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Lahcen El Ammari - One of the best experts on this subject based on the ideXlab platform.
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Crystal structure of 2-(4-methoxyphenyl)-6-nitroimidazo[1,2-a]Pyridine-3-Carbaldehyde
Acta Crystallographica Section E Crystallographic Communications, 2015Co-Authors: Mohamed Koudad, Noureddine Benchat, Abdelmalik Elaatiaoui, Mohamed Saadi, Lahcen El AmmariAbstract:In the title compound, C15H11N3O4, the imidazo[1,2-a] pyridine ring system is almost planar [r.m.s. deviation = 0.028 (2) A]. Its mean plane makes dihedral angles of 33.92 (7) and 34.56 (6)° with the methoxyphenyl ring and the nitro group, respectively. The cohesion of the crystal structure is ensured by C—H⋯N and C—H⋯O hydrogen bonds, forming layers almost parallel to the ac plane.
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Crystal structure of 2-(4-meth-oxy-phen-yl)-6-nitro-imidazo[1,2-a]Pyridine-3-Carbaldehyde.
Acta crystallographica. Section E Crystallographic communications, 2015Co-Authors: Mohamed Koudad, Noureddine Benchat, Abdelmalik Elaatiaoui, Mohamed Saadi, Lahcen El AmmariAbstract:In the title compound, C15H11N3O4, the imidazo[1,2-a] pyridine ring system is almost planar [r.m.s. deviation = 0.028 (2) Å]. Its mean plane makes dihedral angles of 33.92 (7) and 34.56 (6)° with the meth-oxy-phenyl ring and the nitro group, respectively. The cohesion of the crystal structure is ensured by C-H⋯N and C-H⋯O hydrogen bonds, forming layers almost parallel to the ac plane.
Noureddine Benchat - One of the best experts on this subject based on the ideXlab platform.
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Crystal structure of 2-(4-methoxyphenyl)-6-nitroimidazo[1,2-a]Pyridine-3-Carbaldehyde
Acta Crystallographica Section E Crystallographic Communications, 2015Co-Authors: Mohamed Koudad, Noureddine Benchat, Abdelmalik Elaatiaoui, Mohamed Saadi, Lahcen El AmmariAbstract:In the title compound, C15H11N3O4, the imidazo[1,2-a] pyridine ring system is almost planar [r.m.s. deviation = 0.028 (2) A]. Its mean plane makes dihedral angles of 33.92 (7) and 34.56 (6)° with the methoxyphenyl ring and the nitro group, respectively. The cohesion of the crystal structure is ensured by C—H⋯N and C—H⋯O hydrogen bonds, forming layers almost parallel to the ac plane.
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Crystal structure of 2-(4-meth-oxy-phen-yl)-6-nitro-imidazo[1,2-a]Pyridine-3-Carbaldehyde.
Acta crystallographica. Section E Crystallographic communications, 2015Co-Authors: Mohamed Koudad, Noureddine Benchat, Abdelmalik Elaatiaoui, Mohamed Saadi, Lahcen El AmmariAbstract:In the title compound, C15H11N3O4, the imidazo[1,2-a] pyridine ring system is almost planar [r.m.s. deviation = 0.028 (2) Å]. Its mean plane makes dihedral angles of 33.92 (7) and 34.56 (6)° with the meth-oxy-phenyl ring and the nitro group, respectively. The cohesion of the crystal structure is ensured by C-H⋯N and C-H⋯O hydrogen bonds, forming layers almost parallel to the ac plane.
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Synthesis, antimicrobial and antifungal screening of novel chalcones containing imidazo[1,2-a] pyridine nucleus
2014Co-Authors: R. Saddik, A. Gaadaoui, M. Koudad, A. Ousaid, A. Elaatiaoui, Abdellah Hamal, Abdelkader Zarrouk, Noureddine BenchatAbstract:A series of chalcones were prepared by reacting various 2-(phenyl) imidazo [1,2-a] Pyridine-3-Carbaldehyde with acetophenones in the presence of alcoholic alkali. The structure elucidation of synthesized compounds has been done on the basis of elemental analysis, infrared and 1H nuclear magnetic resonance spectroscopy and further supported by Mass spectrometry. All the compounds have been evaluated for their in vitro biological assay like antibacterial activity towards Gram positive and Gram negative bacterial strains and antifungal activity towards Aspergillus niger at a concentration of 40μg/ml. The biological activities of synthesized compounds were compared with standard drugs.
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2-Phenyl-imidazo[1,2-a]Pyridine-3-Carbaldehyde.
