The Experts below are selected from a list of 282 Experts worldwide ranked by ideXlab platform
Hubertus Jarry - One of the best experts on this subject based on the ideXlab platform.
-
Corrigendum to “The opposing roles of estradiol on synaptic protein expression in hippocampal cultures” [Psychoneuroendocrinology 34 (Suppl. 1) (2009) 123–129]
Psychoneuroendocrinology, 2020Co-Authors: Lars Fester, Lepu Zhou, Corinna Voets, Christiana Ossig, Erik Disteldorf, Christian Peters, Florian Blaute, Danuta Dudzinski, Janine Prange-kiel, Hubertus JarryAbstract:Dr. Gabriele M. Rune apologizes for having listed Dr. Christian Peters as a co-author of the paper (Fester et al., 2009) ‘‘The opposing roles of estradiol on synaptic protein expression in hippocampal cultures’’ (Psychoneuroendocrinology 34 (Suppl. 1) 123—129) and having cited the results of his work without his signed authorization. Dr. Peters was not involved in the writing of the paper nor was he informed that his name was in the list of authors of the two versions of the publication. Therefore, the sentence cited below, which refers to the data contributed by Dr. Peters, needs to be deleted from the publication and Dr. Peters’ name needs to be removed from the list of authors. ‘‘In fact, according to real time RT-PCR, which was used to compare the amount of synaptopodin mRNA in estradiol-treated slice cultures to that in non-treated cultures, we found that synaptopodin mRNA expression was clearly downregulated compared to the controls’’ (pages 126—127). Psychoneuroendocrinology (2011) 36, 148
-
corrigendum to the opposing roles of estradiol on synaptic protein expression in hippocampal cultures Psychoneuroendocrinology 34 suppl 1 2009 123 129
Psychoneuroendocrinology, 2011Co-Authors: Lars Fester, Lepu Zhou, Corinna Voets, Christiana Ossig, Erik Disteldorf, Christian Peters, Florian Blaute, Janine Prangekiel, Danuta Dudzinski, Hubertus JarryAbstract:Dr. Gabriele M. Rune apologizes for having listed Dr. Christian Peters as a co-author of the paper (Fester et al., 2009) ‘‘The opposing roles of estradiol on synaptic protein expression in hippocampal cultures’’ (Psychoneuroendocrinology 34 (Suppl. 1) 123—129) and having cited the results of his work without his signed authorization. Dr. Peters was not involved in the writing of the paper nor was he informed that his name was in the list of authors of the two versions of the publication. Therefore, the sentence cited below, which refers to the data contributed by Dr. Peters, needs to be deleted from the publication and Dr. Peters’ name needs to be removed from the list of authors. ‘‘In fact, according to real time RT-PCR, which was used to compare the amount of synaptopodin mRNA in estradiol-treated slice cultures to that in non-treated cultures, we found that synaptopodin mRNA expression was clearly downregulated compared to the controls’’ (pages 126—127). Psychoneuroendocrinology (2011) 36, 148
Jens C Pruessner - One of the best experts on this subject based on the ideXlab platform.
-
conceptual endophenotypes a strategy to advance the impact of Psychoneuroendocrinology in precision medicine
Psychoneuroendocrinology, 2018Co-Authors: Dirk H Hellhammer, Gunther Meinlschmidt, Jens C PruessnerAbstract:Abstract Psychobiological research has generated a tremendous amount of findings on the psychological, neuroendocrine, molecular and environmental processes that are directly relevant for mental and physical health, but have overwhelmed our capacity to meaningfully absorb, integrate, and utilize this knowledge base. Here, we reflect about suitable strategies to improve the translational success of psychoneuroendocrinological research in the era of precision medicine. Following a strategy advocated by the National Research Council and the tradition of endophenotype-based research, we advance here a new approach, termed “conceptual endophenotypes”. We define the contextual and formal criteria of conceptual endophenotypes, outline criteria for filtering and selecting information, and describe how conceptual endophenotypes can be validated and implemented at the bedside. As proof-of-concept, we describe some of our findings from research that has adopted this approach in the context of stress-related disorders. We argue that conceptual endophenotypes engineer a bridge between the bench and the bedside. This approach readily lends itself to being continuously developed and implemented. Recent methodological advances, including digital phenotyping, machine learning, grassroots collaboration, and a learning healthcare system, may accelerate the development and implementation of this conceptual endophenotype approach.
