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Kuan-fu Liao - One of the best experts on this subject based on the ideXlab platform.
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statin use correlates with reduced risk of Pyogenic Liver Abscess a population based case control study
Basic & Clinical Pharmacology & Toxicology, 2017Co-Authors: Kuan-fu Liao, Cheng-li Lin, Kao-chi Cheng, Shih-wei LaiAbstract:Little research is available on the relationship between statin use and Pyogenic Liver Abscess. The objective of the study was to determine whether prior use of statins is associated with Pyogenic Liver Abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of Pyogenic Liver Abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without Pyogenic Liver Abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of Pyogenic Liver Abscess diagnosis, respectively. Relative risk of Pyogenic Liver Abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use <12 months (95% CI 0.43, 1.07), compared with participants with never use of statins. Our findings provide strong evidence that patients with current use of statins are associated with a 35% reduced odds of Pyogenic Liver Abscess. The protective effect is stronger for longer duration of statin use.
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Correlation between proton pump inhibitors and risk of Pyogenic Liver Abscess.
European Journal of Clinical Pharmacology, 2017Co-Authors: Hsien-feng Lin, Kuan-fu Liao, Ching-mei Chang, Cheng-li Lin, Shih-wei LaiAbstract:Background/objective Little is known about the relationship between proton pump inhibitors use and Pyogenic Liver Abscess. The objective of this study was to evaluate the correlation between proton pump inhibitors use and Pyogenic Liver Abscess in Taiwan.
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Statin Use Correlates with Reduced Risk of Pyogenic Liver Abscess: A Population-Based Case-Control Study.
Basic & Clinical Pharmacology & Toxicology, 2017Co-Authors: Kuan-fu Liao, Cheng-li Lin, Kao-chi Cheng, Shih-wei LaiAbstract:Little research is available on the relationship between statin use and Pyogenic Liver Abscess. The objective of the study was to determine whether prior use of statins is associated with Pyogenic Liver Abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of Pyogenic Liver Abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without Pyogenic Liver Abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of Pyogenic Liver Abscess diagnosis, respectively. Relative risk of Pyogenic Liver Abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use
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Appendectomy correlates with increased risk of Pyogenic Liver Abscess: A population-based cohort study in Taiwan
Medicine, 2016Co-Authors: Kuan-fu Liao, Cheng-li Lin, Shih-wei Lai, Sou-hsin ChienAbstract:Little is known on the association between appendectomy and Pyogenic Liver Abscess. The objective of this study was to investigate the association between appendectomy and the risk of Pyogenic Liver Abscess in Taiwan. This population-based retrospective cohort study was conducted using the hospitalization dataset of the Taiwan National Health Insurance Program. There were 212,530 subjects age 20 to 84 years with newly diagnosed appendectomy as the appendectomy group since 1998 to 2010, and 850,099 randomly selected subjects without appendectomy as the nonappendectomy group. Both appendectomy and nonappendectomy groups were matched with sex, age, comorbidities, and index year of diagnosing appendectomy. The incidence of Pyogenic Liver Abscess at the end of 2011 was estimated in both groups. The multivariable Cox proportional hazards regression model was applied to investigate the hazard ratio (HR) and 95% confidence interval (CI) for risk of Pyogenic Liver Abscess associated with appendectomy and other comorbidities including alcoholism, biliary stone, chronic kidney disease, chronic Liver diseases, and diabetes mellitus. The overall incidence of Pyogenic Liver Abscess was 1.73-fold greater in the appendectomy group than that in the nonappendectomy group (3.85 vs 2.22 per 10,000 person-years, 95% CI 1.71, 1.76). The multivariable regression analysis disclosed that the adjusted HR of Pyogenic Liver Abscess was 1.77 for the appendectomy group (95% CI 1.59, 1.97), when compared with the nonappendectomy group. Appendectomy is associated with increased hazard of Pyogenic Liver Abscess. Further studies remain necessary to confirm our findings.
