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Rex E Shepherd - One of the best experts on this subject based on the ideXlab platform.
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synthesis and characterization of ru no bpp cl 2h2o bpp n n bis 2 Pyridinecarboxamide 1 3 propane dianion and ru no bpe cl 2h2o bpe n n bis 2 Pyridinecarboxamide 1 2 ethane dianion
Inorganica Chimica Acta, 2005Co-Authors: Carol F Fortney, Steven J Geib, Rex E ShepherdAbstract:Abstract Two ruthenium nitrosyl bis-pyridyl/biscarboxamido compounds, [Ru(NO)(bpp)Cl · 2H 2 O] [bpp = N , N ′-bis(2-Pyridinecarboxamide)-1,3-propane dianion] and [Ru(NO)(bpe)Cl · 2H 2 O] [bpe = N , N ′-(bis-2-Pyridinecarboxamide)-1,2-ethane dianion] have been characterized by 1 H NMR, 13 C{ 1 H} NMR, and IR spectroscopies, electrospray ionizaton mass spectrometry, and X-ray crystallography.
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Synthesis and characterization of [Ru(NO)(bpp)Cl 2H2O] [bpp = N,N' -bis (2 -Pyridinecarboxamide ) -1,3 -propane dianion] and [Ru(NO)(bpe)Cl 2H2O] [bpe = N,N'-bis(2-Pyridinecarboxamide)- 1,2-ethane dianion]
Inorganica Chimica Acta, 2005Co-Authors: Carol F Fortney, Steven J Geib, Rex E ShepherdAbstract:Abstract Two ruthenium nitrosyl bis-pyridyl/biscarboxamido compounds, [Ru(NO)(bpp)Cl · 2H 2 O] [bpp = N , N ′-bis(2-Pyridinecarboxamide)-1,3-propane dianion] and [Ru(NO)(bpe)Cl · 2H 2 O] [bpe = N , N ′-(bis-2-Pyridinecarboxamide)-1,2-ethane dianion] have been characterized by 1 H NMR, 13 C{ 1 H} NMR, and IR spectroscopies, electrospray ionizaton mass spectrometry, and X-ray crystallography.
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synthesis and characterization of a new runo 6 complex ru no bpb cl bpb n n bis 2 Pyridinecarboxamide 1 2 benzene dianion
Inorganic Chemistry Communications, 2004Co-Authors: Carol F Fortney, Rex E ShepherdAbstract:Abstract As part of our efforts to develop ruthenium nitrosyl compounds for use as nitric oxide delivery agents, a new six coordinate {RuNO}6 compound, [Ru(NO)(bpb)Cl] (bpb = N,N′-bis(2-Pyridinecarboxamide)-1,2-benzene dianion) was prepared from the reaction between [Ru(NO)Cl(H2O)2] and N,N′-bis(2-pyridine carboxamide)-1,2-benzene. We report here the characterization of this new compound by 1H, 13C, HH COSY, HMQC and HMBC NMR spectroscopy, IR spectroscopy (νNO = 1867 cm−1) and ESI-MS (M + Na+ 505.9).
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Synthesis and characterization of a new {RuNO} 6 complex, [Ru(NO)(bpb)Cl] (bpb=N,N¿-bis(2-Pyridinecarboxamide)-1,2-benzene dianion)
Inorganic Chemistry Communications, 2004Co-Authors: Carol F Fortney, Rex E ShepherdAbstract:Abstract As part of our efforts to develop ruthenium nitrosyl compounds for use as nitric oxide delivery agents, a new six coordinate {RuNO}6 compound, [Ru(NO)(bpb)Cl] (bpb = N,N′-bis(2-Pyridinecarboxamide)-1,2-benzene dianion) was prepared from the reaction between [Ru(NO)Cl(H2O)2] and N,N′-bis(2-pyridine carboxamide)-1,2-benzene. We report here the characterization of this new compound by 1H, 13C, HH COSY, HMQC and HMBC NMR spectroscopy, IR spectroscopy (νNO = 1867 cm−1) and ESI-MS (M + Na+ 505.9).
Shimoga R Prakash - One of the best experts on this subject based on the ideXlab platform.
