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Isabelle Billard - One of the best experts on this subject based on the ideXlab platform.
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Are fancy acidic or neutral ligands really needed for synergism in ionic liquids? A comparative study of lanthanoid extraction in CHCl 3 and an ionic liquid
New Journal of Chemistry, 2015Co-Authors: Maria Atanassova, Vanya Kurteva, Lubomir Lubenov, Sabi Varbanov, Isabelle BillardAbstract:The study of trivalent lanthanoid (La, Nd, Eu, Ho and Lu) extraction by two individual ligands, one acidic such as a Pyrazolone Derivative, 3-methyl-1-phenyl-4-(4-phenylbenzoyl)-pyrazol-5-one (HL), and one neutral such as 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis-(dimethylphosphinoylmethoxy)calix[4]arene (SIV), was performed in CHCl3 and in one ionic liquid, IL 1-methyl-1,3-butylimidazolium-bis(trifluoromethanesulfonyl)imide ([C1C4im][Tf2N]), in order to establish and examine the impact of the diluent on individual and synergistic extraction processes. Chloride aqueous medium and constant ionic strength μ = 0.1 M were set in both cases. The parameters of the extraction processes were determined. Comparison between the two diluents was made on the basis of (i) composition of the extracted species: LnL3·HL in CHCl3vs. LnL3 in IL with HL as a single extractant (L− represents the HL anion), and LnL3·SIV in the presence of the phosphorus-containing calix[4]arene in both diluents; and (ii) values of the equilibrium constants and the synergistic enhancements; the separation factors between metals were evaluated as well. The IL medium appears far superior to the molecular solvent in terms of individual and overall synergistic extraction efficiencies. However, the huge differences in extraction efficiencies observed in CHCl3 for chemically different ligands are erased in the IL medium, thus modifying the lever arms on which chemists should rely in order to obtain even better extracting systems in ionic liquid media.
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Comparing extraction, synergism and separation of lanthanoids using acidic and neutral compounds in chloroform and one ionic liquid: is the latter always “better”?
RSC Advances, 2014Co-Authors: Maria Atanassova, Vanya Kurteva, Lubomir Lubenov, Isabelle BillardAbstract:The complexation properties of a Pyrazolone Derivative, 3-methyl-1-phenyl-4-(4-trifluoromethylbenzoyl)-pyrazol-5-one (HL), in chloroform were examined and it was found that it possesses improved complexation ability in comparison with 4-benzoyl, 4-(4-methylbenzoyl) and 4-(4-fluorobenzoyl) Derivatives. Mixed ligand chelate extractions of trivalent lanthanoids (La, Nd, Eu, Ho and Lu) with HL and 5,11,17,23-tetra-tert-butyl-25,26,27-tris(dimethylphosphinoylpropoxy)-28-hydroxy-calix[4]arene (S1) or 5,11,17,23-tetra-tert-butyl-25,27-bis(dimethylphosphinoylpropoxy)-26,28-dihydroxy-calix[4]arene (S2) as synergistic agents were also carried out in chloride medium at constant ionic strength m ¼ 0.1 and CHCl 3 as organic phase. The interactions between the extractants in deuterochloroform were studied by 1 H, 13 C, and 31 P NMR. The composition of the extracted species was established as LnL 3 $HL (L À represents HL anion) with HL as a single extractant, and as LnL 3 $S in the presence of the phosphorus-containing calix[4]arene. On the basis of the experimental data, the values of the equilibrium constants were calculated. The influence of the number of P]O groups of tert-butyl-calix[4]arene on the extraction process was discussed. The synergistic enhancement and separation factors between metals were evaluated. Finally, the extraction of La(III) and Eu(III) ions was performed by using an ionic liquid, 1-butyl-3-methylimidazolium-bis(trifluoromethanesulfonyl)imide, as a solvent and varying the type of ligands. By comparison to CHCl 3 , the ionic liquid offers increased distribution ratios, at the expense of a levelling off of the separation factors. Reasons for such a phenomenon are discussed.
Dianzeng Jia - One of the best experts on this subject based on the ideXlab platform.