-
the combined propranolol tsst paradigm a new method for Psychoneuroendocrinology
PLOS ONE, 2013Co-Authors: Julie Andrews, Jens C PruessnerAbstract:Upon perception of a stimulus as stressful, the human brain reacts with the activation of the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), to mobilize energy resources to better cope with the stressor. Since the perception of the stressor is the initial stimulus, a synchronicity between the subjective perception of stress and the physiological stress reactivity should be expected. However, according to a recent meta-analysis, these associations are weak and inconsistent. The goal of the current study was to investigate the interaction between the SNS, HPA and subjective stress perceptions, by introducing an experimental manipulation of this interaction. For this purpose, we combined the SNS inhibitor propranolol with the Trier Social Stress Test, and measured endocrinological and psychological responses to the stressor. Thirty healthy male participants were recruited and randomly assigned to either a propranolol (PROP; n = 15) or placebo (PLC; n = 15) group. All subjects were administered 80 mg of propranolol 60 minutes prior to exposure to psychosocial stress. Salivary cortisol and alpha amylase (sAA), heart rate, blood pressure and subjective stress responses were assessed throughout the study. We observed significantly reduced sAA levels and heart rate increases in the PROP group in response to stress, with no effects of the drug on systolic or diastolic blood pressure changes. In line with previous studies, a significant increase in cortisol was seen in response to the stress exposure. Importantly, the cortisol increase was significantly higher in the PROP group. A typical increase in subjective stress could be seen in both groups, with no significant group differences emerging. Complementing previous work, this study further demonstrates a significant interaction between the HPA and the SNS during acute stress. The HPA activity was found to be elevated in the presence of a suppressed SNS in reactivity to the TSST.
-
The combined propranolol/TSST paradigm--a new method for Psychoneuroendocrinology.
PLOS ONE, 2013Co-Authors: Julie Andrews, Jens C PruessnerAbstract:Upon perception of a stimulus as stressful, the human brain reacts with the activation of the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), to mobilize energy resources to better cope with the stressor. Since the perception of the stressor is the initial stimulus, a synchronicity between the subjective perception of stress and the physiological stress reactivity should be expected. However, according to a recent meta-analysis, these associations are weak and inconsistent. The goal of the current study was to investigate the interaction between the SNS, HPA and subjective stress perceptions, by introducing an experimental manipulation of this interaction. For this purpose, we combined the SNS inhibitor propranolol with the Trier Social Stress Test, and measured endocrinological and psychological responses to the stressor. Thirty healthy male participants were recruited and randomly assigned to either a propranolol (PROP; n = 15) or placebo (PLC; n = 15) group. All subjects were administered 80 mg of propranolol 60 minutes prior to exposure to psychosocial stress. Salivary cortisol and alpha amylase (sAA), heart rate, blood pressure and subjective stress responses were assessed throughout the study. We observed significantly reduced sAA levels and heart rate increases in the PROP group in response to stress, with no effects of the drug on systolic or diastolic blood pressure changes. In line with previous studies, a significant increase in cortisol was seen in response to the stress exposure. Importantly, the cortisol increase was significantly higher in the PROP group. A typical increase in subjective stress could be seen in both groups, with no significant group differences emerging. Complementing previous work, this study further demonstrates a significant interaction between the HPA and the SNS during acute stress. The HPA activity was found to be elevated in the presence of a suppressed SNS in reactivity to the TSST.
-
the combined dexamethasone tsst paradigm a new method for Psychoneuroendocrinology
PLOS ONE, 2012Co-Authors: Julie Andrews, Catherine Daguiar, Jens C PruessnerAbstract:The two main physiological systems involved in the regulation of the stress response are the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). However, the interaction of these systems on the stress response remains poorly understood. To better understand the cross-regulatory effects of the different systems involved in stress regulation, we developed a new stress paradigm that keeps the activity of the HPA constant when exposing subjects to psychosocial stress. Thirty healthy male participants were recruited and randomly assigned to either a dexamethasone (DEX; n = 15) or placebo (PLC; n = 15) group. All subjects were instructed to take the Dexamethasone (2 mg) or Placebo pill the night before coming to the laboratory to undergo the Trier Social Stress Task (TSST). Salivary cortisol, salivary alpha amylase (sAA), heart rate, blood pressure and subjective stress were assessed throughout the protocol. As expected, the DEX group presented with suppressed cortisol levels. In comparison, their heart rate was elevated by approximately ten base points compared to the PLC group, with increases throughout the protocol and during the TSST. Neither sAA, nor systolic or diastolic blood pressures showed significant group differences. Subjective stress levels significantly increased from baseline, and were found to be higher before and after the TSST after DEX compared to placebo. These results demonstrate a significant interaction between the HPA and the SNS during acute stress. The SNS activity was found to be elevated in the presence of a suppressed HPA axis, with some further effects on subjective levels of stress. The method to suppress the HPA prior to inducing stress was found to completely reliable, without any adverse side effects. Therefore, we propose this paradigm as a new method to investigate the interaction of the two major stress systems in the regulation of the stress response.