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synthesis of c 14 and c 13 h 2 labeled ikk inhibitor 14c and 13c4 d3 n 6 chloro 7 methoxy 9h pyrido 3 4 b indol 8 yl 2 methyl 3 Pyridinecarboxamide
Journal of Labelled Compounds and Radiopharmaceuticals, 2006Co-Authors: Yuexian Li, Mihaela Plesescu, Shimoga R PrakashAbstract:[14C]-N-(6-Chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2-methyl-3-Pyridinecarboxamide (5B), an IKK inhibitor, was synthesized from [14C]-barium carbonate in two steps in an overall radiochemical yield of 41%. The intermediate, [carboxyl-14C]-2-methylnicotinic acid, was prepared by the lithiation and carbonation of 3-bromo-2-methylpyridine. [13C4,D3]-N-(6-chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2-methyl-3-Pyridinecarboxamide (5C) was synthesized from [1,2,3,4-13C4]-ethyl acetoacetate and [D4]-methanol in six steps in an overall yield of 2%. [13C4]-2-methylnicotic acid, was prepared by condensation of [13C4]-ethyl 3-aminocrotonate and acrolein, followed by hydrolysis with lithium hydroxide. Copyright © 2006 John Wiley & Sons, Ltd.
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Synthesis of C‐14 and C‐13, H‐2‐labeled IKK inhibitor: [14C] and [13C4,D3]‐N‐(6‐chloro‐7‐methoxy‐9H‐pyrido[3,4‐b]indol‐8‐yl)‐2‐methyl‐3‐Pyridinecarboxamide
Journal of Labelled Compounds and Radiopharmaceuticals, 2006Co-Authors: Yuexian Li, Mihaela Plesescu, Shimoga R PrakashAbstract:[14C]-N-(6-Chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2-methyl-3-Pyridinecarboxamide (5B), an IKK inhibitor, was synthesized from [14C]-barium carbonate in two steps in an overall radiochemical yield of 41%. The intermediate, [carboxyl-14C]-2-methylnicotinic acid, was prepared by the lithiation and carbonation of 3-bromo-2-methylpyridine. [13C4,D3]-N-(6-chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2-methyl-3-Pyridinecarboxamide (5C) was synthesized from [1,2,3,4-13C4]-ethyl acetoacetate and [D4]-methanol in six steps in an overall yield of 2%. [13C4]-2-methylnicotic acid, was prepared by condensation of [13C4]-ethyl 3-aminocrotonate and acrolein, followed by hydrolysis with lithium hydroxide. Copyright © 2006 John Wiley & Sons, Ltd.
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synthesis of c 14 labeled novel ikk inhibitor 2 14c n 6 chloro 9h pyrido 3 4 b indol 8 yl 3 Pyridinecarboxamide
Journal of Labelled Compounds and Radiopharmaceuticals, 2005Co-Authors: Yuexian Li, Shimoga R PrakashAbstract:2-[14C]-N-(6-Chloro-9H-pyrido [3,4-b]indol-8-yl)-3-Pyridinecarboxamide (9A, also referred to as [14C]-PS-1145) was synthesized from [14C]-paraformaldehyde in five steps in an overall radiochemical yield of 15%. The key intermediate 1-[14C]-6-chloro-1,2,3,4-tetrahydro-β-carboline was obtained by Pictet–Spengler cyclization of chlorotryptamine with [14C]-paraformaldehyde. Similar reactions were conducted with tryptamine to address the generality of the methodology. Copyright © 2005 John Wiley & Sons, Ltd.
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Synthesis of C‐14‐labeled novel IKK inhibitor: 2‐[14C]‐N‐(6‐chloro‐9H‐pyrido [3,4‐b]indol‐8‐yl)‐3‐Pyridinecarboxamide
Journal of Labelled Compounds and Radiopharmaceuticals, 2005Co-Authors: Yuexian Li, Shimoga R PrakashAbstract:2-[14C]-N-(6-Chloro-9H-pyrido [3,4-b]indol-8-yl)-3-Pyridinecarboxamide (9A, also referred to as [14C]-PS-1145) was synthesized from [14C]-paraformaldehyde in five steps in an overall radiochemical yield of 15%. The key intermediate 1-[14C]-6-chloro-1,2,3,4-tetrahydro-β-carboline was obtained by Pictet–Spengler cyclization of chlorotryptamine with [14C]-paraformaldehyde. Similar reactions were conducted with tryptamine to address the generality of the methodology. Copyright © 2005 John Wiley & Sons, Ltd.
Carol F Fortney - One of the best experts on this subject based on the ideXlab platform.
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synthesis and characterization of ru no bpp cl 2h2o bpp n n bis 2 Pyridinecarboxamide 1 3 propane dianion and ru no bpe cl 2h2o bpe n n bis 2 Pyridinecarboxamide 1 2 ethane dianion
Inorganica Chimica Acta, 2005Co-Authors: Carol F Fortney, Steven J Geib, Rex E ShepherdAbstract:Abstract Two ruthenium nitrosyl bis-pyridyl/biscarboxamido compounds, [Ru(NO)(bpp)Cl · 2H 2 O] [bpp = N , N ′-bis(2-Pyridinecarboxamide)-1,3-propane dianion] and [Ru(NO)(bpe)Cl · 2H 2 O] [bpe = N , N ′-(bis-2-Pyridinecarboxamide)-1,2-ethane dianion] have been characterized by 1 H NMR, 13 C{ 1 H} NMR, and IR spectroscopies, electrospray ionizaton mass spectrometry, and X-ray crystallography.