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cadmium ii complexes with a 4 acyl Pyrazolone Derivative and co ligands crystal structures and antitumor activity
RSC Advances, 2016Co-Authors: Huaying Luo, Li Zhang, Dianzeng JiaAbstract:Three cadmium(II) complexes, [Cd(HL)2(CH3OH)2]·(CH3OH) (1), [Cd(HL)2(bpy)]·(CH3OH)2 (2), and [Cd(HL)2(phen)]·(CH3OH)1.5 (3), (where H2L = N-(1-phenyl-3-methyl-4-(4-chlorobenzoyl)-5-Pyrazolone)-2-thiophenecarboxylic acid hydrazide, bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline) have been synthesized and characterized. Single crystal X-ray diffraction analyses indicated that complexes 1–3 exhibit mononuclear octahedral geometry. The spectrophotometric analyses showed that these complexes could bind with herring sperm DNA and bovine serum albumin (BSA). The intrinsic binding constants to HS-DNA were 2.46 × 104 M−1, 2.64 × 104 M−1, and 4.41 × 104 M−1, and the quenching constants to BSA were 1.23 × 106 M−1, 1.85 × 106 M−1, and 2.17 × 106 M−1 for the complexes 1–3, respectively. The complexes have higher cytotoxic activities against HeLa and Eca-109 tumor cells than that of the ligand and cisplatin. Complex 3 shows the highest cytotoxicity for both HeLa and Eca-109, and the IC50 values are 3.35 ± 0.2 μg mL−1 and 7.41 ± 0.07 μg mL−1, respectively. When compared with our previous work, IC50 value of the reported complex CdC20H18N4O3 to Eca-109 cells is 14.18 μg mL−1. We further found that complex 3 inhibits the growth of HeLa cells by inducing apoptosis and arresting the cell cycle during the G0/G1 phase. These results suggest that complex 3 is a potential antitumor drug.
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Solvent-induced two Cu(II) complexes with 4-acyl Pyrazolone Derivative: From discrete structure to 1D helical chain
Inorganic Chemistry Communications, 2014Co-Authors: Li Zhang, Dianzeng JiaAbstract:Abstract Two new copper(II) complexes [Cu2L2(CH3OH)]·CH3OH (1) and [CuL]n (2) (H2L = N-(1-phenyl-3-methyl-4-benzal-Pyrazolone-5)-salicylidene hydrazide) with different structures have been synthesized by the reactions of copper acetate with the 4-acyl Pyrazolone Derivative H2L in MeOH or EtOH solvent, respectively. The X-ray diffraction analyses revealed that 1 displays a dinuclear structure which is further linked by weak coordination interactions and hydrogen bonds to generate an infinite 1D chain. Complex 2 exhibits 1D left-handed and right-handed helical chains structure in a 1:1 ratio along the c axis, and the 1D chains with the same handedness were linked by hydrogen bonds to form a racemic two-fold interpenetrated 3D framework. The results demonstrated that the solvents with different coordination abilities have significant effect on the structure of the complexes. On the other hand, the ligands H2L adopt tridentate chelating mode and tetradentate chelating-bridging mode to coordinate with Cu(II) ions in 1 and 2, which attested that the flexible 4-acyl Pyrazolone Schiff base Derivative can adopt different coordination modes to form complexes with varied structures. The variable temperature magnetic investigation indicates that 2 exhibits typical antiferromagnetic behavior.
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structural diversity and properties of four complexes with 4 acyl Pyrazolone Derivative
Polyhedron, 2013Co-Authors: Li Zhang, Jixi Guo, Dianzeng JiaAbstract:Abstract Four new complexes {[Zn(HL)(H2O)(DMF)](NO3)}n (1), [Cd(HL)2]n (2), {[Mn(HL)2]·CH3CN·2H2O} (3) and {[Mn(L)(μ2-EtOH)]}n (4) (H2L = N-(1-phenyl-3-methyl-4-benzal-Pyrazolone-5)-nicotinic hydrazide) have been synthesized and characterized by elemental analyses, IR spectra, thermal analyses and single crystal X-ray diffraction. The structural analyses reveal that complexes 1, 2 and 3, formed by H2L with metal nitrate, have Zigzag chain, double-stranded chain and mononuclear structures, respectively, and the ligands adopt three different coordination modes in these complexes. While, complex 4, formed by H2L with manganese acetate, represents a 2D network structure with dinuclear units bridged by ethanol molecules. These result demonstrated that the metal atom and counteranion have certain influences on the structures of resulting complexes. In addition, the fluorescent properties of 1 and 2 and the magnetism of 4 were investigated.
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photochromism of a Pyrazolone Derivative in crystalline state and in hpmc composite film
Photochemical and Photobiological Sciences, 2011Co-Authors: Hui Yuan, Dianzeng Jia, Jixi Guo, Mingxi Guo, Lang LiuAbstract:A novel photochromic compound, 1,3-diphenyl-4-(3-chloro-4-fluorobenzal)-5-hydoxypyrazole 4-phenylsemicarbazide (1a), has been synthesized by introducing a phenylsemicarbazide unit. The material exhibits good fatigue resistance and reversible fluorescent switching properties with distinct fluorescence on/off ratio under alternating UV irradiation and heating at 120 °C. For the fabrication of actual application materials, 1a/hydroxypropylmethylcellulose (HPMC) composite film has been successfully fabricated using hydrogel casting method. The 1a/HPMC composite film obtained can also show reversible photochromic reaction under UV irradiation and rapid thermal bleaching properties by heating. The HPMC composite film shows similar good photochromic properties as those of 1 in the crystalline state.