-
The Combined Dexamethasone/TSST Paradigm : a New Method for Psychoneuroendocrinology
PLOS ONE, 2012Co-Authors: Julie Andrews, Catherine D’aguiar, Jens C PruessnerAbstract:The two main physiological systems involved in the regulation of the stress response are the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). However, the interaction of these systems on the stress response remains poorly understood. To better understand the cross-regulatory effects of the different systems involved in stress regulation, we developed a new stress paradigm that keeps the activity of the HPA constant when exposing subjects to psychosocial stress. Thirty healthy male participants were recruited and randomly assigned to either a dexamethasone (DEX; n = 15) or placebo (PLC; n = 15) group. All subjects were instructed to take the Dexamethasone (2 mg) or Placebo pill the night before coming to the laboratory to undergo the Trier Social Stress Task (TSST). Salivary cortisol, salivary alpha amylase (sAA), heart rate, blood pressure and subjective stress were assessed throughout the protocol. As expected, the DEX group presented with suppressed cortisol levels. In comparison, their heart rate was elevated by approximately ten base points compared to the PLC group, with increases throughout the protocol and during the TSST. Neither sAA, nor systolic or diastolic blood pressures showed significant group differences. Subjective stress levels significantly increased from baseline, and were found to be higher before and after the TSST after DEX compared to placebo. These results demonstrate a significant interaction between the HPA and the SNS during acute stress. The SNS activity was found to be elevated in the presence of a suppressed HPA axis, with some further effects on subjective levels of stress. The method to suppress the HPA prior to inducing stress was found to completely reliable, without any adverse side effects. Therefore, we propose this paradigm as a new method to investigate the interaction of the two major stress systems in the regulation of the stress response.
Sophia Vinogradov - One of the best experts on this subject based on the ideXlab platform.
-
corrigendum to oxytocin administration enhances controlled social cognition in patients with schizophrenia Psychoneuroendocrinology 47 2014 116 125
Psychoneuroendocrinology, 2015Co-Authors: Joshua D Woolley, Brandon Chuang, Aoife Odonovan, Katherine P Rankin, Daniel H Mathalon, Sophia VinogradovAbstract:Psychoneuroendocrinology (2015) 52, 13 Available online at www.sciencedirect.com ScienceDirect j ourna l h om epa ge : www.elsevier.com/locate/psyneuen CORRIGENDUM Corrigendum to ‘‘Oxytocin administration enhances controlled social cognition in patients with schizophrenia’’ [Psychoneuroendocrinology 47 (2014) J.D. Woolley a,b,∗ , B. Chuang a , O. Lam a , W. Lai a , A. O’Donovan a,b , K.P. Rankin c,d , D.H. Mathalon a,b , S. Vinogradov a,b a Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA, USA c UCSF Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA d Department of Neurology, University of California San Francisco, San Francisco, CA, USA b We acknowledge that this work was supported by Career Development Award # CX000758 from the United States Department of Veterans Affairs, Office of Research and Development, Clinical Science Research and Development program. DOI of original article:http://dx.doi.org/10.1016/j.psyneuen.2014.04.024. Corresponding author at: 4150 Clement Street, 116C-1, San Francisco, CA 94121, USA. Tel.: +1 415 221 4810x4117. E-mail address: Josh.Woolley@ucsf.edu (J.D. Woolley). http://dx.doi.org/10.1016/j.psyneuen.2014.11.001 0306-4530/Published by Elsevier Ltd.
-
Corrigendum to “Oxytocin administration enhances controlled social cognition in patients with schizophrenia” [Psychoneuroendocrinology 47 (2014) 116–125]
Psychoneuroendocrinology, 2015Co-Authors: Joshua D Woolley, Brandon Chuang, Katherine P Rankin, Daniel H Mathalon, Aoife O'donovan, Sophia VinogradovAbstract:Psychoneuroendocrinology (2015) 52, 13 Available online at www.sciencedirect.com ScienceDirect j ourna l h om epa ge : www.elsevier.com/locate/psyneuen CORRIGENDUM Corrigendum to ‘‘Oxytocin administration enhances controlled social cognition in patients with schizophrenia’’ [Psychoneuroendocrinology 47 (2014) J.D. Woolley a,b,∗ , B. Chuang a , O. Lam a , W. Lai a , A. O’Donovan a,b , K.P. Rankin c,d , D.H. Mathalon a,b , S. Vinogradov a,b a Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA, USA c UCSF Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA d Department of Neurology, University of California San Francisco, San Francisco, CA, USA b We acknowledge that this work was supported by Career Development Award # CX000758 from the United States Department of Veterans Affairs, Office of Research and Development, Clinical Science Research and Development program. DOI of original article:http://dx.doi.org/10.1016/j.psyneuen.2014.04.024. Corresponding author at: 4150 Clement Street, 116C-1, San Francisco, CA 94121, USA. Tel.: +1 415 221 4810x4117. E-mail address: Josh.Woolley@ucsf.edu (J.D. Woolley). http://dx.doi.org/10.1016/j.psyneuen.2014.11.001 0306-4530/Published by Elsevier Ltd.
