The Experts below are selected from a list of 11685 Experts worldwide ranked by ideXlab platform
Gérald Guillaumet - One of the best experts on this subject based on the ideXlab platform.
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Direct Arylation of Imidazo[1,2‐b]Pyridazines: Microwave‐Assisted One‐Pot Suzuki Coupling/Pd‐Catalysed Arylation
European Journal of Organic Chemistry, 2010Co-Authors: Ahmed El Akkaoui, Abderrahim Mouaddib, Sabine Berteina-raboin, Gérald GuillaumetAbstract:Direct intermolecular C-H arylation of 6-chloroimidazo[1,2-b]-pyridazine in its 3-position was achieved, and the tolerance to reaction conditions in the presence of chloro groups was investigated. Various 3-(hetero)arylimidazo[1,2-b]Pyridazines were synthesized in good to excellent yields. This methodology was successfully applied to the synthesis of 3,6-di-and 2,3,6-trisubstituted imidazo[1,2-b]Pyridazines by a microwave-assisted, one-pot, two-step Suzuki cross-coupling/ palladium-catalysed arylation process.
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direct arylation of imidazo 1 2 b Pyridazines microwave assisted one pot suzuki coupling pd catalysed arylation
European Journal of Organic Chemistry, 2010Co-Authors: Ahmed El Akkaoui, Abderrahim Mouaddib, Sabine Berteinaraboin, Gérald GuillaumetAbstract:Direct intermolecular C-H arylation of 6-chloroimidazo[1,2-b]-pyridazine in its 3-position was achieved, and the tolerance to reaction conditions in the presence of chloro groups was investigated. Various 3-(hetero)arylimidazo[1,2-b]Pyridazines were synthesized in good to excellent yields. This methodology was successfully applied to the synthesis of 3,6-di-and 2,3,6-trisubstituted imidazo[1,2-b]Pyridazines by a microwave-assisted, one-pot, two-step Suzuki cross-coupling/ palladium-catalysed arylation process.
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efficient and regioselective functionalization of imidazo 1 2 b Pyridazines via palladium catalyzed cross coupling reaction and snar
Tetrahedron Letters, 2008Co-Authors: El A Akkaoui, Abderrahim Mouaddib, Sabine Berteinaraboin, Jamal Koubachi, El S Kazzouli, Gérald GuillaumetAbstract:The synthesis of 3,6-disubstituted-2-phenylimidazo[1,2-b]pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross-coupling reactions were investigated to introduce alkynyl, alkenyl, and aryl at the 3-position of imidazo[1,2-b]Pyridazines. Then, at the 6-position, palladium-catalyzed N-arylation and direct SNAr were used to introduce amines and alcohols.
Richard T. Lewis - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of pyrido[2,3-d]Pyridazines and pyrazino[2,3-d]-Pyridazines—novel classes of GABAA receptor benzodiazepine binding site ligands
Tetrahedron Letters, 2006Co-Authors: Andrew Mitchinson, Wesley Peter Blackaby, Sylvie Bourrain, Robert W. Carling, Richard T. LewisAbstract:Abstract Novel syntheses of 2,3,8-trisubstituted pyrido[2,3- d ]Pyridazines and 2,3,5-trisubstituted pyrazino[2,3- d ]Pyridazines are described. Two complementary routes to pyrido[2,3- d ]Pyridazines were developed, the first of which began by constructing the pyridine ring, and the second of which started by constructing the pyridazine ring. Pyrazino[2,3- d ]Pyridazines were prepared in a route employing an aza-Wadsworth–Emmons cyclization as the key step. The resulting compounds were found to be high affinity ligands for the GABA A receptor benzodiazepine binding site.
Mohamed Elagawany - One of the best experts on this subject based on the ideXlab platform.
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palladium catalyzed synthesis of substituted pyrido 2 3 d Pyridazines at positions 5 and 8
Synthesis, 2012Co-Authors: Mohamed A Ibrahim, Emilie Blaise, Olivier Lozach, Claude Szalata, Martine Schmitt, Abdallah S Eletrawy, Mohamed ElagawanyAbstract:Several synthetic strategies were developed for the preparation of highly substituted pyrido[2,3- d ]Pyridazines. We particularly focused on the impact of the pyridine nitrogen atom on pyridazine ring reactivity toward aromatic substitutions, alkylations, or pallado-catalyzed cross-coupling reactions.
Mohamed A Ibrahim - One of the best experts on this subject based on the ideXlab platform.
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palladium catalyzed synthesis of substituted pyrido 2 3 d Pyridazines at positions 5 and 8
Synthesis, 2012Co-Authors: Mohamed A Ibrahim, Emilie Blaise, Olivier Lozach, Claude Szalata, Martine Schmitt, Abdallah S Eletrawy, Mohamed ElagawanyAbstract:Several synthetic strategies were developed for the preparation of highly substituted pyrido[2,3- d ]Pyridazines. We particularly focused on the impact of the pyridine nitrogen atom on pyridazine ring reactivity toward aromatic substitutions, alkylations, or pallado-catalyzed cross-coupling reactions.
Abderrahim Mouaddib - One of the best experts on this subject based on the ideXlab platform.
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Direct Arylation of Imidazo[1,2‐b]Pyridazines: Microwave‐Assisted One‐Pot Suzuki Coupling/Pd‐Catalysed Arylation
European Journal of Organic Chemistry, 2010Co-Authors: Ahmed El Akkaoui, Abderrahim Mouaddib, Sabine Berteina-raboin, Gérald GuillaumetAbstract:Direct intermolecular C-H arylation of 6-chloroimidazo[1,2-b]-pyridazine in its 3-position was achieved, and the tolerance to reaction conditions in the presence of chloro groups was investigated. Various 3-(hetero)arylimidazo[1,2-b]Pyridazines were synthesized in good to excellent yields. This methodology was successfully applied to the synthesis of 3,6-di-and 2,3,6-trisubstituted imidazo[1,2-b]Pyridazines by a microwave-assisted, one-pot, two-step Suzuki cross-coupling/ palladium-catalysed arylation process.
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direct arylation of imidazo 1 2 b Pyridazines microwave assisted one pot suzuki coupling pd catalysed arylation
European Journal of Organic Chemistry, 2010Co-Authors: Ahmed El Akkaoui, Abderrahim Mouaddib, Sabine Berteinaraboin, Gérald GuillaumetAbstract:Direct intermolecular C-H arylation of 6-chloroimidazo[1,2-b]-pyridazine in its 3-position was achieved, and the tolerance to reaction conditions in the presence of chloro groups was investigated. Various 3-(hetero)arylimidazo[1,2-b]Pyridazines were synthesized in good to excellent yields. This methodology was successfully applied to the synthesis of 3,6-di-and 2,3,6-trisubstituted imidazo[1,2-b]Pyridazines by a microwave-assisted, one-pot, two-step Suzuki cross-coupling/ palladium-catalysed arylation process.
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efficient and regioselective functionalization of imidazo 1 2 b Pyridazines via palladium catalyzed cross coupling reaction and snar
Tetrahedron Letters, 2008Co-Authors: El A Akkaoui, Abderrahim Mouaddib, Sabine Berteinaraboin, Jamal Koubachi, El S Kazzouli, Gérald GuillaumetAbstract:The synthesis of 3,6-disubstituted-2-phenylimidazo[1,2-b]pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross-coupling reactions were investigated to introduce alkynyl, alkenyl, and aryl at the 3-position of imidazo[1,2-b]Pyridazines. Then, at the 6-position, palladium-catalyzed N-arylation and direct SNAr were used to introduce amines and alcohols.