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kinetics of thermal decomposition of mixed ligand nikkel ii and copper ii complexes of 4 acyl Pyrazolone Derivative and pyridine
Journal of Thermal Analysis and Calorimetry, 2007Co-Authors: Lu Zhang, Lang Liu, Guangfei Liu, Dianzeng JiaAbstract:Thermal behaviors of two mixed-ligand complexes, [Ni(PMPP-SAL)(Py)3] and [Cu(PMPP-SAL)Py]·MeOH, (PMPP-SAL=1-phenyl-3-methyl-4-(salicylidene hydrazide)-propenylidene-Pyrazolone-5, Py=pyridine), were studied by TG-DTG-DTA in dynamic air atmosphere. The complexes show the loss of pyridine molecule is followed by the decomposition of the PMPP-SAL anion and give respective metal oxides as residues. Meanwhile, the Ozawa-Flynn-Wall model-free analyses and multivariate non-linear regressions were applied to perform single and overall steps optimization. Kinetic parameters were given and the most probable mechanism functions were suggested in this study.
Maria Atanassova - One of the best experts on this subject based on the ideXlab platform.
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Are fancy acidic or neutral ligands really needed for synergism in ionic liquids? A comparative study of lanthanoid extraction in CHCl 3 and an ionic liquid
New Journal of Chemistry, 2015Co-Authors: Maria Atanassova, Vanya Kurteva, Lubomir Lubenov, Sabi Varbanov, Isabelle BillardAbstract:The study of trivalent lanthanoid (La, Nd, Eu, Ho and Lu) extraction by two individual ligands, one acidic such as a Pyrazolone Derivative, 3-methyl-1-phenyl-4-(4-phenylbenzoyl)-pyrazol-5-one (HL), and one neutral such as 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis-(dimethylphosphinoylmethoxy)calix[4]arene (SIV), was performed in CHCl3 and in one ionic liquid, IL 1-methyl-1,3-butylimidazolium-bis(trifluoromethanesulfonyl)imide ([C1C4im][Tf2N]), in order to establish and examine the impact of the diluent on individual and synergistic extraction processes. Chloride aqueous medium and constant ionic strength μ = 0.1 M were set in both cases. The parameters of the extraction processes were determined. Comparison between the two diluents was made on the basis of (i) composition of the extracted species: LnL3·HL in CHCl3vs. LnL3 in IL with HL as a single extractant (L− represents the HL anion), and LnL3·SIV in the presence of the phosphorus-containing calix[4]arene in both diluents; and (ii) values of the equilibrium constants and the synergistic enhancements; the separation factors between metals were evaluated as well. The IL medium appears far superior to the molecular solvent in terms of individual and overall synergistic extraction efficiencies. However, the huge differences in extraction efficiencies observed in CHCl3 for chemically different ligands are erased in the IL medium, thus modifying the lever arms on which chemists should rely in order to obtain even better extracting systems in ionic liquid media.
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Comparing extraction, synergism and separation of lanthanoids using acidic and neutral compounds in chloroform and one ionic liquid: is the latter always “better”?
RSC Advances, 2014Co-Authors: Maria Atanassova, Vanya Kurteva, Lubomir Lubenov, Isabelle BillardAbstract:The complexation properties of a Pyrazolone Derivative, 3-methyl-1-phenyl-4-(4-trifluoromethylbenzoyl)-pyrazol-5-one (HL), in chloroform were examined and it was found that it possesses improved complexation ability in comparison with 4-benzoyl, 4-(4-methylbenzoyl) and 4-(4-fluorobenzoyl) Derivatives. Mixed ligand chelate extractions of trivalent lanthanoids (La, Nd, Eu, Ho and Lu) with HL and 5,11,17,23-tetra-tert-butyl-25,26,27-tris(dimethylphosphinoylpropoxy)-28-hydroxy-calix[4]arene (S1) or 5,11,17,23-tetra-tert-butyl-25,27-bis(dimethylphosphinoylpropoxy)-26,28-dihydroxy-calix[4]arene (S2) as synergistic agents were also carried out in chloride medium at constant ionic strength m ¼ 0.1 and CHCl 3 as organic phase. The interactions between the extractants in deuterochloroform were studied by 1 H, 13 C, and 31 P NMR. The composition of the extracted species was established as LnL 3 $HL (L À represents HL anion) with HL as a single extractant, and as LnL 3 $S in the presence of the phosphorus-containing calix[4]arene. On the basis of the experimental data, the values of the equilibrium constants were calculated. The influence of the number of P]O groups of tert-butyl-calix[4]arene on the extraction process was discussed. The synergistic enhancement and separation factors between metals were evaluated. Finally, the extraction of La(III) and Eu(III) ions was performed by using an ionic liquid, 1-butyl-3-methylimidazolium-bis(trifluoromethanesulfonyl)imide, as a solvent and varying the type of ligands. By comparison to CHCl 3 , the ionic liquid offers increased distribution ratios, at the expense of a levelling off of the separation factors. Reasons for such a phenomenon are discussed.