Acta Crystallographica Section E Structure Reports Online, 2008Co-Authors: Abderrahman Anaflous, Hanane Albay, Noureddine Benchat, Brahim El Bali, Michal Dušek, Karla FejfarováAbstract:In the title compound, C14H10N2O, the dihedral angle between the imidazo[1,2-a]pyridine and phenyl rings is 28.61 (4)° The molecules are connected into broad chains parallel to the a axis by weak C—H⋯O and C—H⋯N hydrogen bonds. The linking of the ribbons is provided by π–π stacking interactions between neighbouring pyridine rings, with a centroid–centroid distance of 3.7187 (7) A.
Xuesen Fan - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of naphtho[1′,2′:4,5]imidazo[1,2-a]pyridines via Rh(III)-catalyzed C–H functionalization of 2-arylimidazo[1,2-a]pyridines with cyclic 2-diazo-1,3-diketones featuring with a ring opening and reannulation
Organic Chemistry Frontiers, 2020Co-Authors: Nana Shen, Xinying Zhang, Yang Yujie, Xuesen FanAbstract:An unprecedented synthesis of functionalized naphtho[1′,2′:4,5]imidazo[1,2-a]pyridines via rhodium-catalyzed cascade reactions of 2-arylimidazo[1,2-a]Pyridine-3-Carbaldehydes with cyclic α-diazo-1,3-diketones is presented. To our knowledge, this is the first example in which the title compounds were prepared through Rh(III)-catalyzed C–H bond carbenoid insertion and [5 + 1] annulation by using cyclic α-diazo-1,3-diketones as a C1 synthons featuring with a ring-opening and reannulation. Notably, a wide range of substrates and functional groups were well-tolerated under the optimized reaction conditions to produce products in good to excellent yields.
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Synthesis of fused imidazo[1,2-a]pyridines derivatives through cascade C(sp2)-H functionalizations.
Organic & Biomolecular Chemistry, 2019Co-Authors: Nana Shen, Xinying Zhang, Xuesen FanAbstract:An efficient and convenient synthesis of diversely substituted naphtho[1′,2′:4,5]imidazo[1,2-a]-pyridine derivatives from the cascade reactions of 2-arylimidazo[1,2-a]pyridines with a-diazo carbonyl compounds via Rh(III)-catalyzed regioselective C(sp2)–H alkylation followed by intramolecular annulation is presented. Interestingly, when simple 2-arylimidazo[1,2-a]pyridines were used as the substrates, 5,6-disubstituted naphtho[1′,2′:4,5]imidazo[1,2-a]pyridines were efficiently obtained, whereas using 2-arylimidazo[1,2-a]Pyridine-3-Carbaldehydes as the substrates afforded naphtho[1′,2′:4,5]imidazo[1,2-a]-pyridine-5-carboxylates as the dominating products. Compared with literature methods for the synthesis of naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine derivatives, the protocol presented herein has advantages such as easily obtainable substrates, simple operational procedure, high efficiency and excellent regio- and chemoselectivity.
Senguel Alpay Karaoglu - One of the best experts on this subject based on the ideXlab platform.
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synthesis of some new 1 2 4 triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities
European Journal of Medicinal Chemistry, 2009Co-Authors: Hacer Bayrak, Ahmet Demirbas, Neslihan Demirbas, Senguel Alpay KaraogluAbstract:5-Pyridin-4-yl-1,3,4-oxadiazole-2-thiol (2) was obtained from the reaction of isonicotinic acid hydrazide with carbon disulfide in basic media and converted into 4-amino-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (5) by the treatment with hydrazine hydrate. The synthesis of 3 and 6 was performed from the reaction of 2 and 5 with ethyl bromide. The treatment of 5 with 4-fluorobenzaldehyde or indol-3-carbaldehyde resulted in the formation of 4-[(arylmethylene)amino]-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiols (7a and 7b). The reactions of 2, 5 and 7a with some primary and secondary amines in the presence of formaldehyde afforded the corresponding Mannich bases, 4a, 4b, 9a-9c and 8. All newly synthesized compounds were screened for their antimicrobial activity. The antimicrobial activity study revealed that all the compounds screened showed good or moderate activity except compounds 2, 7a, 7b, 8 and 9b.
Farzaneh Mahmoudi - One of the best experts on this subject based on the ideXlab platform.