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Synthesis and characterization of [Ru(NO)(bpp)Cl 2H2O] [bpp = N,N' -bis (2 -Pyridinecarboxamide ) -1,3 -propane dianion] and [Ru(NO)(bpe)Cl 2H2O] [bpe = N,N'-bis(2-Pyridinecarboxamide)- 1,2-ethane dianion]
Inorganica Chimica Acta, 2005Co-Authors: Carol F Fortney, Steven J Geib, Rex E ShepherdAbstract:Abstract Two ruthenium nitrosyl bis-pyridyl/biscarboxamido compounds, [Ru(NO)(bpp)Cl · 2H 2 O] [bpp = N , N ′-bis(2-Pyridinecarboxamide)-1,3-propane dianion] and [Ru(NO)(bpe)Cl · 2H 2 O] [bpe = N , N ′-(bis-2-Pyridinecarboxamide)-1,2-ethane dianion] have been characterized by 1 H NMR, 13 C{ 1 H} NMR, and IR spectroscopies, electrospray ionizaton mass spectrometry, and X-ray crystallography.
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synthesis and characterization of a new runo 6 complex ru no bpb cl bpb n n bis 2 Pyridinecarboxamide 1 2 benzene dianion
Inorganic Chemistry Communications, 2004Co-Authors: Carol F Fortney, Rex E ShepherdAbstract:Abstract As part of our efforts to develop ruthenium nitrosyl compounds for use as nitric oxide delivery agents, a new six coordinate {RuNO}6 compound, [Ru(NO)(bpb)Cl] (bpb = N,N′-bis(2-Pyridinecarboxamide)-1,2-benzene dianion) was prepared from the reaction between [Ru(NO)Cl(H2O)2] and N,N′-bis(2-pyridine carboxamide)-1,2-benzene. We report here the characterization of this new compound by 1H, 13C, HH COSY, HMQC and HMBC NMR spectroscopy, IR spectroscopy (νNO = 1867 cm−1) and ESI-MS (M + Na+ 505.9).
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Synthesis and characterization of a new {RuNO} 6 complex, [Ru(NO)(bpb)Cl] (bpb=N,N¿-bis(2-Pyridinecarboxamide)-1,2-benzene dianion)
Inorganic Chemistry Communications, 2004Co-Authors: Carol F Fortney, Rex E ShepherdAbstract:Abstract As part of our efforts to develop ruthenium nitrosyl compounds for use as nitric oxide delivery agents, a new six coordinate {RuNO}6 compound, [Ru(NO)(bpb)Cl] (bpb = N,N′-bis(2-Pyridinecarboxamide)-1,2-benzene dianion) was prepared from the reaction between [Ru(NO)Cl(H2O)2] and N,N′-bis(2-pyridine carboxamide)-1,2-benzene. We report here the characterization of this new compound by 1H, 13C, HH COSY, HMQC and HMBC NMR spectroscopy, IR spectroscopy (νNO = 1867 cm−1) and ESI-MS (M + Na+ 505.9).
Yuexian Li - One of the best experts on this subject based on the ideXlab platform.
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synthesis of c 14 and c 13 h 2 labeled ikk inhibitor 14c and 13c4 d3 n 6 chloro 7 methoxy 9h pyrido 3 4 b indol 8 yl 2 methyl 3 Pyridinecarboxamide
Journal of Labelled Compounds and Radiopharmaceuticals, 2006Co-Authors: Yuexian Li, Mihaela Plesescu, Shimoga R PrakashAbstract:[14C]-N-(6-Chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2-methyl-3-Pyridinecarboxamide (5B), an IKK inhibitor, was synthesized from [14C]-barium carbonate in two steps in an overall radiochemical yield of 41%. The intermediate, [carboxyl-14C]-2-methylnicotinic acid, was prepared by the lithiation and carbonation of 3-bromo-2-methylpyridine. [13C4,D3]-N-(6-chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2-methyl-3-Pyridinecarboxamide (5C) was synthesized from [1,2,3,4-13C4]-ethyl acetoacetate and [D4]-methanol in six steps in an overall yield of 2%. [13C4]-2-methylnicotic acid, was prepared by condensation of [13C4]-ethyl 3-aminocrotonate and acrolein, followed by hydrolysis with lithium hydroxide. Copyright © 2006 John Wiley & Sons, Ltd.