Richard D Ye - One of the best experts on this subject based on the ideXlab platform.
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functional characterization of three mouse formyl peptide receptors
Molecular Pharmacology, 2013Co-Authors: Hui Qiong He, Dan Liao, Zhen Guo Wang, Zhong Li Wang, Huchen Zhou, Mingwei Wang, Richard D YeAbstract:The evolutionary relationship and functional correlation between human formyl peptide receptors (FPRs) and their mouse counterparts remain incompletely understood. We examined three members of the mouse formyl peptide receptor subfamily (mFprs) and found that they differ in agonist preference and cellular distributions. When stably expressed in transfected rat basophilic leukemia (RBL-2H3) cells, mFpr1 was readily activated by N-formylated peptides derived from Listeria monocytogenes (fMIVTLF), Staphylococcus aureus (fMIFL), and mitochondria (fMMYALF). In contrast, the Escherichia coli–derived fMLF was 1000-fold less potent. The aforementioned peptides were much less efficacious at mFpr2, which responded better to the synthetic hexapeptide WKYMVm, the synthetic agonists Quin-C1 (a substituted quinazolinone), and compound 43 (a nitrosylated Pyrazolone Derivative). Saturation binding assays showed that mFpr1 and mFpr2 were expressed at similar levels on the cell surface, although their affinity for N-formyl-Met-Leu-Phe-Ile-Ile-Lys-fluorescein isothiocyanate varied by more than 1000-fold [dissociation constant (Kd) values of 2.8 nM for mFpr1 and 4.8 μM for mFpr2]). Contrary to these receptors, mFpr-rs1 responded poorly to all the previously mentioned peptides that were tested. Fluorescent microscopy revealed an intracellular distribution pattern of mFpr-rs1. On the basis of these results, we conclude that mFpr1 is an ortholog of human FPR1 with certain pharmacologic properties of human FPR2/ALX, whereas mFpr2 has much lower affinity for formyl peptides. The intracellular distribution of mFpr-rs1 suggests an evolutionary correlation with human FPR3.
Gamil A A Alhazmi - One of the best experts on this subject based on the ideXlab platform.
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illustration for series of new metal ion complexes extracted from Pyrazolone Derivative spectral thermal qsar dft b3lyp docking and antitumor investigations
Journal of Molecular Liquids, 2017Co-Authors: Fawaz A Saad, Nashwa M Elmetwaly, Thoraya A Farghaly, Marwa G Elghalban, Reem Shah, Gamil A A AlhazmiAbstract:Abstract New VO(II), Mn(II), Co(II), Ni(II) and Cu(II) - Pyrazolone complexes were isolated and deliberately characterized. The analytical and spectral tools emphasis on the isolation of bi-nuclear complexes except Mn(II) one. Spectral parameters and reduced magnetic moments are the bases for proposing bi-nuclear complexes. Variable coordination nos. are observed with isolated complexes in-between four, five or six coordination around central atoms. TG analysis and kinetic parameters are concerned in study to examine the thermal stability of complexes. Implementing Gaussian09 program to optimize the structural formula for the investigated compounds. Applying DFT/B3LYP method, the frontier energy gapes were calculated and other important theoretical parameters. QSAR calculations proposes a distinguish biological activity for Pyrazolone ligand. Molecular docking using Auto Dock tools were utilized to explain the experimental behavior of the organic compound towards the microorganisms through theoretical visualization. The docked complexes of 2YXS, 2CGY and 2JW2 protein receptors for prostate, colon and liver carcinoma were investigated and the complexation energies were calculated. The estimated energies display best expectation for excellence antitumor activity for Pyrazolone compound towards variable carcinoma. IC50 calculated represent an excellent priority for Cu(II) complex in overcoming liver and prostate carcinoma cell lines in comparing with reference drug. Moreover, the Mn(II) complex displays high comparative impact also with colon carcinoma.
