased nocturnal urinary aMT6 concentrations and improvements in her sleep-wake pattern. Melatonin may help disabled children suffering from sleep disorders.
Nicholas Cummins - One of the best experts on this subject based on the ideXlab platform.
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spectro temporal analysis of speech affected by depression and Psychomotor Retardation
International Conference on Acoustics Speech and Signal Processing, 2013Co-Authors: Nicholas Cummins, Julien Epps, Eliathamby AmbikairajahAbstract:To enhance current diagnostic methods used when assessing a depressed individual, an objective screening mechanism, ideally based on non-intrusive behavioral signals, is needed. Given the clinical description of depression speech as `dull, monotonous and flat' and promising previous results from spectral features, we hypothesize that the effects of depression on speech are embedded in spectro-temporal events. To test this hypothesis we explore different methodologies, based on the modulation spectrum, for extracting long-term spectro-temporal information from speech and assess their suitability as a clinical marker of depression. Results indicate that: depressive speech information is captured in the modulation spectrum, long-term spectro-temporal information is important in depressed speech identification and there are potential differences in the effects that depression and Psychomotor Retardation have on speech production mechanisms.
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ICASSP - Spectro-temporal analysis of speech affected by depression and Psychomotor Retardation
2013 IEEE International Conference on Acoustics Speech and Signal Processing, 2013Co-Authors: Nicholas Cummins, Julien Epps, Eliathamby AmbikairajahAbstract:To enhance current diagnostic methods used when assessing a depressed individual, an objective screening mechanism, ideally based on non-intrusive behavioral signals, is needed. Given the clinical description of depression speech as `dull, monotonous and flat' and promising previous results from spectral features, we hypothesize that the effects of depression on speech are embedded in spectro-temporal events. To test this hypothesis we explore different methodologies, based on the modulation spectrum, for extracting long-term spectro-temporal information from speech and assess their suitability as a clinical marker of depression. Results indicate that: depressive speech information is captured in the modulation spectrum, long-term spectro-temporal information is important in depressed speech identification and there are potential differences in the effects that depression and Psychomotor Retardation have on speech production mechanisms.
G. Pillar - One of the best experts on this subject based on the ideXlab platform.
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Melatonin treatment in an institutionalised child with Psychomotor Retardation and an irregular sleep–wake pattern
Archives of disease in childhood, 1998Co-Authors: G. Pillar, A Etzioni, E Shahar, Peretz LavieAbstract:An institutionalised 13 year old girl with Psychomotor Retardation suffered from an irregular sleep-wake pattern. Multiple measurements of urinary sulphatoxymelatonin (aMT6) concentrations were abnormally low, without any significant day-night differences. Administration of exogenous melatonin (3 mg) at 18:00 resulted in increased nocturnal urinary aMT6 concentrations and improvements in her sleep-wake pattern. Melatonin may help disabled children suffering from sleep disorders.
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melatonin treatment in an institutionalised child with Psychomotor Retardation and an irregular sleep wake pattern
Archives of Disease in Childhood, 1998Co-Authors: G. Pillar, A Etzioni, E Shahar, Peretz LavieAbstract:An institutionalised 13 year old girl with Psychomotor Retardation suffered from an irregular sleep-wake pattern. Multiple measurements of urinary sulphatoxymelatonin (aMT6) concentrations were abnormally low, without any significant day-night differences. Administration of exogenous melatonin (3 mg) at 18:00 resulted in increased nocturnal urinary aMT6 concentrations and improvements in her sleep-wake pattern. Melatonin may help disabled children suffering from sleep disorders.
Janet L Taylor - One of the best experts on this subject based on the ideXlab platform.
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a study using transcranial magnetic stimulation to investigate motor mechanisms in Psychomotor Retardation in depression
The International Journal of Neuropsychopharmacology, 2008Co-Authors: Colleen Loo, Perminder S Sachdev, Philip B Mitchell, Simon C Gandevia, Gin S Malhi, Gabrielle Todd, Janet L TaylorAbstract:The pathophysiological basis of Psychomotor Retardation in depression is unclear. In this study, transcranial magnetic stimulation (TMS) was used to examine the functioning of the motor cortical system in 19 depressed patients and 10 healthy control subjects. Motor-evoked potentials were measured in the biceps brachii muscle during a series of tests with the muscle at rest and during voluntary elbow flexion contractions. Maximal voluntary force, as well as force and electromyographic responses to TMS were also measured during fatiguing maximal contractions. Depressed Psychomotor-retarded subjects were less able to produce output from the motor cortex than non-Psychomotor-retarded, depressed subjects and healthy controls during maximal exertion and fatigue. This finding was independent of depression severity. In contrast, responses to TMS elicited during relaxation or weak contractions did not differ between healthy and Psychomotor-retarded subjects. Our study suggests that although the motor pathway from the motor cortex to the muscle is unimpaired, Psychomotor Retardation in depression is characterized by a reduced ability to drive the motor cortex.