The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform
Martin C J Kneyber - One of the best experts on this subject based on the ideXlab platform.
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Concurrent Bacterial Infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease
Intensive Care Medicine, 2005Co-Authors: Martin C J Kneyber, Margreet Van Vliet, Cuno S P M Uiterwaal, Jan L L Kimpen, Heleen Blussé Oud-alblas, Adrianus J Van VughtAbstract:Objective To identify demographic, clinical, and laboratory variables predictive for a concurrent Bacterial Pulmonary Infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. Design and setting Retrospective, observational study in a 14-bed pediatric intensive care unit. Patients 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996 – 2001, of whom 65 were mechanically ventilated. Results Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture ( n =1) or endotracheal aspirate ( n =9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent Bacterial Infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8±0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. Conclusions We observed in ventilated infants a low occurrence of concurrent Bacterial Pulmonary Infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a Pulmonary Bacterial Infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
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concurrent Bacterial Infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease
Intensive Care Medicine, 2005Co-Authors: Martin C J Kneyber, Heleen Blusse J Van Oudalblas, Margreet Van Vliet, Cuno S P M Uiterwaal, Jan L L Kimpen, Adrianus J Van VughtAbstract:To identify demographic, clinical, and laboratory variables predictive for a concurrent Bacterial Pulmonary Infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. Retrospective, observational study in a 14-bed pediatric intensive care unit. 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996 – 2001, of whom 65 were mechanically ventilated. Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture (n=1) or endotracheal aspirate (n=9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent Bacterial Infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8±0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. We observed in ventilated infants a low occurrence of concurrent Bacterial Pulmonary Infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a Pulmonary Bacterial Infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
Adrianus J Van Vught - One of the best experts on this subject based on the ideXlab platform.
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Concurrent Bacterial Infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease
Intensive Care Medicine, 2005Co-Authors: Martin C J Kneyber, Margreet Van Vliet, Cuno S P M Uiterwaal, Jan L L Kimpen, Heleen Blussé Oud-alblas, Adrianus J Van VughtAbstract:Objective To identify demographic, clinical, and laboratory variables predictive for a concurrent Bacterial Pulmonary Infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. Design and setting Retrospective, observational study in a 14-bed pediatric intensive care unit. Patients 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996 – 2001, of whom 65 were mechanically ventilated. Results Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture ( n =1) or endotracheal aspirate ( n =9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent Bacterial Infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8±0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. Conclusions We observed in ventilated infants a low occurrence of concurrent Bacterial Pulmonary Infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a Pulmonary Bacterial Infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
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concurrent Bacterial Infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease
Intensive Care Medicine, 2005Co-Authors: Martin C J Kneyber, Heleen Blusse J Van Oudalblas, Margreet Van Vliet, Cuno S P M Uiterwaal, Jan L L Kimpen, Adrianus J Van VughtAbstract:To identify demographic, clinical, and laboratory variables predictive for a concurrent Bacterial Pulmonary Infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. Retrospective, observational study in a 14-bed pediatric intensive care unit. 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996 – 2001, of whom 65 were mechanically ventilated. Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture (n=1) or endotracheal aspirate (n=9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent Bacterial Infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8±0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. We observed in ventilated infants a low occurrence of concurrent Bacterial Pulmonary Infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a Pulmonary Bacterial Infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
Gesine Hansen - One of the best experts on this subject based on the ideXlab platform.
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Wheeze in preschool age is associated with Pulmonary Bacterial Infection and resolves after antibiotic therapy
European Respiratory Journal, 2012Co-Authors: Folke Brinkmann, Nicolaus Schwerk, Michael Kabech, Gesine HansenAbstract:Introduction: Preschool children with persistent wheezing often respond insufficiently to conventional asthma therapy and management of persistent symptoms is difficult and costly. Recent studies show that colonization of the airways with H. influenzae, Strep. pneumoniae or M. catarrhalis is associated with an increased risk for recurrent wheeze and asthma. Objectives: We assessed the relevance of Bacterial colonization and chronic airway Infection in preschool children with severe persistent wheezing and evaluated the outcome of long-time antibiotic treatment on the clinical course in such children. Methods: Preschool children (n=42) with severe persistent wheeze but no symptoms of acute Pulmonary Infection were investigated by bronchoscopy and bronchoalveolar lavage (BAL). Differential cell counts and microbiological and virological analyses were performed on BAL samples. Patients diagnosed with Bacterial Infection were treated with antibiotics for a mean of 6 weeks (n=29). A modified ISAAC questionnaire was used for follow-up assessment of children at least 6 months after bronchoscopy. Main Results: Of the 42 children with severe wheezing, 34 (81%) showed a neutrophilic inflammation and 20 (59%) of this subgroup had elevated Bacterial counts suggesting Infection. H. influenzae, Strep. pneumoniae and M. catarrhalis were the most frequently isolated species. After treatment with appropriate antibiotics 92% of patients showed a marked improvement of symptoms upon follow-up examination. Conclusion: Chronic Bacterial Infections are relevant in a subgroup of preschool children with persistent wheezing and such children benefit significantly from antibiotic therapy.