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splenectomy correlates with increased risk of Pyogenic Liver Abscess a nationwide cohort study in taiwan
Journal of Epidemiology, 2015Co-Authors: Shih-wei Lai, Cheng-li Lin, Hsueh Chou Lai, Kuan-fu LiaoAbstract:OBJECTIVES Little is known about the risk of Pyogenic Liver Abscess in patients with splenectomy. We explored the relationship between splenectomy and Pyogenic Liver Abscess in Taiwan. METHODS We conducted a nationwide cohort analysis using the hospitalization dataset of the Taiwan National Health Insurance Program. We included 17,779 subjects aged 20-84 years who underwent splenectomy in 1998 to 2010 (splenectomy group) and 70,855 randomly selected subjects without splenectomy (non-splenectomy group). Both groups were matched by sex, age, other comorbidities, and hospitalization year of receiving splenectomy. The incidence of Pyogenic Liver Abscess at the end of 2011 was measured. The multivariable Cox proportional hazard regression model was used to estimate the hazard ratios and 95% confidence intervals for Pyogenic Liver Abscess associated with splenectomy and other comorbidities. RESULTS The overall incidence rate was 3.75-fold higher in the splenectomy group than that in the non-splenectomy group (2.15 vs 0.57 per 1000 person-years; 95% confidence interval, 3.57-3.94). After controlling for potential confounding factors, the adjusted hazard ratio of Pyogenic Liver Abscess was 3.89 in subjects with splenectomy (95% confidence interval, 3.20-4.72) when compared with subjects without splenectomy. In further analysis, the hazard ratio markedly increased to 14.34 for those with splenectomy and having any of the assessed comorbidities, including alcoholism, biliary stone, chronic kidney disease, chronic Liver diseases, and diabetes mellitus (95% confidence interval, 10.61-19.39). CONCLUSIONS Patients with splenectomy are at an increased risk of developing Pyogenic Liver Abscess, particularly when they have comorbid conditions.
Shih-wei Lai - One of the best experts on this subject based on the ideXlab platform.
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statin use correlates with reduced risk of Pyogenic Liver Abscess a population based case control study
Basic & Clinical Pharmacology & Toxicology, 2017Co-Authors: Kuan-fu Liao, Cheng-li Lin, Kao-chi Cheng, Shih-wei LaiAbstract:Little research is available on the relationship between statin use and Pyogenic Liver Abscess. The objective of the study was to determine whether prior use of statins is associated with Pyogenic Liver Abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of Pyogenic Liver Abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without Pyogenic Liver Abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of Pyogenic Liver Abscess diagnosis, respectively. Relative risk of Pyogenic Liver Abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use <12 months (95% CI 0.43, 1.07), compared with participants with never use of statins. Our findings provide strong evidence that patients with current use of statins are associated with a 35% reduced odds of Pyogenic Liver Abscess. The protective effect is stronger for longer duration of statin use.
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Correlation between proton pump inhibitors and risk of Pyogenic Liver Abscess.
European Journal of Clinical Pharmacology, 2017Co-Authors: Hsien-feng Lin, Kuan-fu Liao, Ching-mei Chang, Cheng-li Lin, Shih-wei LaiAbstract:Background/objective Little is known about the relationship between proton pump inhibitors use and Pyogenic Liver Abscess. The objective of this study was to evaluate the correlation between proton pump inhibitors use and Pyogenic Liver Abscess in Taiwan.
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Statin Use Correlates with Reduced Risk of Pyogenic Liver Abscess: A Population-Based Case-Control Study.
Basic & Clinical Pharmacology & Toxicology, 2017Co-Authors: Kuan-fu Liao, Cheng-li Lin, Kao-chi Cheng, Shih-wei LaiAbstract:Little research is available on the relationship between statin use and Pyogenic Liver Abscess. The objective of the study was to determine whether prior use of statins is associated with Pyogenic Liver Abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of Pyogenic Liver Abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without Pyogenic Liver Abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of Pyogenic Liver Abscess diagnosis, respectively. Relative risk of Pyogenic Liver Abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use
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Appendectomy correlates with increased risk of Pyogenic Liver Abscess: A population-based cohort study in Taiwan
Medicine, 2016Co-Authors: Kuan-fu Liao, Cheng-li Lin, Shih-wei Lai, Sou-hsin ChienAbstract:Little is known on the association between appendectomy and Pyogenic Liver Abscess. The objective of this study was to investigate the association between appendectomy and the risk of Pyogenic Liver Abscess in Taiwan. This population-based retrospective cohort study was conducted using the hospitalization dataset of the Taiwan National Health Insurance Program. There were 212,530 subjects age 20 to 84 years with newly diagnosed appendectomy as the appendectomy group since 1998 to 2010, and 850,099 randomly selected subjects without appendectomy as the nonappendectomy group. Both appendectomy and nonappendectomy groups were matched with sex, age, comorbidities, and index year of diagnosing appendectomy. The incidence of Pyogenic Liver Abscess at the end of 2011 was estimated in both groups. The multivariable Cox proportional hazards regression model was applied to investigate the hazard ratio (HR) and 95% confidence interval (CI) for risk of Pyogenic Liver Abscess associated with appendectomy and other comorbidities including alcoholism, biliary stone, chronic kidney disease, chronic Liver diseases, and diabetes mellitus. The overall incidence of Pyogenic Liver Abscess was 1.73-fold greater in the appendectomy group than that in the nonappendectomy group (3.85 vs 2.22 per 10,000 person-years, 95% CI 1.71, 1.76). The multivariable regression analysis disclosed that the adjusted HR of Pyogenic Liver Abscess was 1.77 for the appendectomy group (95% CI 1.59, 1.97), when compared with the nonappendectomy group. Appendectomy is associated with increased hazard of Pyogenic Liver Abscess. Further studies remain necessary to confirm our findings.
