The Experts below are selected from a list of 135 Experts worldwide ranked by ideXlab platform
Ruipei Wang - One of the best experts on this subject based on the ideXlab platform.
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effect of artemisinin and neurectomy of Pterygoid Canal in ovalbumin induced allergic rhinitis mouse model
Allergy Asthma & Clinical Immunology, 2018Co-Authors: Bin Wang, Yingying Luo, Yajie Bian, Ruipei WangAbstract:Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of Pterygoid Canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of Pterygoid Canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry. Artemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of Pterygoid almost abolished the behavioral score increase in AR mice. These results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of Pterygoid showed better efficacy than artemisinin alone.
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Effect of artemisinin and neurectomy of Pterygoid Canal in ovalbumin-induced allergic rhinitis mouse model
'Springer Science and Business Media LLC', 2018Co-Authors: Bin Wang, Yingying Luo, Yajie Bian, Ruipei WangAbstract:Abstract Background Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of Pterygoid Canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Methods Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of Pterygoid Canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry. Results Artemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of Pterygoid almost abolished the behavioral score increase in AR mice. Conclusions These results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of Pterygoid showed better efficacy than artemisinin alone
Bin Wang - One of the best experts on this subject based on the ideXlab platform.
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effect of artemisinin and neurectomy of Pterygoid Canal in ovalbumin induced allergic rhinitis mouse model
Allergy Asthma & Clinical Immunology, 2018Co-Authors: Bin Wang, Yingying Luo, Yajie Bian, Ruipei WangAbstract:Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of Pterygoid Canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of Pterygoid Canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry. Artemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of Pterygoid almost abolished the behavioral score increase in AR mice. These results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of Pterygoid showed better efficacy than artemisinin alone.
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Effect of artemisinin and neurectomy of Pterygoid Canal in ovalbumin-induced allergic rhinitis mouse model
'Springer Science and Business Media LLC', 2018Co-Authors: Bin Wang, Yingying Luo, Yajie Bian, Ruipei WangAbstract:Abstract Background Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of Pterygoid Canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Methods Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of Pterygoid Canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry. Results Artemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of Pterygoid almost abolished the behavioral score increase in AR mice. Conclusions These results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of Pterygoid showed better efficacy than artemisinin alone
I H Chung - One of the best experts on this subject based on the ideXlab platform.
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High-resolution CT of the pterygopalatine fossa and its communications.
Neuroradiology, 1996Co-Authors: H S Kim, D I Kim, I H ChungAbstract:The pterygopalatine fossa is an important space because it communicates with the middle cranial fossa, orbit, nasal cavity, oral cavity, pharynx, foramen lacerum, and the infratemporal fossa via eight foramina and Canals. We studied the pterygopalatine fossa, foramen rotundum, inferior orbital fissure, sphenopalatine foramen, Pterygoid Canal, greater and lesser palatine foramen, palatinovaginal Canal, and the pterygomaxillary fissure with high-resolution CT to characterise the anatomy and variants of these structures. These structures were evaluated using axial and coronal planes. In the morphometric study, the distance between the foramina rotunda did not show statistically significant differences between the anterior and posterior segments. The Pterygoid Canal was slightly narrower in the anterior segment (23.9 mm) than in the posterior segment (25.2 mm). The Pterygoid Canal narrowed in the anterior (1.8 mm) to posterior (1.2 mm) direction (P < 0.01). The distance between the Pterygoid Canal and the lower wall of the sphenoid sinus was 2.2 mm anteriorly and 2.8 mm posteriorly (P < 0.01). The Pterygoid Canal showed various relationships with the sphenoid and ethmoid sinuses. In addition, a previously unreported situation, where the foramen rotundum was surrounded by the spheroid sinus, was observed.
Yajie Bian - One of the best experts on this subject based on the ideXlab platform.
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effect of artemisinin and neurectomy of Pterygoid Canal in ovalbumin induced allergic rhinitis mouse model
Allergy Asthma & Clinical Immunology, 2018Co-Authors: Bin Wang, Yingying Luo, Yajie Bian, Ruipei WangAbstract:Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of Pterygoid Canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of Pterygoid Canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry. Artemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of Pterygoid almost abolished the behavioral score increase in AR mice. These results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of Pterygoid showed better efficacy than artemisinin alone.
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Effect of artemisinin and neurectomy of Pterygoid Canal in ovalbumin-induced allergic rhinitis mouse model
'Springer Science and Business Media LLC', 2018Co-Authors: Bin Wang, Yingying Luo, Yajie Bian, Ruipei WangAbstract:Abstract Background Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of Pterygoid Canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Methods Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of Pterygoid Canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry. Results Artemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of Pterygoid almost abolished the behavioral score increase in AR mice. Conclusions These results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of Pterygoid showed better efficacy than artemisinin alone
Yingying Luo - One of the best experts on this subject based on the ideXlab platform.
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effect of artemisinin and neurectomy of Pterygoid Canal in ovalbumin induced allergic rhinitis mouse model
Allergy Asthma & Clinical Immunology, 2018Co-Authors: Bin Wang, Yingying Luo, Yajie Bian, Ruipei WangAbstract:Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of Pterygoid Canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of Pterygoid Canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry. Artemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of Pterygoid almost abolished the behavioral score increase in AR mice. These results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of Pterygoid showed better efficacy than artemisinin alone.
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Effect of artemisinin and neurectomy of Pterygoid Canal in ovalbumin-induced allergic rhinitis mouse model
'Springer Science and Business Media LLC', 2018Co-Authors: Bin Wang, Yingying Luo, Yajie Bian, Ruipei WangAbstract:Abstract Background Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of Pterygoid Canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Methods Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of Pterygoid Canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry. Results Artemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of Pterygoid almost abolished the behavioral score increase in AR mice. Conclusions These results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of Pterygoid showed better efficacy than artemisinin alone