Lars Fester - One of the best experts on this subject based on the ideXlab platform.
-
Corrigendum to “The opposing roles of estradiol on synaptic protein expression in hippocampal cultures” [Psychoneuroendocrinology 34 (Suppl. 1) (2009) 123–129]
Psychoneuroendocrinology, 2020Co-Authors: Lars Fester, Lepu Zhou, Corinna Voets, Christiana Ossig, Erik Disteldorf, Christian Peters, Florian Blaute, Danuta Dudzinski, Janine Prange-kiel, Hubertus JarryAbstract:Dr. Gabriele M. Rune apologizes for having listed Dr. Christian Peters as a co-author of the paper (Fester et al., 2009) ‘‘The opposing roles of estradiol on synaptic protein expression in hippocampal cultures’’ (Psychoneuroendocrinology 34 (Suppl. 1) 123—129) and having cited the results of his work without his signed authorization. Dr. Peters was not involved in the writing of the paper nor was he informed that his name was in the list of authors of the two versions of the publication. Therefore, the sentence cited below, which refers to the data contributed by Dr. Peters, needs to be deleted from the publication and Dr. Peters’ name needs to be removed from the list of authors. ‘‘In fact, according to real time RT-PCR, which was used to compare the amount of synaptopodin mRNA in estradiol-treated slice cultures to that in non-treated cultures, we found that synaptopodin mRNA expression was clearly downregulated compared to the controls’’ (pages 126—127). Psychoneuroendocrinology (2011) 36, 148
-
corrigendum to the opposing roles of estradiol on synaptic protein expression in hippocampal cultures Psychoneuroendocrinology 34 suppl 1 2009 123 129
Psychoneuroendocrinology, 2011Co-Authors: Lars Fester, Lepu Zhou, Corinna Voets, Christiana Ossig, Erik Disteldorf, Christian Peters, Florian Blaute, Janine Prangekiel, Danuta Dudzinski, Hubertus JarryAbstract:Dr. Gabriele M. Rune apologizes for having listed Dr. Christian Peters as a co-author of the paper (Fester et al., 2009) ‘‘The opposing roles of estradiol on synaptic protein expression in hippocampal cultures’’ (Psychoneuroendocrinology 34 (Suppl. 1) 123—129) and having cited the results of his work without his signed authorization. Dr. Peters was not involved in the writing of the paper nor was he informed that his name was in the list of authors of the two versions of the publication. Therefore, the sentence cited below, which refers to the data contributed by Dr. Peters, needs to be deleted from the publication and Dr. Peters’ name needs to be removed from the list of authors. ‘‘In fact, according to real time RT-PCR, which was used to compare the amount of synaptopodin mRNA in estradiol-treated slice cultures to that in non-treated cultures, we found that synaptopodin mRNA expression was clearly downregulated compared to the controls’’ (pages 126—127). Psychoneuroendocrinology (2011) 36, 148
Derek Renshaw - One of the best experts on this subject based on the ideXlab platform.
-
corrigendum to annexin a1 protein and its relationship to cortisol in human saliva Psychoneuroendocrinology 38 5 2013 722 727
Psychoneuroendocrinology, 2014Co-Authors: Robert C Fowkes, N Moradibidhendi, Vincenzo Branceleone, Gulrez M Zariwala, Daniel Brady, David S Jessop, Mauro Perretti, Derek RenshawAbstract:a Endocrine Signalling Group, Royal Veterinary College, Royal College Street, London NW1 0TU, UK Centre for Biochemical Pharmacology, The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK Department of Chemistry, University of Basilicata, Potenza, Italy d School of Life Sciences, University of Westminster, London W1W 6UW, UK Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, UK
-
CORRIGENDUM TO “ANNEXIN-A1 PROTEIN AND ITS RELATIONSHIP TO CORTISOL IN HUMAN SALIVA” [Psychoneuroendocrinology 38 (5) (2013) 722–727]
Psychoneuroendocrinology, 2014Co-Authors: Robert C Fowkes, Vincenzo Branceleone, Daniel Brady, David S Jessop, Mauro Perretti, N. Moradi-bidhendi, M. Gulrez Zariwala, Derek RenshawAbstract:a Endocrine Signalling Group, Royal Veterinary College, Royal College Street, London NW1 0TU, UK Centre for Biochemical Pharmacology, The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK Department of Chemistry, University of Basilicata, Potenza, Italy d School of Life Sciences, University of Westminster, London W1W 6UW, UK Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, UK