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splenectomy correlates with increased risk of Pyogenic Liver Abscess a nationwide cohort study in taiwan
Journal of Epidemiology, 2015Co-Authors: Shih-wei Lai, Cheng-li Lin, Hsueh Chou Lai, Kuan-fu LiaoAbstract:OBJECTIVES Little is known about the risk of Pyogenic Liver Abscess in patients with splenectomy. We explored the relationship between splenectomy and Pyogenic Liver Abscess in Taiwan. METHODS We conducted a nationwide cohort analysis using the hospitalization dataset of the Taiwan National Health Insurance Program. We included 17,779 subjects aged 20-84 years who underwent splenectomy in 1998 to 2010 (splenectomy group) and 70,855 randomly selected subjects without splenectomy (non-splenectomy group). Both groups were matched by sex, age, other comorbidities, and hospitalization year of receiving splenectomy. The incidence of Pyogenic Liver Abscess at the end of 2011 was measured. The multivariable Cox proportional hazard regression model was used to estimate the hazard ratios and 95% confidence intervals for Pyogenic Liver Abscess associated with splenectomy and other comorbidities. RESULTS The overall incidence rate was 3.75-fold higher in the splenectomy group than that in the non-splenectomy group (2.15 vs 0.57 per 1000 person-years; 95% confidence interval, 3.57-3.94). After controlling for potential confounding factors, the adjusted hazard ratio of Pyogenic Liver Abscess was 3.89 in subjects with splenectomy (95% confidence interval, 3.20-4.72) when compared with subjects without splenectomy. In further analysis, the hazard ratio markedly increased to 14.34 for those with splenectomy and having any of the assessed comorbidities, including alcoholism, biliary stone, chronic kidney disease, chronic Liver diseases, and diabetes mellitus (95% confidence interval, 10.61-19.39). CONCLUSIONS Patients with splenectomy are at an increased risk of developing Pyogenic Liver Abscess, particularly when they have comorbid conditions.
Cheng-li Lin - One of the best experts on this subject based on the ideXlab platform.
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statin use correlates with reduced risk of Pyogenic Liver Abscess a population based case control study
Basic & Clinical Pharmacology & Toxicology, 2017Co-Authors: Kuan-fu Liao, Cheng-li Lin, Kao-chi Cheng, Shih-wei LaiAbstract:Little research is available on the relationship between statin use and Pyogenic Liver Abscess. The objective of the study was to determine whether prior use of statins is associated with Pyogenic Liver Abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of Pyogenic Liver Abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without Pyogenic Liver Abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of Pyogenic Liver Abscess diagnosis, respectively. Relative risk of Pyogenic Liver Abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use <12 months (95% CI 0.43, 1.07), compared with participants with never use of statins. Our findings provide strong evidence that patients with current use of statins are associated with a 35% reduced odds of Pyogenic Liver Abscess. The protective effect is stronger for longer duration of statin use.
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Correlation between proton pump inhibitors and risk of Pyogenic Liver Abscess.
European Journal of Clinical Pharmacology, 2017Co-Authors: Hsien-feng Lin, Kuan-fu Liao, Ching-mei Chang, Cheng-li Lin, Shih-wei LaiAbstract:Background/objective Little is known about the relationship between proton pump inhibitors use and Pyogenic Liver Abscess. The objective of this study was to evaluate the correlation between proton pump inhibitors use and Pyogenic Liver Abscess in Taiwan.