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a new nanohybrid material constructed from keggin type polyoxometalate and cd ii semicarbazone schiff base complex with excellent adsorption properties for the removal of cationic dye pollutants
Journal of Molecular Structure, 2017Co-Authors: Saeed Farhadi, Michal Dušek, Mostafa M Amini, Monika Kucerakova, Farzaneh MahmoudiAbstract:Abstract A novel nanohybrid material containing a Cd(II) semicarbazone Schiff base complex and phosphomolybdic acid, [Cd(H2L+)6][H2L]+4[PMo12O40]4·18CH3OH·4H2O (1), [HL = pyridine-2-carbaldehyde semicarbazone] was prepared by a simple sonochemical route and characterized by 1HNMR, 13CNMR, FT-IR, UV–vis, PXRD, FESEM, TG-DTA and BET-BJH surface area analysis. Also the single crystal 1, was characterized by single-crystal X-ray diffraction analysis. It crystallizes in the triclinic system with space group P-1 and is assembled into 3D supramolecular structure via hydrogen intermolecular interactions. The nanohybrid 1 was tested for the adsorption and removal of organic dyes such as methylene blue (MB), Rhodamine B (RhB) and methyl orange (MO) from aqueous solutions. The effects of parameters such as the dosage of adsorbent, the initial concentration and pH of dye solution were investigated on the removal efficiency of methylene blue. The nanohybrid 1 exhibited excellent adsorption ability towards cationic dyes. Moreover, it could be easily separated from the reaction solution and recycled up to three times without significant loss of adsorption activity.
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a new nano scale manganese ii coordination polymer constructed from semicarbazone schiff base and dicyanamide ligands synthesis crystal structure and dft calculations
Journal of Molecular Structure, 2016Co-Authors: Saeed Farhadi, Farzaneh Mahmoudi, Jim SimpsonAbstract:Abstract A new nano-structured Mn(II) coordination polymer [Mn(HL)(dca)(Cl)]n (1), [HL= Pyridine-2-carbaldehyde semicarbazone, dca= dicyanamide] has been synthesized by a sonochemical method and has been characterized by scanning electron microscopy, X-ray powder diffraction elemental analysis and IR spectroscopy. Single crystals of compound 1 was synthesized by slow evaporation method and was structurally characterised by single crystal X-ray diffraction. The single crystal structure shows one dimensional zig-zag chains with end-to-end dicyanamide-bridged ligand. A distorted octahedral geometry around the Mn2+centers was achieved by NNO atoms from HL, two nitrogen atoms of dicyanamide and one chlorine atom. Also for more details, the structure of 1, has been optimized by density functional theory (DFT calculations).
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two coordination polymers based on semicarbazone schiff base and azide synthesis crystal structure electrochemistry magnetic properties and biological activity
Journal of Coordination Chemistry, 2013Co-Authors: Behrouz Shaabani, Michal Dušek, Farzaneh Mahmoudi, Ali Akbar Khandar, Michaela Pojarova, A Feher, M KajňakovaAbstract:[Mn(L)(μ1,1–N3)2]2 n [Mn(H2O)2(μ1,1–N3)2] n (1) and [Cd(HL)(μ1,1–N3)2] n (2) have been synthesized from HL (HL: pyridine-2-carbaldehyde semicarbazone) and azide ligands, characterized by FT-IR, UV–vis spectroscopy and X-ray crystallography. Single crystal X-ray diffraction revealed that 1 is a coordination polymer consisting of two infinite 1-D chains: chain A with [Mn(L)(μ1,1–N3)2]2 n and chain B with [Mn(H2O)2(μ1,1–N3)2] n . In both chains, Mn centers are connected via two double end-on (EO) azide bridges. 2 is a coordination polymer consisting of a 1-D infinite chain, where Cd centers are connected via two double EO azide bridges. The electrochemistry of HL, 1 and 2 were studied by cyclic voltammetry. Magnetic susceptibility measurements indicate bulk ferromagnetic coupling for 1 below 5 K. Antimicrobial activities of both compounds 1 and 2 were greater than HL, with the strongest effect for 2 consistent with its larger radius and electronegativity of Cd(II) ions.
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synthesis crystal structure antimicrobial activity and electrochemistry study of chromium iii and copper ii complexes based on semicarbazone schiff base and azide ligands
Inorganica Chimica Acta, 2013Co-Authors: Behrouz Shaabani, Michal Dušek, Ali Akbar Khandar, Michaela Pojarova, Farzaneh MahmoudiAbstract:A tridentate NNO donor Schiff base ligand HL [HL: C5H4NCH=NNHCONH2] was obtained by condensation of pyridine 2-carbaldehyde with semicarbazide. The HL and azide ligands with Cr(III) and Cu(II) ions have been used to synthesize a dinuclear complex [Cr(L)(N3)(OCH3)]2(1) and a coordination polymer complex [Cu(L)(N3)]n(2). The ligand, 1 and 2 were clearly characterised by elemental analysis, FT-IR, UV–Vis spectral studies and the structures of the 1 and 2, have been studied by single crystal X-ray diffraction analysis. The results of X-ray diffraction analysis revealed Cr(III) and Cu(II) center are coordinated in a distorted octahedral and a square pyramidal geometries for 1 and 2 respectively. The ligand and the complexes were tested for their efficiency towards antimicrobial activity and the MIC data revealed that the HL, 1 and 2 have not strong activity in comparison to the standard drugs. The electrochemistry of the HL and its complexes were studied by cyclic voltammetry.