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Wheeze in Preschool Age Is Associated with Pulmonary Bacterial Infection and Resolves after Antibiotic Therapy
PloS one, 2011Co-Authors: Nicolaus Schwerk, Folke Brinkmann, Bisharah Soudah, Michael Kabesch, Gesine HansenAbstract:Background Neonates with airways colonized by Haemophilus influenzae, Streptococcus pneumoniae or Moraxella catarrhalis are at increased risk for recurrent wheeze which may resemble asthma early in life. It is not clear whether chronic colonization by these pathogens is causative for severe persistent wheeze in some preschool children and whether these children might benefit from antibiotic treatment. We assessed the relevance of Bacterial colonization and chronic airway Infection in preschool children with severe persistent wheezing and evaluated the outcome of long-time antibiotic treatment on the clinical course in such children. Methodology/Principal Findings Preschool children (n = 42) with severe persistent wheeze but no symptoms of acute Pulmonary Infection were investigated by bronchoscopy and bronchoalveolar lavage (BAL). Differential cell counts and microbiological and virological analyses were performed on BAL samples. Patients diagnosed with Bacterial Infection were treated with antibiotics for 2–16 weeks (n = 29). A modified ISAAC questionnaire was used for follow-up assessment of children at least 6 months after bronchoscopy. Of the 42 children with severe wheezing, 34 (81%) showed a neutrophilic inflammation and 20 (59%) of this subgroup had elevated Bacterial counts (≥104 colony forming units per milliliter) suggesting Infection. Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis were the most frequently isolated species. After treatment with appropriate antibiotics 92% of patients showed a marked improvement of symptoms upon follow-up examination. Conclusions/Significance Chronic Bacterial Infections are relevant in a subgroup of preschool children with persistent wheezing and such children benefit significantly from antibiotic therapy.
Margreet Van Vliet - One of the best experts on this subject based on the ideXlab platform.
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Concurrent Bacterial Infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease
Intensive Care Medicine, 2005Co-Authors: Martin C J Kneyber, Margreet Van Vliet, Cuno S P M Uiterwaal, Jan L L Kimpen, Heleen Blussé Oud-alblas, Adrianus J Van VughtAbstract:Objective To identify demographic, clinical, and laboratory variables predictive for a concurrent Bacterial Pulmonary Infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. Design and setting Retrospective, observational study in a 14-bed pediatric intensive care unit. Patients 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996 – 2001, of whom 65 were mechanically ventilated. Results Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture ( n =1) or endotracheal aspirate ( n =9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent Bacterial Infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8±0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. Conclusions We observed in ventilated infants a low occurrence of concurrent Bacterial Pulmonary Infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a Pulmonary Bacterial Infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
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concurrent Bacterial Infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease
Intensive Care Medicine, 2005Co-Authors: Martin C J Kneyber, Heleen Blusse J Van Oudalblas, Margreet Van Vliet, Cuno S P M Uiterwaal, Jan L L Kimpen, Adrianus J Van VughtAbstract:To identify demographic, clinical, and laboratory variables predictive for a concurrent Bacterial Pulmonary Infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. Retrospective, observational study in a 14-bed pediatric intensive care unit. 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996 – 2001, of whom 65 were mechanically ventilated. Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture (n=1) or endotracheal aspirate (n=9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent Bacterial Infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8±0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. We observed in ventilated infants a low occurrence of concurrent Bacterial Pulmonary Infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a Pulmonary Bacterial Infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
Cuno S P M Uiterwaal - One of the best experts on this subject based on the ideXlab platform.
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Concurrent Bacterial Infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease
Intensive Care Medicine, 2005Co-Authors: Martin C J Kneyber, Margreet Van Vliet, Cuno S P M Uiterwaal, Jan L L Kimpen, Heleen Blussé Oud-alblas, Adrianus J Van VughtAbstract:Objective To identify demographic, clinical, and laboratory variables predictive for a concurrent Bacterial Pulmonary Infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. Design and setting Retrospective, observational study in a 14-bed pediatric intensive care unit. Patients 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996 – 2001, of whom 65 were mechanically ventilated. Results Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture ( n =1) or endotracheal aspirate ( n =9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent Bacterial Infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8±0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. Conclusions We observed in ventilated infants a low occurrence of concurrent Bacterial Pulmonary Infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a Pulmonary Bacterial Infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
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concurrent Bacterial Infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease
Intensive Care Medicine, 2005Co-Authors: Martin C J Kneyber, Heleen Blusse J Van Oudalblas, Margreet Van Vliet, Cuno S P M Uiterwaal, Jan L L Kimpen, Adrianus J Van VughtAbstract:To identify demographic, clinical, and laboratory variables predictive for a concurrent Bacterial Pulmonary Infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. Retrospective, observational study in a 14-bed pediatric intensive care unit. 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996 – 2001, of whom 65 were mechanically ventilated. Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture (n=1) or endotracheal aspirate (n=9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent Bacterial Infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8±0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. We observed in ventilated infants a low occurrence of concurrent Bacterial Pulmonary Infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a Pulmonary Bacterial Infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