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Statin Use Correlates with Reduced Risk of Pyogenic Liver Abscess: A Population-Based Case-Control Study.
Basic & Clinical Pharmacology & Toxicology, 2017Co-Authors: Kuan-fu Liao, Cheng-li Lin, Kao-chi Cheng, Shih-wei LaiAbstract:Little research is available on the relationship between statin use and Pyogenic Liver Abscess. The objective of the study was to determine whether prior use of statins is associated with Pyogenic Liver Abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of Pyogenic Liver Abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without Pyogenic Liver Abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of Pyogenic Liver Abscess diagnosis, respectively. Relative risk of Pyogenic Liver Abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of Pyogenic Liver Abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use
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Appendectomy correlates with increased risk of Pyogenic Liver Abscess: A population-based cohort study in Taiwan
Medicine, 2016Co-Authors: Kuan-fu Liao, Cheng-li Lin, Shih-wei Lai, Sou-hsin ChienAbstract:Little is known on the association between appendectomy and Pyogenic Liver Abscess. The objective of this study was to investigate the association between appendectomy and the risk of Pyogenic Liver Abscess in Taiwan. This population-based retrospective cohort study was conducted using the hospitalization dataset of the Taiwan National Health Insurance Program. There were 212,530 subjects age 20 to 84 years with newly diagnosed appendectomy as the appendectomy group since 1998 to 2010, and 850,099 randomly selected subjects without appendectomy as the nonappendectomy group. Both appendectomy and nonappendectomy groups were matched with sex, age, comorbidities, and index year of diagnosing appendectomy. The incidence of Pyogenic Liver Abscess at the end of 2011 was estimated in both groups. The multivariable Cox proportional hazards regression model was applied to investigate the hazard ratio (HR) and 95% confidence interval (CI) for risk of Pyogenic Liver Abscess associated with appendectomy and other comorbidities including alcoholism, biliary stone, chronic kidney disease, chronic Liver diseases, and diabetes mellitus. The overall incidence of Pyogenic Liver Abscess was 1.73-fold greater in the appendectomy group than that in the nonappendectomy group (3.85 vs 2.22 per 10,000 person-years, 95% CI 1.71, 1.76). The multivariable regression analysis disclosed that the adjusted HR of Pyogenic Liver Abscess was 1.77 for the appendectomy group (95% CI 1.59, 1.97), when compared with the nonappendectomy group. Appendectomy is associated with increased hazard of Pyogenic Liver Abscess. Further studies remain necessary to confirm our findings.
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splenectomy correlates with increased risk of Pyogenic Liver Abscess a nationwide cohort study in taiwan
Journal of Epidemiology, 2015Co-Authors: Shih-wei Lai, Cheng-li Lin, Hsueh Chou Lai, Kuan-fu LiaoAbstract:OBJECTIVES Little is known about the risk of Pyogenic Liver Abscess in patients with splenectomy. We explored the relationship between splenectomy and Pyogenic Liver Abscess in Taiwan. METHODS We conducted a nationwide cohort analysis using the hospitalization dataset of the Taiwan National Health Insurance Program. We included 17,779 subjects aged 20-84 years who underwent splenectomy in 1998 to 2010 (splenectomy group) and 70,855 randomly selected subjects without splenectomy (non-splenectomy group). Both groups were matched by sex, age, other comorbidities, and hospitalization year of receiving splenectomy. The incidence of Pyogenic Liver Abscess at the end of 2011 was measured. The multivariable Cox proportional hazard regression model was used to estimate the hazard ratios and 95% confidence intervals for Pyogenic Liver Abscess associated with splenectomy and other comorbidities. RESULTS The overall incidence rate was 3.75-fold higher in the splenectomy group than that in the non-splenectomy group (2.15 vs 0.57 per 1000 person-years; 95% confidence interval, 3.57-3.94). After controlling for potential confounding factors, the adjusted hazard ratio of Pyogenic Liver Abscess was 3.89 in subjects with splenectomy (95% confidence interval, 3.20-4.72) when compared with subjects without splenectomy. In further analysis, the hazard ratio markedly increased to 14.34 for those with splenectomy and having any of the assessed comorbidities, including alcoholism, biliary stone, chronic kidney disease, chronic Liver diseases, and diabetes mellitus (95% confidence interval, 10.61-19.39). CONCLUSIONS Patients with splenectomy are at an increased risk of developing Pyogenic Liver Abscess, particularly when they have comorbid conditions.