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Synthesis of C‐14 and C‐13, H‐2‐labeled IKK inhibitor: [14C] and [13C4,D3]‐N‐(6‐chloro‐7‐methoxy‐9H‐pyrido[3,4‐b]indol‐8‐yl)‐2‐methyl‐3‐Pyridinecarboxamide
Journal of Labelled Compounds and Radiopharmaceuticals, 2006Co-Authors: Yuexian Li, Mihaela Plesescu, Shimoga R PrakashAbstract:[14C]-N-(6-Chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2-methyl-3-Pyridinecarboxamide (5B), an IKK inhibitor, was synthesized from [14C]-barium carbonate in two steps in an overall radiochemical yield of 41%. The intermediate, [carboxyl-14C]-2-methylnicotinic acid, was prepared by the lithiation and carbonation of 3-bromo-2-methylpyridine. [13C4,D3]-N-(6-chloro-7-methoxy-9H-pyrido [3,4-b]indol-8-yl)-2-methyl-3-Pyridinecarboxamide (5C) was synthesized from [1,2,3,4-13C4]-ethyl acetoacetate and [D4]-methanol in six steps in an overall yield of 2%. [13C4]-2-methylnicotic acid, was prepared by condensation of [13C4]-ethyl 3-aminocrotonate and acrolein, followed by hydrolysis with lithium hydroxide. Copyright © 2006 John Wiley & Sons, Ltd.
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synthesis of c 14 labeled novel ikk inhibitor 2 14c n 6 chloro 9h pyrido 3 4 b indol 8 yl 3 Pyridinecarboxamide
Journal of Labelled Compounds and Radiopharmaceuticals, 2005Co-Authors: Yuexian Li, Shimoga R PrakashAbstract:2-[14C]-N-(6-Chloro-9H-pyrido [3,4-b]indol-8-yl)-3-Pyridinecarboxamide (9A, also referred to as [14C]-PS-1145) was synthesized from [14C]-paraformaldehyde in five steps in an overall radiochemical yield of 15%. The key intermediate 1-[14C]-6-chloro-1,2,3,4-tetrahydro-β-carboline was obtained by Pictet–Spengler cyclization of chlorotryptamine with [14C]-paraformaldehyde. Similar reactions were conducted with tryptamine to address the generality of the methodology. Copyright © 2005 John Wiley & Sons, Ltd.
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Synthesis of C‐14‐labeled novel IKK inhibitor: 2‐[14C]‐N‐(6‐chloro‐9H‐pyrido [3,4‐b]indol‐8‐yl)‐3‐Pyridinecarboxamide
Journal of Labelled Compounds and Radiopharmaceuticals, 2005Co-Authors: Yuexian Li, Shimoga R PrakashAbstract:2-[14C]-N-(6-Chloro-9H-pyrido [3,4-b]indol-8-yl)-3-Pyridinecarboxamide (9A, also referred to as [14C]-PS-1145) was synthesized from [14C]-paraformaldehyde in five steps in an overall radiochemical yield of 15%. The key intermediate 1-[14C]-6-chloro-1,2,3,4-tetrahydro-β-carboline was obtained by Pictet–Spengler cyclization of chlorotryptamine with [14C]-paraformaldehyde. Similar reactions were conducted with tryptamine to address the generality of the methodology. Copyright © 2005 John Wiley & Sons, Ltd.
Rudong Yang - One of the best experts on this subject based on the ideXlab platform.
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synthesis characterization and luminescence properties of n n bis 2 Pyridinecarboxamide 1 n oxide 1 2 ethane and corresponding lanthanide iii complexes
Journal of Luminescence, 2007Co-Authors: Haijun Zhang, Gang Li, Rudong YangAbstract:Abstract Several lanthanide (Ln) complexes (Ln=Eu(III), Gd(III), Tb(III)) with a new ligand N,N′-bis(2-Pyridinecarboxamide-1-N-oxide)-1,2-ethane (LH2), containing two pyridine N-oxide chromophores and a flexibly connected N,N′-dicarboxamide-1,2-ethane, have been prepared and characterized by elemental analysis, conductivity measurements, IR spectra and thermal studies. The luminescence properties of the series of lanthanide complexes in solid state were investigated. Also, we compared the relative fluorescent intensities of these complexes with corresponding complexes with nonoxide derivative N,N′-bis(2-Pyridinecarboxamide)-1,2-ethane (L′H2). The results have shown that pyridine-N-oxide group is an excellent sensitizer to lanthanide luminescence over pyridine group.