Abdullah Alanazi - One of the best experts on this subject based on the ideXlab platform.
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Pyogenic Liver Abscess and papillon lefevre syndrome not a rare association
Pediatrics, 2003Co-Authors: Maha Almuneef, Sultan Al Khenaizan, Sulaiman Al Ajaji, Abdullah AlanaziAbstract:Papillon-Lefevre syndrome is a rare, autosomal recessive disease comprising palmoplantar keratoderma and periodontitis. Pyogenic Liver Abscess is an increasingly recognized complication. We report a new case of this association and review the current literature.
Henrik Toft Sørensen - One of the best experts on this subject based on the ideXlab platform.
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a nationwide study of the incidence and 30 day mortality rate of Pyogenic Liver Abscess in denmark 1977 2002
Alimentary Pharmacology & Therapeutics, 2005Co-Authors: Peter Uhd Jepsen, Hendrik Vilstrup, Henrik Toft Sørensen, Henrik Carl SchonheyderAbstract:SUMMARY Background: Pyogenic Liver Abscess is a life-threatening disease. Accurate data on incidence and prognosis are important, but scarce. Aim: To examine changes in the incidence and 30-day mortality rate of patients with Pyogenic Liver Abscess in Denmark. Methods: Using nationwide administrative registers, we identified all patients diagnosed with Pyogenic Liver Abscess in Denmark, 1977–2002, and their dates of death. We computed annual standardized incidence and 30-day mortality rates, and used Poisson regression to adjust gender-specific mortality rates for year-by-year differences in age at diagnosis. Results: We identified 1448 patients with Pyogenic Liver Abscess, of whom 54% were men. The crude incidence rate for the entire study period was 11.8 per 1 000 000 for men and 9.7 per 1 000 000 for women. Between 1977 and 2002, the incidence rate increased from 6 to 18 per 1 000 000 for men and from 8 to 12 per 1 000 000 for women. The cumulative 30-day mortality rate was 15% for men and 23% for women. The adjusted 30-day mortality rate decreased from 40% for men and 50% for women to around 10% for both genders. Conclusions: In this large nationwide study spanning a 26-year period, we found an increasing incidence rate and a decreasing mortality rate of Pyogenic Liver Abscess. We believe that these changes are primarily explained by more sensitive diagnostic tools.
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increased risk and case fatality rate of Pyogenic Liver Abscess in patients with Liver cirrhosis a nationwide study in denmark
Gut, 2001Co-Authors: Ingolf Mølle, Ane Marie Thulstrup, Hendrik Vilstrup, Henrik Toft SørensenAbstract:BACKGROUND—Patients with Liver cirrhosis are at increased risk of serious bacterial infections carrying a high case fatality rate. Case reports have suggested an association between Liver cirrhosis and Pyogenic Liver Abscess. AIMS—To estimate the risk and case fatality rate of Pyogenic Liver Abscess in Danish patients with Liver cirrhosis compared with the background population. METHODS—Identification of all patients with Liver cirrhosis and Pyogenic Liver Abscess over a 17 year period in the National Registry of Patients. Information on death was obtained from the Danish Central Person Registry. RESULTS—We identified 22 764 patients with Liver cirrhosis and 665 patients with Pyogenic Liver Abscess, of whom 21 were cirrhotics and 644 were non-cirrhotics. The crude incidence rate of Liver Abscess in cirrhotics was 23.3 (95% CI 14.4-35.6) per 100 000 person years. The age adjusted risk of Liver Abscess was increased 15-fold in patients with cirrhosis compared with the background population. The 30 day case fatality rates in patients with Liver Abscess and cirrhosis were 38.5% (13.9-68.4) in alcoholic cirrhosis and 62.5% (24.5-91.5) in non-alcoholic cirrhosis compared with 26.9% (23.5-30.5) in Liver Abscess patients from the background population. After adjustment for sex, age, and comorbidity, the relative risk of death was increased more than fourfold in alcoholic cirrhosis and non-alcoholic cirrhosis compared with the background population. CONCLUSIONS—Liver cirrhosis is a strong risk factor for Pyogenic Liver Abscess associated with a poor prognosis. Keywords: bacterial infections; complications; epidemiology; Liver Abscess; Liver cirrhosis; mortality
